检索结果-南通市图书馆

Petrogenesis of Quebrada de la Mina and Altar north porphyries (Cordillera of San Juan, Argentina): Crustal assimilation and metallogenic implications

引用

Geoscience Frontiers 2017年第5期8卷 1135-1159页

作者： laura maydagán Marta Franchini Massimo Chiaradia Verónica Bouhier noelia Di Giuseppe Roger Rey Luis Dimieri Centro Patagónico de Estudios Metalogenéticos-COnICET Argentina InGEOSUR-COnICET Departamento de Geología Universidad Nacional del Sur San Juan 670 8000 Bahía Blanca Argentina Instituto de Investigación en Paleobiología y Geología Universidad Nacional de Río Negro Av. Roca 1242 8332 Roca Argentina Departamento de Geología y Petróleo Facultad de Ingeniería Universidad Nacional del Comahue Buenos Aires 1400 8300 Neuquén Argentina Section of Earth and Environmental Sciences University of Geneva Switzerland Minera Peregrine Argentina S.A Santa Fe (Oeste) 117 Piso 4B Edificio Derby Ciudad San Juan Argentina

We investigate the geology of Altar north(Cu-Au) and Quebrada de la Mina(Au) porphyry deposits located in San Juan Province(Argentina), close to the large Altar porphyry copper deposit(995 Mt,0.35% Cu, 0.083 g/t Au), to present constraints on the magmatic processes that occurred in the parental magma chambers of these magmatic-hydrothermal systems. Altar north deposit comprises a plagioclase-amphibole-phyric dacite intrusion(Altar north barren porphyry) and a plagioclaseamphibole-biotite-phyric dacite stock(Altar north mineralized porphyry, 11.98 ± 0.19 Ma). In Quebrada de la Mina, a plagioclase-amphibole-biotite-quartz-phyric dacite stock(QDM porphyry,11.91±0.33 Ma) crops out. High Sr/Y ratios(92-142) and amphibole compositions of Altar north barren and QDM porphyries reflect high magmatic oxidation states(fO_2= nnO+1.1 to+1.6) and high fH_2O conditions in their magmas. Zones and rims enriched in anorthite(An_(37-48))), SrO(0.22-0.33 wt.%)and FeO(0.21-0.37 wt.%) in plagioclase phenocrysts are evidences of magmatic recharge processes in the magma chambers. Altar north and Quebrada de la Mina intrusions have relatively homogeneous isotopic compositions(^(87)Sr/^(86)Sr_(t)= 0.70450-0.70466, ε_(nD)(t) = +0.2 to +1.2) consistent with mixed mantle and crust contributions in their magmas. Higher Pb isotopes ratios(^(207)Pb/^(204)Pb=15.6276-15.6294) of these intrusions compared to other porphyries of the district, reflect an increase in the assimilation of high radiogenic Pb components in the magmas. Ages of zircon xenocrysts(297,210,204,69 Ma) revealed that the magmas have experienced assimilation of Miocene, Cretaceous, Triassic and Carboniferous crustal *** that precipitated sulfides in the Altar deposit may have remobilized Pb from the host rocks, as indicated by the ore minerals being more radiogenic(207Pb/204 Pb = 15.6243-15.6269) than their host intrusions. Au/Cu ratio in Altar porphyries(average Au/Cu ratio of 0.14 ×10^(-4)by weight in Altar Central)is hig

关键词： Porphyry High sulfidation epithermal Magmatic recharge Radiogenic isotopes Crustal assimilation Argentinian Andes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

引用

neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma L.Clayton UK Dementia Research Institute at King’s College London LondonUK Department of Basic and Clinical neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(ALS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and ALS affecting upper and lower motor neurons),these two diseases are complexly *** and ALS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Telencephalic stab wound injury induces regenerative angiogenesis and neurogenesis in zebrafish:unveiling the role of vascular endothelial growth factor signaling and microglia

引用

neural Regeneration Research 2025年第10期20卷 2938-2954页

作者： Danielle Fernezelian Philippe Rondeau laura Gence nicolas Diotel Universitéde La Réunion INSERMUMR 1188Diabète athérothrombose Thérapies Réunion Océan Indien(DéTROI)Saint PierreLa RéunionFrance

After brain damage,regenerative angiogenesis and neurogenesis have been shown to occur simultaneously in mammals,suggesting a close link between these ***,the mechanisms by which these processes interact are not well *** this work,we aimed to study the correlation between angiogenesis and neurogenesis after a telencephalic stab wound *** this end,we used zebrafish as a relevant model of neuroplasticity and brain repair ***,using the Tg(fli1:EGFP×mpeg1.1:mCherry)zebrafish line,which enables visualization of blood vessels and microglia respectively,we analyzed regenerative angiogenesis from 1 to 21 days *** parallel,we monitored brain cell proliferation in neurogenic niches localized in the ventricular zone by using *** found that after brain damage,the blood vessel area and width as well as expression of the fli1 transgene and vascular endothelial growth factor(vegfaa and vegfbb)were *** the same time,neural stem cell proliferation was also increased,peaking between 3 and 5 days post-lesion in a manner similar to angiogenesis,along with the recruitment of ***,through pharmacological manipulation by injecting an anti-angiogenic drug(Tivozanib)or Vegf at the lesion site,we demonstrated that blocking or activating Vegf signaling modulated both angiogenic and neurogenic processes,as well as microglial ***,we showed that inhibition of microglia by clodronate-containing liposome injection or dexamethasone treatment impairs regenerative neurogenesis,as previously described,as well as injury-induced *** conclusion,we have described regenerative angiogenesis in zebrafish for the first time and have highlighted the role of inflammation in this *** addition,we have shown that both angiogenesis and neurogenesis are involved in brain repair and that microglia and inflammation-dependent mechanisms activated by Vegf signaling are important contributors to

关键词： angiogenesis cerebral damage inflammation neurogenesis stab wound telencephalon vascular endothelial growth factor zebrafish

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

引用

neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot laura Reiche Andrew Chan Robert Hoepner Patrick Küry Department of neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DnA.

关键词： endogenous inflammation Human

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

引用

neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk laura nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75nTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the n-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

引用

neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha J.Holdsworth Alistair J.Gunn laura Bennet Hamid Abbasi Mātai Medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Telecentres in Mountain Regions-A Peruvian Case Study of the Impact of Information and Communication Technologies on Remoteness and Exclusion

引用

Journal of Mountain Science 2009年第4期6卷 320-330页

作者： Richard Heeks laura León Kanashiro Centre for Development Informatics Arthur Lewis BuildingUniversity of Manchester

Communities in developing country mountain areas,in part due to their remoteness,find themselves excluded from social,political and economic systems; and excluded from access to resources. This paper aims to study the impact of information and communication technologies (ICTs) on remoteness and exclusion. It utilises two models - the resource movement framework,and the "information chain" - to analyse a telecentre in one district of mountainous Huancavelica,Peru's poorest region,set in the high Andes. It finds ICTs enabling new and positive resource flows for the two key user groups:teenaged school students and young farmers. These help to maintain social networks. They also support information searches that have improved agricultural practice where other information chain resources have been available. But non-use and ineffective use of the telecentre are found where information chain resources are lacking. ICTs have some impacts on intangible elements of remoteness. In this particular example,they also offer access to some previously-excluded resources. But they have not really addressed the systematic exclusions faced by mountain communities. And they so far appear to be a technology of inequality; favouring those residents who begin with better resource *** paper concludes by offering some recommendations for mountain ICT project practice.

关键词： Exclusion Telecentre Information and communication technologies (ICTs) new technology Andes Peru

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

noise-induced hippocampal damage:potential mechanisms

引用

neural Regeneration Research 2022年第3期17卷 563-564页

作者： Sonia Jazmín Molina laura Ruth Guelman Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicas y TécnicasCentro de Estudios Farmacológicos y Botánicos(CEFyBOUBA-CONICET)Facultad de MedicinaBuenos AiresArgentina Universidad de Buenos Aires Facultad de Medicina1^(a) Cátedra de FarmacologíaBuenos AiresArgentina

Exposure to noise of high intensities(> 80 dB) is considered a stressful event and might produce both auditory and extra-auditory damage,including different central nervous system(CnS) *** the CnS,the hippocampus(HC),a structure related to several cognitive functions,has shown to be particularly susceptible to the effects of noise.

关键词： damage auditory injuries

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of insoluble materials on the volumetric behavior of rock salt

引用

Journal of Rock Mechanics and Geotechnical Engineering 2021年第1期13卷 84-97页

作者： Mejda Azabou Ahmed Rouabhi laura Blanco-Martìn MInES ParisTech PSL Research UniversityCentre de Géosciences35 rue St HonoréFontainebleau77300France

This paper focuses on the presence of nodules of insoluble materials within salt specimens,and their effect on the volumetric strain measurements and the dilatancy *** analyzed experimental results of over 120 conventional triaxial compression tests,and found that in 20%of the cases,the volumetric strain measurements were *** also noted that the natural variability of the specimens can lead to a non-negligible data scattering in the volumetric strain measurements when different specimens are subjected to the same *** is expected given the small magnitude of those strains,but it occasionally implies that the corresponding specimens are not representative of the volumetric behavior of the studied *** order to understand these results,we numerically investigated salt specimens modeled as halite matrices with inclusions of *** of triaxial compression tests on these structures proved that such heterogeneities can induce dilatancy,and their presence can lead to the appearance of tensile zones which is physically translated into a micro-cracking *** modeling approach is validated as the patterns displayed in the numerical results are identical to that in the *** was then employed to explain the observed irregularities in experimental *** studied the natural variability effect as well and proposed a methodology to overcome the issue of specimen representativity from both deviatoric and volumetric perspectives.

关键词： Rock salt Dilatancy Material heterogeneity natural variability Triaxial tests Virtual laboratory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

引用

neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：