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母亲暴露于常规空气污染物与后代的先天性心脏缺陷:来自全国出生缺陷预防研究的结果

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环境与职业医学 2014年第12期31卷 929-929页

作者： jeanette A.Stingone thomas j.Luben julie L.Daniels Montserrat Fuentes David B.Richardson Arthur S.Aylsworth Amy H.Herring Marlene Anderka Lorenzo Botto Adolfo Correa Suzanne M.Gilboa Peter H.Langlois Bridget Mosley Gary M.Shaw Csaba Siffel Andrew F.Olshan National Birth Defects Prevention Study

[背景]流行病学文献表明,空气污染物暴露与胎儿的发育相关联。[目的]探讨产妇在妊娠2-8周期间的空气污染物暴露及其与先天性心脏缺陷的关联。[方法]此项出生缺陷预防研究是一项由9个州参加的病例对照研究。给参加这项研究的妊娠妇女分配... 详细信息

[背景]流行病学文献表明,空气污染物暴露与胎儿的发育相关联。[目的]探讨产妇在妊娠2-8周期间的空气污染物暴露及其与先天性心脏缺陷的关联。[方法]此项出生缺陷预防研究是一项由9个州参加的病例对照研究。给参加这项研究的妊娠妇女分配1周和7周里一氧化碳、二氧化氮、臭氧、二氧化硫的每日最高浓度平均值,以及细颗粒物和粗颗粒物的24 h测量值,采用的方法是在妊娠早期收集这些妇女住所50 km内最接近的空气监测点的测量值。根据不同的污染物,最多4 632例活产对照和3 328例活产、死胎或流产病例有空气污染暴露的数据。应用分层回归模型,并以产妇的人口统计学、烟草和酒精使用情况进行调整。对于多污染物共同暴露的情况,则采用主成分分析来评估这些关联。[结果]二氧化氮暴露与主动脉缩窄及肺动脉瓣狭窄之间存在正性关联。细颗粒物暴露与左室发育不良心脏综合征呈正性相关,但与房间隔缺损呈负性相关。检测个体的暴露周数表明,使用7周的平均水平未观察到污染物与缺陷之间的关联。多污染物分析的结果支持左室流出道阻塞与二氧化氮之间、左室发育不良心脏综合征与颗粒物之间存在关联,尽管在最高的暴露水平时估计值是下降的。[结论]采用每日最高污染物水平探讨个体暴露周数揭示了某些污染物与心脏缺陷之间存在一些正向关联,并且提示在妊娠期间存在潜在的敏感性窗口期。

关键词：先天性心脏缺陷空气污染物出生缺陷预防母亲暴露病例对照研究心脏综合征细颗粒物后代

放射技师协同阅片对放射学专家在英国肺癌筛查的阅片时间和表现影响的研究

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国际医学放射学杂志 2018年第2期 238-238页

作者： N.Arjun j.S.Nicholas A.H.john j.Diane C.Leigh B.Bruce 王习 Department of Radiology Guy ’s and St Thomas’ NHS Foundation Trust

摘要目的比较分析放射技师协同医师阅片和医师独立阅片在肺癌CT筛查中的表现差别。方法英国肺癌筛查369例受检者CT影像,分别经过放射科医师独立阅片或者

关键词：肺癌筛查敏感度

英夫利昔单抗治疗重度、难治性银屑病:一项前瞻性、开放标记研究

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世界核心医学期刊文摘（皮肤病学分册） 2006年第9期2卷 39-40页

作者： Smith C. H. jackson K. Bashir S. j. 朱国兴(译) TherapyResearch Unit St. John's Institute of Dermatology St. Thomas' Hospital Lambeth Palace Road London SE1 7EH United Kingdom 不详

Background: Infliximab, a mouse-human chimeric monoclonal antibody directed against tumour necrosis factor-α , has been shown to be effective for moderate to severe psoriasis, but there are few data published on its use in recalcitrant, treatment-resistant resistant disease or in combination with other antipsoriatic therapies. Objectives: To report our experience with infliximab in the treatment of patients attending a tertiary referral service with severe recalcitrant disease. Methods: All patients attending a tertiary referral service for severe psoriasis who were treated with infliximab between 2002 and july 2005 were entered into a prospective, open-label study. Details on disease phenotype, clinical course and adverse events were recorded together with measures of disease severity [Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index, clinical photography] at baseline, weeks 2 and 6, and then at 2-monthly intervals throughout the treatment period. Results: Twenty three patients were treated with infliximab during the study; one patient had pustular psoriasis and was therefore excluded from statistical analysis. All had severe disease (baseline PASI 26.5 ± 6.7, mean ± SD, n = 22) and had received at least two systemic therapies for psoriasis in the past; 16 were taking one or more concomitant therapies at the time of treatment initiation. At week 10, 95% had achieved a 50% or greater improvement in baseline PASI (PASI 50), and 77% had achieved a 75% or greater improvement (PASI 75). Efficacy was sustained in the longer term, with eight of 10 patients on treatment for more than 11 months maintaining at least a PASI 50. Only one patient had treatment withdrawn due to lack of efficacy, two suffered severe systemic infections including extrapulmonary tuberculosis (splenic abscess) and cellulitis, and six have discontinued due to adverse effects including infusion reactions (two), severe thrombocytopenia (one), hepatitis (one) and malignancy (two)

关键词：中重度银屑病单抗治疗难治性皮肤病生活质量指数肿瘤坏死因子-α 严重不良反应疾病严重性嵌合单克隆抗体

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来自幼发拉底河彼岸的观点

基督教文化学刊 2020年第1期43卷 118-154页

作者： [美]斯蒂夫·帕特森王梓(译) 美国威拉默特大学中央民族大学宗教研究院

一个新的起点此文旨在通过被新约学者们称为"第五福音书"的《多马福音》(The Gopsel of thomas)拓展我们对基督教起源的理解视角。正如学者们所知,在这部福音书中,大约有一半的内容都与对观福音书相吻合,然而它却使用了一种独特的方式... 详细信息

一个新的起点此文旨在通过被新约学者们称为"第五福音书"的《多马福音》(The Gopsel of thomas)拓展我们对基督教起源的理解视角。正如学者们所知,在这部福音书中,大约有一半的内容都与对观福音书相吻合,然而它却使用了一种独特的方式——语录汇编——来呈现这些大体相似的内容;由此,它被理解为是一种迥然不同的神学类型:智慧神学。这是一部独特的福音书,一部智慧福音,在这部福音书中,耶稣的话语(logoi)处于核心地位。

关键词： The Gospel of thomas Edessa Difference Q canonical tradition

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Nature:揭示干细胞惊人异质性

岭南现代临床外科 2014年第6期14卷 722-722页

作者： Roshan M.Kumar Patrick Cahan Alex K.Shalek Rahul Satija A.jay Daley Keyser Hu Li jin Zhang Keith Pardee David Gennert john j.Trombetta thomas C.Ferrante Aviv Regev George Q.Daley james j. Collins

论文作者George Daley教授说：＂这是一项非常基础的研究,但它阐明了多能性状态广泛性。我们捕获了干细胞不同状态的详细分子谱。＂研究人员通过采用多种变量如不同的化学物质、培养环境和遗传敲除来扰乱多能干细胞,研究人员探究了它们... 详细信息

论文作者George Daley教授说：＂这是一项非常基础的研究,但它阐明了多能性状态广泛性。我们捕获了干细胞不同状态的详细分子谱。＂研究人员通过采用多种变量如不同的化学物质、培养环境和遗传敲除来扰乱多能干细胞,研究人员探究了它们的发育景观。随后,他们分析了每个细胞的遗传组成,观察了每个细胞多能状态的微小波动。他们发现内部、化学和环境信号影响干细胞方式的许多细微差异,揭示出了复杂的发育调控因子＂决策＂回路。

关键词：环境信号 Nature 多能性异质性发育调控化学物质细胞类型 pluripotent 博士后研究人员 heterogeneity

染色体1完全性父系等二倍体导致Herlitz交界型大疱性表皮松解症

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世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 60-61页

作者： Fassihi H. Wessagowit V. Ashton G.H.S. j.A. McGrath 张宪旗 Genetic Skin Disea se Group St. John's Institute of Dermatology St. Thomas'Hospital Lambeth Pa lace Road London SE17EH United Kingdom

Herlitz junctional epidermolysis bullosa (jEB) is an autosomal recessive mecha nobullous disorder that results from loss-of-function mutations in the genes e ncoding the basement membrane component, laminin 5. Typically, there are framesh ift, splice site or nonsense mutations on both alleles of either theLAMA3,LAMB3o rLAMC2genes,withaffectedindividuals inheriting one mutated allele from each pare nt. In this report, we describe a patient with Herlitz jEB in whom DNA analysis revealed homozygosity for the recurrent nonsense mutation R635X in LAMB3, locate d on chromosome 1q32.2. However, screening of parental DNA showed that although the patient’s father was a heterozygous carrier of this mutation, the mother’s DNA showed only wild-type sequence. Subsequent genotype analysis using 13 micr osatellite markers spanning chromosome 1 revealed that the affected child was ho mozygous for the entire seriesofmarkerstestedandthatalloftheallelesoriginatedfro m the father. These results indicate that the Herlitz jEB phenotype in this pati ent is due to complete paternal isodisomy of chromosome 1 and reduction to homoz ygosity of the mutant LAMB3 gene locus. This is the fourth case of uniparental d isomy to be described in Herlitz jEB, but it represents the first example of com plete paternal isodisomy for chromosome 1 with a pathogenic mutation in the LAMB 3 gene. These findings have important implications for mutation screening in jEB and for genetic counselling.

关键词： Herlitz 完全性遗传咨询基因突变无义突变常染色体隐性纯合性层黏连蛋白单亲二倍体大疱

经十二指肠EUS确定原发性硬化性胆管炎中肝外胆管树管壁增厚

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世界核心医学期刊文摘（胃肠病学分册） 2006年第8期2卷 27-28页

作者： Mesenas S. Vu C. Doig L. Meenan j. 陈瑜(译) 郑世成(校) 不详 Department of Gastroenterology College House St. Thomas' Hospital London SE1 7EH United Kingdom

Background: Diagnosing primary sclerosing cholangitis (PSC) is problematic and requires meeting a burden of proof through clinical, biochemical, radiologic, and histological features. Endoscopic ultrasound yields detailed images of the extrahepatic biliary tree, but its value in contributing to the diagnosis of this condition is unknown. Objectives: To determine the potential for transduodenal EUS to detect common bile duct wall thickening in ***: A prospective, controlled study with retrospective, blinded data analysis. Setting: Single tertiary referral center for inflammatory bowel disease and EUS. Patients: Four groups of patients were assessed with radial endosonography: PSC (n = 9); inflammatory bowel disease (IBD) with abnormal liver blood tests (n = 21); choledocholithiasis (n = 15); and normal controls (n = 50). Measurements were made of the common bile duct diameter and wall thickness. Interventions: Transduodenal radial EUS of the biliary tree. Main Outcome Measurements: Common bile duct diameter and wall thickness. Results: The mean diameter (SD) of the common bile duct for the PSC, IBD, choledocholithiasis, and normal control groups measured 8.9 mm (2.8), 5.4 mm (1.7), 7.2 mm (2.2), and 5.0 mm (1.9), respectively (PSC and chole-docholithiasis groups compared to the IBD group, P 1.5 mm) of the common bile duct wall is seen in patients with PSC but not in those with aPPArently uncomplicated IBD or choledocholithiasis. The results of this study suggest that standard

关键词：超声内镜(EUS) 原发性硬化性胆管炎经十二指肠胆总管壁胆管树增厚肝外胆总管直径影像学检查管壁厚度

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建筑的回响哈尔滨大剧院

室内设计与装修 2016年第7期 58-65页

作者：马岩松党群 [日]早野洋介 jordan Kanter Daniel Gillen Bas van Wyick 刘会英傅昌瑞赵伟李健郑芳 julian Sattlor jackob Boer j Travis Russott Sohith Perera Colby thomas Suter 于魁 Philppe Brysse 黄伟 Flora Lee 王伟谢怡邦 Lyo Hengliu Alexander Cornelius Alex Gornelius 毛蓓宏 Gianantonio Bongiorno jei Kim 陈元宇于浩臣覃立超 Pil-Sun Ham Mingyu Seol 林国敏张海峡李广崇 Wilson Wu 马宁 Davide Signorato Nick Tran 向玲 Gustavo Alired Van Staveren 杨杰 Adam Mork(摄影) 无不详 mad建筑事务所 Hufton+Crow

历时6年时间，MAD建筑事务所从概念设计到建成竣工，完成了包含哈尔滨大剧院、市民文化中心和剧院周围景观湿地在内的整体规划设计。哈尔滨大剧院规划用地1．8km^2，总建筑面积79000m^2，由包含1600座的大剧场及400座的小剧场组成，是... 详细信息

历时6年时间，MAD建筑事务所从概念设计到建成竣工，完成了包含哈尔滨大剧院、市民文化中心和剧院周围景观湿地在内的整体规划设计。哈尔滨大剧院规划用地1．8km^2，总建筑面积79000m^2，由包含1600座的大剧场及400座的小剧场组成，是一座出落于北国自然风貌的公共文化建筑。

关键词：建筑事务所大剧院哈尔滨概念设计整体规划文化中心规划用地建筑面积

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儿童功能性胃肠病罗马Ⅳ标准

中华儿科杂志 2017年第1期55卷 4-14页

作者： Marc A. Benninga Samuel Nurko Christophe Faure Paul E. Hyman Ian St. james Roberts Neil L. Schechter jeffrey S. Hyams Carlo Di Lorenzo Miguel Saps Robert j. Shulman Annamaria Staiano Miranda van Tilburg Pediatric Gastroenterology Emma Children's HospitalAcademic Medical CenterAmsterdamThe Netherlands Center for Motility and Functional Gastrointestinal Disorders Boston Children' s HospitalBostonMassachusetts Pediatric Gastroenterology Sainte-Justine HospitalMontrealQuebecCanada Pediatric Gastroenterology Children' s HospitalNew OrleansLouisiana thomas Coram Research Unit University College London Institute of EducationUniversity College LondonLondonUK Pediatric Pain Center Boston Children' s HospitalBostonMassachusetts Division of Digestive Diseases Hepatologyand NutritionConnecticut Children's Medical CenterHartfordConnecticut Division of Digestive Diseases Hepatologyand NutritionNationwide Children' s HospitalColumbus Ohio Baylor College ofMedicine Children's Nutrition Research CenterTexas Children's HospitalHoustonTexas Department ofTranslational Science Section of PediatricsUniversity of NaplesFederico IINaplesItaly Department of Gastroenterology and Hepatology University of North Carolina at ChapelHillChapel HillNorth Carolina

罗马标准是目前关于功能性胃肠病（ FGID）分类最全面且不断更新的标准。罗马Ⅰ、Ⅱ标准分别于1994年、1999年发布。罗马Ⅱ标准开始单列儿童FGID分类。2006年，根据年龄不同，婴幼儿（0-36个月）和儿童（〉36个月） FGID的罗马Ⅲ诊断标... 详细信息

罗马标准是目前关于功能性胃肠病（ FGID）分类最全面且不断更新的标准。罗马Ⅰ、Ⅱ标准分别于1994年、1999年发布。罗马Ⅱ标准开始单列儿童FGID分类。2006年，根据年龄不同，婴幼儿（0-36个月）和儿童（〉36个月） FGID的罗马Ⅲ诊断标准发布，但相关的流行病学、病理生理学、诊断检查、治疗策略以及预后等资料都很少。

关键词：功能性胃肠病罗马标准儿童 FGID 罗马Ⅱ标准病理生理学诊断标准流行病学