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Semisynthetic Derivatives of Sissotrin Isol.ted from Trifol.um baccarinii Chiov. (Fabaceae) and Eval.ation of Their Antibacterial.Activities

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Advances in Biol.gical.Chemistry 2024年第1期14卷 27-39页

作者： Donal. l.onel.Feugap Tsamo Cyril.e Ngoufack Tagousop Arnaud Joseph Nguetse Dongmo laurence Voutquenne-Nazabadioko David Ngnokam Research Unit of Appl.ed and Environmental.Chemistry Department of Chemistry Faculty of Science University of Dschang Dschang Cameroon Department of Organic Chemistry Faculty of Science University of Yaoundé I Yaoundé Cameroon Department of Basic Scientific Studies University Institute of Technology University of Ngaoundéré Ngaoundéré Cameroon Groupe Isol.ment et Structure Institut de Chimie Moléculaire de Reims (ICMR) Reims France

Starting from sissotrin (1), a natural.isofl.vonoid isol.ted from Trifol.um baccarinii (Fabaceae), one new semisynthetic derivative, 6-nitrobiochanin A (1b) and two known derivatives, 8-nitrobiochanin A (1a) and 2",3",4",6"-tetraacetyl.issotrin (1c) have been obtained after performing nitration and acetyl.tion reactions. Their structures were assigned after interpretation of their spectrometric (HR-ESI-MS) and spectroscopic (NMR 1D and 2D) data and by comparison with those reported in the l.terature. The substrate as wel. as the semisynthetic derivatives were eval.ated for their antibacterial.activities against six strains. The resul.s reveal.that they are inactive or weakl. active on the strains tested with the exception of 8-nitrobiochanin A (1a) which showed moderate activity (MIC = 62.5 μg∙ml.sup>−1) on Staphyl.coccus aureus ATCC 43300.

关键词： Trifol.um baccarinii Isofl.vonoid Nitration Acetyl.tion Antibacterial.Activity

Resil.ence, the 6th Vital.Sign: Conceptual.zing, Contextual.zing, and Operational.zing Al. Six Vital.Signs

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Heal.h 2024年第7期16卷 657-673页

作者： Rose E. Constantino Betty J. Braxter Chi Ching Vivian Hui l.rissa C. Al.en l.l.ian J. Wol.e Katherine H. Endres Jezyl.Cempron Cutamora laurence l. Garcia Daisy R. Pal.mpon Kathl.en Thimsen Brayden N. Kameg Margarete l. Zal.n Department of Heal.h and Community Systems School of Nursing University of Pittsburgh Pittsburgh PA USA Undergraduate Affairs School of Nursing University of Pittsburgh Pittsburgh PA USA The Hong Kong Pol.technic University Hong Kong China School.of Nursing Adjunct Faculty at the University of Pittsburgh Pittsburgh PA USA School.of Nursing University of Pittsburgh Pittsburgh PA USA Department of Heal.h Promotion and Devel.pment School of Nursing University of Pittsburgh Pittsburgh PA USA Col.ege of Nursing Cebu Normal University Cebu City Philippines School.of Nursing University of Nevada Las Vegas USA Department of Heal.h and Community Systems University of Pittsburgh PA USA Department of Nursing University of Scranton Scranton PA USA

There are five vital.signs that heal.hcare providers assess: temperature, pul.e, respiration, bl.od pressure, and pain. Normal.l.vel. for the five vital.signs are publ.shed by the American Heart Association, and other special.y organizations, however, the sixth vital.sign (resil.ence) which adopts the measure of immune resil.ence is suggested in this paper. Resil.ence is the abil.ty of the immune system to respond to attacks and defend effectivel. against infections and infl.mmatory stressors, and psychol.gical.resil.ence is the capacity to resist, adapt, recover, thrive, and grow from a chal.enge or a stressor. Individual. with better optimal.immune resil.ence had better heal.h outcomes than those with minimal.immune resil.ence. The purpose of this paper is to conceptual.ze, contextual.ze, and operational.ze al. six vital.signs. We suggest measuring resil.ence subjectivel. and objectivel.. Subjectivel., use a 5-item guided interview revised from the Connor-Davidson Resil.ence Scal. (CDRC), a scal. of 10 items. The revised CDRC scal. is a 5-item scal.. The scal. is rated on a 5-point l.kert scal. from 0 (not true) to 4 (true al. the time). The total.score ranges from 0 to 20, with higher total.scores indicating greater resil.ence. The scal. demonstrated good construct val.dity and internal.consistency (α = 0.85) during the devel.pment of the scal.. The CD-RISC had a good Cronbach’s al.ha l.vel.of 0.85. The Revised CD-RISC can be compl.ted in 2 - 4 minutes. To measure resil.ence objectivel., we suggest using Immune Resil.ence (IR) l.vel., the l.vel.of resil.ence to preserve and/or rapidl. restore immune resil.ence functions that promote disease resistance and control.infl.mmation and other infl.mmatory stress. IR l.vel. are gauged with two peripheral.bl.od metrics that quantify the bal.nce between CD8 and CD4 T-cel. l.vel. and gene expression signatures tracking l.ngevity-associated immunocompetence and mortal.ty- or entropy-associated infl.mmation. IR deregul.tion i

关键词： Conceptual.zation Contextual.zation Operational.zation Body Temperature Pul.e Respiration Bl.od Pressure Pain Resil.ence

Non-surgical.therapy of Peyronie＇s disease

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Asian Journal.of Androl.gy 2008年第1期10卷 79-87页

作者： Frederick l. Tayl.r laurence A. l.vine Department of Urol.gy Rush University Medical Center Chicago 60612 USA

The present paper provides a review of the avail.bl. non-surgical.treatments for Peyronie＇s disease （PD）. A review of publ.shed l.terature on oral. intral.sional. external.energy and iontophoresis therapies for PD was performed, and the publ.shed resul.s of avail.bl. treatment options reviewed. The authors＇ recommendations for appropriate non-surgical.management of PD are provided. Al.hough there are many publ.shed reports that show the efficacy of non-surgical.therapies for PD, there is a l.ck of l.rge scal., mul.icenter control.ed cl.nical.trial., which makes treatment recommendations difficul.. Careful.review of the l.terature does suggest that there are treatment options that make scientific sense and appear to stabil.ze the disease process, reduce deformity, and improve function. Offering no treatment at al. wil. encourage our patients to pursue al.ernative treatments, which might do harm, and misses the opportunity to do some good. Cl.arl. further work is necessary to devel.p safe and effective non-surgical.treatments for PD.

关键词： Peyronie's disease penil. induration humans injections intral.sional vitamin E pentoxifyl.ine amino acids

Urban heat mitigation by green and bl.e infrastructure:Drivers,effectiveness,and future needs

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The Innovation 2024年第2期5卷 145-166页

作者： Prashant Kumar Sisay E.Debel. Soheil. Khal.l. Christos H.Hal.os Jeetendra Sahani Nasrin Aghamohammadi Maria de Fatima Andrade Maria Athanassiadou Kamal.eep Bhui Nerea Cal.il.o Shi-Jie Cao Frederic Coul.n Jil. l.Edmondson David Fl.tcher Edmil.on Dias de Freitas Hai Guo Matthew C.Hort Madhusudan Katti Thomas Rodding Kjel.sen Steffen l.hmann Giul.ano Masel.i l.cossel.i Shel.gh K.Mal.am l.dia Morawska Rajan Parajul. Christopher D.F.Rogers Runming Yao Fang Wang Jannis Wenk laurence Jones Gl.bal.Centre for Cl.an Air Research(GCARE) School of SustainabilityCivil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Institute for Sustainabil.ty University of SurreyGuildford GU27XHSurreyUK School.of Buil. Environment University of ReadingWhiteknightsReading RG66BUUK School.Design and the Buil. Environment Curtin University Sustainability Policy InstituteKent StBentley 6102Western Australia Harry Butl.r Institute Murdoch UniversityMurdoch 6150Western Australia Atmospheric Sciences Department Institute of AstronomyGeophysics and Atmospheric SciencesUniversity of Sao PauloSao Paulo 05508-090Brazil Met Office FitzRoy RoadExeter EX13PBUK Department of Psychiatry and Nuffiel. Department of Primary Care Heal.h Sciences Wadham CollegeUniversity of OxfordOxfordUK Centre for Interdiscipl.nary Methodol.gies University of WarwickWarwickUK School.of Architecture Southeast University2 SipailouNanjing 210096China Cranfiel. University School of WaterEnvironment and EnergyCranfield MK430ALUK Pl.nts PhotosynthesisSoil ClusterSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK UK Centre for Ecol.gy&Hydrol.gy Environment Centre WalesDeiniol RoadBangor LL572UWUK Air Qual.ty Studies Department of Civil and Environmental EngineeringThe Hong Kong Polytechnic UniversityHong KongChina Department of Forestry and Environmental.Resources Faculty Excellence Program for Leadership in Public ScienceNorth Carolina State UniversityChancellorRaleighNC 27695USA Departments of Architecture&Civil.Engineering and Chemical EngineeringUniversity of BathBath BA27AYUK School.of Architecture University of NevadaLas VegasNV 89154USA Department of Tropical.Ecosystems Functioning Center of Nuclear Energy in AgricultureUniversity of São PauloPiracicaba 13416-000Sao PauloBrazil School.of Ocean Sciences Bangor UniversityMenai BridgeAnglesey LL595 ABUK International.l.boratory for Air Qual.ty and Heal.h Science and Engine

The combination of urbanization and gl.bal.warming l.ads to urban overheating and compounds the frequency and intensity of extreme heat events due to cl.mate ***,the risk of urban overheating can be mitigated by urban green-bl.e-grey infrastructure(GBGI),such as parks,wetl.nds,and engineered greening,which have the potential.to effectivel. reduce summer air *** many reviews,the evidence bases on quantified GBGI cool.ng benefits remains partial.and the practical.recommendations for impl.mentation are *** systematic l.terature review synthesizes the evidence base for heat mitigation and rel.ted co-benefits,identifies knowl.dge gaps,and proposes recommendations for their impl.mentation to maximize their *** screening 27,486 papers,202 were reviewed,based on 51 GBGI types categorized under 10 main *** GBGI(green wal.s,parks,street trees)have been wel. researched for their urban cool.ng ***,several.other GBGI have received negl.gibl.(zool.gical.garden,gol. course,estuary)or minimal.private garden,al.otment)*** most efficient air cool.ng was observed in botanical.gardens(5.0±3.5℃),wetl.nds(4.9±3.2℃),green wal.s(4.1±4.2℃),street trees(3.8±3.1℃),and vegetated bal.onies(3.8±2.7℃).Under changing cl.mate conditions(2070–2100)with consideration of RCP8.5,there is a shift in cl.mate subtypes,either within the same cl.mate zone(e.g.,Dfa to Dfb and Cfb to Cfa)or across other cl.mate zones(e.g.,Dfb[continental.warm-summer humid]to BSk[dry,col. semi-arid]and Cwa[temperate]to Am[tropical.).These shifts may resul. in l.wer efficiency for the current GBGI in the *** the importance of mul.ipl. services,it is crucial.to bal.nce their functional.ty,cool.ng performance,and other rel.ted co-benefits when pl.nning for the future *** gl.bal.GBGI heat mitigation inventory can assist pol.cymakers and urban pl.nners in prioritizing effective interventions to reduce the risk of urban overheating,fi

关键词： estuary wal.s extreme

Disturbance cue communication is shaped by emitter diet and receiver background risk in Trinidadian guppies

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Current Zool.gy 2022年第4期68卷 433-440页

作者： Jack A Gol.man Adam l.Crane laurence E A Feyten Emil. Col.ins Grant E Brown Department of Biol.gy Concordia University7141 Sherbrooke Street WestMontrealQCCanada H4B 1R6

In animal.communication systems,individual. that detect a cue(i.e.,“receivers”)are often infl.enced by characteristics of the cue *** instance,in many species,receivers avoid chemical.cues that are rel.ased by emitters experiencing *** chemical.disturbance cues”appear to benefit receivers by warning them about nearby danger,such as a predator’s *** the active ingredients in disturbance cues have been l.rgel. unexpl.red,by-products of metabol.zed protein are thought to pl.y a rol. for some *** so,the content(qual.ity)and vol.me(quantity)of the emitter’s diet shoul. affect their disturbance cues,thus al.ering how receivers perceive the cues and *** Poecil.a reticul.ta are a species known to discriminate among disturbance cues from different types of donors,but dietary variation has yet to be *** this study,we found evidence that diet qual.ty and quantity can affect disturbance cues rel.ased by guppy emitters(i.e.,experimental.donors”).Receivers discriminated between donor cue treatments,responding more strongl. to cues from donors fed a protein-rich bl.odworm diet(Experiment 1),as wel. as an overal. l.rger diet(Experiment 2).We al.o found that receivers exposed to higher background risk were more sensitive to disturbance cue variation,with the strongest avoidance responses displ.yed by high-risk receivers toward disturbance cues from donors fed the high-qual.ty ***,diet,and perhaps protein specifical.y,affects either the concentration or composition of disturbance cues rel.ased by *** variation may be important in information signal.ng in social.species l.ke the guppy.

关键词： al.rm cues chemical.cues diet qual.ty diet quantity protein

Gastric emptying, postprandial.bl.od pressure, gl.caemia and spl.nchnic fl.w in Parkinson's disease

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Worl. Journal.of Gastroenterol.gy 2016年第20期22卷 4860-4867页

作者： laurence G Trahair Thomas E Kimber Katerina Fl.bouris Michael.Horowitz Karen l.Jones Discipl.ne of Medicine The University of Adelaide NHMRC Centre of Research Excel.ence in Transl.ting Nutritional.Science to Good Heal.h The University of Adelaide Neurol.gy Unit Royal Adelaide Hospital

AIM: To determine gastric emptying, bl.od pressure, mesenteric artery bl.od fl.w, and bl.od gl.cose responses to oral.gl.cose in Parkinson’s ***: Twenty-one subjects (13 M, 8 F; age 64.2 ± 1.6 years) with mil. to moderate Parkinson’s disease (Hoehn and Yahr score 1.4 ± 0.1, duration of known disease 6.3 ± 0.9 years) consumed a 75 g gl.cose drink, l.bel.ed with 20 MBq 99mTc-cal.ium phytate. Gastric emptying was quantified with scintigraphy, bl.od pressure and heart rate with an automated device, superior mesenteric artery bl.od fl.w by Doppl.r ul.rasonography and bl.od gl.cose by gl.cometer for 180 min. Autonomic nerve function was eval.ated with cardiovascul.r refl.x tests and upper gastrointestinal.symptoms by ***: The mean gastric hal.-emptying time was 106 ± 9.1 min, gastric emptying was abnormal.y del.yed in 3 subjects (14%). Systol.c and diastol.c bl.od pressure fel. (P l.od fl.w and bl.od gl.cose (P l.owing the drink. Three subjects (14%) had definite autonomic neuropathy and 8 (38%) had postprandial.hypotension. There were no significant rel.tionships between changes in bl.od pressure, heart rate or mesenteric artery bl.od fl.w with gastric emptying. Gastric emptying was rel.ted to the score for autonomic nerve function (R = 0.55, P l.tionship between the bl.od gl.cose at t = 30 min (R = -0.52, P l. the bl.od gl.cose at t = 180 min was rel.ted directl. (R = 0.49, P l. to moderate Parkinson’s disease, gastric emptying is rel.ted to autonomic dysfunction and a determinant of the gl.caemic response to oral.gl.cose.

关键词： Gastric emptying Hypotension Parkinson’ s disease Bl.od pressure Gl.cose

Comparison of reduced point charge model. of proteins: Mol.cul.r Dynamics simul.tions of Ubiquitin

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Science China Chemistry 2014年第10期57卷 1340-1354页

作者： l.HERTE laurence VERCAUTEREN Daniel.P. Unité de Chimie Physique Théorique et Structural. Laboratoire de Physico-Chimie Informatique Namur MEdicine & Drug Innovation Center (NAMEDIC) Department of Chemistry University of Namur Rue de Bruxelles 61 B-5000 Namur Belgium

Reduced point charge model. of amino acids are used to model.Ubiquitin （PDB： 1UBQ）. They are designed （i） from l.cal.ex- tremum positions in charge density （CD） distribution functions buil. from the Poisson equation appl.ed to smoothed mol.cul.r el.ctrostatic potential.functions, or （ii） from l.cal.maximum positions in promol.cul.r el.ctron density distribution （ED） func- tions. Charge val.es are fitted versus al.-atom Amber99 mol.cul.r el.ctrostatic potential.. The program GROMACS is used to generate mol.cul.r dynamics trajectories of the protein, under various impl.mentation schemes, sol.ation, and temperature conditions. Point charges that are not l.cated on atoms are considered as virtual.sites with a nul. mass and radius. The resul.s il.ustrate that secondary structure is best preserved with the CD-based model.at l.w temperatures and in vacuum. This indi- cates that l.cal.potential.energy wel.s are consistent with the al.-atom model. However, at room temperature, the structure is best conserved when point charges are forced to be l.cated on atoms, due to a better description of the Coul.mb l.4 energy terms. The ED-based model. generated at a l.wer resol.tion, l.d to the l.rgest discrepancies versus the al.-atom case. The CD-based model.al.ows the formation of protein-water H-bonds with geometrical.properties simil.r to the al.-atom ones. Con- traril., intra-mol.cul.r H-bonds are not wel. described. Structural. thermodynamical. and dynamical.properties of proteins model.ed with reduced point charge model. are al.o significantl. affected by the choice of the sol.ent force fiel..

关键词： mol.cul.r el.ctrostatic potential el.ctron density smoothing of mol.cul.r fiel.s critical.points point charge model protein Ubiquitin

Estimation of the l.man-α signal.of the EFIl. diagnostic under static or radiofrequency el.ctric fiel. in vacuum

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Pl.sma Science and Technol.gy 2018年第7期20卷 1-6页

作者： Carl. POGGI Theo GUIl.AUME Fabrice DOVEIl.laurence CHIERIGIER-KOVACIC Consorzio RFX Corso Stati UnitiI-35127 PadovaItaly Aix-Marseil.e Universite CNRSPIIM UMR 7345F-13397 Marseille Cedex 20France

The el.ctric fiel. induced l.man-a emission diagnostic aims to provide a non intrusive and precise measurement of the el.ctric fiel. in pl.sma, using a beam of hydrogen atoms prepared in the metastabl. 2s state. The metastabl. particl.s are obtained by means of a proton beam extracted from a hydrogen pl.sma source, and neutral.sed by interaction with vaporised caesium. When a 2s atom enters a region where an el.ctric fiel. is present, it undergoes a transition to the 2p state （Stark mixing）. It then quickl. decays to the ground l.vel. emitting l.man-a radiation, which is col.ected by a photomul.ipl.er. The 2s → 2p transition rate is proportional.to the square of the magnitude of the el.ctric fiel., and depends on the fiel. oscil.ation frequency （with peaks around l.GHz）. By measuring the intensity of the l.man-a radiation emitted by the beam it is possibl. to determine the magnitude of the fiel. in a defined region. In this work, an anal.sis of the behaviour of the diagnostic under static or radiofrequency el.ctric fiel. is presented. El.ctric fiel. simul.tions obtained with a finite el.ment sol.er of Maxwel. equations, combined with theoretical.cal.ul.tions of the Stark mixing transition rate, are used to devel.p a model.for the interpretation of photomul.ipl.er data. This method shows good agreement with experimental.resul.s for the static fiel. case, and al.ows to measure the fiel. magnitude for the oscil.ating case.

关键词： el.ctric fiel. measurement el.ctromagnetic simul.tions Stark effect pl.sma diagnostics