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WONOEP评价:癫痫的分子和细胞生物标记物

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癫痫杂志 2017年第3期3卷 267-275页

作者： lauren E walker Damir Janigro Uwe Heinemann 江欣玥慕洁

外周生物标志物具有许多潜在用途,可用于癫痫的治疗、预测、预后和药物安全监视作用。目前为止,虽然多个候选标记物在研究中,但还没有单一的外周生物标记物已经证明有效。文章中讨论的重点领域,包括炎症、血脑屏障功能障碍、氧化还原改... 详细信息

外周生物标志物具有许多潜在用途,可用于癫痫的治疗、预测、预后和药物安全监视作用。目前为止,虽然多个候选标记物在研究中,但还没有单一的外周生物标记物已经证明有效。文章中讨论的重点领域,包括炎症、血脑屏障功能障碍、氧化还原改变、代谢、激素和生长因子。

关键词：炎症血脑屏障高迁移率组框1(HMGB1) S100B 脑源性神经营养因子胰岛素样生长因子

Psychosocial mechanisms for the transmission of somatic symptoms from parents to children

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World Journal of Gastroenterology 2015年第18期21卷 5532-5541页

作者： Miranda AL van Tilburg Rona L Levy Lynn S walker Michael Von Korff lauren D Feld Michelle Garner Andrew D Feld William E Whitehead Center for Functional GI and Motility Disorders University of North Carolina School of Social Work University of Washington Department of Pediatrics Vanderbilt University School of Medicine Nashville TN 37201 United States Group Health Research Institute Mount Sinai School of Medicine Department of Social Work University of Washington Tacoma Group Health Cooperative

AIM: To examine familial aggregation of irritable bowel syndrome(IBS) via parental reinforcement/modeling of symptoms, coping, psychological distress, and exposure to ***:Mothers of children between the ages of8 and 15 years with and without IBS were identified through the Group Health Cooperative of Puget *** completed questionnaires,including the Child Behavior Checklist(child psychological distress),the Family Inventory of Life Events(family exposure to stress),SCL-90R(mother psychological distress),and the Pain Response Inventory(beliefs about pain).Children were interviewed separately from their parents and completed the Pain Beliefs Questionnaire(beliefs about pain),Pain Response Inventory(coping)and Child Symptom Checklist[gastrointestinal(GI)symptoms].In addition,health care utilization data was obtained from the automated database of Group Health *** with IBS(n=207)and their 296 children were compared to 240 control mothers and their 335 children,while controlling for age and ***:Hypothesis 1:reinforcement of expression of GI problems is only related to GI symptoms,but not others(cold symptoms)in *** was no significant correlation between parental reinforcement of symptoms and child expression of GI or other *** 2:modeling of GI symptomsis related to GI but not non-GI symptom reporting in *** of parents with IBS reported more non-GI(8.97 vs 6.70,P<0.01)as well as more GI(3.24 vs 2.27,P<0.01)*** health care visits made by the mother correlated with visits made by the child(rho=0.35,P<0.001 for cases,rho=0.26,P<0.001 for controls).Hypothesis 3:children learn to share the methods of coping with illness that their mothers *** used by children to cope with stomachaches differed from methods used by their *** 2/16 scales showed weak but significant correlations(stoicism rho=0.13,P<0.05;acceptance rho=0.13,P<0.05).Hypothesis 4:mothers and chi

关键词： Abdominal pain Coping Illness behaviors Psychological distress Social learning Stress

Feeding Soy with Probiotic Attenuates Obesity-Related Metabolic Syndrome Traits in Obese Zucker Rats

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Food and Nutrition Sciences 2015年第9期6卷 780-789页

作者： lauren Mounts Rajitha Sunkara Louis Shackelford Simon Ogutu Lloyd T. walker Martha Verghese Nutritional Biochemistry Laboratory Department of Food & Animal Sciences Alabama A & M University Normal AL USA Food Chemistry Laboratory Department of Food & Animal Sciences Alabama A & M University Normal AL USA

Obesity has reached pandemic levels, being a major concern of health. Overweight and obesity are the precursors for metabolic disturbances in the body. Probiotics and prebiotics administrations have shown to reduce the characteristics of obesity-induced metabolic syndrome in animals. The present study examined the effects of dietary supplementation of soybean meal and Bifidobacterium longum (BB536) singly and in combination on obesity-related traits in obese Zucker rats. Control group rats were fed with AIN93-M diet and treatment groups were fed with soybean meal (5 % or 10%) and Bifidobacterium longum (0.1%) in single and combinations for 100 days. Weight gain, feed intake, and % of fat in liver were recorded. Serum biochemical parameters such as cholesterol, triglycerides, insulin and glucose were analyzed. Activities of liver enzymatic markers (alanine aminotransferase (ALT), gamma glutamyl-transferase (GGT), and alkaline phosphatase (ALP)) were determined. Dietary supplementation of soymeal at 10% with B. longum reduced the weight gain by 30% and liver fat content by 35%. Feeding Bifidobacterium longum alone did not have any effect in analyzing serum biochemical parameters and activity of liver enzymatic markers. Serum glucose and insulin levels in rats were lowered by 18% - 24% and 22% - 25% respectively when fed with administration of combinational feeding of soymeal at 5% and 10% with Bifidobacterium longum. Hepatic enzyme activity was reduced by 1.3 fold with the combinational diet at higher concentration (soy 10%). The present study provides evidence that supplementation with soymeal with probiotic, B. longum attenuates the metabolic disorders induced by obesity in obese Zucker rats.

关键词： Obesity Metabolic Syndrome Soy Bifidobacterium longum

Improving the Evaluation and Management of Cystotomy in Gynecologic Surgery with a Cadaver Surgical Curriculum

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Open Journal of Obstetrics and Gynecology 2021年第9期11卷 1202-1216页

作者： Cassandra Presti Conway Xu Chang Liu Larry walker lauren Scott S. Abbas Shobeiri Francine McLeod Department of Obstetrics and Gynecology Inova Fairfax Hospital Falls Church USA Department of Surgery Inova Fairfax Hospital Falls Church USA Advanced Surgical Technology and Education Center Inova Fairfax Hospital Falls Church USA Division of Female Pelvic Medicine and Reconstructive Surgery Inova Fairfax Hospital Falls Church USA

Objectives: Urinary tract injuries are a known complication of gynecologic surgery, occurring in 0.18% - 0.80% of procedures and most commonly involving the bladder. Appropriate identification, evaluation, treatment, and follow-up by gynecologic surgeons are important to reduce the associated long-term morbidities. The purpose of this study was to implement a comprehensive cadaver curriculum in cystotomy repair for OBGYN residents. Methods: This was a prospective observational cohort study including 10 OBGYN residents (PGY1-3) at a single institution in 2020 (56% of the 18 eligible residents). The curriculum consisted of a one-hour didactic lecture and one-hour hands-on surgical skills training with fresh frozen cadavers. Residents were evaluated in three domains: 1) knowledge, 2) surgical skills, and 3) confidence. Knowledge, confidence, and resident satisfaction were evaluated with pre- and post-surveys. The bladder model, derived from the ACOG Simulation Working Group, was used to evaluate surgical skills at baseline and at completion of the curriculum. Results: Across all three P

关键词： Bladder Injury Cystotomy Repair Cadaver Lab Resident Curriculum