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A scoping review on the field validation and implementation of rapid diagnostic tests for vector-borne and other infectious diseases of poverty in urban areas

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Infectious Diseases of Poverty 2018年第1期7卷 879-896页

作者： Lyda osorio Jonny Alejandro Garcia Luis Gabriel Parra Victor Garcia laura Torres Stephanie Degroote Valery Ridde Epidemiology and Population Health Research Group School of Public HealthUniversidad del ValleCalle 4B No.36-00 Edif 118 Escuela de Salud PúblicaUniversidad del Valle Campus San FernandoCaliColombia School of Medicine Universidad del ValleCaliColombia University of Montreal Public Health Research Institute(IRSPUM) MontrealCanada French Institute for Research on Sustainable Development(IRD) Paris Descartes UniversityPopulation and Development Center(CEPED)UniversiteParis Sorbonne CiteNational Institute of Health and Medical Research(INSERM)HealthVulnerabilities and Gender Relations South(SAGESUD)ParisFrance

Background:Health personnel face challenges in diagnosing vector-borne and other diseases of poverty in urban *** is a need to know what rapid diagnostic technologies are available,have been properly assessed,and are being implemented to improve control of these diseases in the urban *** paper characterizes evidence on the field validation and implementation in urban areas of rapid diagnostics for vector-borne diseases and other diseases of *** body:A scoping review was ***-reviewed and grey literature were searched using terms describing the targeted infectious diseases,diagnostics evaluations,rapid tests,and urban *** review was limited to studies published between 2000 and 2016 in English,Spanish,French,and *** and exclusion criteria were refined post hoc to identify relevant literature regardless of study design and geography.A total of 179 documents of the 7806 initially screened were included in the ***(n=100)and tuberculosis(n=47)accounted for the majority of studies that reported diagnostics performance,impact,and implementation *** studies,assessing mainly performance,were identified for visceral leishmaniasis(n=9),filariasis and leptospirosis(each n=5),enteric fever and schistosomiasis(each n=3),dengue and leprosy(each n=2),and Chagas disease,human African trypanosomiasis,and cholera(each n=1).Reported sensitivity of rapid tests was variable depending on several ***,specificities were high(>80%),except for schistosomiasis and *** and implementation outcomes,mainly acceptability and cost,followed by adoption,feasibility,and sustainability of rapid tests are being evaluated in the *** to implementing rapid tests range from cultural to technical and administrative ***:Rapid diagnostic tests for vector-borne and other diseases of poverty are being used in the urban context with demonstrated impact on case ***

关键词： Communicable diseases Diagnostic services Point-of-care testing Field evaluation Sensitivity and specificity Implementation Evaluation studies Urban health

On the potential of documenting decadal-scale avifaunal change from before-and-after comparisons of museum and observational data across North America

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Avian Research 2022年第1期13卷 1-10页

作者： Fernando Machado-Stredel Benedictus Freeman Daniel Jiménez-Garcia Marlon E.Cobos Claudia Nunez-Penichet laura Jiménez Ed Komp Utku Perktas Ali Khalighifar Kate Ingenloff Walter Tapondjou Thilina de Silva Sumudu Fernando Luis osorio-Olvera A.Townsend Peterson Biodiversity Institute and Department of Ecology and Evolutionary Biology University of KansasLawrenceKSUSA Centro de Agroecología y Ambiente Instituto de CienciasBenemérita Universidad Autónoma de PueblaPueblaPueblaMexico Information and Telecommunication Technology Center(ITTC) University of KansasLawrenceKSUSA Department of Biology(Zoology Section-Biogeography Research Lab.) Faculty of ScienceHacettepe UniversityBeytepeAnkaraTurkey Department of Ornithology American Museum of Natural HistoryCentral Park West at 79th StreetNew YorkNYUSA Departamento de Ecología de la Biodiversidad Instituto de EcologíaUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico

Studies of biodiversity dynamics have been cast on either long(systematics)or short(ecology)time scales,leaving a gap in coverage for moderate time scales of decades to ***-scale biodiversity information resources now available offer opportunities to fill this gap for many parts of the world via detailed,quantitative comparisons of assemblage composition,particularly for regions without rich time series *** explore the possibility that such changes in avifaunas across the United States and Canada before and after the first three decades of marked global change(i.e.,prior to 1980 versus after 2010)can be reconstructed and characterized from existing primary biodiversity *** an illustration of the potential of this methodology for sites even in regions not as well sampled as the United States and Canada,we also explored changes at a single site in Mexico(Chichén-Itzá).We analyzed two large-scale datasets:one summarizing bird records in the United States and Canada before 1980,and one for the same region after *** used probabilistic inventory completeness analyses to identify sites that have avifaunas that have likely been inventoried more or less *** prepared detailed comparisons between the two time periods to analyze species showing distributional changes over the time period *** identified 139 sites on a 0.05°grid that were demonstrably well-inventoried before 1980 in the United States and Canada,of which 108 were also well-inventoried after *** presence/absence patterns between the two time periods for 601 bird species,we found significant spatial autocorrelation in overall avifaunal turnover(species gained and lost),but not in numbers of species *** noted potential northward retractions of ranges of several species with high-latitude(boreal)distributions,while other species showed dominant patterns of population loss,either rangewide(e.g.,Tympanuchus cupido)or regionally(e.g.,Thryomanes bewickii).We dev

关键词： Biodiversity dynamics Birds Climate change Inventory completeness Time scale Turnover

Human Prion Protein Conformational Changes Susceptibility: A Molecular Dynamics Simulation Study

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Open Journal of Biophysics 2014年第4期4卷 169-175页

作者： laura Alejandra Mandujano-Rosas Daniel osorio-González Pedro Guillermo Reyes-Romero Jorge Mulia-Rodríguez Laboratory of Molecular Biophysics Faculty of Sciences Autonomous University of State of Mexico Toluca Mexico Laboratory of Advaced Physics Faculty of Sciences Autonomous University of State of Mexico Toluca Mexico

Prion proteins are related to the development of incurable and invariably fatal neurodegenerative diseases in humans and animals. The pathogenicity involves the conversion of the host-encoded-alpha rich isoform of prion protein, PrPC, into a misfolded beta-strand rich conformer, PrPSc. Although it has already been described that many punctual mutations alter the stability of PrPC, making it more prone to adopt an abnormal misfolded structure, the majority of cases reported among general population are sporadic in wild-type organisms. Thus, in this work we studied the dynamics and stability profiles of wild-type human prion protein by Molecular Dynamics (MD) simulation at different solvent temperatures. This analysis brought out certain residues and segments of the prion protein as critical to conformational changes;these results are consistent with experimental reports showing that protein mutants in those positions are related to the development of disease.

关键词： Prion Protein Misfolding Susceptibility Molecular Dynamics Simulation

Effect of Nanoparticles on Mechanical Properties of Cement-Sand Mortar Applications

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Advances in Chemical Engineering and Science 2017年第3期7卷 270-276页

作者： José Salvador Cavazos Gustavo González Oxana V. Kharissova Beatriz Ortega laura Peñ a Mario osorio Mauricio Garza-Castañ ón Universidad de Monterrey Physics and Mathematics Department Engineering and Technologies Division San Pedro Garza-García N.L.México Universidad Autónoma de Nuevo León Facultad de Ciencias Físico-Matemáticas Pedro de Alba S/N Ciudad Universitaria San Nicolás de los Garza N.L. Mexico

Cement-sand mortar is a construction material widely used;tile adhesive is one of the main applications where the compressive strength is the key performance metric. Nanoparticles like MWCNTs and HNTs are currently being used to improve the mechanical performance of the cement mortar due to their properties. The cost of MWCNTs has limited their application in the construction industry. This study focuses on the effect of two different concentrations of MWCNTs and HNTs in cement mortar;HNTs are proposed in this study to compare performance and cost overall benefits. A common problem with MWCNTs is agglomeration;to achieve a proper dispersion an ultrasonic processor was utilized. Mechanical properties of a cement mortar modified with nanoparticles were investigated with compression and bending tests on specimens performed at the age of 7 days. Results showed that concentrations of 0.1% of MWCNTs increase in compression strength by 56% and concentrations of 0.1% of HNTs performance increased by 31%, both compared to plain cement mortar.

关键词： Mechanical Properties Compressive Strength Cement Cement Manufacture