AIM:To compare results of liver stiffness measurements by transient elastography(TE) obtained in our patients population with that used in a recently published ***:This was a single center cross-sectional *** patients...
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AIM:To compare results of liver stiffness measurements by transient elastography(TE) obtained in our patients population with that used in a recently published ***:This was a single center cross-sectional *** patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were *** was carried out by using FibroScan(Echosens,Paris,France).Liver biopsy was performed on the same day as TE,as day case *** was staged according to the Metavir scoring *** diagnostic performance of TE was assessed by using receiver operating characteristic(ROC) curves and the area under the ROC curve ***:Two hundred and fifty-two patients met the inclusion ***(2%) patients were excluded due to unreliable TE ***,246(171 men and 75 women) patients were *** hundred and ninety-five(79.3%) patients had chronic hepatitis C,41(16.7%) had chronic hepatitis B,and 10(4.0%) were coinfected with human immunodeficiency *** curve analysis identified optimal cut-off value of TE as high as 6.9 kPa forF ≥ 2;7.9 kPa forF ≥ 3;9.6 kPa for F = 4 in all patients(n = 246),and as high as 6.9 kPa for F ≥ 2;7.3 kPa for F ≥ 3;9.3 kPa for F = 4 in patients with hepatitis C(n = 195).Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F ≥ 2;9.6 kPa for F ≥ 3;12.2 kPa for F = 4 in all patients(n = 246),and as high as 7.0 kPa forF ≥ 2;9.3 kPa forF ≥ 3;12.3 kPa forF = 4 in patients with hepatitis C(n = 195).CONCLUSION:The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies.
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