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Adverse effects of androgen deprivation therapy in men with prostate cancer： a focus on metabolic and cardiovascular complications

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Asian Journal of Andrology 2012年第2期14卷 222-225页

作者： lauren collins Shehzad Basaria Department of Medicine Division of Endocrinology and MetabolismBoston University School of MedicineBostonMA 02118USA

Prostate cancer （PCa） is the most common malignancy in men. Prostate being an androgen responsive tissue, androgen deprivation therapy （ADT） is used in the management of locally advanced （improves survival） and metastatic （improves pain and quality of life） PCa. Over the past two decades, the use of ADT has significantly increased as it is also being used in patients with localized disease and those experiencing biochemical recurrences, though without any evidence of survival advantage. Hypogonadism resulting from ADT is associated with decreased muscle mass and strength, increased fat mass, sexual dysfunction, vasomotor symptoms, decreased quality of life, anemia and bone loss. Insulin resistance, diabetes and cardiovascular disease have recently been added to the list of these complications. As the majority of men with PCa die of conditions other than their primary malignancy, recognition and management of these adverse effects is paramount. Here we review data evaluating metabolic and cardiovascular complications of ADT.

关键词： androgen deprivation therapy cardiovascular disease diabetes hypogonadism prostate cancer

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Legacy earthen berms influence vegetation and hydrologic complexity in the Altar Valley,Arizona

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International Soil and Water Conservation Research 2023年第4期11卷 755-763页

作者： Mary H.Nichols Sara E.Duke Chandra Holifield collins lauren Thompson Southwest Watershed Research Center USDA-ARS2000 E.Allen Rd.TucsonAZ85719USA Southern Plains Area Research Center USDA-ARSSPARCCollege StationTX77845USA University of Arizona College of Science GraduateTucsonAZ85719USA

Across the American Southwest water development has played a critical role in managing *** berms have been constructed throughout US rangelands to manage runoff and reduce *** berms altered runoff patterns to increase soil moisture with positive local vegetative ***,altered runoff patterns can be considered a disturbance that affects broader scale vegetation *** hypothesized that the hydrologic impacts of earthen berms in semiarid rangelands will be reflected in contrasting upslope and downslope vegetation patterns.A supervised classification of grass,shrubs,and bare soil was performed using orthographic imagery taken in June 2016 to quantify the effects of 181 earthen berms in the uplands and floodplain of the Altar Valley in Southern Arizona,*** berms blocked runoff,creating downslope runoff"shadows"within which the precipitation is the dominant water *** documented more bare soil downslope of intact berms in comparison with *** and shrub cover affected by berms were related to soil *** and shrub cover were not different above and below intact berms on fine textured soils,but on sites with coarser textured soil,grass cover was lower downslope of *** breaches occurred on coarser textured soils,the up and downslope differences in grass cover *** study points to the role of conservation structures in adding additional complexity to already heterogeneous landscapes by creating patchwork assemblages of vegetation and bare soil proximal to earthen runoff and erosion control berms.

关键词： Legacy conservation structure Earthen bank Earthen berm Land degradation Rangeland

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