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SARS-CoV-2 t.iggers Dickkopf-1(Dkk-1)modulat.on of t.helper cells and lung pat.ology in mice

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Genes & Diseases 2024年第4期11卷 9-12页

作者： Yifan Wu Freedom M.Green St.phen A.Shaw lauren J.Bonilla Shannon E.Ronca Maria Elena Bot.azzi Farrah Kheradmand Jill E.Weat.erhead Depart.ent.of Pat.ology&Immunology One Baylor PlazaHoustonTX 77030USA Depart.ent.of Pediat.ics One Baylor PlazaHoustonTX 77030USA Depart.ent.of Medicine One Baylor PlazaHoustonTX 77030USA Nat.onal School of t.opical Medicine One Baylor PlazaHoustonTX 77030USA Molecular Virology&Microbiology One Baylor PlazaHoustonTX77030USA Biologyof Inflammat.on Cent.r Baylor College of MedicineOne BaylorPlazaHoustonTX77030USA Michael E.DeBakey VA Cent.r for t.anslat.onal Research on Inflammat.ry Diseases HoustonTX 77030USA

Severe acut. respirat.ry syndrome coronavirus 2(SARSCov-2)is t.e et.ologic agent.of t.e coronavirus disease 19(COVID-19)*** viral infect.ons like SARS-CoV-2,a robust.ant.-viral t.pe 1 immune response,including upregulat.on of t.pe 1 CD4+t.helper cells(t.1),is required for effect.ve viral clearance while minimizing end-organ pat.ology and collat.ral t.ssue damage.

关键词： pat.ology acut. respirat.ry

A rat.model of mult.compart.ent.l t.aumat.c injury and hemorrhagic shock induces bone marrow dysfunct.on and profound anemia

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Animal Models and Experiment.l Medicine 2024年第3期7卷 367-376页

作者： lauren S.Kelly Jennifer A.Munley Erick E.Pons Kolenkode B.Kannan Elizabet. M.Whit.ey Let.t.a E.Bible Philip A.Efron Alicia M.Mohr Depart.ent.of Surgery and Sepsis and Crit.cal Illness Research Cent.r University of Florida College of MedicineGainesvilleFloridaUSA Pat.ogenesis LLCGainesvilleFloridaUSA

Background:Severe t.auma is associat.d wit. syst.mic inflammat.on and organ *** rodent.t.auma models are t.e mainst.y of post.njury research but.have been crit.cized for not.fully replicat.ng severe human *** aim of t.is st.dy was t. creat. a rat.model of mult.compart.ent.l injury which recreat.s profound t.aumat.c ***:Male Sprague-Dawley rat. were subject.d t. unilat.ral lung cont.sion and hemorrhagic shock(LCHS),mult.compart.ent.l polyt.auma(Pt.(unilat.ral lung cont.sion,hemorrhagic shock,cecect.my,bifemoral pseudofract.re),or na?ve ***,plasma t.ll-l ike recept.r 4(t.R4),hemoglobin,spleen t. body weight.rat.o,bone marrow(BM)eryt.roid progenit.r(CFU-GEMM,BFU-E,and CFU-E)growt.,plasma granulocyt. colony-st.mulat.ng fact.r(G-CSF)and right.lung hist.logic injury were assessed on day 7,wit. significance defined as p valuest.:Polyt.auma result.d in markedly more profound inhibit.on of weight.gain compared t. LCHS(p=0.0002)along wit. elevat.d plasma t.R4(pt. body weight.rat.os(p=0.004).Bot. LCHS and Pt.demonst.at.d suppression of CFU-E and BFU-E growt. compared t. naive(pt.d in Pt.compared t. bot. na?ve and LCHS(pt.demonst.at.d significant.hist.logic right.lung injury wit. poor alveolar wall int.grit. and int.rst.t.al ***:Mult.compart.ent.l injury as described here est.blishes a reproducible model of mult.compart.ent.l injury wit. worsened anemia,splenic t.ssue enlargement.weight.loss,and increased inflammat.ry act.vit. compared t. a less severe *** may serve as a more effect.ve model t. recreat. profound t.aumat.c injury t. replicat. t.e human inflammat.ry response post.njury.

关键词： anemia i nflammat.on polyt.auma pseudofract.re shock

Impact.of diet.ry supplement.t.on of one-carbon met.bolism on neural recovery

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Neural Regenerat.on Research 2017年第7期12卷 1075-1076页

作者： Joshua t.Emmerson lauren K.Murray Nafisa M.Jadavji Depart.ent.of Neuroscience Carleton University Ottawa ONCanada

In t.e cell,one-carbon met.bolism modulat.s nucleot.de synt.esis,DNA repair,as well as met.ylat.on t.rough t.e reduct.on of homocyst.ine（Figure 1）.High levels of plasma homocyst.ine have been associat.d wit. negat.ve healt. out.omes in humans（Murray et.al.,2017）.Folat.s,B-vit.mins,are a major component.of one-carbon met.bolism and play an import.nt.role in brain ***,t.ey are involved in nucleot.de synt.esis,DNA repair,met.ylat.on,second messenger syst.ms,ion channels,prot.in,

关键词： of et is as Impact.of diet.ry supplement.t.on of one-carbon met.bolism on neural recovery int. been were t.at on Mt.FR for DHFR

Funct.onal Equivalence of Creat.d Wet.and Wat.r Qualit.: A Comparison of Amphibian Met.morphic Success

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Open Journal of Ecology 2020年第7期10卷 418-439页

作者： lauren A. McPherson Ida Holásková James t. Anderson School of Nat.ral Resources West Virginia University Morgantown WV USA Office of St.t.st.cs Davis College of Agriculture Natural Resources and Design West Virginia University Morgantown WV USA

Wet.ands are oft.n creat.d t.rough wet.and mit.gat.on t. replace lost.nat.ral wet.ands, but.furt.er evaluat.on is needed t. det.rmine t.e abilit. of a creat.d wet.and t. replace lost.wet.and funct.ons, especially providing wildlife habit.t. We used a mesocosm design t. compare t.e wat.r qualit. bet.een t.ree creat.d wet.ands and t.ree nat.ral wet.ands in West.Virginia, USA and t. evaluat. how t.e wat.r qualit. from t.e t.o wet.and t.pes were able t. support.met.morphosis in larval spring peepers (Pseudacris crucifer) and wood frogs (Lit.obat.s sylvat.cus) across t.o years (2014-2015). Responses in met.morphosis rat.s differed bet.een species and bet.een years. Spring peepers displayed similar met.morphosis rat.s in t.e creat.d and nat.ral wet.ands in bot. years of t.e st.dy. Wood frogs displayed similar met.morphosis rat.s in creat.d and nat.ral wet.ands in 2015, but.in 2014 wood frogs reached met.morphosis in less t.me and at.a larger body size in t.e nat.ral wet.ands, suggest.ng t.at.t.e wood frogs t.at.developed in t.e nat.ral wet.ands may have higher fit.ess t.an t.ose t.at.developed in t.e creat.d wet.ands. Wat.r qualit. was largely similar bet.een creat.d and nat.ral wet.ands, alt.ough dissolved oxygen, conduct.vit., and pH varied bet.een mesocosms and wet.ands. Our st.dy suggest. t.at.creat.d wet.ands may be providing part.al mit.gat.on in t.rms of wat.r qualit. for amphibian development. We recommend t.at.fut.re monit.ring of creat.d wet.ands include measures of juvenile amphibian recruit.ent.as well as addit.onal habit.t.variables t. bet.er det.rmine t.e abilit. of creat.d wet.ands t. funct.on as amphibian habit.t.

关键词： Appalachians Pseudacris crucifer Spring Peeper Lit.obat.s sylvat.cus West.Virginia Wood Frog

Healt. pract.t.oner pract.ces and t.eir influence on nut.it.onal int.ke of hospit.lised pat.ent.

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Int.rnat.onal Journal of Nursing Sciences 2019年第2期6卷 162-168页

作者： Andrea P.Marshall t.hnie t.kefala lauren t.Williams Alan Spencer Laurie Grealish Shelley Robert. Menzies Healt. Inst.t.t. Queensland Griffith UniversityParklands DriveSouthportQLDAustralia School of Nursing and Midwifery Griffith UniversityParklands DriveSouthportQLDAustralia Nursing and Midwifery Educat.on and Research Unit Gold Coast University Hospital1 Hospital BlvdQLDAustralia School of Allied Healt. Sciences Griffith UniversityGold Coast CampusParklands DriveSouthportQLDAustralia Depart.ent.of Nut.it.on and Diet.t.cs Gold Coast Health1 Hospital BlvdQLDAustralia

Object.ves:In t.e hospit.l set.ing,poor diet.ry int.ke int.ract. wit. disease and represent. a major and modifiable cause of *** barriers t. adequat. diet.ry int.ke is an import.nt.st.at.gy t. guide t.e development.of int.rvent.ons t. improve nut.it.on *** aim of t.is st.dy report.d in t.is paper was t. explore pat.ent.family and healt. care professionals'percept.ons of barriers t. and enablers of adequat. nut.it.on care and diet.ry int.ke of medical ***:An explorat.ry qualit.t.ve st.dy design incorporat.ng group and individual int.rviews of pat.ent.(n=14),t.eir family members(n=4),and healt. care professionals(n=18)was *** were recruit.d pragmat.cally,using a mix of convenience and purposive sampling.A t.eoret.cally informed,semi-st.uct.red int.rview schedule was based on observat.ons of pract.ce and t.e t.eoret.cal Domains *** were audio-recorded,t.anscribed verbat.m and analysed induct.vely using a general induct.ve ***:t.ree key t.emes emerged from analysing part.cipant.*** approaches t. nut.it.on care reflect.d t.e diverse range of healt. care professionals responsible for nut.it.on care but.who oft.n worked in isolat.on from t.eir *** work priorit.es for nurses reflect.d t.e challenge in priorit.se nut.it.on care which was oft.n const.ained because of ot.er care needs or work-relat.d *** pat.ent. t. eat.highlight.d t.at.nurses were oft.n t.e only healt. care professional who would provide assist.nce t. pat.ent. at.mealt.mes and lack of available st.ff could negat.vely influence pat.ent.'nut.it.on ***:We have ident.fied many complex and int.rrelat.d barriers which preclude adequat. diet.ry int.ke in acut. medical *** predominant.y reflect.issues inherent.in t.e hospit.l cult.re and ***-facet.d and sust.inable int.rvent.ons t.at.support.a facilit.t.ng nut.it.on cult.re and mult.discip

关键词： Cognit.on Diet.ry services Pat.ent. Personnel,Hospit.l Qualit.t.ve research

Novel dat.-driven subt.pes and st.ges of brain at.ophy in t.e ALS-Ft. spect.um

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t.anslat.onal Neurodegenerat.on 2023年第1期12卷 50-69页

作者： t.ng Shen Jacob W.Vogel Jeffrey Duda Jeffrey S.Phillips Philip ACook James Gee lauren Elman Colin Quinn Defne A.Amado Michael Baer lauren Massimo Murray Grossman David J.Irwin Corey t.McMillan Penn Front.t.mporal Degenerat.on Cent.r Department of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Depart.ent.of Clinical Sciences SciLifeLabLund University22242 LundSweden Penn Image Comput.ng and Science Lab(PICSL) Department of RadiologyPerelman School of MedicineUniversity of Penn-sylvaniaPhiladelphiaPA 19104USA Depart.ent.of Neurology Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Digit.l Neuropat.ology Laborat.ry Department of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA.

Background t.P-43 prot.inopat.ies represent.a spect.um of neurological disorders,anchored clinically on eit.er end by amyot.ophic lat.ral sclerosis(ALS)and front.t.mporal degenerat.on(Ft.).t.e ALS-Ft. spect.um exhibit. a diverse range of clinical present.t.ons wit. overlapping phenot.pes,highlight.ng it. *** st.dy was aimed t. use disease progression modeling t. ident.fy novel dat.-driven spat.al and t.mporal subt.pes of brain at.ophy and it. progression in t.e ALS-Ft. *** We used a dat.-driven procedure t. ident.fy 13 anat.mic clust.rs of brain volume for 57 behavioral variant.Ft.(bvFt.;wit. eit.er aut.psy-confirmed t.P-43 or t.P-43 prot.inopat.y-associat.d genet.c variant.),103 ALS,and 47 ALS-Ft. pat.ent. wit. likely t.P-43.A Subt.pe and St.ge Inference(SuSt.In)model was t.ained t. ident.fy subt.pes of individuals along t.e ALS-Ft. spect.um wit. dist.nct.brain at.ophy pat.erns,and we relat.d subt.pes and st.ges t. clinical,genet.c,and neuropat.ological feat.res of *** SuSt.In ident.fied t.ree novel subt.pes:t.o disease subt.pes wit. predominant.brain at.ophy in eit.er prefront.l/somat.mot.r regions or limbic-relat.d regions,and a normal-appearing group wit.out.obvious brain *** limbic-predominant.subt.pe t.nded t. present.wit. more impaired cognit.on,higher frequencies of pat.ogenic variant. in t.K1 and t.RDBP genes,and a higher proport.on of t.P-43 t.pes B,E and *** cont.ast.t.e prefront.l/somat.mot.r-predominant.subt.pe had higher frequencies of pat.ogenic variant. in C9orf72 and GRN genes and higher proport.on of t.P-43 t.pe *** normal-appearing brain group showed higher frequency of ALS relat.ve t. ALS-Ft. and bvFt. pat.ent.,higher cognit.ve capacit.,higher proport.on of lower mot.r neuron onset.milder mot.r sympt.ms,and lower frequencies of genet.c pat.ogenic *** overall SuSt.In st.ges also correlat.d wit. evidence for clinical progression including longer disease durat.on,higher King’s st.ge,and cog

关键词： Amyot.ophic lat.ral sclerosis Front.t.mporal degenerat.on Disease het.rogeneit. SuSt.In model

Feeding Soy wit. Probiot.c At.enuat.s Obesit.-Relat.d Met.bolic Syndrome t.ait. in Obese Zucker Rat.

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Food and Nut.it.on Sciences 2015年第9期6卷 780-789页

作者： lauren Mount. Rajit.a Sunkara Louis Shackelford Simon Ogut. Lloyd t. Walker Mart.a Verghese Nut.it.onal Biochemist.y Laborat.ry Department of Food & Animal Sciences Alabama A & M University Normal AL USA Food Chemist.y Laborat.ry Department of Food & Animal Sciences Alabama A & M University Normal AL USA

Obesit. has reached pandemic levels, being a major concern of healt.. Overweight.and obesit. are t.e precursors for met.bolic dist.rbances in t.e body. Probiot.cs and prebiot.cs administ.at.ons have shown t. reduce t.e charact.rist.cs of obesit.-induced met.bolic syndrome in animals. t.e present.st.dy examined t.e effect. of diet.ry supplement.t.on of soybean meal and Bifidobact.rium longum (BB536) singly and in combinat.on on obesit.-relat.d t.ait. in obese Zucker rat.. Cont.ol group rat. were fed wit. AIN93-M diet.and t.eat.ent.groups were fed wit. soybean meal (5 % or 10%) and Bifidobact.rium longum (0.1%) in single and combinat.ons for 100 days. Weight.gain, feed int.ke, and % of fat.in liver were recorded. Serum biochemical paramet.rs such as cholest.rol, t.iglycerides, insulin and glucose were analyzed. Act.vit.es of liver enzymat.c markers (alanine aminot.ansferase (ALt., gamma glut.myl-t.ansferase (GGt., and alkaline phosphat.se (ALP)) were det.rmined. Diet.ry supplement.t.on of soymeal at.10% wit. B. longum reduced t.e weight.gain by 30% and liver fat.cont.nt.by 35%. Feeding Bifidobact.rium longum alone did not.have any effect.in analyzing serum biochemical paramet.rs and act.vit. of liver enzymat.c markers. Serum glucose and insulin levels in rat. were lowered by 18% - 24% and 22% - 25% respect.vely when fed wit. administ.at.on of combinat.onal feeding of soymeal at.5% and 10% wit. Bifidobact.rium longum. Hepat.c enzyme act.vit. was reduced by 1.3 fold wit. t.e combinat.onal diet.at.higher concent.at.on (soy 10%). t.e present.st.dy provides evidence t.at.supplement.t.on wit. soymeal wit. probiot.c, B. longum at.enuat.s t.e met.bolic disorders induced by obesit. in obese Zucker rat..

关键词： Obesit. Met.bolic Syndrome Soy Bifidobact.rium longum

Mult.-scale invest.gat.on of short.range order and dislocat.on glide in MoNbt. and t.Nbt. mult.-principal element.alloys

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npj Comput.t.onal Mat.rials 2023年第1期9卷 1430-1442页

作者： Hui Zheng lauren t.W.Fey Xiang-Guo Li Yong-Jie Hu Liang Qi Chi Chen Shuozhi Xu Irene J.Beyerlein Shyue Ping Ong Depart.ent.of NanoEngineering University of California San DiegoLa JollaCA 92093-0448USA Mat.rials Depart.ent University of CaliforniaSanta BarbaraCA 93106-5050USA Depart.ent.of Mat.rials Science and Engineering University of MichiganAnn ArborMI 48109USA Depart.ent.of Mat.rials Science and Engineering Drexel UniversityPhiladelphiaPA 19104USA Depart.ent.of Mechanical Engineering University of CaliforniaSanta BarbaraCA 93106-5070USA

Refract.ry mult.-principal element.alloys(RMPEAs)are promising mat.rials for high-t.mperat.re st.uct.ral ***,we invest.gat. t.e role of short.range ordering(SRO)on dislocat.on glide in t.e MoNbt. and t.Nbt. RMPEAs using a mult.-scale modeling *** carlo/molecular dynamics simulat.ons wit. a moment.t.nsor pot.nt.al show t.at.MoNbt. exhibit. a much great.r degree of SRO t.an t.Nbt. and t.e local composit.on has a direct.effect.on t.e unst.ble st.cking fault.energies(USFEs).From mesoscale phase-field dislocat.on dynamics simulat.ons,we find t.at.increasing SRO leads t. higher mean USFEs and st.ess required for dislocat.on *** gliding dislocat.ons experience significant.hardening due t. pinning and depinning caused by random composit.onal fluct.at.ons,wit. higher SRO decreasing t.e degree of USFE dispersion and hence,amount.of ***,we show how t.e morphology of an expanding dislocat.on loop is affect.d by t.e applied st.ess.

关键词： alloys dislocat.on element

Hypoxia-inducing cryogels uncover key cancer-immune cell int.ract.ons in an oxygen-deficient.t.mor microenvironment

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Bioact.ve Mat.rials 2023年第11期29卷 279-295页

作者： t.ibault.Colombani Zachary JRogers Khushbu Bhat. James Sinoimeri lauren Gerbereux Mohammad Hamrangsekachaee Sidi ABencherif Depart.ent.of Chemical Engineering Northeastern UniversityBostonMA 02115United States Depart.ent.of Pharmaceut.cal Sciences Northeastern UniversityBostonMAUnited States Depart.ent.of Bioengineering Northeastern UniversityBostonMA 02115United States Harvard John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138United States Biomechanics and Bioengineering(BMBI) UTC CNRS UMR 7338University of Technology of Compi`egneSorbonne University60203 Compi`egneFrance

Hypoxia is a major fact.r shaping t.e immune landscape,and several cancer models have been developed t. emulat. hypoxic ***,t. dat.,t.ey st.ll have several limit.t.ons,such as t.e lack of reproducibilit.,inadequat. biophysical cues,limit.d immune cell infilt.at.on,and poor oxygen(O_(2))cont.ol,leading t. non-pat.ophysiological t.mor ***,it.is essent.al t. develop bet.er cancer models t.at.mimic key feat.res of t.e t.mor ext.acellular mat.ix and recreat. t.mor-associat.d hypoxia while allowing cell infilt.at.on and cancer-immune cell ***,hypoxia-inducing cryogels(HICs)have been engineered using hyaluronic acid(HA)t. fabricat. t.ree-dimensional microt.ssues and model a hypoxic t.mor ***,t.mor cell-laden HICs have been designed t. deplet. O_(2) locally and induce long-st.nding *** promot.d changes in hypoxia-responsive gene expression and phenot.pe,a met.bolic adapt.t.on t. anaerobic glycolysis,and chemot.erapy ***,HIC-support.d t.mor models induced dendrit.c cell(DC)inhibit.on,revealing a phenot.pic change in t.e plasmacyt.id DC(pDC)subset.and an impaired convent.onal DC(cDC)response in ***,our HIC-based melanoma model induced CD8^(+)t.cell inhibit.on,a condit.on associat.d wit. t.e downregulat.on of pro-inflammat.ry cyt.kine secret.on,increased expression of immunomodulat.ry fact.rs,and decreased degranulat.on and cyt.t.xic capacit. of t.***,t.ese dat. suggest.t.at.HICs can be used as a t.ol t. model solid-like t.mor microenvironment. and has great.pot.nt.al t. deepen our underst.nding of cancer-immune cell relat.onship in low O_(2) condit.ons and may pave t.e way for developing more effect.ve t.erapies.

关键词： Cryogels Hypoxia Cancer Immunosuppression Drug resist.nce