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Prevalence of HIV and HCV infections in two populations of Malian women and serological assays performances

World Journal of Hepatology 2012年第12期4卷 365-373页

作者： Nouhoum Bouare Dolores Vaira Andre Gothot Jean Delwaide Sebastien Bontems laurence seidel Paul Gerard Christiane Gerard Department of Hematobiology Immuno-Hematology and AIDS Reference Laboratory B35CHU-ULg4000 LiegeBelgium Department of Hepatology and Gastroenterology CHU-ULg4000 LiegeBelgium Department of Public Health(Biostatistics) CHU-ULg4000 LiegeBelgium Institute of Mathematics ULg4000 LiegeBelgium

AIM: To estimate the prevalence of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections in women in Mali and to evaluate the performance of serological assays.

关键词： Human immunodeficiency virus Hepatitis C virus Serology Molecular diagnostics Women West Africa Bamako

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Epidemiological profiles of human immunodeficiency virus and hepatitis C virus infections in Malian women:Risk factors and relevance of disparities

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World Journal of Hepatology 2013年第4期5卷 196-205页

作者： Nouhoum Bouare Andre Gothot Jean Delwaide Sebastien Bontems Dolores Vaira laurence seidel Paul Gerard Christiane Gerard Department of Clinical Biology Laboratory HematologyImmuno-Hematology and AIDS Reference Laboratory B35Centre Hospitalier UniversitaireUniversité de Liège4000 LiègeBelgium Department of Hepatology and Gastroenterology Centre Hospitalier UniversitaireUniversité de Liège4000 LiègeBelgium Department of Public Health(Biostatistics) Centre Hospitalier UniversitaireUniversité de Liège4000 LiègeBelgium Institute of Mathematics Université de Liège4000 LiègeBelgium

AIM:To document the epidemiologic patterns and risk factors of human immunodeficiency virus(HIV)and hepatitis C virus(HCV)infections in Mali in order to develop prevention means for both ***:Two prospective studies were conducted in Bamako in 2009 among 1000 pregnant women(i.e.,young women)who consulted six reference health centers,and in 2010,among 231 older women who attended general practice in two *** tests and molecular analysis(performed only for HCV)were used to quantify the frequencies of both *** data were collected from patients recruited through a *** risk factors of both diseases were identified by univariate and multivariate ***:HCV seroprevalence was 0.2% for young and 6.5% for older *** prevalence was similar in both populations(4.1% vs 6.1%).In older women,the analysis of risk factors highlighted an association between HCV infection and episodes of hospitalization(P < 0.01).The study did not show an association between HIV infection and the variables such as hospitalization,transfusion,tattoo,dental care,and endoscopy.A significant decrease of HIV seroprevalence was detected in young women who used condoms for contraception more than for other purposes(P < 0.01).By contrast,HIV seroprevalence was significantly increased in young women using condoms mainly to prevent sexual infections rather than for contraception(P < 0.01).No HCV/HIV coinfection was detected in our ***:Risk factors and epidemiologic data of HIV and HCV as well as the absence of co-infection strongly suggest epidemiological disparities between these diseases.

关键词： Hepatitis C virus Human immunodeficiency virus Epidemiology Risk factors Women Mali Bamako

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Blood groups, hemoglobin phenotypes and clinical disorders of consanguineous Yansi population

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World Journal of Hematology 2013年第4期2卷 109-114页

作者： Nana Munlemvo Mavanga Franois Boemer laurence seidel André Nkebolo Malafu André Gothot Christiane Gerard Department of Hematobiology and Immuno-Hematology CHU-ULg 4000 Liege Belgium Centre National de Transfusion Sanguine Kinshasa BP 7555 KIN I Democratic Republic of the Congo Department of Genetics CHU-ULg 4000 Liege Belgium Department of Public Health (Biostatistics) CHU-ULg 4000 Liege Belgium Institut Supérieur des Techniques Médicales de Kinshasa (ISTM/KIN) Laboratoire Spécial d’Analyses Biomédicales Kinshasa BP 774 KIN XI Democratic Republic of the Congo

AIM:To study frequency of blood groups,prevalence of sickle-cell anemia trait and glucose-6-phosphate dehydrogenase deficiency(G6PD),among consanguineous Yansi ***:A total of 525 blood samples were collected,of which 256 among the Yansi population,and269 for the unrelated control group in the Bandunduprovince of Democratic Republic of *** group antigens were determined in the following systems:ABO,Rh,Kell,Duffy,Kidd and *** grouping and extended phenotype tests were performed according to standard immunohematological *** tests and tandem mass spectrometry were used respectively for the assessment of G6PD and sickle-cell anemia ***:The frequency of ABO phenotypes conformed to the following order O>A>B>AB with notably 62.5%,23.8%,12.1%and 1.6%for the Yansi,and 54.6%,27.5%,14.1%and 3.7%for the unrelated control group,respectively(P=0.19).As for the Rh phenotypes,the most frequent were cc ***,cc ***,Cc ***,corresponding to 71.5%,12.1%and 12.1%for the Yansi,and 70.6%,15.6%and 8.2%,for the unrelated control group(P=0.27).The frequency of MN and Ss phenotypes were statistically different between groups(P=0.0021 and P=0.0006).G6PD was observed in 11.3%of subjects in the Yansi group,and in 12.4%of controls(P=0.74).The sickle-cell anemia trait was present in 22.4%of Yansi subjects and 17.8%in the control group(P=0.24).Miscarriages and deaths in young age were more common among Yansi ***:This study shows a significant difference in MNS blood group distribution between the Yansi tribe and a control *** distribution of other blood groups and the prevalence of hemoglobinopathies did not differ in the Yansi tribe.

关键词： Blood group antigens Blood group phenotype Glucose-6-phosphate dehydrogenase deficiency Sickle-cell anemia Hemoglobin electrophoresis Clinical disorders Consanguinity Yansi

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