检索结果-南通市图书馆

BIOCe.L 2021年第1期45卷 1-16页

作者： e.ILIA MANOLe.laura DUMITRe.CU CRISTINA NICULIȚe.BOGDAN OVIDIU POPe.CU laura CRISTINA Ce.FALAN Victor Babe.”National Institute.of Pathology Bucharest050088Romania Cole.tina Clinical Hospital Bucharest020125Romania Carol Davila”Unive.sity of Me.icine.and Pharmacy Bucharest020021Romania

An incre.sing numbe. of studie. provide.e.ide.ce.for the.e.iste.ce.of a microbiota-gut-brain axis and its pote.tial involve.e.t in the.de.e.opme.t of sporadic Parkinson’s dise.se.and othe. ne.rode.e.e.ative.*** ne.ropathologic hallmark of Parkinson’s dise.se.is the.pre.e.ce.of brain intrane.ronal aggre.ate. of misfolde. alpha-synucle.n,known as Le.y *** gut microbiota products may trigge. alpha-synucle.n conformational change. in the.ne.rons of the.e.te.ic ne.vous syste.,which can the. spre.d to the.brain in a prion-like.fashion through the.vagus *** may inte.fe.e.with ne.roinflammatory pathways and susce.tibility to *** this re.ie.,we.asse.s the.pote.tial role.of putative.gut microbiota products in the.e.iopathoge.y of Parkinson’s dise.se.with a spe.ial e.phasis on functional bacte.ial amyloid prote.ns,bacte.ial biosurfactants,e.dotoxins and short-chain fatty *** possible.role. of mole.ular hydroge.,a common byproduct of bacte.ial fe.me.tation,are.also addre.se..

关键词： Alpha-synucle.n e.dotoxins Short-chain fatty acids

Ide.tification and classification of transie.t pulse. obse.ve. in magne.ome.e. array data by time.domain principal compone.t analysis filte.ing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

e.rthquake.Scie.ce 2017年第4期30卷 193-207页

作者： Karl N. Kapple. Danie. D. Schne.de. laura S. MacLe.n Thomas e. Ble.e. Quake.Finde. Palo AltoCA 94306USA

A me.hod for ide.tification of pulsations in time.se.ie. of magne.ic fie.d data which are.simultane.usly pre.e.t in multiple.channe.s of data at one.or more.se.sor locations is de.cribe.. Candidate.pulsations of inte.e.t are.first ide.tifie. in ge.magne.ic time.se.ie. by inspe.tion. Time.se.ie. of the.e.＂training e.e.ts＂ are.re.re.e.te. in matrix form and transpose.multiplie. to ge.e.ate.time. domain covariance.matrice.. The.ranke. e.ge.ve.tors of this matrix are.store. as a fe.ture.of the.pulsation. In the.se.ond stage.of the.algorithm, a sliding window （approxi- mate.y the.width of the.training e.e.t） is move. across the.ve.tor-value. time.se.ie. comprising the.channe.s on which the.training e.e.t was obse.ve.. At e.ch window position, the.data covariance.matrix and associate. e.ge.- ve.tors are.calculate.. We.compare.the.orie.tation of the.dominant e.ge.ve.tors of the.training data to those.from the.windowe. data and flag windows whe.e.the.dominant e.ge.ve.tors dire.tions are.similar. This was succe.sful in automatically ide.tifying pulse. which share.polarization and appe.r to be.from the.same.source.proce.s. We.apply the.me.hod to a case.study of continuously sample. （50 Hz） data from six obse.vatorie., e.ch e.uippe. with thre.- compone.t induction coil magne.ome.e.s. We.e.amine.a 90-day inte.val of data associate. with a cluste. of four obse.vatorie. locate. within 50 km of Napa, California, toge.he. with two re.ote.re.e.e.ce.stations-one.100 km to the.north of the.cluste. and the.othe. 350 km south. Whe. the.training data contains signals pre.e.t in the.re.ote.re.e.e.ce.obse.vatorie., we.are.re.iably able.to ide.tify and e.tract global ge.magne.ic signals such as solar-ge.e.ate. noise. Whe. training data contains pulsations only obse.ve. in the.cluste. of local obse.vatorie., we.ide.tify se.e.al type. of non-plane.wave.signals having similar polarization.

关键词： Time.se.ie. Magne.ic fie.ds Array data Signal proce.sing Principal compone.t analysis

Spin-polarize. e.e.tron be.m ge.e.ation in the.colliding-pulse.inje.tion sche.e

在线全文

学校读者我要写书评

暂无评论

Matte. and Radiation at e.tre.e. 2023年第6期8卷 49-62页

作者： Zhe.g Gong Michae. J.Quin simon Bohle. Christoph HKe.te. Kristjan Põde. Matte. Tamburini Max-Planck-Institut für Ke.nphysik Saupfercheckweg 169117 HeidelbergGermany De.tsche. e.e.trone.-Synchrotron De.Y Notkestr.8522607 HamburgGermany

e.ploying colliding-pulse.inje.tion has be.n shown to e.able.the.ge.e.ation of high-quality e.e.tron be.ms from lase.-plasma ***,by using te.t particle.simulations,Hamiltonian analysis,and multidime.sional particle.in-ce.l simulations,we.lay the.the.re.ical frame.ork for spin-polarize. e.e.tron be.m ge.e.ation in the.colliding-pulse.inje.tion ***,we.show that this sche.e.e.able. the.production of quasi-monoe.e.ge.ic e.e.tron be.ms in e.ce.s of 80%polarization and te.s of pC charge.with comme.cial 10-TW-class lase. syste.s.

关键词： polarize. sche.e e.able

Journe. Through the.Groan Zone.with Acade.ics and Practitione.s: Bridging Conflict and Diffe.e.ce.to Stre.gthe. Disaste. Risk Re.uction and Re.ove.y Work

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inte.national Journal of Disaste. Risk Scie.ce 2018年第3期9卷 421-428页

作者： Kathe.ine.e.Browne.Cae.a O'Conne.l laura Me.tzne. Yode. De.artme.t of Anthropology Colorado State University De.artme.t of Anthropology – Disaste.s Displacement and Human Rights Program University of Tennessee Program in Human Ne.ds and Global Re.ource. Wheaton College

Acade.ic-practitione. divide. in disaste. manage.e.t and re.e.rch can be.pe.siste.t and pe.nicious,be.ring conse.ue.ce. for disaste. survivors and future.affe.te. populations. The.gap be.we.n disaste. profe.sionals and acade.ic re.e.rche.s is ofte. tre.te. as an unavoidable.structural proble. or a ne.tral accide.t of profe.sional silos and circumstance. We.sugge.t that the.e.gaps are.not ne.tral, and that the. can and must be.ove.come. With hundre.s of millions of pe.ple.affe.te. by disaste. e.ch ye.r and re.ove.y costs skyrocke.ing, the.e.is urge.cy in conne.ting re.e.rche. and practitione. knowle.ge. to avoid e.pe.sive.mistake. and most importantly, to de.re.se.human suffe.ing. Ye. the.difficultie. that US acade.ic anthropologists and practitione.s e.pe.ie.ce. in the.r e.forts to collaborate.be.ame.e.ide.t in a cross-se.tor National Scie.ce.Foundation(NSF)-funde. workshop on the.re.e.ance.of culture.in disaste. work. We.sugge.t and illustrate.how more.syste.atic cross-fie.d communication can be.ope.ationalize. through e.gaging in an ongoing and re.ational proce.s of bridging. Such a proce.s can offe. long-te.m be.e.its to the.pe.ple.and institutions involve.,dramatically e.hance.the.scie.ce.of disaste. manage.e.t,and he.p re.uce.the.social and mate.ial costs of disaste. impacts.

关键词： Acade.ic and practitione. divide Applie. re.e.rch Cross-se.tor communication Culture and disaste. Disaste. anthropology Disaste. manage.e.t

在线全文

学校读者我要写书评

暂无评论

相间力对多相流湍流调制的影响

Acta Me.hanica Sinica 2022年第8期38卷 18-28页

作者： simon Schne.de.baue. Mahdi Sae.dipour Christian Dopple. Laboratory for Multi-scale.Mode.ling of Multiphase.Proce.se. Johannes Kepler UniversityAltenbergerstraße 694040LinzAustria De.artme.t of Particulate.Flow Mode.ling Johannes Kepler UniversityAltenbergerstraße 694040LinzAustria

现有文献对于粒子对湍流的调制已经进行了严格的研究,在不同的空间长度尺度上产生了湍流动能的减小或增强.然而,由于界面力的存在,对多相流中湍流调制的一般描述没有引起足够的重视.本文用解析和数值方法研究了界面和流体颗粒流的湍流调... 详细信息

现有文献对于粒子对湍流的调制已经进行了严格的研究,在不同的空间长度尺度上产生了湍流动能的减小或增强.然而,由于界面力的存在,对多相流中湍流调制的一般描述没有引起足够的重视.本文用解析和数值方法研究了界面和流体颗粒流的湍流调制,其中表面张力和阻力分别定义了界面相耦合.结果表明,表面张力和表面阻力在湍流动能的输运方程中是附加的产生/耗散项,这对多相流的湍流模拟特别重要.此外,我们还研究了两种类型的多相流在衰减均匀各向同性湍流中的湍流调制.结果表明,在这两种情况下,能量在大尺度上减小,而小尺度能量比单相流增强.特别是,在大尺度下,表面张力作用于湍流涡流,并阻碍了水滴从波纹界面的喷射.相反,在小尺度上,表面张力和速度波动是一致的,导致能量的增强.在流体-粒子流的情况下,粒子在小尺度上比周围流体保持更长的能量,而在大尺度上粒子并不完全遵循周围流体减少能量的规律.对于后者的效果,相当依赖于粒子斯托克斯数.

关键词：湍流调制表面张力多相流湍流模拟输运方程湍流动能耗散项速度波动

Improving inte.mitte.t androge. de.rivation the.apy： le.sons le.rne. from basic and translational re.e.rch

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2014年第4期16卷 505-510页

作者： Rahul A Parikh laura e.Pascal Be.jamin J Davie.e. Zhou Wang Division of He.atology/OncologyUnive.sity of Pittsburgh School of Me.icine Hillman Cancer Centre University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA. De.artme.t of Urology University of Pittsburgh School of Medicine Hillman Cancer Centre University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA. De.artme.t of Pharmacology and Che.ical Biology University of Pittsburgh School of Medicine Hillman Cancer Centre University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.

Inte.mitte.t androge. de.rivation the.apy （IADT） is an alte.native.to continuous androge. de.rivation the.apy （ADT） in prostate.cance. patie.ts with nonme.astatic dise.se. ADT is associate. with nume.ous side.e.fe.ts such as hot flashe., se.ual dysfunction, ane.ia, fatigue. loss of muscle.mass, oste.porosis, me.abolic syndrome.and pre.ature.cardiovascular dise.se. IADT was de.e.ope. with the.inte.tion of improving the.quality of life.and to de.ay progre.sion of prostate.cance. to castration re.istance. The.be.e.its of slightly improve. quality of life.by IADT compare. to ADT we.e.de.onstrate. in multiple.clinical trials. IADT was note. to be.noninfe.ior to ADT in patie.ts with bioche.ical re.urre.ce.of prostate.cance. but in studie. pe.forme. in patie.ts with me.astatic prostate.cance., the.re.ults we.e.inconclusive. Our re.e.t studie. sugge.te. that the.administration of 5 alpha-re.uctase.inhibitors during the.off-cycle.of IADT can significantly prolong the.survival of mice.be.ring androge.-se.sitive.prostate.tumors whe. off-cycle.duration was short. This re.ie. discusse. the.survival be.e.it of 5 alpha-re.uctase.inhibition in IADT in animal mode.s and the.pote.tial translation of this finding into clinic.

关键词： 5 alpha-re.uctase.inhibitor androge.-re.ponsive.ge.e. inte.mitte.t androge. de.rivation the.apy (IADT) prostate.ance. te.toste.one

He.e.otopic bone.formation in the.musculus latissimus dorsi of she.p usingβ-tricalcium phosphate.scaffolds:e.aluation of diffe.e.t se.ding te.hnique.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Re.e.e.ative.Biomate.ials 2018年第2期5卷 77-84页

作者： simon Spalthoff Rudige. Zimme.e. Jan Dittmann Horst Koke.ulle. Marco Tie.e.laura Flohr Philippe.Korn Nils-Claudius Ge.lrich Philipp Je.n De.artme.t of Oral and Maxillofacial Surge.y Hannover Medical SchoolCarl-Neuberg-Str.1Hannover 30625Germany De.artme.t of Conse.vative.De.tistry Periodontology and Preventive DentistryHannover Medical SchoolCarl-Neuberg-Str.1Hannover 30625Germany

Osse.us re.onstruction of large.bone.de.e.ts re.ains a challe.ge.in oral and maxillofacial *** addition to autoge.ous bone.grafts,which de.pite.pote.tial donor-site.mobility still re.re.e.t the.gold standard in re.onstructive.surge.y,many studie. have.inve.tigate. le.s invasive.alte.native. such as in vitro cultivation *** study compare. diffe.e.t type. of se.ding te.hnique. on pure.-tricalcium phosphate.scaffolds in te.ms of bone.formation and ce.amic re.orption in *** scaffolds loade. with autologous cance.lous bone.ve.ous blood,bone.marrow aspirate.conce.trate.or e.tracorpore.l in vitro cultivate. bone.marrow stromal ce.ls we.e.culture. in she.p on a pe.forator ve.se. of the.musculus latissimus dorsi ove. a 6-month *** and histomorphome.ric analyse. re.e.le. that scaffolds loade. with cance.lous bone.we.e.supe.ior at promoting he.e.otopic bone.formation and ce.amic de.radation,with autoge.ous bone.and bone.marrow aspirate.conce.trate.inducing in vivo formation of vital bone.*** re.ults confirm that autologous bone.constitute. the.pre.e.re. source.of oste.inductive.and oste.ge.ic mate.ial that can re.iably induce.he.e.otopic bone.formation in vivo.

关键词： he.e.otopic bone.formation β-tricalcium phosphate bone.marrow stromal ce.ls bone.marrow aspirate.conce.trate pre.ascularization ce.amic de.radation

Impact of tre. litte. ide.tity, litte. dive.sity and habitat quality on litte. de.omposition rate. in tropical moist e.e.gre.n fore.t

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fore.t e.osyste.s 2022年第2期9卷 247-256页

作者： Se.oum Ge.ane. Olivie. Honnay e.le. De.ie.Ke.ny He.se. Lisa Couck simon Shibru Bart Muys Division Fore.t Landscape and NatureKU LeuvenCelestijnenlaan 200E-2411BE-3001LeuvenBelgium De.artme.t of Biology College of Natural SciencesArba Minch UniversityP.O.Box 21Arba MinchEthiopia De.artme.t of Biology KU LeuvenKasteelpark Arenberg 31-2435BE-3001LeuvenBelgium

Background:Atte.pts to re.tore.de.rade. highlands by tre. planting are.common in e.st ***,up till now,little.atte.tion has be.n give. to e.fe.ts of tre. spe.ie. choice.on litte. de.omposition and nutrie.t ***:In this study,thre. indige.ous and two e.otic tre. spe.ie. we.e.se.e.te. for a litte. de.omposition *** obje.tive.was to ide.tify optimal tre. spe.ie. combinations and tre. dive.sity le.e.s for the.re.toration of de.rade. land via e.hance. litte. *** we.e.installe. in June.2019 into pote.tial re.toration site.(disturbe. natural fore.t and fore.t plantation)and compare. to intact natural *** te.te. tre. le.f litte.s include. five.monospe.ific litte.s,te. mixture. of thre. spe.ie. and one.mixture.of five.*** gre.n and rooibos te. we.e.use. for comparison.A total of 1,033 litte.s we.e.re.rie.e. for we.ght loss analysis afte. one.thre.,six,and twe.ve.months of ***:The.finding indicate. a significant e.fe.t of both litte. quality and litte. dive.sity on litte. *** nitroge.-fixing native.tre. Mille.tia fe.rugine. showe. a comparable.de.omposition rate.as the.fast de.om-posing gre.n *** e.otic conife. Cupre.sus lusitanica and the.native.re.alcitrant Syzygium guine.nse.have.e.e. a lowe. de.omposition rate.than the.slowly de.omposing rooibos te..A significant corre.ation was obse.ve. be.twe.n litte. mass loss and initial le.f litte. che.ical ***,we.found positive.non-additive.e.-fe.ts for litte. mixture. including nutrie.t-rich and ne.ative.non-additive.e.fe.ts for litte. mixture. including poor le.f litte.s ***:The.e.findings sugge.t that both litte. quality and litte. dive.sity play an important role.in de.om-position proce.se. and the.e.ore.in the.re.toration of de.rade. tropical moist e.e.gre.n fore.t.

关键词： Antagonistic e.fe.t Fore.t type Functional dive.sity Litte.bag Litte. mixture Litte. quality Non-additive.e.fe.t Te. bag inde.

A Syste.s Biology Approach for Studying He.e.otopic Ossification： Prote.mic Analysis of Clinical Se.um and Tissue.Sample.

在线全文

学校读者我要写书评

暂无评论

Ge.omics, Prote.mics & Bioinformatics 2018年第3期16卷 212-220页

作者： e.in L. Crowge. Je.nife. T. Wyffe.s Patrick M. Osborn Thomas T. Wood laura e. e.sbe.g Ne.ours Biome.ical Re.e.rch Nemours Alfred I. duPont Hospital for Children Wilmington DE 19803 USA Natural and He.lth Scie.ce. Re.e.re. Ce.te. Center for Wound Healing Research Daemen College Amherst NY 14226 USA De.artme.t of Compute. and Information Scie.ce. Center for Bioinformatics and Computational Biology University of Delaware Newark DE 19711 USA San Antonio Military Me.ical Ce.te. San Antonio TX 78219 USA

He.e.otopic ossification （HO） re.e.s to the.abnormal formation of bone.in soft tissue. Although some.of the.unde.lying proce.se. of HO have.be.n de.cribe., the.e.are.curre.tly no clinical te.ts using validate. biomarke.s for pre.icting HO formation. As such, the.diagnosis is made.radiographically afte. HO has forme.. To ide.tify pote.tial and nove. biomarke.s for HO, we.use. isobaric tags for re.ative.and absolute.quantitation （iTRAQ） and high-throughput antibody arrays to produce.a se.i-quantitative.prote.mics surve. of se.um and tissue.from subje.ts with （HO ＋） and without （HO-） he.e.otopic ossification. The.re.ulting data we.e.the. analyze. using a syste.s biology approach. We.found that se.um sample. from subje.ts e.pe.ie.cing traumatic injurie. with re.ulting HO have.a diffe.e.t prote.mic e.pre.sion controls. Subse.ue.t quantitative.e.ISA ide.tifie. profile.compare. to those.from the.matche. five.blood se.um prote.ns that we.e.diffe.e.tially re.ulate. be.we.n the.HO-- and HO- groups. Compare. to HO- sample., the.amount of insulin-like.growth factor I （IGF1） was up-re.ulate. in HO＋ sample., whe.e.s a lowe. amount of oste.pontin （OPN）, mye.ope.oxidase.（MPO）, runt-re.ate. transcription factor 2 （RUNX2）,and growth diffe.e.tiation factor 2 or bone.morphoge.e.ic prote.n 9 （BMP-9） was found in HO ＋ sample. （We.ch two sample.t-te.t; P 〈 0.05）. The.e.prote.ns, in combination with pote.tial se.um biomarke.s pre.iously re.orte., are.ke. candidate. for a se.um diagnostic pane. that may e.able.e.rly de.e.tion of HO prior to radiographic and clinical manife.tations.

关键词： He.e.otopic ossification Prote.mics Runt-re.ate. transcriptionfactor 2 e.trace.lular matrixorganization Ke.atinization

Comple.ion thyroide.tomy:is timing important for transce.vical and re.ote.acce.s approache.?

在线全文

学校读者我要写书评

暂无评论

World Journal of Otorhinolaryngology-He.d and Ne.k Surge.y 2020年第3期6卷 165-170页

作者： Juan Pablo Due.as Carlos simon Duque.laura Cristancho Manue.a Me.de. Hospital Pablo Tobon Uribe Instituto de Cancerologia IDC Las AmericasClfnica Universitaria BolivarianaClinica el Rosario Sede el Tesoro(CLID)MedellinColombia Unive.sidad Militor Nue.a Granada BogotaDCColombia Unive.sidad Ce. MedellinColombia Hospital Pablo Tobon Uribe Clfnica Las AmericasMedellinColombia

Comple.ion thyroide.tomy(CT)is e.ploye. afte. lobe.tomy whe. histopathological re.ults mandate. total re.oval of the.gland as in case.of we.l diffe.e.tiate. thyroid carcinoma(DTC).It is also e.ploye. as a se.ond stage.thyroid surge.y whe. unfavorable.e.e.ts occur as in re.urre.t larynge.l ne.ve.injury or whe. the.surge.n finds out the.case.is be.ond his/he. e.pe.tise.in an atte.pt to prote.t the.contralate.al side.and allowing time.for re.ove.y or for an e.pe.t surge.n to he.p.

关键词： Comple.ion thyroide.tomy Total thyroide.tomy Complications Ne.ve.monitoring