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Comparative study of breast cancer in Mexican and Mexican-American women

Health 2010年第9期2卷 1040-1048页

作者： Maria Elena Martinez Luis Enrique Gutierrez-Millan Melissa Bondy Adrian Daneri-Navarro Maria Mercedes Meza-Montenegro Ivan Anduro-Corona Ma Isabel Aramburo-Rubio Luz Maria Adriana Balderas-Pena Jose Adelfo Barragan-Ruiz Abenaa Brewster Graciela Caire-Juvera Juan Manuel Castro-Cervantes Mario Alberto Chavez Zamudio Giovanna Cruz Alicia Del Toro-Arreola Mary EEdgerton Maria Rosa Flores-Marquez Ramon Antonio Franco-Topete Helga Garcia Susan Andrea Gutierrez-Rubio Karin Hahn Luz Margarita Jimenez-perez Ian KKomenaka Zoila Areli Lopez Bujanda Dihui Lu Gilberto Morgan-Villela James LMurray Jesse NNodora Antonio Oceguera-Villanueva Miguel Angel Ortiz Martinez laura perez michel Antonio Quintero-Ramos Aysegul Sahin Jeong Yun Shim Maureen Stewart Gonzalo Vazquez-Camacho Betsy Wertheim Rachel Zenuk Patricia Thompson Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health University of ArizonaTucsonUSA Departamento de Investigaciones Cientificas y Tecnologicas Universidad de SonoraHermosilloMexico University of Texas M.D.Anderson Cancer Center HoustonUSA Departamento de Fisiologia Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Instituto Tecnologico de Sonora Ciudad ObregónMexico Instituto Mexicano del Seguro Social HermosilloMexico Instituto Mexicano del Seguro Social CMNOGuadalajaraJalisco Centro de Investigacion en Alimentacion y Desarrollo HermosilloMexico Instituto Mexicano del Seguro Social Ciudad ObregonMexico OPD Hospital Civil de Guadalajara GuadalajaraMexico Departamento de Salud Publica Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Maricopa Medical Center Department of SurgeryPhoenixUSA University of North Carolina Lineberger Cancer CenterChapel HillUSA Arizona Cancer Center and Department of Family and Community Medicine University of ArizonaTucsonUSA Instituto Jalisciense de Cancerologia GuadalajaraMexico

Breast cancer is the number one cause of can- cer deaths among Hispanic women in the United States, and in Mexico, it recently became the primary cause of cancer deaths. This malign- nancy represents a poorly understood and un- derstudied disease in Hispanic women. The ELLA Binational Breast Cancer Study was es- tablished in 2006 as a multi-center study to as- sess patterns of breast tumor markers, clinical characteristics, and their risk factors in women of Mexican descent. We describe the design and implementation of the ELLA Study and provide a risk factor comparison between women in the U.S. and those in Mexico based on a sample of 765 patients (364 in the U.S. and 401 in Mexico). Compared to women in Mexico, U.S. women had significantly (p < 0.05) lower parity (3.2 vs. 3.9 mean live births) and breastfeeding rates (57.5% vs. 80.5%), higher use of oral contraceptives (60.7% vs. 50.1%) and hormone replacement therapy (23.3% vs. 7.6%), and higher family history of breast cancer (15.7% vs. 9.0%). Re- sults show that differences in breast cancer risk factor patterns exist between Mexico and U.S. women. We provide lessons learned from the conduct of our study. Binational studies are an important step in understanding disease pat- terns and etiology for women in both countries.

关键词： Binational Study Breast Cancer Hispanics Mexico United States

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Development and application of an interface constitutive model for fully grouted rock-bolts and cable-bolts

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第4期13卷 811-819页

作者： Emad Jahangir laura Blanco-Martin Faouzi Hadj-Hassen michel Tijani MINES ParisTech PSL Research UniversityDepartment of Geosciences35 Rue Saint Honoré77300FontainebleauFrance

This paper proposes a new interface constitutive model for fully grouted rock-bolts and cable-bolts based on pull-out test results.A database was created combining published experimental data with in-house *** means of a comprehensive framework,a Coulomb-type failure criterion accounting for friction mobilization was *** the elastic phase,in which the interface joint is not yet created,the proposed model provides zero radial displacement,and once the interface joint is created,interface dilatancy is modeled using a non-associated plastic potential inspired from the behavior of rock *** results predicted by the proposed model are in good agreement with experimental *** model has been implemented in a finite element method(FEM)code and numerical simulations have been performed at the elementary and the structural *** results obtained provide confidence in the ability of the new model to assist in the design and optimization of bolting patterns.

关键词： Fully grouted bolts Interface constitutive model Dilatancy Pull-out tests Finite element method(FEM)modeling

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Apaf1 inhibition promotes cell recovery From apoptosis

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Protein & Cell 2015年第11期6卷 833-843页

作者： Anna Gortat Monica Sancho laura Mondragon Angel Messeguer Enrique perez-Paya Mar Orzaez Laboratory of Peptide and Protein Chemistry Centro de Investigaci6n Principe Felipe 46012 Valencia Spain Department of Chemical and Biomolecular Nanotechnology Instituto Quimica Avanzada de CataluSa (CSIC) 08034 Barcelona Spain Instituto de Biomedicina de Valencia IBV-CSIC 46010 Valencia Spain

The protein apoptoUc protease activating factor I （Apafl） is the central component of the apoptosome, a multiprotein complex that activates procaspase-9 after cytochrome c release from the mitochondria in the intrinsic pathway of apoptosis. We have developed a vital method that allows fluorescence-activated cell sorting of cells at different stages of the apoptotic pathway and demonstrated that upon pharmacological inhibition of Apafl, cells recover from doxorubicinor hypoxia-induced early apoptosis to normal healthy cell. Inhibiting Apafl not only prevents procaspase-9 activation but delays massive mitochondrial damage allowing cell recovery.

关键词： Apaf1 Apaf1 inhibitors apoptosis,apoptosome autophagy cell recovery

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Turning carbon dots into selenium bearing nanoplatforms with in vitro GPx-like activity and pro-oxidant activity

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Nano Research 2023年第5期16卷 7784-7791页

作者： laura perez-Garrido Mariano Ortega-Muñoz Fernando Hernandez-Mateo F.Javier Lopez-Jaramillo Francisco Santoyo-Gonzalez Department of Organic Chemistry Biotechnology InstituteSchool of SciencesCampus Fuentenueva snUniversity of Granada18071-GranadaSpain

Selenium(Se)has been defined as the“Janus element”,with one face showing antioxidant activity and the other pro-oxidant *** biological effect of Se depends on both dose and *** nanoparticles are attracting major interest,although their large-scale preparation for biomedical applications is not *** hypothesize that acid anhydride-coated carbon dots(AACD)are an attractive platform for preparing nanoparticles containing chemically defined *** reaction of AA-CD with 3-selenocyanatopropan-1-amine yields carbon dots bearing selenocyanate and carboxylate groups(CD-SeCN)that allow for tuning the ***-SeCN has a Se content of 0.36μmol per mg of nanoparticles,they show the typical photoluminescence of carbon *** selenocyanate groups(SeCN)exhibited glutathione peroxidase-like activity and *** show that antioxidant behavior differs between normal and tumor cells,the evaluation on HEK293 and A549 cells reveals that the toxicity of CD-SeCN depends on dose,time,intracellular glutathione(GSH)*** toxicity of CD-SeCN decreases with the time of incubation and the cell death mechanism switches from necrosis to apoptosis,indicating that CD-SeCN is ***,high levels of intracellular GSH exert a protective *** results support a pharmacological potential in cancers with low levels of intracellular *** use of AA-CD as nanoplatforms is a general strategy that paves the way for the engineering of advanced nanosystems.

关键词： selenium nanoparticles carbon dots glutathione peroxidase-like activity Janus element nanomedicine

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Conducting polymer tattoo electrodes in clinical electro-and magneto-encephalography

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npj Flexible Electronics 2020年第1期4卷 36-44页

作者： laura M.Ferrari Usein Ismailov Jean-michel Badier Francesco Greco Esma Ismailova Center for MicroBiorobotics Istituto Italiano di Tecnologia56025 PontederaItaly The BioRobotics Institute Scuola Superiore Sant’Anna56025 PontederaItaly Department of Bioelectronics Ecole Nationale Supérieure des Mines de Saint EtienneCMP-EMSEMOC1354 GardanneFrance Aix Marseille Univ INSERMINSInst Neurosci SystMarseilleFrance Institute of Solid State Physics NAWI GrazGraz University of Technology8010 GrazAustria Department of Life Science and Medical Bioscience Waseda University169-8480 TokyoJapan

Temporary tattoo electrodes are the most recent development in the field of cutaneous *** have successfully demonstrated their performances in the monitoring of various electrophysiological signals on the *** epidermal electronic devices offer a conformal and imperceptible contact with the wearer while enabling good quality recordings over *** of brain activity in clinical practice face multiple limitations,where such electrodes can provide realistic technological solutions and increase diagnostics *** we present the performance of inkjet-printed conducting polymer tattoo electrodes in clinical electroencephalography and their compatibility with *** working mechanism of these dry sensors is investigated through the modeling of the skin/electrode impedance for better understanding of the biosignals transduction at this ***,a custom-made skin phantom platform demonstrates the feasibility of high-density recordings,which are essential in localizing neuropathological *** evaluations provide valuable input for the successful application of these ultrathin electronic tattoos sensors in multimodal brain monitoring and diagnosis.

关键词： polymer recording conformal

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Endoscopic ultrasonography guided drainage:Summary of consortium meeting,May 21,2012,San Diego,California

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World Journal of Gastroenterology 2015年第3期21卷 726-741页

作者： michel Kahaleh Everson LA Artifon Manuel perez-Miranda Monica Gaidhane Carlos Rondon Takao Itoi Marc Giovannini Division of Gastroenterology and Hepatology Department of MedicineWeill Cornell Medical CenterNew YorkNY 10021United States Department of Surgery University of Sao Paulo Medical SchoolSao Paulo 05403-000Brazil Endoscopy Unit Hospital Universitario Rio Hortega47012 ValladolidSpain Department of Gastroenterology and Hematology Tokyo Medical UniversityTokyo 160-0023Japan Department of Gastroenterology PaoliCalmettes Institute13273 MarseilleFrance

Endoscopic retrograde cholangiopancreatography(ERCP) is the preferred procedure for biliary and pancreatic *** ERCP is successful in about 95% of cases,a small subset of cases are unsuccessful due to altered anatomy,peri-ampullary pathology,or malignant *** ultrasound-guided drainage is a promising technique for biliary,pancreatic and recently gallbladder decompression,which provides multiple advantages over percutaneous or surgical biliary *** retrospective and some prospective studies have shown endoscopic ultrasoundguided drainage to be safe and *** on the currently reported literature,regardless of the approach,the cumulative success rate is 84%-93% with an overall complication rate of 16%-35%.endoscopic ultrasoundguided drainage seems a viable therapeutic modality for failed conventional drainage when performed by highly skilled advanced endoscopists at tertiary centers with expertise in both echo-endoscopy and therapeutic

关键词： Endoscopic ultrasound Endoscopic ultrasoundguided

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Influence of surface roughness on the color of dental-resin composites

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第7期12卷 552-562页

作者： Razvan GHINEA laura UGARTE-ALVAN Ana YEBRA Oscar E.PECHO Rade D.PARAVINA Maria del Mar perez Department of Optics Faculty of ScienceUniversity of Granada Department of Stomatology Faculty of OdontologyUniversity of Granada Houston Center for Biomaterials and Biomimetics & Department of Restorative Dentistry and Biomaterials University of Texas Dental Branch at Houston

This study deals with the influence of surface roughness on the color of resin *** resin composites (microfilled,hybrid,and microhybrid) were each polished with 500-grit,1 200-grit,2 000-grit,and 4 000-grit SiC *** roughness parameter (Ra) was measured using a Plμ confocal microscope,and field-emission scanning electron microscope (Fe-SEM) images were used to investigate filler *** was measured using a spectroradiometer and a D65 standard illuminant (geometry diffuse/0° specular component excluded (SCE) mode).Surface roughness decreased with grit number and was not influenced by filler size or size distribution.A significant influence of Ra on lightness (L*) was *** increased with decreases in roughness,except for specimens that underwent polishing procedure 4 (PP4;500-grit,1 200-grit,2 000-grit,and 4 000-grit SiC papers consecutively).Generally,it was found that surface roughness influenced the color of resin *** composites that underwent PP1 (500-grit SiC paper) exhibited significant differences in chroma (C*),hue (h°),and lightness (L*) compared to composites that underwent PP3 (500-grit,1 200-grit,and 2 000-grit SiC papers consecutively) and *** difference (E*) between the polishing procedures was within acceptability thresholds in dentistry.

关键词： Color measurement Dental resin composites Roughness

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Assessment of Methods for Determining Bioavailability of Trace Elements in Soils: A Review

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Pedosphere 2017年第3期27卷 389-406页

作者： Jurate KUMPIENE laura GIAGNONI Bernd MARSCHNER Sébastien DENYS michel MENCH Kristin ADRIAENSEN Jaco VANGRONSVELD Markus PUSCHENREITER Giancarlo RENELLA Waste Science & Technology Lule University of Technology Department of Agrifood Production and Environmental Sciences University of Florence Ruhr-Universitt Bochum Joint Research Unit (UMR) Biodiversity Genes & Communities (BIOGECO) French National Institute for Agricultural Research (INRA) Agence Nationale de Sécurité Sanitaire (Anses) i-CLEANTECH Vlaanderen Hasselt University Centre for Environmental Sciences University of Natural Resources and Life Sciences Vienna

Trace element-contaminated soils(TECSs) are one of the consequences of the past industrial development worldwide. Excessive exposure to trace elements(TEs) represents a permanent threat to ecosystems and humans worldwide owing to the capacity of metal(loid)s to cross the cell membranes of living organisms and of human epithelia, and their interference with cell *** of TE bioavailability in soils is complicated due to the polyphasic and reactive nature of soil constituents. To unravel critical factors controlling soil TE bioavailability and to quantify the ecological toxicity of TECSs, TEs are pivotal for evaluating excessive exposure or deficiencies and controlling the ecological risks. While current knowledge on TE bioavailability and related cumulative consequences is growing, the lack of an integrated use of this concept still hinders its utilization for a more holistic view of ecosystem vulnerability and risks for human health. Bioavailability is not generally included in models for decision making in the appraisal of TECS remediation options. In this review we describe the methods for determining the TE bioavailability and technological developments, gaps in current knowledge, and research needed to better understand how TE bioavailability can be controlled by sustainable TECS management altering key chemical properties, which would allow policy decisions for environmental protection and risk management.

关键词： bioaccessibility bioavailability biosensors chemical extractions contaminated soils 'metalloids metals

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Self-centering steel plate shear walls for improving seismic resilience

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Frontiers of Structural and Civil Engineering 2016年第3期10卷 283-290页

作者： Patricia M. CLAYTON Daniel M. DOWDEN Chao-Hsien LI Jeffrey W. BERMAN michel BRUNEAU laura N. LOWES Keh-Chuan TSAI Department of Civil Architectural and Environmental Engineering University of Texas at Austin Austin TX 78705 USA Department of Civil Structural and Environmental Engineering University at Buffalo New York 14260-1660 USA National Center for Research on Earthquake Engineering Taipei Taiwan China Department of Civil and Environmental Engineering University of Washington Seattle WA 98195-2700 USA Department of Civil Structural and Environmental Engineering Taiwan University Taipei Taiwan China

As part of a Network for Earthquake Engineering Simulation research project led by researchers at the University of Washington with collaborators at University at Buffalo, and Taiwan National Center for Research on Earthquake Engineering, a self-centering steel plate shear wall （SC-SPSW） system has been developed to achieve enhanced seismic performance objectives, including recentering. The SC-SPSW consists of thin steel infill panels, referred to as web plates that serve as the primary lateral load-resisting and energy dissipating element of the system. Post- tensioned （PT） beam-to-column connections provide system recentering capabilities. A performance-based design procedure has been developed for the SC-SPSW, and a series of nonlinear response history analyses have been conducted to verify intended seismic performance at multiple hazard levels. Quasi-static subassembly tests, quasi-static and shake table tests of scaled three-story specimens, and pseudo-dynamic tests of two full-scale two-story SC-SPSWs have been conducted. As a culmination of this multi-year, multi-institutional project, this paper will present an overview of the SC- SPSW numerical and experimental research programs. This paper will also discuss innovative PT connection and web plate designs that were investigated to improve constructability, resilience, and seismic performance and that can be applied to other self-centering and steel plate shear wall systems.

关键词： self-centering steel plate shear walls large-scale experiment post-tensioned connections performance-baseddesign

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Simultaneous pars plana vitrectomy,panretinal photocoagulation,cryotherapy,and Ahmed valve implantation for neovascular glaucoma

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International Journal of Ophthalmology(English edition) 2021年第9期14卷 1396-1401页

作者： Carolina Bernal-Morales Marina Dotti-Boada Alvaro Olate-perez Manuel J.Navarro-Angulo laura Pelegrín Marc Figueras-Roca Institut Clínic d’Oftalmologia(ICOF) Hospital ClínicBarcelona 08028Spain August Pi i Sunyer Biomedical Research Institute(IDIBAPS) Barcelona 08028Spain

AIM:To describe and evaluate the efficacy of Ahmed glaucoma valve implantation(AGV)combined with pars plana vitrectomy(PPV)in a single surgical act for the treatment of advanced neovascular glaucoma(NVG).METHODS:Retrospective observational case series included 51 eyes from 50 patients with severe NVG treated with PPV,AGV,and panretinal photocoagulation and/or cryotherapy in a single surgical act during a 13-year period(2005-2018).Preoperative,intraoperative and postoperative data at day 1 and months 1,3,6,21,and 24 were systematically *** of surgical success was stablished at IOP between 6 and 21 mm Hg with or without topical ***:Main indications for surgery were NVG secondary to proliferative diabetic retinopathy(39.2%)and central retinal vein occlusion(37.3%).Mean(±SD)preoperative IOP was 42.0±11.2 mm Hg decreasing to 15.5±7.1 mm Hg at 12 mo and 15.8±9.1 mm Hg at 24 mo of follow *** incidence of success of IOP control was 76.0%at first postoperative month,reaching 88.3%at 6 *** of successful IOP control at long term was 74.4%at 12 mo and 71.4%at 24 *** evisceration for unsuccessful NVG management was required in 1 case(2.0%).CONCLUSION:Combination of AGV implantation and PPV in a single act may be a suitable option for severe forms of NVG in a case-by-case basis for effective IOP control and a complete panretinal photocoagulation.

关键词： neovascular glaucoma Ahmed valve pars plana vitrectomy panretinal photocoagulation cryotherapy

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