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Intertwined leukocyte balances in tumours and peripheral blood as robust predictors of right and left colorectal cancer survival

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 295-318页

作者： Ramón Cantero-Cid Karla Marina Montalbán-Hernández Jenny Guevara Alejandro Pascual-Iglesias Elisa Pulido JoséCarlos Casalvilla Cristóbal Marcano Cristina Barragán Serrano Jaime Valentín Gloria Cristina Bonel-Pérez JoséAvendaño-Ortiz Verónica Terrón Roberto Lozano-Rodríguez Alejandro Martín-Quirós Elvira Marín Eva Pena laura guerra-Pastrián Eduardo López-Collazo Luis Augusto Aguirre Tumor Immunology Laboratory The Innate Immune Response GroupHospital La Paz Institute for Health Research(IdiPAZ)Madrid 28046Spain Digestive Surgery Service La Paz University HospitalMadrid 28046Spain Emergency Department and Emergent Pathology Research Group Hospital La Paz Institute for Health Research(IdiPAZ)Madrid 28046Spain Pathologic Anatomy Service Hospital La PazMadrid 28046Spain

BACKGROUND Colorectal cancer(CRC)accounts for 9.4%of overall cancer deaths,ranking second after lung *** the large number of factors tested to predict their outcome,most patients with similar variables show big differences in ***,right-sided CRC(RCRC)and left-sided CRC(LCRC)patients exhibit large differences in outcome after surgical intervention as assessed by preoperative blood leukocyte *** hypothesised that stronger indexes than circulating(blood)leukocyte ratios to predict RCRC and LCRC patient outcomes will result from combining both circulating and infiltrated(tumour/peritumour fixed tissues)concentrations of *** To seek variables involving leukocyte balances in peripheral blood and tumour tissues and to predict the outcome of CRC *** Sixty-five patients diagnosed with colon adenocarcinoma by the Digestive Surgery Service of the La Paz University Hospital(Madrid,Spain)were enrolled in this study:43 with RCRC and 22 with *** were followed-up from January 2017 to March 2021 to record overall survival(OS)and recurrence-free survival(RFS)after surgical *** concentrations in peripheral blood were determined by routine laboratory ***-fixed samples of tumour and peritumoural tissues were assessed for leukocyte concentrations by immunohistochemical detection of CD4,CD8,and CD14 marker *** of leukocyte concentration in blood and tissues were calculated and evaluated for their predictor values for OS and RFS with Spearman correlations and Cox univariate and multivariate proportional hazards regression,followed by the calculation of the receiver-operating characteristic and area under the curve(AUC)and the determination of Youden’s optimal cutoff values for those variables that significantly correlated with either RCRC or LCRC patient *** patients from the cohort were randomly assigned to modelling and validation sets,and clinician-friendly nomogra

关键词： Left colorectal cancer Leukocyte ratios Prognostic variables Recurrence-free survival Right colorectal cancer Overall survival

Neuropsychological Profile of a Patient with Acquired Brain Damage Following Vascular Lesion of the Left Anterior Cingulate Cortex

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Neuroscience & Medicine 2024年第1期15卷 66-75页

作者： Jimmy Zúñiga-Márquez Lina Borda-Camargo Diego Buitrago-Mora Lorely guerra-Valdés laura González Patricia Quintero-Cusgüen Nataly Gutierrez-Ávila Hospital Universitario de la Samaritana Bogotá Colombia Neuropsychological Assessment and Diagnosis Graduate Program School of Psychology Universidad San Buenaventura Bogotá Bogotá Colombia

Stroke is a physiological alteration associated with changes in blood flow that can result in sudden-onset cognitive impairment. It has a heterogenous clinical presentation with varying degrees of severity correlated with specific central nervous system zones or areas, and its prognosis is uncertain. This case study describes a 62-year-old male patient with acquired brain damage of the anterior cingulate cortex as a result of an ischemic event in the territory of the left anterior cerebral artery. Cognitive function was assessed using the neuropsychological executive function and frontal lobe test battery (BANFE-2) as well as other neuropsychological tests. The results show a profile of higher mental functions characterized by the presence of dysexecutive syndrome with marked behavioral alteration and diencephalic amnesia. .

关键词： Ischemic Stroke Anterior Cingulate Cortex Neuropsychology Acquired Brain Damage

Neuropsychological Profile of a Patient with Acquired Brain Damage Following Vascular Lesion of the Left Anterior Cingulate Cortex

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Inhaler Technique Questionnaire(InTeQ)in pediatric patients with asthma

Neuroscience & Medicine（神经系统科学与医药） 2024年第1期 66页

作者： Jimmy Zúñiga-Márquez Lina Borda-Camargo Diego Buitrago-Mora Lorely guerra-Valdés laura González Patricia Quintero-Cusgüen Nataly Gutierrez-Ávila

来源：博看期刊评论

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世界儿科杂志:英文版 2023年第8期19卷 798-804页

作者： Catalina Lizano‑Barrantes Olatz Garin Alexandra Lelia Dima Karina Mayoral Angels Pont Eva María Ortiz María Araceli Caballero‑Rabasco Manuel Praena‑Crespo laura Valdesoiro‑Navarrete María Teresa guerra Alberto Bercedo‑Sanz Gimena Hernández Camila Maroni Inés de Mir MaríaÁngeles Carrasco Marta Ortega Alberto Servan JoséAntonio Castillo Eva Tato Montse Ferrer Health Services Research Group IMIM(Hospital del Mar Medical Research Institute)Barcelona Biomedical Research ParkDoctor Aiguader8808003 BarcelonaSpain Department of Medicine and Life Sciences Universitat Pompeu FabraBarcelonaSpain Department of Pharmaceutical Care and Clinical Pharmacy Faculty of PharmacyUniversidad de Costa RicaSan JoseCosta Rica Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública CIBERESP MadridSpain Research and Development Unit Institut de Recerca Sant Joan de DéuBarcelonaSpain Department of Pediatrics Obstetrics and Gynaecology and Preventive MedicineUniversitat Autònoma de BarcelonaBarcelonaSpain Pediatric Allergy and Pulmonology Unit Pediatric ServiceHospital del MarBarcelonaSpain Pediatric Allergy and Pulmonology Unit Pediatric ServiceHospital Universitari Parc TaulíSabadellSpain Centro de Salud La Candelaria Servicio Andaluz de SaludSevilleSpain Grupo de Vías Respiratorias de La Asociación Española de Pediatras de Atención Primaria(AEPAP) MadridSpain Centro de Salud Jerez Sur Servicio Andaluz de SaludSevilleSpain Centro de Salud La Sagrera BarcelonaSpain Centro de Salud Los Castros CantabriaSpain Facultat de Medicina Universitat Autònoma de BarcelonaBarcelonaSpain Pediatric Allergy and Pulmonology and Cystic Fibrosis UnitHospital Universitari Vall d’HebronBarcelonaSpain Consultorio Sevilla la Nueva MadridSpain Centro de Salud Dos de Mayo MadridSpain Hospital Miguel Servet ZaragozaSpain Hospital Universitario Araba Vitoria-GasteizSpain Departamento de Farmacologia Pediatría y RadiologíaUniversidad de SevillaSevilleSpain Institut d’Investigaciói InnovacióParc Taulí SabadellSpain

Asthma in school-aged children is a major public health problem worldwide[1,2].Inhaled medications are the mainstay of its pharmacological management[2],but only 8%-22%of children with asthma use their inhalers correc... 详细信息

关键词： asthma pediatric patients

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巴西Catuaba农场住宅

现代装饰 2017年第5期 38-45页

作者： Marcio Kogan Lair Reis Carlos Costa Flavia Maritan laura Guedes Mariana Simas Oswaldo Pessano Fernando guerra 姜敏华

这是一栋坐落于海拔1500米的山谷上的住宅项目。在一年四季的大多数时间里,它都与自然保持着紧密的联系。设计的主要目的在于为用户提供居住舒适度的同时,提升能源的使用效率,降低能源消耗,实现与自然的和谐相融。住宅采用了国际FSC森... 详细信息

这是一栋坐落于海拔1500米的山谷上的住宅项目。在一年四季的大多数时间里,它都与自然保持着紧密的联系。设计的主要目的在于为用户提供居住舒适度的同时,提升能源的使用效率,降低能源消耗,实现与自然的和谐相融。住宅采用了国际FSC森林认证的预制木结构,不直接接触地面,而是通过一些柱子进行支撑。如此设计,充分考虑了项目地形的崎岖,以及远离城市等诸多现实问题和必要考虑的因素。

关键词：住宅 Catu aba

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新罕布什尔休闲寓所美国新罕布什

世界建筑导报 2018年第2期33卷 90-93页

作者： nader tehrani katherine faulkner ryan murphy sergio verrillo marta guerra tim wong tom beresford lisa lacharité john houser alda black laura williams wes hiatt 不详 AIA

新罕布什尔休闲寓所位于白山总统山脉北麓中．由一系列的独立房间组成——每个房间都是一幅画，捕捉周围山顶的景色。新罕布什尔休闲寓所采用按线性顺序展开，一端用于卧室套房，另一端用于服务区域的方案。

关键词：布什休闲美国服务区域房间景色山顶套房

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丹尼尔斯大厦加拿大多伦多

世界建筑导报 2018年第2期33卷 72-77页

作者： richard lee tom beresford john houser amin tadj alda black marta guerra animations james juricevich parke macdowell dane asmussen laura williams peter sprowls noora al musallam tammy teng wesley hiatt john mars mazyar kahali 不详

多伦多大学丹尼尔斯建筑、景观和设计学院的设计采用了分期的方法，包括修复和扩建以前称为“知识学院”的标志性建筑，将现有建筑物改造成与教学和需求更相关的框架体系。这个十九世纪遗址的总体规划是通过对预期用途模式和场地生态的... 详细信息

多伦多大学丹尼尔斯建筑、景观和设计学院的设计采用了分期的方法，包括修复和扩建以前称为“知识学院”的标志性建筑，将现有建筑物改造成与教学和需求更相关的框架体系。这个十九世纪遗址的总体规划是通过对预期用途模式和场地生态的分析而制定的，目的是重新定位校园西南角与安大略湖的轴线，并为学院创造新的特性。丹尼尔斯建筑、景观和设计学院需要一个可持续发展的新型工作原型．以适应工作室、金属加工车间、教室、办公室、图书馆、

关键词：多伦多大学加拿大标志性建筑设计学院大厦建筑物改造可持续发展安大略湖

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丹尼尔斯大楼

当代建筑 2020年第4期 42-55页

作者：无 Nader Tehrani Katherine Faulkner John Houser Amin Tadj Tim Wong Alda Black Marta guerra James Juricevich Parke Macdowell Nicole Sakr Dane Asmussen laura Williams Peter Sprowls Noora Al Musallam Tammy Teng Wesley Hiatt John Mars Mazyar Kahali Matthew Waxman Luisel Zayas Nic Lehoux(摄) NADAAA建筑事务所不详

2009年,多伦多大学丹尼尔斯建筑、景观与设计学院(DFALD)发起一场竞赛,要求将其现有丹尼尔斯大楼改造成一座与院校教学和愿景更加契合的建筑。2011年,DFALD明确指出应当将项目(以前这里是知名的诺克斯学院)重新定位为斯帕迪纳新月区的... 详细信息

2009年,多伦多大学丹尼尔斯建筑、景观与设计学院(DFALD)发起一场竞赛,要求将其现有丹尼尔斯大楼改造成一座与院校教学和愿景更加契合的建筑。2011年,DFALD明确指出应当将项目(以前这里是知名的诺克斯学院)重新定位为斯帕迪纳新月区的城市地标,并且分两个阶段完成翻新和扩建工程。通过分析预期的使用模式和场地的生态环境,设计师为这处19世纪的场地制定出总体规划,旨在将校园的西南角重新设置于湖心轴线上,为该院校打造出新的标识。DFALD要求创建一个新的可持续的工作场所,包括工作室、制造车间、教室、办公室、图书馆、咖啡厅、展览空间、礼堂和最先进的"城市剧院"等。丹尼尔斯大楼所处的环形场地位于繁忙的城市主干道上,外围有一条有轨电车线路,是一处被城市各种活动包围的独立地带。尽管,南北轴线对城市有着重要的意义,但东西轴线才是日常交通的活跃地带。因此,该场地实际上是双向轴线的,且所有方向都有明显的标识物。

关键词：南北轴线展览空间城市地标多伦多大学制造车间丹尼尔斯生态环境标识物