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Successful Treatment with ¹⁷⁷Lutetium-Dotatate and Maintenance Octreotide in a Patient with Esthesioneuroblastoma with Central Nervous System Invasion: Case Report and Review of the Literature

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International Journal of Otolaryngology and Head & Neck Surgery 2023年第1期12卷 8-20页

作者： Gabriela Dombrowski laura fernandes ferreira dalcin Francisco Assis Coelho Patricia Massucheto Ledesma Daniel Herchenhorn Department of Clinical Oncology Instituto D’Or de Pesquisa e Ensino Rio de Janeiro Brazil Clínica de Diagnóstico por Imagem CDPI DASA Instituto D’Or de Pesquisa e Ensino Rio de Janeiro Brazil Clínica de Medicina Nuclear Villela Pedras Clínica de Diagnóstico por Imagem CDPI DASA Rio de Janeiro Brazil

This article presents a case of a patient with relapsed esthesioneuroblastoma (ENB), an aggressive rare tumor that arises from the specialized sensory epithelial olfactory cells in the skull base area, which was initially treated with endoscopic surgery, followed by adjuvant radiotherapy. After local relapse, new surgical approaches and subsequent lines of platin-based chemotherapy were performed. A PET-CT with 68GALIUM DOTATATOC (PET-DOTATOC) showed intense uptake of disease, compatible with the presence of somatostatin receptors, in the face, nodes, liver, bones, and meningeal area. Treatment with 4 cycles of 177Lutetium-Dotatate was performed, followed by maintenance octreotide, with a major radiological and clinical response that is lasting more than 1 year after treatment. This article describes a rare case of a skull-base tumor, with multiple recurrences, in which disease control was achieved with a targeted Peptide Receptor Radionuclide Therapy (PRRT) with 177Lutetium-Dotatate, and discusses factors that could influence the incorporation of this form of therapy. Previous case reports proved the potential efficacy of this therapy usually given for low-grade neuroendocrine tumors and will be carefully reviewed.

关键词： Esthesioneuroblastoma Olfactory Neuroblastoma Peptide Receptor Radionuclide Therapy PRRT 177Lutetium

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Different no-till grain production systems with Urochloa *** soil microbial community structure,biomass and activity in a tropical Ultisol

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Soil Ecology Letters 2024年第1期6卷 119-129页

作者： Matheus Emannuel Oliveira Vieira Lucas Dantas Lopes France Mario Costa Viviane Talamini Edson Patto Pacheco Marcelo ferreira fernandes PPGAGRI Universidade Federal de SergipeAv.Marechal Rondons/n-49100-000-Sao CristovaoSEBrazil Embrapa Coastal Tablelands Av Govemador Paulo Barreto de Menezesn°3250-49025-040-AracajuSEBrazil

Integrated grain cropping systems promote soil health(SH)and *** biomass and activity(MBA)and community structure(MCS)are key to *** of maize with Urochloa pastures strongly impacts MBA and *** is more sensitive than MCS to shifts in grain cropping *** under continuous Urochloa increased microbial activity and AMF *** soils are prone to *** of conservation agricultural practices is essential to improve soil health,which is influenced by soil *** this study we analyzed shifts in microbial biomass and activity(MBA)and microbial community structure(MCS)based on fatty acid methyl esthers(FAMEs)between five no-till agricultural practices:maize monoculture(MM);maize annualy intercropped with Urochloa decumbens(M/Ud);M/Ud with soybean rotation every other year(M/Ud-S);M/Ud keeping the pasture for the next two years(M/Ud-Ud-Ud);and maize intercropped with *** keeping the pasture for the next two years(M/Ur-Ur-Ur).Results indicated that MBA was affected by the inclusion of Urochloa intercropping and by rotation with *** under a longer residence time with Urochloa in the field had higherβ-glucosidase activity and soil basal respiration,indicating a greater microbial *** was less affected than MBA by the investigated cropping *** changed only in the continuous pasture systems,which were enriched in arbuscular mycorrhyzal fungi(AMF).Additionally,the continuous pasture systems had lower microbial stress ratios than the other agricultural *** sum,our study showed that utilization of Urochloa *** longer periods in no-till agricultural practices contributes to increase microbial activity,AMF abundance and decrease microbial stress *** changes are primarily beneficial for soil health.

关键词： crop-pasture integration crop rotation no-tillage soil health microbial ecology

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Production of Artificial Fog in the PAVIN Fog and Rain Platform: In Search of Big Droplets Fog

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Atmospheric and Climate Sciences 2024年第1期14卷 42-61页

作者： Pierre Duthon Mickaël ferreira fernandes Sébastien Liandrat Cerema Reasearch Team STI 8-10 Rue Bernard Palissy Clermont-Ferrand France

In fog, visibility is reduced. This reduction in visibility is measured by the meteorological optical range (MOR), which is important for studying human perception and various sensors in foggy conditions. The Cerema PAVIN Fog & Rain platform is capable of producing calibrated fog in order to better analyses it and understand its consequences. The problem is that the droplets produced by the platform are not large enough to resemble real fog. This can have a major impact on measurements since the interaction between electromagnetic waves and fog depends on the wavelength and diameter of the droplets. To remedy this, Cerema is building a new platform with new equipment capable of generating fog. This study analyses different nozzles and associated usage parameters such as the type of water used and the pressure used. The aim is to select the best nozzle with the associated parameters for producing large-diameter droplets and therefore more realistic fog.

关键词： Fog Physical Simulation Droplets Size Distribution Meteorological Optical Range

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Effect of Turbidity on Semi-Automatic Analysis of Copepod Size and Abundance Distribution in the Water Column

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Advances in Bioscience and Biotechnology 2024年第6期15卷 380-395页

作者： Thiago da Silva Matos Carolina Siqueira dos Reis laura de Andrade Moura Márcio Abreu Ricardo Coutinho Lohengrin fernandes IEAPM/UFF Marine Biotechnology Post-Graduate Program Arraial do Cabo Brazil Instituto de Estudos do Mar Almirante Paulo Moreira Arraial do Cabo Brazil

Automated image systems to characterize aquatic organisms improve research and enable fast response to environmental risk situations. In November 2015, a dam in Mariana City-MG (Brazil) collapsed and led to the disposal of mud tailings from the mining process to the Doce River. The accident resulted in several casualties and incalculable damage to surrounding communities and the environment. The mud increased water turbidity, an essential condition to the functioning of the image analysis systems, and directly affected the characterization of the organisms, making it impossible to distinguish copepods in the mud, due to the blurred outline. To get a quick response evaluating environmental situations, this work aimed to develop and test different algorithms characterizing and classifying copepods by their size (length and area) using in situ images acquired by the Lightframe On-Sight Keyspecies Investigation device. Field tests were carried out under different turbidity levels throughout the gradient observed in the coastal zone adjacent to the Doce River. The best algorithm reduced nearly 50% of the noise in some images when compared with manual treatment and led to 96% accuracy in measurement and counting. Semi-automated devices that perform post-processing corrections are suitable for fast environmental evaluation under high turbidity scenarios.

关键词： Imaging Zooplankton Doce River LOKI Copepod

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Integrating geochemical(surface waters, stream sediments)and biological(diatoms) approaches to assess AMD environmental impact in a pyritic mining area： Aljustrel(Alentejo, Portugal)

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Journal of Environmental Sciences 2016年第4期28卷 215-226页

作者： Ana Teresa Luís Nuno Duraes Saloméfernandes Pinheiro de Almeida Eduardo ferreira da Silva University of Aveiro Department of GeosciencesGeoBioTec--GeobiosciencesGeotechnologies and Geoengineering Research CenterCampus de Santiago3810-193 AveiroPortugal University of Aveiro Department of BiologyGeoBioTec--GeobiosciencesGeotechnologies and Geoengineering Research CenterCampus de Santiago3810-193 AveiroPortugal Centro de Ciencias do Mar CCMARUniversidade do AlgarveCampus de Gambelas8005-139 FaroPortugal

Aljustrel mines were classified as having high environmental hazard due to their large tailings volume and high metal concentrations in waters and *** assess acid mine drainage impacted systems whose environmental conditions change quickly,the use of biological indicators with short generation time such as diatoms is *** study combined geochemical and diatom data,whose results were highlighted in 3 groups：Group 1,with low p H（1.9–5.1）and high metal/metalloid（Al,As,Cd,Co,Cu,Fe,Mn,Ni,Pb,Zn;0.65–1032 mg/L）and SO4（405–39124 mg/L）*** acidophilic species,Pinnularia aljustrelica,was perfectly adapted to the adverse conditions;in contrast,teratological forms of Eunotia exigua were found,showing that metal toxicity affected this *** low availability of metals/metalloids in sediments of this group indicates that metals/metalloids of the exchangeable fractions had been solubilized,which in fact enables metal/metalloid diatom uptake and consequently the occurrence of teratologies;Group 2,with sites of near neutral p H（5.0–6.8）and intermediate metal/metalloid（0.002–6 mg/L）and SO4（302–2179 mg/L）concentrations;this enabled the existence of typical species of uncontaminated streams（Brachysira neglectissima,Achnanthidium minutissimum）;Group 3,with samples from unimpacted sites,showing low metal/metalloid（0–0.8 mg/L）and SO4（10–315 mg/L）concentrations,high pH（7.0–8.4）and Cl contents（10–2119 mg/L）and the presence of brackish to marine species（Entomoneis paludosa）.For similar conditions of acidity,differences in diversity,abundance and teratologies of diatoms can be explained by the levels of metals/metalloids.

关键词： Surface waters Stream sediments Diatoms Metals/metalloids AMD Teratologies

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Insights into the oxidation resistance mechanism and tribological behaviors of multilayered TiSiN/CrVxN hard coatings

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International Journal of Minerals,Metallurgy and Materials 2023年第12期30卷 2459-2468页

作者： Hongbo Ju Moussa Athmani Jing Luan Abbas AL-Rjoub Albano Cavaleiro Talha Bin Yaqub Abdelouahad Chala Fabio ferreira Filipe fernandes School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Laboratory of Physics of Thin Films and Applications University of Mohamed KhiderBP 145 RPBiskra 07000Algeria CEMMPRE ARISEDepartment of Mechanical EngineeringUniversity of CoimbraCoimbra 3030-788Portugal IPN-LED&MAT-Instituto Pedro Nunes Laboratory of TestsWear and MaterialsCoimbra 3030-199Portugal ISEP Polytechnic of PortoRua Dr.António Bernardino de AlmeidaPorto 4249-015Portugal

In the last decades,vanadium alloyed coatings have been introduced as potential candidates for self-lubrication due to their perfect tribological *** this work,the influence of V incorporation on the wear performance and oxidation resistance of TiSiN/CrN film coatings deposited by direct current(DC)reactive magnetron sputtering is *** results show that vanadium incorporation significantly decreases the oxidation resistance of the *** general,two layers are formed during the oxidation process:i)Ti(V)O_(2) on top,followed by a protective layer,which is subdivided into two layers,Cr_(2)O_(3) and ***)The diffusion of V controls the oxidation of V-containing *** addition of vanadium improves the wear resistance of coatings,and the wear rate decreases with increasing V content in the coatings;however,the friction coefficient is independent of the chemical composition of the *** wear of the V-containing coatings is driven by polishing wear.

关键词： DC magnetron sputtering TiSiN/CrVxN multilayer coatings oxidation resistance tribology wear rate

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Near-infrared leaf reflectance modeling of Annona emarginata seedlings for early detection of variations in nitrogen concentration

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Journal of Forestry Research 2023年第1期34卷 269-282页

作者： Rafaela Lancas Gomes Marília Caixeta Sousa Felipe Girotto Campos Carmen Sílvia fernandes Boaro José Raimundo de Souza Passos Gisela ferreira Bioestatistic Plant BiologyParasitology and Zoology DepartmentBioscience Institute(IBB)Universidade Estadual Paulista(UNESP)BotucatuSao PauloBrazil

Nitrogen(N)monitoring is essential in nurseries to ensure the production of high-quality *** spectroscopy(NIRS)is an instantaneous,nondestructive method to monitor *** data such as NIRS can also provide the basis for developing a new vegetation spectral index(VSI).Here,we evaluated whether NIRS combined with statistical modeling can accurately detect early variations in N concentration in leaves of young plants of Annona emargiaata and developed a new VSI for this *** were grown in a hydroponics system with 0,2.75,5.5or 11 mM N for 45 *** we measured gas exchange,chlorophylla fluorescence,and pigments in leaves;analyzed complete leaf nutrients,and recorded spectral data for leaves at 966 to 1685 nm using *** a statistical learning approach,the dimensionality of the spectral data was reduced,then models were generated using two classes(N deficiency,N)or four classes(0,2.75,5.5,11 mM N).The best combination of techniques for dimensionality reduction and classification,respectively,was stepwise regression(PROC STEPDISC)and linear discriminant *** was possible to detect N deficiency in seedlings leaves with 100%precision,and the four N concentrations with93.55%accuracy before photosynthetic damage to the plant ***,NIRS combined with statistical modeling of multidimensional data is effective for detecting N variations in seedlings leaves of ***.

关键词： Mineral nutrition of plants Near-infrared spectroscopy Spectral vegetation index Digital signature Statistical learning Fluorescence of chlorophylla

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Prevalence and risk factors for acquired long QT syndrome in the emergency department:a retrospective observational study

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World Journal of Emergency Medicine 2023年第6期14卷 454-461页

作者： Diogo de Almeida fernandes Guilherme de Freitas Camoes Diana ferreira Carolina Queijo Carlos Fontes-Ribeiro Lino Gongalves Rui Pina Natalia Antonio Department of Cardiology Coimbra Hospital and University Centre(CHUC)Coimbra 3000-075Portugal Department of Internal Medicine Coimbra Hospital and University Centre(CHUC)Coimbra 3000-075Portugal Faculty of Medicine University of CoimbraCoimbra 3000-370Portugal Institute for Clinical and Biomedical Research Faculty of MedicineUniversity of CoimbraCoimbra 3000-548Portugal

BACKGROUND: Long QT syndrome(LQTS) is a heterogeneous syndrome that may be congenital or, more frequently, acquired. The real-world prevalence of acquired LQTS(aLQTS) in the emergency department(ED) remains to be determined. The aim of this study was to determine prevalence of aLQTS and its impact on symptoms on ED ***: Electrocardiograms(ECG) of 5,056 consecutively patients admitted in the ED of a tertiary hospital between January 28th and March 17th of 2020 were reviewed. All patients with aLQTS were included. Clinical data with a focus on QT prolonging drugs and clinical factors were recorded. Statistical comparison was made between the groups with and without corrected QT(QTc) interval greater than 500 ms(value that is considered severely increased).RESULTS: A total of 383 ECGs with prolonged QTc were recognized, corresponding to a prevalence of aLQTS at admission of 7.82%. Patients with aLQTS were more commonly men(53.3%) with an age of(73.49±14.79) years old and QTc interval of(505.3±32.4) ms. Only 20.4% of these patients with aLQTS were symptomatic. No ventricular arrhythmias were recorded. Patients with QT interval greater than 500 ms were more frequently female(59.5%;P<0.001) and were more frequently on QT prolonging drugs(77.3%;P=0.025). Main contributing factor was intake of antibiotics(odds ratio [OR] 4.680) followed by female gender(OR 2.473) and intake of antipsychotics(OR 1.925).CONCLUSION: aLQTS is particularly prevalent in the ED. Female patients on antibiotics and antipsychotics are at particularly high risk. Efforts must be made to avoid, detect and treat aLQTS as early as possible.

关键词： Long QT syndrome Epidemiology Drug interactions Emergency department

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Epigenetic marks are modulated by gender and time of the day in the hippocampi of adolescent rats:a preliminary study

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Neural Regeneration Research 2018年第12期13卷 2160-2163页

作者： Viviane Rostirola Elsner laura Reck Cechinel Louisiana Carolina ferreira de Meireles Karine Bertoldi Ionara Rodrigues Siqueira Programa de Pós-Graduacao em Ciências Biológicas:Fisiologia Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul Programa de Pós-Graduacao em Biociências e Reabilitacao Centro Universitário Metodista-IPA Curso de Fisioterapia Centro Universitário Metodista-IPA

Although the involvement of gender in epigenetic machinery in peripheral tissues during the neonatal period has been suggested, the gender-related epigenetic profile of brain areas during the adolescent period is rarely exploited. Furthermore, the influence of time of day on hippocampal acetylation marks has been demonstrated in young adult and aged rats; however, there are no studies reporting epigenetic changes in the adolescent period. Therefore, this study aimed to investigate the effects of gender on hippocampal DNA methyltransferase 1 content and histone deacetylase（HDAC） activity of adolescent rats at different time points, specifically early morning and afternoon. Both epigenetic markers increased significantly in the hippocampi of female rats compared to the male group, an indicator of reduced transcriptional activity. In addition, HDAC activity during the early morning was higher compared to afternoon groups in both male and female rats, while DNA methyltransferase 1 content was not altered by the time of day. Our findings demonstrate that hippocampal DNA methylation and histone acetylation status can be influenced by gender during the adolescent period, while the time of the day impacts HDAC activity.

关键词： adolescent rats DNA methyltransferase 1 histone deacetylase hippocampus time of the day gender epigenetic marks

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Validation of a novel imaging approach using multi-slice CT and cone-beam CT to follow-up on condylar remodeling after bimaxillary surgery

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International Journal of Oral Science 2017年第3期9卷 139-144页

作者： laura ferreira pinheiro nicolielo jeroen van dessel eman shaheen carolina letelier marina codari constantinus politis ivo lambrichts reinhilde jacobs omfs-impath research group department of imaging and pathologyfaculty of medicineuniversity of leuven and maxillofacial surgery departmentuniversity hospitals leuvenLeuvenBelgium department of oral and maxillofacial radiology university of los andessantiagochileSantiagoChile unit of radiology irccs policlinico san donato MilaneseMilanItaly department of morphology faculty of medicineuniversity of hasseltcampusDiepenbeekBelgium department of dental medicine karolinska institutetHuddingeSweden

The main goal of this study was to introduce a novel three-dimensional procedure to objectively quantify both inner and outer condylar remodelling on preoperative multi-slice computed tomography （MSCT） and postoperative cone-beam computed tomography （CBCT） images. Second, the reliability and accuracy of this condylar volume quantification method was assessed. The mandibles of 20 patients （11 female and 9 male） who underwent bimaxillary surgery were semi-automatically extracted from MSCT/CBCT scans and rendered in 3D. The resulting condyles were spatially matched by using an anatomical landmark-based registration procedure. A standardized sphere was created around each condyle, and the condylar bone volume within this selected region of interest was automatically calculated. To investigate the reproducibility of the method, inter- and intra-observer reliability was calculated for assessments made by two experienced radiologists twice five months apart in a set of ten randomly selected patients. To test the accuracy of the bone segmentation, the inner and outer bone structures of one dry mandible, scanned according to the clinical set-up, were compared with the gold standard, micro-CT. Thirty-eight condyles showed a significant （P〈O.05） mean bone volume decrease of 26.4%_ 11.4% （502.9 mm3＋ 268.1 mm3）. No significant effects of side, sex or age were found. Good to excellent （ICC〉 0.6） intra- and inter-observer reliability was observed for both MSCT and CBCT. Moreover, the bone segmentation accuracy was less than one voxel （0.4 mm） for MSCT （0.3 mm __. 0.2 mm） and CBCT （0.4 mm _ 0.3 mm）, thus indicating the clinical potential of this method for objective follow-up in pathological condylar resorption.

关键词： condylar resorption Cone-beam computed tomography mandibular condyle multi-slice computed tomography three-dimensional imaging

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