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Therapeutic application of stem cells in gastroenterology:An up-date

World Journal of Gastroenterology 2011年第34期17卷 3870-3880页

作者： Patrizia Burra Debora Bizzaro Rachele Ciccocioppo Fabio Marra Anna Chiara Piscaglia laura porretti Antonio Gasbarrini Francesco Paolo Russo Department of Surgical and Gastroenterological Sciences Gastroenterology Section University of Padua First Department of Internal Medicine IRCCS Policlinico San Matteo Foundation University of Pavia Department of Internal Medicine University of Florence Department of Internal Medicine Gemelli Hospital "Gastrointestinal and Liver Stem Cell Research Group" (GILSteR) Catholic University of Rome Center of Transfusion Medicine Cell Therapand Cryobiology IRCCS Fondazione Ospedale Maggiore Poli-clinico Mangiagalli e Regina Elena

Adult stem cells represent the self-renewing progenitors of numerous body tissues, and they are currently classified according to their origin and differentiation ability. In recent years, the research on stem cells has expanded enormously and holds therapeutic promises for many patients suffering from currently disabling diseases. This paper focuses on the possible use of stem cells in the two main clinical settings in gastro-enterology, i.e., hepatic and intestinal diseases, which have a strong impact on public health worldwide. Despite encouraging results obtained in both regenerative medicine and immunemediated conditions,further studies are needed to fully understand the biology of stem cellsand carefully assess their put ativeonco- genicproperties.Moreover,there searchonstemcellsarousesferventethical,socialandpoliticaldebate.TheItalianSocietyofGastroenterologysponsoredaworkshoponstemcellsheldinVeronaduringtheⅩⅥCongressoftheFederationofItalianSocietiesofDigestiveDiseases(March 6-9,2010).Here,we report on the issues discussed,including liver and intestinal diseases that may benefit from stemcell therapy,the biology of hepatic and intestinal tissue repair,and stem cell usage inclinical trials.

关键词：干细胞治疗胃肠病应用肠道疾病自我更新分化能力公众健康世界范围

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