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稳定型心绞痛患者成功进行经皮冠状动脉介入后血清心肌标记物与其后运动耐量的关系：一项初步研究

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世界核心医学期刊文摘（心脏病学分册） 2005年第8期1卷 26-27页

作者： Williams S.G. Stables R.H. Wright D.j. 王永兴 Cardiothoracic Centre Thomas Drive Liverpool L14 3PE United Kingdom

We performed a pilot study to assess the significance of modest, asymptomatic, elevated serum cardiac markers- troponin T(TnT) and creatinine kinase- MB(CK- MB)- 18- 24 h following successful elective percutaneous coronary intervention(PCI) and to explore their relationship with changes in aerobic exercise capacity, as measured by peak oxygen consumption(VO2), 6 weeks following the procedure. Twenty-three patients with single-vessel disease and chronic angina performed an incremental cardiopulmonary exercise test before and 6 weeks after successful uncomplicated PCI. A venous blood sample was taken at rest before PCI and 18-24 h after the procedure. Successful PCI resulted in a trend towards an increased peak VO2 [21. 62 ±0. 64(pre) vs. 23. 03±0. 75 ml/kg/min(post), p = 0. 07; mean ± SEM] . There was a significant increase [median(IQR) ] in TnT, from 0. 00(0. 00) μg/l at baseline increasing to 0.02(0.03) μg/l at 18-24 h, p = 0. 002. CK-MB levels showed no significant difference. In the group of 15/23(65%) patients with an elevation in serum TnT( FF>> 0. 01 μg/l), 18-24 h after successful PCI, there was no significant increase in peak VO2 [23. 31 ±0. 96(pre)vs. 23. 89 ± 1. 09 ml/kg/min(post), p=0. 57] . In 8(35% ) patients with no rise in TnT at 18 - 24 h, a significant increase in peak VO2 was observed following successful PCI[23. 10 ±0. 91 (pre) vs. 25. 09 ± 0. 75 ml/ kg/min(post), p =0. 02]. Although 7 of these 8 patients increased their peak VO2, the absence of a TnT rise at 18-24 h was not significantly associated with an increase in peak VO2 following successful PCI(p =0. 18). To confirm these interesting initial results and investigate the relationship of serum cardiac markers following successful PCI and subsequent exercise capacity, further studies are required.

关键词：稳定型心绞痛运动耐量血清心肌单支血管病变肌酸肌酶肌钙蛋白无症状介入治疗耗氧量

经颈静脉肝内门体分流术(TIPSS)与肝移植

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中华肝胆外科杂志 2002年第11期8卷 652-654页

作者：周光文蔡伟耀李宏为朱岳 Forrest Dodson john j Fung 上海第二医科大学附属瑞金医院外科上海市200025 Pitisburgh thomas StarzlTransplant Institute

目的　经颈静脉肝内门体分流术 (TIPSS)正逐渐成为控制食管曲张静脉破裂出血和肝移植之间的桥梁。目前国内没有有关TIPSS对原位肝移植手术影响的报道。方法　回顾性研究接受术前TIPSS治疗的肝移植病人 ,即评价TIPSS作为肝移植桥梁的有... 详细信息

目的　经颈静脉肝内门体分流术 (TIPSS)正逐渐成为控制食管曲张静脉破裂出血和肝移植之间的桥梁。目前国内没有有关TIPSS对原位肝移植手术影响的报道。方法　回顾性研究接受术前TIPSS治疗的肝移植病人 ,即评价TIPSS作为肝移植桥梁的有效性和是否影响移植手术。结果　匹兹堡移植中心 5例术前接受TIPSS的肝移植病人。行TIPSS与肝移植间隔时间为 9 6 (0 2～2 4 7)个月 ,3例病人在肝移植前能有效地控制出血。 4例病人的支架位于肝实质内 ,并不影响手术 ;1例部分突出于肝外门静脉 ,术中需要移去支架。术后随访时间平均 4 2 (2～ 7)个月 ,无门静脉血栓形成。手术时间和术中输血量无显著性差异。结论　TIPSS是一种有效的桥梁 ,并没有增加移植术后并发症发生率和死亡率 ;鉴于有潜在的手术风险 ,支架最好放置在肝实质内 ,但肝外支架并不构成移植手术的反指征。

关键词：经颈静脉肝内门体分流术肝移植

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化学减容法治疗视网膜母细胞瘤的远期视力

世界核心医学期刊文摘(眼科学分册) 2006年第3期 21-22页

作者： Demirci H Shields C.L Meadows A.T Shields j.A. 陈立军 Ocular Oncology Service Wills Eye Hospital Thomas Jefferson University 840 Walnut St Philadelphia PA 19107 United StatesDr.

Objective: To evaluate long-term visual outcome following chemoreduction. Design: Interventional case series evaluating 54 eyes of 40 children with retinoblastoma successfully treated with chemoreduction, consisting of a combination of intravenous carboplatin, etoposide phosphate, and vincristine sulfate plus focal therapy without external beam radiotherapy or enucleation. All patients were followed up for at least 5 years. Patient and tumor data were analyzed for their effect on the main outcome measures (final visual acuities of 20/40 or better and of 20/200 or better) using univariate and multivariate regression models. Patien ts who failed chemoreduction were excluded. Results: There were 4 eyes in Reese -Ellsworth group I, 7 in group II, 3 in group III, 15 in group IV, and 25 in gr oup V. The mean distance from the posterior tumor margin to the optic disc was 2 mm, and from the tumor margin to the foveola it was 3 mm. After a mean follow- up of 68 months, 27 eyes (50%) had a final visual acuity of 20/40 or better, an d 36 eyes (67%) had final visual acuity of 20/200 or better. Of 33 eyes with ma cular tumor, only 8 (24%) had a final visual acuity of 20/40 or better, and 15 (45%) had a final visual acuity of 20/200 or better. Of 21 eyes with extramacul ar tumor, 19 (90%) had a final visual acuity of 20/40 or better, and all (100% ) had a final visual acuity of 20/200 or better. Conclusion: The clinical factor s that predicted visual acuity of 20/40 or better were a tumor margin at least 3 mm from the foveola and optic disc and an absence of sub-retinal fluid.

关键词：视网膜母细胞瘤视力减容

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高粱环境适应性指标——基础温度(G50)

国外农学-杂粮作物 1989年第1期 54-55页

作者： j.A.Mann F.R.Miller 张忠旭邵国君李德华

1978年美国的Miller和thomas曾报导过高粱发芽的基础温度(G50)与其适应性有着明显的关系。在此基础上,thomas(1980)、Mann等(1984)、Miller等(1985)又进行了深入

关键词：适应性高粱 G50 Miller TE

An acoustofluidic scanning nanoscope using enhanced image stacking and processing

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Microsystems & Nanoengineering 2022年第4期8卷 191-198页

作者： Geonsoo jin joseph Rich jianping Xia Albert jHe Chenglong Zhao Tony jun Huang thomas Lord Department of Mechanical Engineering and Material Science Duke UniversityDurhamNC 27708USA Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA Department of Physics University of Dayton300 College ParkDaytonOH 45469USA Department of Electro-Optics and Photonics University of Dayton300 College ParkDaytonOH 45469USA

Nanoscale optical resolution with a large field of view is a critical feature for many research and industry areas,such as semiconductor fabrication,biomedical imaging,and nanoscale material *** scanning microscopes have been developed to resolve the inverse relationship between the resolution and field of view;however,those scanning microscopes still rely upon fluorescence labeling and complex optical *** overcome these limitations,we developed a dual-camera acoustofluidic nanoscope with a seamless image merging algorithm(alphablending process).This design allows us to precisely image both the sample and the microspheres simultaneously and accurately track the particle path and ***,the number of images required to capture the entire field of view(200×200μm)by using our acoustofluidic scanning nanoscope is reduced by 55-fold compared with previous ***,the image quality is also greatly improved by applying an alpha-blending imaging technique,which is critical for accurately depicting and identifying nanoscale objects or *** dual-camera acoustofluidic nanoscope paves the way for enhanced nanoimaging with high resolution and a large field of view.

关键词： image overcome stacking

模拟日光射线对接触性过敏反应诱发阶段的影响在多形性日光疹患者和对照无区别

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世界核心医学期刊文摘（皮肤病学分册） 2005年第11期1卷 7-8页

作者： Palmer R.A. Hawk j.L.M. Young A.R. Walker S.L. 刘安 Dr. Photobiology Unit St. John's Institute of Dermatology St. Thomas'Hospital London SE1 7EH United Kingdom

It has been suggested that polymorphic light eruption (PLE) is characterized by a failure of ultraviolet radiation (UVR)-induced immunosuppression, resulting in a type-IV hypersensitivity response to photoinduced antigens. We measured the effect of solar-simulated radiation (SSR) on the elicitation phase of contact hypersensitivity to 2,4-dinitrochlorobenzene (DNCB), in ten PLE patients and 11 controls. Subjects were given a sensitizing dose of DNCB, and 3 wk later were exposed to 0.75 and 2 minimum erythema doses (MED) of SSR on the upper inner arm. Immediately and 24 h later these sites, and a non-irradiated control site, were challenged with DNCB. The resulting increase in skin thickness was measured with high-frequency ultrasound. Overall, 2 MED caused 17%-20%suppression of elicitation responses (compared with 93%suppression of sensitization reported previously), but the effect of SSR varied greatly between subjects, with some subjects showing potentiated responses, which may be of relevance to false-positive reactions in photopatch testing. In a repeated measures general linear model, SSR overall caused significant suppression of responses (p jects (p=0.009) but there was no significant difference between PLE patients and age-matched normal controls. These results contrast with our previous finding of a resistance to UVR-induced suppression of sensitization toDNCB in PLE. This difference may reflect the greater importance of Langerhans cells in the sensitization phase, and is consistent with the hypothesis that PLE arises from impaired suppression of Langerhans cell activation or migration.

关键词：多形性日光疹接触性过敏反应 Ⅳ型过敏反应 DNCB 红斑剂量朗格汉斯细胞反应抑制假阳性反应二硝基苯免疫抑制

先天性血管萎缩性皮肤异色症并发汗孔角化症及双侧虹膜发育不全的特殊病例1例

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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 38-39页

作者： Mak R.K.H. Griffiths W.A.D. Mellerio j.E. 吴佳纹 St. john' s Institute of Dermatology St. Thomas' s Hospital Lambeth Palace Road London SE1 7EH United Kingdom Dr.

Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive genodermatosis characterized by poikiloderma and the variable presence of other features including skeletal and ocular abnormalities, ectodermal defects, and suscept-ibility to certain malignancies. We report a 40-year-old woman with known RTS who developed porokeratoses on her limbs in adulthood, an association that has not previou-sly been reported. In addition, she had bilateral iris dysgenesis, which has only been described once before in RTS.

关键词：汗孔角化症虹膜发育不全特殊病例遗传性皮肤病皮肤异色症眼部异常常染色体隐性

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相对似真性及其批评

证据科学 2020年第4期28卷 433-482页

作者： [美]罗纳德·j·艾伦 [美]迈克尔·S·帕尔多熊晓彪郑凯心(译) 张保生(校) 美国西北大学阿拉巴马大学法学院吉林大学司法文明协同创新中心中国政法大学证据科学研究院

法学界有一种使用(也许是过度使用)"范式转型"(paradigm shift)的倾向,但其方式却与托马斯·库恩(thomas Kuhn)的著名描述过程大相径庭。然而,在证据法领域,一种非常类似于库恩意义上的范式转型现象正在发生。它虽未达到从牛顿到爱因斯... 详细信息

法学界有一种使用(也许是过度使用)"范式转型"(paradigm shift)的倾向,但其方式却与托马斯·库恩(thomas Kuhn)的著名描述过程大相径庭。然而,在证据法领域,一种非常类似于库恩意义上的范式转型现象正在发生。它虽未达到从牛顿到爱因斯坦物理学或其他科学结构转型那样的规模,但对司法证明的最佳理解正在从概率主义向解释主义转型。几百年来,审判中的证明都被假定为概率性的。这种假定自从1968年约翰·卡普兰(john Kaplan)的开拓性文章发表以来,受到了学术界的持续关注与支持。这是一篇以概率来解释司法证明几乎所有方面的文献,从相关性的基本性质到信息处理,再到关于事实的最终裁决。虽然概率主义很快就成为主流范式,但从乔纳森·科恩(L. jonathan Cohen)对特定证明悖论(proof paradoxes)的论证开始,一些分析上的困难很早就被发现了(用库恩的话说,就是"异常"或"刺激物")。罗纳德·艾伦(Ronald Allen)对此进行了拓展,他还论证了贝叶斯推理与审判的不相容,并提出了一种分析性替代方法。随之,主流范式的捍卫者炮制了大量文献,试图通过解释来消除那些异常现象,或者守护概率范式免受潜在的侵蚀影响(事实上,库恩在一个非常小的范围内关于科学范式转型的解释和预见正是如此)。在过去二十年里,这些异常现象已变得令人烦恼到不能再忽略它的程度,而与之竞争的解释性推论(相对似真性理论)范式的优势,已变得如此具有说服力而不容忽视。因此,该领域正在经历这种范式转型。在此,我们对相对似真性理论以及概率范式的改进做了总结。正如库恩所指出的,当范式转变时并非所有人都赞同,总是有坚守者、反对者和异议者。最近有三篇主要论证相对似真性不足的论文发表。我们对其进行了分析,论证了他们的反对意见不是不合时宜就是徒劳的,从而奠定了相对似真性作为司法证明之最佳解释的基础。有趣的是,在我们所讨论的三种批评意见中,竟有两种实际上同意概率范式存在着不足(他们提供了替代方案)。第三种批评意见则承认,解释主义可能提供了一种关于司法证明的更佳进路,却试图鉴于一种特定的分析困难,复兴对证明责任的概率解释(即将证明责任适用于犯罪、民事诉求及辩护的单一因素而非当事人的完整案情,从而导致了合取难题的出现)。在分析我们的批评者所提出的替代性主张时,我们论证了他们的观点每一种都并不比相对似真性提供了更好的解释。

关键词：证据证明认识论概率最佳解释推论

Brava和自体脂肪移植是一种安全有效的隆乳选择：一项6年，81例多中心前瞻性研究结果（摘要）

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中国美容整形外科杂志 2012年第7期23卷 I0003-I0003页

作者： Roger K. Khouri Marita Eisenmann-Klein Eufemiano. Cardoso Brian C. Cooley Daniel. Kacher Eva Gombos thomas j. Baker 朱利娜魏峰高景恒张晨迈阿密乳房中心美国佛罗里达州比斯坎湾《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

背景与目的隆乳术中采用自体脂肪移植是经科学认证的有吸引力的选择。方法多中心前瞻性研究中，纳入81例女性，年龄17—63岁，均使用Brava设备4周。Brava是一个类似乳罩装置、负压体外组织扩张器。而后利用10～14个针刺位点以三维扇形... 详细信息

背景与目的隆乳术中采用自体脂肪移植是经科学认证的有吸引力的选择。方法多中心前瞻性研究中，纳入81例女性，年龄17—63岁，均使用Brava设备4周。Brava是一个类似乳罩装置、负压体外组织扩张器。而后利用10～14个针刺位点以三维扇形模式对每个乳房注射自体脂肪（平均每个乳房注射277ml）。受试者在注射后24h内重新使用Brava，并使用7d以上。利用磁共振成像技术扫描治疗前和治疗后的乳房体积，并与6篇已报道的自体脂肪隆乳术（未使用扩张器）报道的Meta分析结果相比较。随访期为1～6年（平均为3．7年）。结果3—6个月内乳房体积没有变化。接受治疗的女性中有71例按要求使用Brava，其结果是1年内每个乳房体积增加233ml，而之前报道的没有使用Brava的女性乳房体积只增加134ml（P〈0．00001）。使用Brava扩张的移植存活率为（82±18）％，而未使用Brava的移植存活率为（55±18）％（P〈0．00001）。且移植前的Brava扩张与乳房增大的体积有强烈的线性相关性（R2=0．87）。未发现可疑的乳房肿块或结节。1年后影像评估时，磁共振成像技术发现脂肪坏死的发生率为16％。结论自体脂肪移植术前使用Brava扩张器可使乳房体积明显增大，且脂肪植入点更多，移植成活率更高，移植物坏死和并发症最少，证明该方法具有很高的安全性和有效性。临床问题／证据等级：疗法，Ⅳ级。

关键词：多中心前瞻性研究自体脂肪移植隆乳术安全性磁共振成像技术组织扩张器乳房体积移植存活率