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Flippe. classroom approach to global outre.ch:cross-cultural te.ching of horizontal strabismus to Chine.e.ophthalmology re.ide.ts

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Inte.national Journal of Ophthalmology(e.glish e.ition) 2023年第2期16卷 280-285页

作者： Randy Lu Ryan e.Dodge.Ⅲ Joce.yn Lam laura e.ye.i Tammy Yanovitch Nandini Gandhi Le.na Ding Miche.le.T Cabre.a Unive.sity of Washington School of Me.icine SeattleWA 98195USA De.artme.t of Ane.the.ia Massachusetts General HospitalBostonMA 02114USA e.e.e.lth Northwe.t PortlandOR 97209USA De.artme.t of Ophthalmology Duke UniversityDurhamNC 27708USA De.artme.t of Ophthalmology University of OklahomaOklahoma CityOK 73019USA De.artme.t of Ophthalmology University of California DavisSacramentoCA 95817USA De.artme.t of Ophthalmology University of WashingtonSeattleWA 98195USA Division of Ophthalmology Seattle Children’s HospitalSeattleWA 98105USA

AIM:To e.aluate.the.flippe. classroom mode. for te.ching horizontal strabismus didactics in an ophthalmology re.ide.cy program in China as part of a visiting profe.sorship from the.Unite. ***:Re.ide.ts from an ophthalmology re.ide.cy program in China we.e.invite. to participate.in flippe. classroom se.sions taught by an e.pe.ie.ce. Ame.ican ophthalmology faculty in *** we.e.instructe. to watch a pre.class vide. le.ture.prior to the.in-class-case.ase. *** te.ts(5 Ophthalmic Knowle.ge.Asse.sme.t Program style.que.tions)and surve.s we.e.administe.e. be.ore.and afte. the.classroom se.sions(100%re.ponse.rate..The.e.re.ults we.e.compare. to that of an Ame.ican cohort who we.e.taught the.same.***:The.Chine.e.cohort of 12 re.ide.ts pre.e.re. the.flippe. classroom to the.traditional classroom at highe. rate. than the.Ame.ican cohort of 40 re.ide.ts(92%vs 55%,P=0.04)and fe.t that all ophthalmology topics would be.appropriate.for the.flippe. classroom te.ching style.P-value. be.we.n 0.008 ande.e.and Ame.ican cohorts,we.found that the.e.otropia curriculum saw a small but significant improve.e.t in pe.formance.following the.flippe. classroom se.sion(P=0.025 for Chine.e.re.ide.ts;P=0.001 for US re.ide.ts),whe.e.s score. in both groups for the.e.otropia course.did not significantly ***:This is the.first study to e.aluate.the.flippe. classroom mode. imple.e.te. by a visiting ophthalmology profe.sor in a global outre.ch *** flippe. classroom se.sions are.vie.e. favorably by the.Chine.e.re.ide.ts re.ative.to the.US cohort with a mode.t impact on *** in-pe.son inte.pre.e. re.uire.e.t and incre.se. stude.t e.gage.e.t make.this mode. valuable.in cross-cultural visiting profe.sorship ***,the.flippe. classroom may le.d itse.f we.l to a virtual format to pre.e.t the.transmission of COVID-19,although such a format re.uire. furthe. study.

关键词： flippe. classroom inte.national ophthalmology re.ide.cy graduate.me.ical e.ucation China active.le.rning me.ical e.ucation ophthalmology

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e.trace.lular ve.icle. in live. dise.se.and be.ond

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World Journal of Gastroe.te.ology 2018年第40期24卷 4519-4526页

作者： laura Morán Francisco Javie. Cube.o De.artme.t of Immunology Ophthalmology and ORLComplutense University School of MedicineMadrid 28040Spain 12 de.Octubre.He.lth Re.e.rch Institute.imas12) Madrid 28041Spain

e.trace.lular ve.icle.(e.s) are.me.brane.de.ive. ve.icle. which can be.re.e.se. by diffe.e.t ce.l type., including he.atocyte., he.atic ste.late.ce.ls and immune.ce.ls in normal and pathological conditions. e.s carry lipids, prote.ns, coding and non-coding RNAs and mitochondrial DNA causing modifications on the.re.ipie.t ce.ls. The.e.ve.icle. are.conside.e. pote.tial biomarke.s and the.ape.tic age.ts for human diagnostic and prognostic due.to the.r function as inte.ce.lular me.iators of ce.l-ce.l communication within the.live. and be.we.n othe. organs. Howe.e., the.de.e.opme.t and optimization of me.hods for e.s isolation is re.uire. to characte.ize.the.r biological functions as we.l as the.r pote.tial as a tre.tme.t option in the.clinic. Ne.e.the.e.s, many que.tions re.ain unanswe.e. re.ate. to the.function of e.s unde. physiological and pathological conditions. In the.curre.t e.itorial, the.re.ults obtaine. in diffe.e.t studie. that inve.tigate. the.role.of intrahe.atic e.s during live. dise.se., including drug-induce. live. injury, non-alcoholic fatty live., nonalcoholic ste.tohe.atitis, alcoholic live. dise.se.and he.atoce.lular carcinoma and e.trahe.atic e.s in re.ote.organs during pathological e.e.ts such as pulmonary dise.se. cardiovascular dise.se., ne.rode.e.e.ative.disorde.s e.g., Alzhe.me.'s dise.se. Parkinson's dise.se.and multiple.scle.osis as we.l as in immunopathological proce.se., are.discusse.. Although much light ne.ds to be.she. on the.me.hanisms of e.s, the.e.me.brane.e.ive. ve.icle. re.re.e.t both a nove. promising diagnostic, and a the.ape.tic tool for clinical use.that we.e.phasize.in the.curre.t e.itorial.

关键词： e.trace.lular ve.icle. microRNA He.atocyte. Drug-induce. live. injury Alcoholic live. dise.se Nonalcoholic fatty live. dise.se Non-alcoholic ste.tohe.atitis He.atoce.lular carcinoma

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Fe.e.e.Gauss Spe.tral e.e.e.ts for Incompre.sible.Navie.-Stoke. Flows:The.Two-Dime.sional Case

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Communications in Computational Physics 2013年第5期13卷 1309-1329页

作者： laura Lazar Richard Pasque.ti France.ca Rape.ti Lab.J.A.Die.donne UMR 7351 CNRS UNSUniversite de Nice-Sophia Antipolis06108 Nice Cedex 02France

Spe.tral e.e.e.t me.hods on simplicial me.he.,say TSe.,show both the.advantage. of spe.tral and finite.e.e.e.t me.hods,i.e.,spe.tral accuracy and ge.me.rical *** pre.e.t a TSe. solve. of the.two-dime.sional(2D)incompre.sible.Navie.-Stoke. e.uations,with possible.e.te.sion to the.3D *** use. a proje.tion me.hod in time.and pie.e.ise.polynomial basis functions of arbitrary de.re. in *** so-calle. Fe.e.e.Gauss TSe. is e.ploye.,i.e.,Fe.e.e.***)points of the.triangle.are.use. as inte.polation(***)*** the.sake.of consiste.cy,isoparame.ric e.e.e.ts are.use. to approximate.curve. *** re.olution algorithm is base. on an e.ficie.t Schur comple.e.t me.hod,so that one.only solve. for the.e.e.e.t boundary ***,the.alge.raic syste. is ne.e. asse.ble.,the.e.ore.the.numbe. of de.re.s of fre.dom is not *** accuracy study is carrie. out and re.ults are.provide. for classical be.chmarks:the.drive. cavity flow,the.flow be.we.n e.ce.tric cylinde.s and the.flow past a cylinde..

关键词： Spe.tral e.e.e.ts simplicial me.he. Fe.e.e.Gauss approximation Navie.-Stoke. e.uations proje.tion me.hods domain de.omposition

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Mature.ve.sus e.e.ging te.hnologie. for CO2 capture.in powe. plants： Ke. ope. issue. in post-combustion amine. scrubbing and in che.ical looping combustion

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Frontie.s of Che.ical Scie.ce.and e.gine.ring 2018年第2期12卷 315-325页

作者： Giorgia De.Guido Matte. Compagnoni laura A. Pe.le.rini Ile.ia Rosse.ti De.artme.t of Che.istry Materials and Chemical Engineering "Giulio Natta" Politecnico di Milano Piazza Leonardo da Vinci 32 20133 MilanItaly De.artme.t of Che.istry Universita degli Studi di Milano INSTM Unit Milano-Universita and CNR-ISTM Via Camillo Golgi 19 20133 Milan Italy

Carbon capture.and storage.（CCS） have.acquire. an incre.sing importance.in the.de.ate.on global wanning as a me.n to de.re.se.the.e.vironme.tal impact of e.e.gy conve.sion te.hnologie., by capturing the.CO2 produce. from the.use.of fossil fue.s in e.e.tricity ge.e.ation and industrial proce.se.. In this re.pe.t, post-combustion syste.s have.re.e.ve. gre.t atte.tion as a possible.ne.r-te.m CO2 capture.te.hnology that can be.re.rofitte. to e.isting powe. plants. This capture.te.hnology is, howe.e., e.e.gy-inte.sive.and re.ults in large.e.uipme.t size. be.ause.of the.large.volume. of the.flue.gas to be.tre.te.. To cope.with the.de.e.its of othe. CCS te.hnologie., the.che.ical looping combustion （CLC） proce.s has be.n re.e.tly conside.e. as a solution for CO2 se.aration. It is typically re.e.re. to as a te.hnology without e.e.gy pe.alty. Inde.d, in CLC the.fue. and the.combustion air are.ne.e. mixe. and the.gase. from the.oxidation of the.fue. （i.e., CO2 and H2O） le.ve.the.syste. as a se.arate.stre.m and can be.se.arate. by conde.sation of H2O without any loss of e.e.gy. The.ke. issue.for the.CLC proce.s is to find a suitable.oxyge. carrie., which provide. the.fue. with the.activate. oxyge. ne.de. for combustion. The.aim of this work is to e.plore.the.fe.sibility of using pe.ovskite. as oxyge. carrie.s in CLC and to conside. the.possible.advantage. with re.pe.t to the.scrubbing proce.s with amine., a mature.post-combustion te.hnology for CO2 se.aration.

关键词： CO2 capture monoe.hanolamine che.ical looping combustion oxyge. carde. pe.ovskite.

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He.rt mitochondrial dysfunction in diabe.ic rats

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BIOCe.L 2016年第1期40卷 7-10页

作者： SILVINA S.BOMBICINO DARIO e.IGLe.IAS IVANA A.RUKAVINA MIKUSIC ALBe.TO BOVe.IS laura B.VALDe. 不详

Diabe.ic cardiomyopathy,*** ve.tricular dysfunction in the.abse.ce.of hype.te.sion or coronary arte.ial dise.se.is a common complication of diabe.e. me.litus that le.ds to a he.ghte.e. risk of he.rt failure.and de.th among diabe.ic *** contractile.dysfunction could be.associate. to mitochondrial dysfunction,in which mitochondrial bioge.e.is could e.e.ge.as a compe.satory me.hanism trigge.e. in re.ponse.to *** has be.n propose. that nitric oxide.synthase.activitie. with e.hance. NO production are.involve. in this *** in the.contractile.re.ponse.and lusitropic re.e.ve.we.e.obse.ve. in stre.tozotocin diabe.ic rats afte.β-adre.e.gic ***,tissue.O_(2) consumption was de.line..A condition of mitochondrial dysfunction with de.re.se. mitochondrial state.3 O_(2) consumption,re.piratory control ratio,mitochondrial re.piratory comple.e. activitie. and ATP production we.e.pre.e.t in he.rts of diabe.ic *** obse.ve. an incre.se.in NO production by he.rt mitochondria and in cytochrome.oxidase.activity in he.rt *** latte. sugge.ts an incre.se.of ne.ly forme. ***,the.impairme.t of mitochondrial function with incre.se. mitochondrial bioge.e.is may pre.e.e.the.onse. of diabe.ic ***,mitochondrial bioge.e.is doe. not ne.e.sarily imply that the.re.ultant mitochondria are.functional,which might e.plain the.change. in cardiac e.e.gy me.abolism occurring in he.rts of diabe.ic rats.

关键词： Diabe.e. Diabe.ic cardiomyopathy he.rt mitochondria nitric oxide

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SOX13 ge.e.downre.ulation in pe.iphe.al blood mononucle.r ce.ls of patie.ts with Kline.e.te. syndrome

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Asian Journal of Andrology 2021年第2期23卷 157-162页

作者： Rosse.la Cannare.la Miche.e.Sale.i Rosita A Condore.li laura Cimino Giorgio Giurato Giovanna Marche.e.Ange.a Corde.la Corrado Romano Sandro La Vigne.a Aldo e.Caloge.o De.artme.t of Clinical and e.pe.ime.tal Me.icine University of CataniaCatania 95123Italy Oasi Re.e.rch Institute.IRCCS Troina(EN)94018Italy Ge.omix4Life.Srl Department of MedicineSurgery and Dentistry“Schola Medica Salernitana”University of SalernoBaronissi(SA)84081Italy

Kline.e.te. syndrome.KS)is the.most common se. chromosome.disorde. in *** is characte.ize. by ge.m ce.l loss and othe. variable.clinical fe.ture.,including *** se.-de.e.mining re.ion of Y(SRY)-box 13(Sox13)ge.e.is e.pre.se. in mouse.*** addition,it has be.n ide.tifie. as isle. ce.l autoantige. 12(ICA12),which is involve. in the.pathoge.e.is of autoimmune.dise.se.,including type.1 diabe.e. me.litus(DM)and primary biliary ***13 e.pre.sion has ne.e. be.n inve.tigate. in patie.ts with *** this age.matche.,case.control study pe.forme. on te. patie.ts with KS and te. controls,we.found that SOX13 is significantly downre.ulate. in pe.iphe.al blood mononucle.r ce.ls of patie.ts with KS compare. to *** finding might be.consiste.t with the.ge.m ce.l loss typical of patie.ts with ***,the.role.of SOX13 in the.pathoge.e.is of ge.m ce.l loss and humoral autoimmunity in patie.ts with KS de.e.ve. to be.furthe. e.plore..

关键词： ge.m ce.ls inte.le.tual disability Kline.e.te. syndrome rare.dise.se se.-de.e.mining re.ion of Y-box 13(SOX13)

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The.Coming Of The.King

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语数外学习(初中版) 2023年第10期 44-46页

作者： laura e.Richards

一天，几个孩子正在游乐场玩耍的时候，一个传令官骑着马穿城而过，鸣号呐喊：“国王！国王陛下今天打此路过，准备迎驾！”孩子们停止了游戏，你瞅瞅我，我瞅瞅你。“你们听见了吧？国王要来了。他没准会看到墙里面，瞧见我们的游乐场...

一天，几个孩子正在游乐场玩耍的时候，一个传令官骑着马穿城而过，鸣号呐喊：“国王！国王陛下今天打此路过，准备迎驾！”孩子们停止了游戏，你瞅瞅我，我瞅瞅你。“你们听见了吧？国王要来了。他没准会看到墙里面，瞧见我们的游乐场；谁知道呢。反正咱们得把这里收拾整齐。”

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Iron-Modification of Pyroclastic Mate.ial from PCCVC e.uption (Chile.: Characte.ization and Application to Re.ove.Arse.ic from Groundwate.

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Journal of e.vironme.tal Prote.tion 2015年第10期6卷 1124-1133页

作者： María J. Gonzále. Lia Botto María e. Canafoglia laura Coccaro e.gardo Soto Ce.UINOR (CCT-La Plata-CONICe.-UNLP) La Plata Argentina INRe.I (CICPBA-UNLP) La Plata Argentina CINDe.A (CCT-La Plata-CONICe.-UNLP) La Plata Argentina

Pyroclastic mate.ial from the.PCCVC e.uption (Chile. was modifie. with iron (III) solutions le.ding to the.formation of fe.rihydrite.surface.de.osits. The.aim of the.che.ical tre.tme.t was to pre.are.an adsorbe.t to re.ove.arse.ic from wate. by using low-cost mine.al waste.. Physicoche.ical characte.ization of original and modifie. mate.ials was carrie. out by XRD, Be.-N2 adsorption, Se.-e.S microscopy and ICP-Ae. che.ical analysis. The.modifie. ash re.e.le. that the.incre.se.of bulk iron conte.t was close.to 5% (e.pre.se. as Fe.O3) whe.e.s surface.value. we.e.20.6% Fe.O3. Surface.prope.tie. showe. an incre.se.of Be. spe.ific surface.with pre.ale.ce.of me.opore. and an incre.se.of total pore.volume.attribute. to pre.e.ce.of nanoscopic iron phase. Kine.ic and e.uilibrium studie. we.e.dire.te. to optimize.the.ope.ative.conditions re.ate. to the.mate.ial adsorptive.capacity for re.oving arse.ate.spe.ie.. He.ce. the.adsorbe.t dose. contact time. pH, stirring and se.ime.tation we.e.e.aluate. in batch proce.s. The.optimal adsorption dose.was 40 g ·L-1 and the.solid-liquid contact time.was stirring (1 h) and se.ime.tation (23 h), e.ough to e.sure.an ade.uate.turbidity value.valid for a pH range.be.we.n 3.77 and 8.95. The.analysis of the.isothe.m e.uilibrium by using the.Langmuir line.r me.hod showe. a R2 = 0.995 value. The.pe.formance.of the.tre.tme.t to re.ove.arse.ic by using a cost-e.fe.tive.adsorbe.t pre.are. from volcanic mate.ial is a promising te.hnology to apply in the.e.vironme.tal fie.d.

关键词： Volcanic Ash Iron Modification Arse.ic Re.oval Groundwate.

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Die. and microbiome.in the.be.inning of the.se.ue.ce.of gut inflammation

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World Journal of Clinical Case. 2021年第36期9卷 11122-11147页

作者： Danie. Ce.allos A He.nánde.-Camba laura Ramos De.artme.t of Gastroe.te.ology Hospital Universitario de Gran Canaria Doctor NegrinLas Palmas 35019CanariasSpain De.artme.t of Gastroe.te.ology Hospital Universitario Nuestra Señora de La CandelariaSanta Cruz de Tenerife 38010CanariasSpain De.artme.t of Gastroe.te.ology Hospital Universitario de CanariasSan Cristóbal de La Laguna 38320CanariasSpain

Inflammatory bowe. dise.se.IBD)is a chronic inflammatory condition of the.gastrointe.tinal tract due.at le.st partially,to an abe.rant and e.ce.sive.mucosal immune.re.ponse.to gut bacte.ia in ge.e.ically-pre.ispose. individuals unde. ce.tain e.vironme.tal *** incide.ce.of IBD is rising in we.te.n and ne.ly industrialize. countrie.,paralle.ing the.incre.se.of we.te.nize. die.ary patte.ns,through ne. antige.s,e.ithe.ial function and pe.me.bility,e.ige.e.ic me.hanisms(e.g.,DNA me.hylation),and alte.ation of the.gut *** in the.composition and functionality of the.gut microbiome.including bacte.ia,viruse. and fungi)se.ms to be.a nucle.r pathoge.ic *** microbiome.itse.f is dynamic,and the.change. in food quality,die.ary habits,living conditions and hygie.e.of the.e.we.te.n socie.ie.,could inte.act in a comple. manne. as modulators of dysbiosis,the.e.y influe.cing the.activation of immune.ce.ls’promoting *** microbiome.produce. dive.se.small mole.ule. via se.e.al me.abolic ways,with the.fibe.-de.ive. short-chain fatty acids(i.e.,butyrate.as main e.e.e.ts and having anti-inflammatory *** me.abolite. and some.micronutrie.ts of the.die.(i.e.,vitamins,folic acid,be.a carote.e.and trace.e.e.e.ts)are.re.ulators of innate.and adaptive.inte.tinal immune.*** e.ce.sive.and unhe.lthy consumption of sugar,animal fat and a low-ve.e.able.and-fibe. die. are.risk factors for IBD ***,me.abolism of nutrie.ts in inte.tinal e.ithe.ium and in gut microbiota is alte.e. by inflammation,changing the.de.and for nutrie.ts ne.de. for *** role.of food and a re.uce. gut microbial dive.sity in causing IBD might also have.a prophylactic or the.ape.tic role.for *** re.ationship be.we.n die.ary intake.symptoms,and bowe. inflammation could le.d to die.ary and life.tyle.re.omme.dations,including die.s with abundant fruits,ve.e.able.,olive.oil and oily fish,which have.anti-inflammatory e.fe.ts and could pre

关键词： Die. Microbiome Inflammatory bowe. dise.se Pathoge.ia

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Contribution of Major Hydrophilic and Lipophilic Antioxidants from Papaya Fruit to Total Antioxidant Capacity

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Food and Nutrition Scie.ce. 2013年第8期4卷 93-100页

作者： laura e. Gayosso-García Sancho e.hadi M. Yahia Gustavo A. Gonzále.-Aguilar Coordinación de.Te.nología de.Alime.tos de.Orige. Ve.e.al Centro de Investigación en Alimentación y Desarrollo Hermosillo México Facultad de.Cie.cias Naturale. Universidad Autónoma de Querétaro Querétaro México Je.atura de.Nutrición Humana Universidad Estatal de Sonora Hermosillo México

Se.e.al studie. have.shown that phe.olic and carote.oid compounds prote.t against oxidative.stre.s, re.ucing the.risk of cardiovascular dise.se. and some.type. of cance.s. The.obje.tive.of this re.e.rch was to de.e.mine.the.individual contribution of the.main phe.olic compounds from the.papaya fruit skin and the.individual contribution of main carote.oids from the.pulp for total antioxidant capacity at four ripe.ing stage.;and the.individual and combine. radical scave.ging ability use. the.e.says DPPH (radical 2, 2-diphe.yl-1-picryhydrazyl) and ABTS (radical 2, 20-azino-bis (3-e.hylbe.zothiazoline.-6 sulphonic acid). Phe.olic acids standards for this study we.e.fe.ulic (FA), caffe.c (CA) and p-coumaric (pCA) acids and carote.oids studie. we.e.Lycope.e. β-carote.e.and β-cryptoxanthin. The.phe.ol that showe. the.be.t DPPH· and ABTS·+ radical scave.ging ability was CA, with 89.47% and 92.98%, re.pe.tive.y. Lycope.e.contribute. the.gre.te.t to the.TAC (11.9-43.2). Lycope.e.also showe. the.be.t DPPH· and ABTS ·+ radical scave.ging ability with 62.12% and 94.26%, re.pe.tive.y. Antiradical ability of phe.olics and carote.oids de.e.de. on the.structure.of the.compound and its conce.tration.

关键词： Carica Papaya Carote.oids Phe.olics Radical Scave.ging Activity Te.C DPPH

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