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Moving fast, thinking fast:The relations of physical activity levels and bouts to neuroelectric indices of inhibitory control in preadolescents

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Journal of Sport and Health Science 2019年第4期8卷 301-314页

作者： Dominika M.Pindus Eric S.Drollette lauren b.raine Shih-Chun Kao Naiman Khan Daniel R.Westfall Morgan Hamill Rebecca Shorin Emily Calobrisi Dinesh John Arthur F.Kramer Charles H.Hillman Department of Kinesiology and Community Health University of Illinois at Urbana-ChampaignUrbanaIL 61801USA School of Health and Human Sciences University of North Carolina GreensboroGreensboroNC 6170USA Department of Psychology Northeastern UniversityBostonMA 02115USA Department of Health and Kinesiology Purdue UniversityWest LafayetteIN 47907USA Department of Health Sciences Northeastern UniversityBostonMA 02115USA Department of Physical Therapy Movement&Rehabilitation SciencesNortheastern UniversityBostonMA 02115USA

background:Structured vigorous physical activity(VPA)can improve cognitive control in children,but studies relating daily physical activity(PA)to cognitive control have yielded conflicting *** objectively measured daily PA summarizes all occurrences of PA within a registered period,a minimum duration of continuous PA is required for registration of a PA *** brief bouts of high-intensity PA can account for a large proportion of children’s daily activity-related energy expenditure,this study assessed whether daily and bouted VPA were selectively related to cognitive control in preadolescents relative to other PA ***:A total of 75 children between the ages of 8 and 10 years(49%girls)wore an ActiGraph wGT 3 X+on the hip for 7 *** acceleration signal from the vertical axis was summarized over 1 s,5 s,and 15 s *** and boutecd modercate PA,moderate-to-vigorous PA,and VPA were *** bouts were expressed as the frequency and time spent in 2 different continuous PA bouts,one lasting≥10 s and the other lasting≥30 s at a given *** control was assessed using behavioral responses to a modified flanker task(mean reaction time(RTmean)and accuracy).Attentional resource allocation and co gnitive processing speed were measured using the amplitude and latency of the P3 component of event-related brain potentials,*** between PA,behavioral indices of inhibitory control,P3 amplitude,and latency were assessed using hierarchical regression ***:Daily VPA was not related to RTmean or accuracy on either congruent or incongruent *** contrast,more time spent in VPA bouts lasting≥30 s predicted shorter P3 latency across epochs and flanker congruencies(allβ≤-0.24,all p≤0.04).The associations between shorter P3 latency and the time spent in moderate-to-vigorous PA bouts lasting≥30 s were less consistent and largely limited to congruent trials(congruent:β(-0.3 1,-0.34)).No significant asso

关键词： Accelerometry bouts Children ERPs Inhibitory control P3 Physical activity

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How to establish an endoscopic bariatric practice

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World Journal of Gastrointestinal Endoscopy 2024年第4期16卷 178-186页

作者： Daniel b Maselli lauren L Donnangelo brian Coan Christopher E McGowan Clinical Research True You Weight LossAtlantaGA 30342United States Clinical Research True You Weight LossCaryNC 27513United States

Obesity is a chronic,progressive,and relapsing disease of excess adiposity that contributes to more than two hundred medical conditions and is projected to affect more than half the adult population of the United States by the year *** the limited penetrance of traditional bariatric surgery,as well as the cost and adherence barriers to anti-obesity medications,there is growing interest in the rapidly evolving field of endoscopic bariatric therapies(EbTs).EbTs are minimally invasive,same-day,per-oral endoscopic procedures and include endoscopic sleeve gastroplasty,intragastric balloons,and endoscopic bariatric revisional *** field represents an exciting and innovative subspe-cialty within ***,building a successful endoscopic bariatric practice requires intentional,coordinated,and sustained efforts to overcome the numerous obstacles to *** barriers include acquisition of the technical and cognitive skillset,practice limitations including the availability of nutrition counseling,facility capabilities,direct-to-consumer marketing,and financial pressures such as facility and anesthesia *** the highest-volume center for metabolic and bariatric endoscopy in the United States,we provide insights into successfully establishing an endoscopic bariatric program.

关键词： Obesity Endoscopic bariatric therapies bariatric endoscopy Endoscopic sleeve gastroplasty Intragastric balloon Practice management

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A rat model of multicompartmental traumatic injury and hemorrhagic shock induces bone marrow dysfunction and profound anemia

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Animal Models and Experimental Medicine 2024年第3期7卷 367-376页

作者： lauren S.Kelly Jennifer A.Munley Erick E.Pons Kolenkode b.Kannan Elizabeth M.Whitley Letitia E.bible Philip A.Efron Alicia M.Mohr Department of Surgery and Sepsis and Critical Illness Research Center University of Florida College of MedicineGainesvilleFloridaUSA Pathogenesis LLCGainesvilleFloridaUSA

background:Severe trauma is associated with systemic inflammation and organ *** rodent trauma models are the mainstay of postinjury research but have been criticized for not fully replicating severe human *** aim of this study was to create a rat model of multicompartmental injury which recreates profound traumatic ***:Male Sprague-Dawley rats were subjected to unilateral lung contusion and hemorrhagic shock(LCHS),multicompartmental polytrauma(PT)(unilateral lung contusion,hemorrhagic shock,cecectomy,bifemoral pseudofracture),or na?ve ***,plasma toll-l ike receptor 4(TLR4),hemoglobin,spleen to body weight ratio,bone marrow(bM)erythroid progenitor(CFU-GEMM,bFU-E,and CFU-E)growth,plasma granulocyte colony-stimulating factor(G-CSF)and right lung histologic injury were assessed on day 7,with significance defined as p valuesbition of weight gain compared to LCHS(p=0.0002)along with elevated plasma TLR4(pbin(pbody weight ratios(p=0.004).both LCHS and PT demonstrated suppression of CFU-E and bFU-E growth compared to naive(pboth na?ve and LCHS(pbed here establishes a reproducible model of multicompartmental injury with worsened anemia,splenic tissue enlargement,weight loss,and increased inflammatory activity compared to a less severe *** may serve as a more effective model to recreate profound traumatic injury to replicate the human inflammatory response postinjury.

关键词： anemia i nflammation polytrauma pseudofracture shock

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Exercise training improves long-term memory in obese mice

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Life Metabolism 2024年第1期3卷 37-50页

作者： Oliver K.Fuller Casey L.Egan Tina L.Robinson Nimna Perera Heidy K.Latchman lauren V.Terry Emma D.McLennan Carolina Chavez Emma L.burrows John W.Scott Robyn M.Murphy Henriette van Praag Martin Whitham Mark A.Febbraio Monash Institute of Pharmaceutical Sciences Monash UniversityMelbourneVictoria3052Australia La Trobe Institute for Molecular Science La Trobe UniversityMelbourneVictoria3086Australia Florey Institute of Neuroscience and Mental Health University of MelbourneMelbourneVictoria3052Australia Department of biomedical Sciences Charles E.Schmidt College of Medicineand Stiles-Nicholson Brain InstituteFlorida Atlantic UniversityJupiterFL 33458United States College of Life and Environmental Sciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom

Obesity has been linked to a range of pathologies,including *** contrast,regular physical activity is associated with the prevention or reduced progression of ***,physical activity can improve memory and spatial cognition,reduce age-related cognitive decline,and preserve brain volume,but the mechanisms are not fully ***,we investigated whether any detrimental effects of high-fat diet(HFD)-induced obesity on cognition,motor behavior,adult hippocampal neurogenesis,and brain-derived neurotrophic factor(bDNF)could be mitigated by voluntary exercise training in male C57bl/6 ***-induced impairment of motor function was not reversed by ***,voluntary wheel running improved long-term memory and increased hippocampal neurogenesis,suggesting that regular physical activity may prevent cognitive decline in obesity.

关键词： obesity exercise cognition

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Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes following liver transplantation: A retrospective study

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World Journal of Transplantation 2024年第3期14卷 120-131页

作者： William Chung Kevin Wong Noel Ravindranayagam lauren Tang Josephine Grace Darren Wong Danny Con Marie Sinclair Avik Majumdar Numan Kutaiba Samuel Hui Paul Gow Vijayaragavan Muralidharan Alexander Dobrovic Adam Testro Department of Gastroenterology Austin HealthHeidelberg 3084VictoriaAustralia Victorian Liver Transplant Unit Austin HealthHeidelberg 3084VictoriaAustralia Department of Radiology Austin HealthHeidelberg 3084VictoriaAustralia Department of Gastroenterology Monash HealthClayton 3168VictoriaAustralia Department of Surgery University of MelbourneAustin HealthHeidelberg 3048VictoriaAustralia Department of Surgery Beacon LaboratoryAustin PrecinctThe University of MelbourneAustin HospitalHeidelberg 3048VictoriaAustralia

bACKGROUND Liver transplantation(LT)is a potentially curative therapy for patients with hepatocellular carcinoma(HCC).HCC-recurrence following LT is associated with reduced *** is increasing interest in chemoprophylaxis to improve HCC-related outcomes *** To investigate whether there is any benefit for the use of drugs with proposed chemoprophylactic properties against HCC,and patient outcomes following *** This was a retrospective study of adult patients who received Deceased Donor LT for HCC from 2005-2022,from a single Australian *** use was defined as statin,aspirin or metformin therapy for≥29 days,within 24 months post-LT.A cox proportional-hazards model with time-dependent covariates was used for survival *** measures were the composite-endpoint of HCC-recurrence and all-cause mortality,HCC-recurrence and HCC-related *** analysis was performed to account for immortality time bias and statin *** Three hundred and five patients were included in this study,with 253(82.95%)males with a median age of 58.90 *** of liver disease were 150(49.18%)hepatitis C,73(23.93%)hepatitis b(HbV)and 33(10.82%)non-alcoholic fatty liver disease(NAFLD).56(18.36%)took statins,51(16.72%)aspirin and 50(16.39%)*** a median follow-up time of 59.90 months,34(11.15%)developed HCC-recurrence,48(15.74%)died,17(5.57%)from HCC-related ***,aspirin or metformin use was not associated with statistically significant differences in the composite endpoint of HCC-recurrence or all-cause mortality[hazard ratio(HR):1.16,95%CI:0.58-2.30;HR:1.21,95%CI:0.28-5.27;HR:0.61,95%CI:0.27-1.36],HCC-recurrence(HR:0.52,95%CI:0.20-1.35;HR:0.51,95%CI:0.14-1.93;HR 1.00,95%CI:0.37-2.72),or HCC-related mortality(HR:0.32,95%CI:0.033-3.09;HR:0.71,95%CI:0.14-3.73;HR:1.57,95%CI:0.61-4.04)*** dosing was not associated with statist-ically significant differences in HCC-related ***

关键词： Liver transplantation Hepatocellular carcinoma Transplant oncology Statins HMG-Co-A reductase Aspirin Metformin Mammalian target of rapamycin

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biological buffers and the impacts of climate change

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Integrative Zoology 2018年第4期13卷 349-354页

作者： Raymond b.HUEY lauren b.bUCKLEY Weiguo DU University of Washington SeattleWashingtonUSA Institute of Zoology Chinese Academy of SciencesChina

INTRODUCTION This special issue of Integrative Zoology(the official journal of the International Society of Zoological Sciences)explores how biological buffers(behavior,plasticity and evolution)potentially alleviate negative impacts of climate *** papers result from the 9th International Symposium of Integrative Zoology,which was held in Xining,Qinghai Province,China from 27 to 31 August 2017.

关键词： journal change official

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Supplementation of oligosaccharide-based polymer enhanced growth and disease resistance of weaned pigs by modulating intestinal integrity and systemic immunity

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Journal of Animal Science and biotechnology 2022年第3期13卷 802-815页

作者： Kwangwook Kim Yijie He Cynthia Jinno lauren Kovanda Xunde Li David bravo Eric Cox Yanhong Liu Department of Animal Science University of CaliforniaDavisCA 95616USA School of Veterinary Medicine University of CaliforniaDavisCA 95616USA Pancosma ADM 1180 RolleSwitzerland Department of Virology Parasitology and ImmunologyGhent University9000 GhentBelgium

background:There is a great demand for antibiotic alternatives to maintain animal health and *** objective of this experiment was to determine the efficacy of dietary supplementation of a blood group A6 type 1antigen oligosaccharides-based polymer(Coligo)on growth performance,diarrhea severity,intestinal health,and systemic immunity of weaned pigs experimentally infected with an enterotoxigenic Escherichia coli(ETEC),when compared with ***:Pigs in antibiotic carbadox or Coligo treatment groups had greater(Pbody weight on d 5 or d 11post-inoculation(PI)than pigs in the control group,*** of antibiotics or Coligo enhanced(Pbiotics reduced(Pbiotics or Coligo groups had reduced(Pbin concentration compared to pigs in the control group on d 2 and 5 *** in Coligo had reduced(Pbiotics or Coligo groups had reduced(Pbut less(Pb,IL6,and TNF in ileal mucosa,in comparison with pigs in the control *** of antibiotics enhanced(Pbut decreased(Pb and IL6 gene expression in ileal mucosa,compared with the *** d 11 PI,supplementation of antibiotics or Coligo up-regulated(Pbut Coligo reduced(P<0.05)IL6 gene expression in ileal mucosa compared to pigs in the control ***:Supplementation of Coligo improved growth performance,al

关键词： Enterotoxigenic E.coli Growth rate Intestinal barrier function Oligosaccharide-based polymer Systemic immunity Weaned pigs

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Changes in physical activity,sedentary behavior,and self-reported cognitive function in cancer survivors before and during the COVID-19 pandemic:A cross-sectional study

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Journal of Sport and Health Science 2023年第6期12卷 653-663页

作者： Linda Trinh Allyson Tabaczynski Denise bastas Alyssa R.Neville M.lauren Voss Alexis Whitehorn Faculty of Kinesiology&Physical Education University of TorontoTorontoOT M5S 2W6Canada

background Physical activity(PA)and reductions in sedentary behavior(SED)may mitigate cancer-related cognitive *** purpose of this study was to examine(a)the associations between changes in PA,SED,and cognitive function in cancer survivors before and during the coronavirus disease 2019(COVID-19)pandemic;and(b)clinical subgroups that moderate this *** A cross-sectional survey was administered online to adult cancer survivors globally between July and November of *** was a secondary analysis of a cross-sectional survey examining changes in self-reported PA and quality of life in cancer survivors before and during the COVID-19 ***-reported Questionnaires assessed moderate-to-vigorous PA(MVPA)using the modified Godin Leisure Time Exercise Questionnaire,cognitive function using the Functional Assessment of Cancer Therapy-Cognitive Function(FACT-Cog)scale,and SED using the Domain-specific Sitting Time *** survivors were classified into no change in behavior,desirable change(i.e.,increase MVPA to meet PA guidelines or decrease SED by≥60 min/day),and undesirable change(i.e.,decrease MVPA toby≥60 min/day).Analysis of covariance examined differences in FACT-Cog scores across the activity change *** contrasts compared differences in FACT-Cog scores between cancer survivors with(a)no meaningful change *** change,and(b)a desirable change *** undesirable *** There were no significant differences in FACT-Cog scores across activity-change categories in the full sample of cancer survivors(n=371;age=48.6±15.3 years(mean±SD)).However,cancer survivors who were diagnosed≥5 years ago(t(160)=–2.15,p=0.03)or who received treatment≥5 years ago(t(102)=–2.23,p=0.03)and who had a desirable change in activity reported better perceived cognitive abilities than those who had an undesirable *** PA promotion efforts should consider reducing SED in addition to mainta

关键词： Cancer-related cognitive impairment Cancer survivorship Exercise Sedentary time

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Abnormal psychology : current perspectives / 8th ed.

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1999年

作者： lauren b.Alloy.

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Insects: an underrepresented resource for the discovery of biologically active natural products

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Acta Pharmaceutica Sinica b 2017年第4期7卷 409-426页

作者： lauren Seabrooks Longqin Hu Department of Medicinal Chemistry Ernest Mario School of Pharmacy Rutgers The State University of New Jersey Cancer Institute of New Jersey

Nature has been the source of life-changing and-saving medications for centuries. Aspirin,penicillin and morphine are prime examples of Nature's gifts to medicine. These discoveries catalyzed the field of natural product drug discovery which has mostly focused on plants. However, insects have more than twice the number of species and entomotherapy has been in practice for as long as and often in conjunction with medicinal plants and is an important alternative to modern medicine in many parts of the world. Herein, an overview of current traditional medicinal applications of insects and characterization of isolated biologically active molecules starting from approximately 2010 is presented. Insect natural products reviewed were isolated from ants, bees, wasps, beetles, cockroaches, termites, flies, true bugs,moths and more. biological activities of these natural products from insects include antimicrobial,antifungal, antiviral, anticancer, antioxidant, anti-inflammatory and immunomodulatory effects.

关键词：自然产品昆虫 Entomotherapy 传统的药药发现

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