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Mobile Robotic Platform for Contactless Vital Sign Monitoring

Cyborg and Bionic Systems 2022年第1期2022卷 87-97页

作者： Hen-Wei Huang jack Chen Peter R.Chai Claas Ehmke Philipp Rupp Farah Z.Dadabhoy Annie Feng Canchen Li Akhil j.thomas Marco da Silva Edward W.Boyer Giovanni Traverso Department of Mechanical Engineering Massachusetts Institute of TechnologyUSA The Koch Institute of Integrated Cancer Rssearch Massachusetts Institute of TechnologyUSA Division of Gast roenterology Brigham and Women's HospitalHarvard Medical SchoolUSA Department of Engineering Science University of TorontoCanada Department of Emergency Medicine Brigham and Women's HospitalHarvard Medical SchoolUSA Department of Psychosocial Oncology and Plliative Care Dana Farber Cancer InstituteUSA The Fenway Institute USA Boston Dynamics USA

The COVID-19 pandemic has accelerated methods to faciltate contactless evaluation of patients in hospital *** minimizing in-person contact with individuals who may have COVID 19,healthcare workers can prevent disease transmission and conserve personal protective *** vital signs is a ubiquitous task that is commonly done in person by healthcare *** eliminate the need for in-person contact for vital sign measurement in the hospital setting,we developed ***,a mobile quadruped robotic *** system includes IR and RGB cameras for vital sign monitoring and a tablet computer for face-to-face medical *** is teleoperated by trained clinical staff to simultaneously measure the skin temperature,respiratory rate,and heart rate while maintaining social distancing from patients and without removing their *** enable accurate,contactless measurements on a mobile system without a static black body as reference,we propose novel methods for skin temperature compensation and respiratory rate measurement at various distances between the subject and the cameras,up to 5 *** compensation,the skin temperature MAE is 13℃.Using the proposed compensation method,the skin temperature MAE is reduced to 0.3℃.The respiratory rate method can provide continuous monitoring with a MAE of 1.6 BPM in 30s or rapid screening with a MAE of 2.1 BPM in *** the heart rate estimation,our system is able to achieve a MAE less than 8 BPM in 10s measured in arbitrary indoor light conditions at any distance below 2 m.

关键词： removing protective eliminate

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Retinal microvascular signs and recurrent vascular events in patients with TIA or minor stroke

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Stroke & Vascular Neurology 2023年第5期8卷 379-386,I0001-I0007页

作者： Philipp Klyscz thomas Ihl Inga Laumeier Maureen Steinicke Matthias Endres Georg Michelson Heinrich j Audebert Neurology Charité-Universitätsmedizin BerlinBerlinGermany Center for Stroke Research Berlin Charité-Universitätsmedizin BerlinBerlinGermany Berlin Institute of Health BerlinGermany Excellence Cluster NeuroCure Charité-Universitätsmedizin BerlinBerlinGermany German Center for Neurodegenerative Diseases partner site BerlinGermany German Center for Cardiovascular Research partner site BerlinGermany Ophthalmology Friedrich-Alexander-Universität Erlangen-Nürnberg Medizinische FakultätErlangenGermany Talkingeyes&More GmbH ErlangenGermany

Background and purpose Retinal pathologies are an independent risk factor for ischaemic stroke,but research on the predictive value of retinal abnormalities for recurrent vascular events in patients with prior stroke is *** investigated the association of retinal pathologies with subsequent vascular *** In a substudy of the Intensified secondary prevention intending a reduction of recurrent events in TIA and minor stroke patients(INSPiRE-TMS)trial,we enrolled patients with recent transient ischaemic attack(TIA)or minor stroke with at least one modifiable risk *** outcome was the composite of subsequent vascular *** photographs were taken at baseline and categorised into three different fundus groups by a telemedically linked *** 722 patients participated in the current study and 109 major vascular events *** multivariable adjustments,we did not find a significant association between fundus categories and risk for subsequent vascular events(HRs for moderate vascular retinopathy and vascular retinopathy with vessel rarefaction in comparison to no vascular retinopathy 1.03(95%CI 0.64 to 1.67),p=0.905 and 1.17(95%CI 0.62 to 2.20),p=0.626).In a selective post hoc analysis in patients with diabetes mellitus and hypertension,patients with vascular retinopathy with vessel rarefaction had a higher risk for recurrent stroke(HR 24.14(95%CI 2.74 to 212.50),p=0.004).Conclusions Retinal changes did not predict major subsequent vascular events in patients with recent TIA or minor *** studies are needed to examine the utility of fundus photography in assessing the risk of stroke recurrence in patients with diabetes mellitus and hypertension.

关键词： patients Retinal prevention

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Toward Single-Atomic-Layer Lithography on Highly Oriented Pyrolytic Graphite Surfaces Using AFM-Based Electrochemical Etching

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Nanomanufacturing and Metrology 2022年第1期5卷 32-38页

作者： Wei Han Paven thomas Mathew Srikanth Kolagatla Brian j.Rodriguez Fengzhou Fang Centre of Micro/Nano Manufacturing Technology(MNMT-Dublin) University College DublinDublin D04 V1W&I reland Shanghai Engineering Research Centre of Ultra-Precision Optical Manufacturing Fudan UniversityShanghai 200433China School of Physics University College DublinDublin D04 V1W&Ireland Conway Institute of Biomolecular and Biomedical Research University College DublinDublin D04 V1W&Ireland State Key Laboratory of Precision Measuring Technology and Instruments Laboratory of Micro/Nano Manufacturing Technology(MNMT)Tianjin UniversityTianjin 300072China

Atomic force microscopy(AFM)-based electrochemical etching of a highly oriented pyrolytic graphite(HOPG)surface is studied toward the single-atomic-layer lithography of intricate *** etching is performed in the water meniscus formed between the AFM tip apex and HOPG surface due to a capillary effect under controlled high relative humid-ity(~75%)at otherwise ambient *** conditions to etch nano-holes,nano-lines,and other intricate patterns are *** clectrochemical reactions of HOPG etching should not generatc debris duc to the conversion of graphite to gaseous CO and CO_(2)based on etching ***,debris is observed on the etched HOPG surface,and incom-plete gasification of carbon occurs during the etching process,resulting in the generation of solid ***,the applied potential is of critical importance for precise etching,and the precision is also significantly influenced by the AFM tip *** study shows that the AFM-based electrochemical etching has the potential to remove the material in a single-atomic-layer *** result is likely because the etching process is based on anodic dissolution,resulting in the material removal atom by atom.

关键词： Etching Lithography Electrochemical machining Atomic and close-to-atomic scale manufacturing(ACSM)

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Return to sport following toe phalanx fractures:A systematic review

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World journal of Orthopedics 2023年第6期14卷 471-484页

作者： Greg A j Robertson Amit Sinha thomas Hodkinson Togay Koç Department of Orthopaedic Surgery Queen Alexandra HospitalPortsmouth PO63LYUnited Kingdom Department of Trauma and Orthopaedic Surgery Wales DeaneryCardiff CF157QQUnited Kingdom Department of Orthopaedic Surgery Hull University Teaching Hospitals NHS TrustHull HU32JZUnited Kingdom Department of Trauma and Orthopaedic Surgery Southampton General HospitalSouthampton SO166YDUnited Kingdom

BACKGROUND Evidence-based guidance on return to sport following toe phalanx fractures is *** To systemically review all studies recording return to sport following toe phalanx fractures(both acute fractures and stress fractures),and to collate information on return rates to sport(RRS)and mean return times(RTS)to the *** A systematic search of PubMed,MEDLINE,EMBASE,CINAHL,Cochrane Library,Physiotherapy Evidence Database,and Google Scholar was performed in December 2022 using the keywords‘Toe’,‘Phalanx’,‘Fracture’,‘injury’,‘athletes’,‘sports’,‘non-operative’,‘conservative’,‘operative’,‘return to sport’.All studies which recorded RRS and RTS following toe phalanx fractures were *** Thirteen studies were included:one retrospective cohort study and twelve case *** studies reported on acute *** studies reported on stress *** the acute fractures(n=156),63 were treated with primary conservative management(PCM),6 with primary surgical management(PSM)(all displaced intra-articular(physeal)fractures of the great toe base of the proximal phalanx),1 with secondary surgical management(SSM)and 87 did not specify treatment *** the stress fractures(n=26),23 were treated with PCM,3 with PSM,and 6 with *** acute fractures,RRS with PCM ranged from 0 to 100%,and RTS with PCM ranged from 1.2 to 24 *** acute fractures,RRS with PSM were all 100%,and RTS with PSM ranged from 12 to 24 *** case of an undisplaced intra-articular(physeal)fracture treated conservatively required conversion to SSM on refracture with a return to *** stress fractures,RRS with PCM ranged from 0%to 100%,and RTS with PCM ranged from 5 to 10 *** stress fractures,RRS with PSM were all 100%,and RTS with surgical management ranged from 10 to 16 *** cases of conservatively-managed stress fractures required conversion to *** of these cases were associated with a prolonged delay to diagnosis(1 year,2 years)and four cases with an un

关键词： Acute Stress Fracture Toe Phalanx Return Sport Rate Time

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Exome sequencing identifies a likely causative variant in 53%of families with ciliopathy-related features on renal ultrasound after excluding NPHP1 deletions

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Genes & Diseases 2024年第5期11卷 40-43页

作者： Konstantin Deutsch Verena Klambt thomas M.Kitzler Tilman jobst-Schwan Ronen Schneider Florian Buerger Steve Seltzsam Sherif El Desoky jameela A.Kari Farkhanda Hafeez Maria Szczepanska Loai A.Eid Hazem S.Awad Muna Al-Saffar Neveen A.Soliman Velibor Tasic Camille Nicolas-Frank Kirollos Yousef Luca M.Schierbaum Sophia Schneider Abdul Halawi Izzeldin Elmubarak Katharina Lemberg Shirlee Shril Shrikant M.Mane Nancy Rodig Friedhelm Hildebrandt Division of Nephrology Department of PediatricsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatric Gastroenterology Nephrology and Metabolic DiseasesCharite Universitatsmedizin BerlinBerlin 13353Germany Berlin Institute of Health at Charitee Universitatsmedizin Berlin BIH Biomedical Innovation AcademyBIH Charite Clinician Scientist ProgramBerlin 10178Germany Department of Nephrology and Hypertension FriedrichAlexander-Universitat Erlangen-NurnbergErlangen 91054Germany Department of Pediatrics Faculty of Medicine King Abdulaziz UniversityPediatric Nephrology Center of ExcellenceKing Abdulaziz University HospitalJeddah 21589Saudi Arabia Department of Pediatric Nephrology The Children’s Hospital and Institute of Child HealthLahore 54000Pakistan Department of Pediatrics Faculty of Medical Sciences in ZabrzeMedical University of Silesia in KatowiceKatowice 40-752Poland Dubai Hospital and Al-jalila Children’s Specialty Hospital Kidney Center of ExcellenceDubai 4545United Arab Emirates Department of Genetics and Genomics UAE UniversityAbu Dhabi 15551United Arab Emirates Department of Pediatrics Division of Genetics and GenomicsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatrics Center of Pediatric Nephrology and TransplantationKasr Al Ainy School of MedicineCairo UniversityCairo 11562Egypt Egypt Center for Research and Regenerative Medicine(ECRRM) Cairo 11511Egypt Medical Faculty Skopje University Children’s HospitalSkopje 1000North Macedonia Department of Genetics Yale University School of MedicineNew HavenCT 06520USA

Nephronophthisis-related ciliopathies(NPHP-RC)represent one of the most common causes of chronic kidney disease in the first three decades of life and are characterized by a broad genetic and clinical heterogeneity.1 To date,more than 90 genes have been identified that cause autosomalrecessive NPHP-RC if mutated,accounting for up to 60%of cases.1 Among these,homozygous deletions of NPHP1 are the most common *** genes localize to primary cilia,basal bodies,or the centrosome and lead to a primary ciliary disruption if mutated,thereby causing a broad phenotypical spectrum.1 Patients that suffer from NPHP-RC can either have an isolated renal phenotype,such as polyuria,polydipsia,decreased urinary concentration ability,and secondary enuresis due to loss of tubular function,or present with extrarenal symptoms including retinal degeneration,cerebellar vermis hypoplasia,or hepatic *** are often diagnosed in early adolescence,reaching end-stage renal disease before 25 years of age,but early onset and rapidly progressive forms of NPHP-RC also exist.1 Renal ultrasound indicates kidneys of normal or reduced renal length with increased echogenicity and corticomedullary cysts.

关键词： degeneration urinary likely

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The effect of temperature on ionic liquid modified Fe-N-C catalysts for alkaline oxygen reduction reaction

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journal of Energy Chemistry 2022年第5期31卷 324-329页

作者： thomas Wolker Kai Brunnengräber Ioanna Martinaiou Nick Lorenz Gui-Rong Zhang Ulrike I.Kramm Bastian j.M.Etzold Department of Chemistry Ernst-Berl-Institut für Technische und Makromolekulare ChemieTechnical University of Darmstadt64287 DarmstadtGermany Department of Chemistry Catalysts and Electrocatalysts GroupTechnical University of Darmstadt64287 DarmstadtGermany Graduate School of Excellence Energy Science and Engineering Technical University of Darmstadt64287 DarmstadtGermany Department of Materials and Earth Sciences Technical University of Darmstadt64287 DarmstadtGermany School of Chemical Engineering and Technology Tiangong UniversityTianjin 300387China

Modifying solid catalysts with an ionic liquid layer is an effective approach for boosting the performance of both Pt-based and non-precious metal catalysts toward the oxygen reduction reaction. While most studies operated at room temperature it remains unclear whether the IL-associated boosting effect can be maintained at elevated temperature, which is of high relevance for practical applications in low temperature fuel cells. Herein, Fe-N-C catalysts were modified by introducing small amounts of hydrophobic ionic liquid, resulting in boosted electrocatalytic activity towards the alkaline oxygen reduction reaction at room temperature. It is demonstrated that the boosting effect can be maintained and even strengthened when increasing the electrolyte temperature up to 70℃. These findings show for the first time that the incorporation of ionic liquid is a suited method to obtain advanced noble metal-free electrocatalysts that can be applied at operating temperature condition.

关键词： Oxygen reduction reaction Non-precious metal catalyst Ionic liquid Fe-N-C catalyst Temperature effect

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从多组份冷凝汽-气系统的同时传热和传质

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化学工程 1975年第5期 78-89页

作者： j.thomas Schrodt 北京石油化工总厂设计院技术室

曾用描述对冷凝液膜的同时传热和传质的一组线性化速度方程式的数值解来分析不凝性气体存在下的多组份蒸汽冷凝。对于甲醇及水和乙醇及甲苯在立管和卧管冷凝器中从湍流空气流中冷凝的具体例子,已经证明,随着冷凝从起始过热的,富含醇的... 详细信息

曾用描述对冷凝液膜的同时传热和传质的一组线性化速度方程式的数值解来分析不凝性气体存在下的多组份蒸汽冷凝。对于甲醇及水和乙醇及甲苯在立管和卧管冷凝器中从湍流空气流中冷凝的具体例子,已经证明,随着冷凝从起始过热的,富含醇的气相向前推进,液相和气相中醇浓度都增高了;液相含醇量也变得越来越富。蒸汽的质量流强度随着它们的有关传质系数和就地浓度推动力而变。在立管冷凝器中,醇的流强度通过一个最高点。随着混合物的冷却,气相的饱度也逐渐趋近而最后一点痕量的蒸汽变得更难于冷凝。界面性质是从有限的汽-液平衡数据、溶解热数据和一个预测方程式计算的。求解和分析技术对于不管直立或水平排列的冷却-冷凝器的设计都是通用的。

关键词：立式冷凝器甲苯乙醇冷却剂蒸汽冷凝不凝性气体方程式组份甲醇芳基甲烷酒醇一元醇方程冷凝器面积凝液传质

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Development of a standardized in vitro approach to evaluate microphysical,chemical,and toxicological properties of combustion-derived fine and ultrafine particles

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journal of Environmental Sciences 2022年第3期34卷 104-117页

作者： Ana Teresa juarez-Facio Clement Castilla Cecile Corbiere Helene Lavanant Carlos Afonso Christophe Morin Nadine Merlet-Machour laurence Chevalier jean-Marie Vaugeois jerome Yon Christelle Monteil Normandie Univ UNIROUENUNICAEN ABTE76000 RouenFrance Normandie Univ UNIROUENINSA RouenCNRSCOBRA76000 RouenFrance Normandie Univ UNIROUENINSA RouenCNRSGPM-UMR663476000 RouenFrance Normandie Univ UNIROUENINSA RouenCNRSCORIA76000 RouenFrance

Ultrafine particles represent a growing concern in the public health community but their precise role in many illnesses is still unknown. This lack of knowledge is related to the experimental difficulty in linking their biological effects to their multiple properties, which are important determinants of toxicity. Our aim is to propose an interdisciplinary approach to study fine(FP) and ultrafine(UFP) particles, generated in a controlled manner using a mini CAST(Combustion Aerosol Standard) soot generator used with two different operating conditions(CAST1 and CAST3). The chemical characterization was performed by an untargeted analysis using ultra-high resolution mass spectrometry. In conjunction with this approach, subsequent analysis by gas chromatography–mass spectrometry(GC–MS) was performed to identify polycyclic aromatic hydrocarbons(PAH). CAST1 enabled the generation of FP with a predominance of small PAH molecules, and CAST3 enabled the generation of UFP, which presented higher numbers of carbon atoms corresponding to larger PAH molecules. Healthy normal human bronchial epithelial(NHBE) cells differentiated at the air-liquid interface(ALI) were directly exposed to these freshly emitted FP and UFP. Expression of MUC5AC, FOXj1, OCLN and ZOI as well as microscopic observation confirmed the ciliated pseudostratified epithelial phenotype. Study of the mass deposition efficiency revealed a difference between the two operating conditions, probably due to the morphological differences between the two categories of particles. We demonstrated that only NHBE cells exposed to CAST3 particles induced upregulation in the gene expression of IL-8 and NQO1. This approach offers new perspectives to study FP and UFP with stable and controlled properties.

关键词： In vitro Air-liquid interface MiniCAST Fine and ultrafine particles Organic compounds OC/TC

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An Index-Based Approach to Assess Social Vulnerability for Hamburg, Germany

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International journal of Disaster Risk Science 2023年第5期14卷 782-794页

作者： Malte von Szombathely Franziska S.Hanf janka Bareis Linda Meier jürgen Oßenbrügge thomas Pohl Institute for Geography Center for Earth System Research and SustainabilityUniversität Hamburg20146HamburgGermany Meteorological Institute Center for Earth System Research and SustainabilityUniversität Hamburg20146HamburgGermany Institute for Geography Universität Hamburg20146HamburgGermany Research Unit for Sustainability and Climate Risks Center for Earth System Research and SustainabilityUniversität Hamburg20144HamburgGermany

In this study,we set out to develop a new social vulnerability index(SVI).In doing so,we suggest some conceptual improvements that can be made to existing methodical approaches to assessing social *** make the entanglement of socio-spatial inequalities visible,we are conducting a small-scale study on heterogeneous urban development in the city of Hamburg,*** kind of high-resolution analysis was not previously available,but is increasingly requested by political decision *** can thus show hot spots of social vulnerability(SV)in Hamburg,considering the effects of social welfare,education,and *** doing so,we defined SV as a contextual concept that follows the recent shift in discourse in line with the Intergovernmental Panel on Climate Change’s(IPCC)concepts of risk and *** SVI consists of two subcomponents:sensitivity and coping *** areas of Hamburg were identified using satellite information and merged with the social data units of the *** with high SVI are distributed over the entire city,notably in the district of Harburg and the Reiherstieg quarter in Wilhelmsburg near the Elbe,as well as in the densely populated inner city areas of Eimsbüttel and *** a map at a detailed scale,our SVI can be a useful tool to identify areas where the population is most vulnerable to climate-related *** conclude that an enhanced understanding of urban social vulnerability is a prerequisite for urban risk management and urban resilience planning.

关键词： Climate change adaptation Hamburg Risk approach Social vulnerability Social vulnerability index

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High-Intensity Interval Training Prescribed Within the Secondary Severe-Intensity Domain Improves Critical Speed But Not Finite Distance Capacity

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journal of Science in Sport and Exercise 2020年第2期2卷 154-166页

作者： Emma jthomas Robert W.Pettitt Mark Kramer Biokinetics and Sport Science Unit Nelson Mandela UniversityPort Elizabeth 6070South Africa Rocky Mountain University of Health Professions ProvoUT 84606USA Physical Activity Sport and Recreation Research Focus AreaNorth West UniversityPotchefstroom 2520South Africa

Purpose Improvements in D'(the fatigability constant for running)subsequent to training interventions remain ***-intensity interval training(HIIT)within the severe intensity domain for short durations(<2-min)have been theorized to improve D'.The purpose of the present study was to assess this in a group of moderately trained *** Eighteen participants completed graded exercise testing(GXT),40-m sprint testing and a 3-min all-out test(3MT)for running to determine key mechanistic and physiological *** were randomly assigned into one of two groups based on intensity prescription(G140%=140%of critical speed[CS]),or time intervals(G90-s=90-s)to complete a twice-weekly training intervention for 6-weeks followed by *** No between-group differences were present either prior to or following the *** and meaning-ful improvements were detected during the post-intervention period for both groups for VO2max(G140%:+7.60%;G90-s:+11.67%),speed evoking VO2max(sVO2max;G140%:+4.33%;G90_s:+2.92%),gas exchange threshold(GET;G140%:+12.02%;G90-s:+20.52%),speed evoking GET(sGET;G140%:+4.17%;G90_s:+7.92%),CS(G140%:M=0.62 m/s;G90-s:M=0.46 m/s),D'(G140%:M=-56.34 m;G90-s:M=-18.36 m),FI%(G140%M=-6.75%;G90-s:M=-4.38%)and maximal distance(G140%:M=49.67 m;G90_s:M=58.38 m).Conclusions The prescribed intensities and durations were insufficient to elicit improvements in D'.Improvements in D'may be dependent on very short-duration intervals(i.e.<60 to 90-s)at speeds exceeding 140%CS but below maximal sprint speed.

关键词： Moderately active Severe intensity Threshold

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