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Ide.tification and classification of transie.t pulse. obse.ve. in magne.ome.e. array data by time.domain principal compone.t analysis filte.ing

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e.rthquake.Scie.ce 2017年第4期30卷 193-207页

作者： Karl N. Kapple. Danie. D. Schne.de. laura S. MacLe.n Thomas e. Ble.e. Quake.Finde. Palo AltoCA 94306USA

A me.hod for ide.tification of pulsations in time.se.ie. of magne.ic fie.d data which are.simultane.usly pre.e.t in multiple.channe.s of data at one.or more.se.sor locations is de.cribe.. Candidate.pulsations of inte.e.t are.first ide.tifie. in ge.magne.ic time.se.ie. by inspe.tion. Time.se.ie. of the.e.＂training e.e.ts＂ are.re.re.e.te. in matrix form and transpose.multiplie. to ge.e.ate.time. domain covariance.matrice.. The.ranke. e.ge.ve.tors of this matrix are.store. as a fe.ture.of the.pulsation. In the.se.ond stage.of the.algorithm, a sliding window （approxi- mate.y the.width of the.training e.e.t） is move. across the.ve.tor-value. time.se.ie. comprising the.channe.s on which the.training e.e.t was obse.ve.. At e.ch window position, the.data covariance.matrix and associate. e.ge.- ve.tors are.calculate.. We.compare.the.orie.tation of the.dominant e.ge.ve.tors of the.training data to those.from the.windowe. data and flag windows whe.e.the.dominant e.ge.ve.tors dire.tions are.similar. This was succe.sful in automatically ide.tifying pulse. which share.polarization and appe.r to be.from the.same.source.proce.s. We.apply the.me.hod to a case.study of continuously sample. （50 Hz） data from six obse.vatorie., e.ch e.uippe. with thre.- compone.t induction coil magne.ome.e.s. We.e.amine.a 90-day inte.val of data associate. with a cluste. of four obse.vatorie. locate. within 50 km of Napa, California, toge.he. with two re.ote.re.e.e.ce.stations-one.100 km to the.north of the.cluste. and the.othe. 350 km south. Whe. the.training data contains signals pre.e.t in the.re.ote.re.e.e.ce.obse.vatorie., we.are.re.iably able.to ide.tify and e.tract global ge.magne.ic signals such as solar-ge.e.ate. noise. Whe. training data contains pulsations only obse.ve. in the.cluste. of local obse.vatorie., we.ide.tify se.e.al type. of non-plane.wave.signals having similar polarization.

关键词： Time.se.ie. Magne.ic fie.ds Array data Signal proce.sing Principal compone.t analysis

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Journe. Through the.Groan Zone.with Acade.ics and Practitione.s: Bridging Conflict and Diffe.e.ce.to Stre.gthe. Disaste. Risk Re.uction and Re.ove.y Work

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Inte.national Journal of Disaste. Risk Scie.ce 2018年第3期9卷 421-428页

作者： Kathe.ine.e.Browne.Cae.a O'Conne.l laura Me.tzne. Yode. De.artme.t of Anthropology Colorado State University De.artme.t of Anthropology – Disaste.s Displacement and Human Rights Program University of Tennessee Program in Human Ne.ds and Global Re.ource. Wheaton College

Acade.ic-practitione. divide. in disaste. manage.e.t and re.e.rch can be.pe.siste.t and pe.nicious,be.ring conse.ue.ce. for disaste. survivors and future.affe.te. populations. The.gap be.we.n disaste. profe.sionals and acade.ic re.e.rche.s is ofte. tre.te. as an unavoidable.structural proble. or a ne.tral accide.t of profe.sional silos and circumstance. We.sugge.t that the.e.gaps are.not ne.tral, and that the. can and must be.ove.come. With hundre.s of millions of pe.ple.affe.te. by disaste. e.ch ye.r and re.ove.y costs skyrocke.ing, the.e.is urge.cy in conne.ting re.e.rche. and practitione. knowle.ge. to avoid e.pe.sive.mistake. and most importantly, to de.re.se.human suffe.ing. Ye. the.difficultie. that US acade.ic anthropologists and practitione.s e.pe.ie.ce. in the.r e.forts to collaborate.be.ame.e.ide.t in a cross-se.tor National Scie.ce.Foundation(NSF)-funde. workshop on the.re.e.ance.of culture.in disaste. work. We.sugge.t and illustrate.how more.syste.atic cross-fie.d communication can be.ope.ationalize. through e.gaging in an ongoing and re.ational proce.s of bridging. Such a proce.s can offe. long-te.m be.e.its to the.pe.ple.and institutions involve.,dramatically e.hance.the.scie.ce.of disaste. manage.e.t,and he.p re.uce.the.social and mate.ial costs of disaste. impacts.

关键词： Acade.ic and practitione. divide Applie. re.e.rch Cross-se.tor communication Culture and disaste. Disaste. anthropology Disaste. manage.e.t

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Improving inte.mitte.t androge. de.rivation the.apy： le.sons le.rne. from basic and translational re.e.rch

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Asian Journal of Andrology 2014年第4期16卷 505-510页

作者： Rahul A Parikh laura e.Pascal Be.jamin J Davie.e. Zhou Wang Division of He.atology/OncologyUnive.sity of Pittsburgh School of Me.icine Hillman Cancer Centre University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA. De.artme.t of Urology University of Pittsburgh School of Medicine Hillman Cancer Centre University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA. De.artme.t of Pharmacology and Che.ical Biology University of Pittsburgh School of Medicine Hillman Cancer Centre University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.

Inte.mitte.t androge. de.rivation the.apy （IADT） is an alte.native.to continuous androge. de.rivation the.apy （ADT） in prostate.cance. patie.ts with nonme.astatic dise.se. ADT is associate. with nume.ous side.e.fe.ts such as hot flashe., se.ual dysfunction, ane.ia, fatigue. loss of muscle.mass, oste.porosis, me.abolic syndrome.and pre.ature.cardiovascular dise.se. IADT was de.e.ope. with the.inte.tion of improving the.quality of life.and to de.ay progre.sion of prostate.cance. to castration re.istance. The.be.e.its of slightly improve. quality of life.by IADT compare. to ADT we.e.de.onstrate. in multiple.clinical trials. IADT was note. to be.noninfe.ior to ADT in patie.ts with bioche.ical re.urre.ce.of prostate.cance. but in studie. pe.forme. in patie.ts with me.astatic prostate.cance., the.re.ults we.e.inconclusive. Our re.e.t studie. sugge.te. that the.administration of 5 alpha-re.uctase.inhibitors during the.off-cycle.of IADT can significantly prolong the.survival of mice.be.ring androge.-se.sitive.prostate.tumors whe. off-cycle.duration was short. This re.ie. discusse. the.survival be.e.it of 5 alpha-re.uctase.inhibition in IADT in animal mode.s and the.pote.tial translation of this finding into clinic.

关键词： 5 alpha-re.uctase.inhibitor androge.-re.ponsive.ge.e. inte.mitte.t androge. de.rivation the.apy (IADT) prostate.ance. te.toste.one

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A Syste.s Biology Approach for Studying He.e.otopic Ossification： Prote.mic Analysis of Clinical Se.um and Tissue.Sample.

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Ge.omics, Prote.mics & Bioinformatics 2018年第3期16卷 212-220页

作者： e.in L. Crowge. Je.nife. T. Wyffe.s Patrick M. Osborn Thomas T. Wood laura e. e.sbe.g Ne.ours Biome.ical Re.e.rch Nemours Alfred I. duPont Hospital for Children Wilmington DE 19803 USA Natural and He.lth Scie.ce. Re.e.re. Ce.te. Center for Wound Healing Research Daemen College Amherst NY 14226 USA De.artme.t of Compute. and Information Scie.ce. Center for Bioinformatics and Computational Biology University of Delaware Newark DE 19711 USA San Antonio Military Me.ical Ce.te. San Antonio TX 78219 USA

He.e.otopic ossification （HO） re.e.s to the.abnormal formation of bone.in soft tissue. Although some.of the.unde.lying proce.se. of HO have.be.n de.cribe., the.e.are.curre.tly no clinical te.ts using validate. biomarke.s for pre.icting HO formation. As such, the.diagnosis is made.radiographically afte. HO has forme.. To ide.tify pote.tial and nove. biomarke.s for HO, we.use. isobaric tags for re.ative.and absolute.quantitation （iTRAQ） and high-throughput antibody arrays to produce.a se.i-quantitative.prote.mics surve. of se.um and tissue.from subje.ts with （HO ＋） and without （HO-） he.e.otopic ossification. The.re.ulting data we.e.the. analyze. using a syste.s biology approach. We.found that se.um sample. from subje.ts e.pe.ie.cing traumatic injurie. with re.ulting HO have.a diffe.e.t prote.mic e.pre.sion controls. Subse.ue.t quantitative.e.ISA ide.tifie. profile.compare. to those.from the.matche. five.blood se.um prote.ns that we.e.diffe.e.tially re.ulate. be.we.n the.HO-- and HO- groups. Compare. to HO- sample., the.amount of insulin-like.growth factor I （IGF1） was up-re.ulate. in HO＋ sample., whe.e.s a lowe. amount of oste.pontin （OPN）, mye.ope.oxidase.（MPO）, runt-re.ate. transcription factor 2 （RUNX2）,and growth diffe.e.tiation factor 2 or bone.morphoge.e.ic prote.n 9 （BMP-9） was found in HO ＋ sample. （We.ch two sample.t-te.t; P 〈 0.05）. The.e.prote.ns, in combination with pote.tial se.um biomarke.s pre.iously re.orte., are.ke. candidate. for a se.um diagnostic pane. that may e.able.e.rly de.e.tion of HO prior to radiographic and clinical manife.tations.

关键词： He.e.otopic ossification Prote.mics Runt-re.ate. transcriptionfactor 2 e.trace.lular matrixorganization Ke.atinization

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Nove. e.doscopic manage.e.t of burie. bumpe. syndrome.in pe.cutane.us e.doscopic gastrostomy: The.Olympus Hook Knife

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World Journal of Gastroe.te.ology 2017年第35期23卷 6546-6548页

作者： laura e.Wolpe.t Dominic M Summe.s Andre. Tsang De.artme.t of Ge.e.al Surge.y Peterborough City HospitalEdith Cavell Campus

Burie. bumpe. syndrome.BBS) is an uncommon but se.ious complication of pe.cutane.us e.doscopic gastrostomy. It involve. the.inte.nal fixation de.ice. or "bumpe.", migrating into the.gastric wall and subse.ue.t mucosal ove.growth. We.de.cribe. a case.se.ie. of four patie.ts with BBS tre.te. with a nove. e.doscopic te.hnique.using a Hook Knife.be.we.n June.2016 and Fe.ruary 2017. The.Hook Knife.is a rotating L-shape. cutting wire.de.igne. for hooking tissue.and pulling it away from the.gastric wall towards the.lume.. The.te.hnique.was succe.sful in all four case. with no complications. e.ch patie.t was discharge. on the.day of tre.tme.t. The.Hook Knife.is a manoe.vrable. safe.and e.fe.tive.de.ice.for e.doscopic re.oval of burie. bumpe.s and could avoid surge.y in a high risk group of patie.ts. To our knowle.ge.this te.hnique.has not be.n de.cribe. pre.iously. We.sugge.t that this te.hnique.should be.adde. to the.tre.tme.t algorithms for managing BBS.

关键词： Burie. bumpe. syndrome Pe.cutane.us e.doscopic gastrostomy Hook Knife

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Follicular lymphoma:the.diminishing role.of che.othe.apy

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Journal of Cance. Me.astasis and Tre.tme.t 2022年第1期8卷 393-411页

作者： Be.trice.Casade. laura Nanni Gine.ra Lolli Pie. Luigi Zinzani IRCCS Azie.da Ospe.alie.o-Unive.sitaria di Bologna Istituto di Ematologia“Seràgnoli”Bologna 40138Italy Dipartime.to di Me.icina Spe.ialistica Diagnostica e SperimentaleUniversitàdi BolognaBologna 40138Italy

Follicular lymphoma(FL)is the.most common indole.t non-Hodgkin lymphoma,accounting for 70%of case. in We.te.n *** this unique.name.FL is an e.tre.e.y he.e.oge.e.us dise.se.both clinically and *** basis of FL he.e.oge.e.ty lie. in the.diffe.e.t biological pathways which can be.activate.,be.ause.of the.varie.y of ge.e.mutations that can ***,the.e.is a growing inte.e.t in the.knowle.ge.of the.e.activate. pathways,which is also te.tifie. by the.pre.e.ce.of a ne. mode. that incorporate. FL mutations to de.ine.patie.t’s prognosis(m7-FLIPI).The.e.e.aluations are.also appe.ling be.ause.of the.re.e.t possibility of using“targe.e. the.apie.”.Targe.e. the.apie. are.ne. tools,curre.tly applicable.in the.se.ting of re.apse.re.ractory(R/R)dise.se.whe.e.we.can find a gre.t varie.y of“che.o-fre.”*** in othe. he.atologic malignancie.,“ce.lular the.apy”e.riche. FL drug sce.ario,including T-ce.l de.e.de.t bispe.ific antibodie. and chime.ic antige. re.e.tor(CAR)*** FL he.e.oge.e.ty is the.basis of the.diffe.e.ce.in the.ape.tic e.ficacy and dise.se.course.among patie.ts,the.hope.for the.future.is to unde.stand FL biology more.de.ply,to be.te. compre.e.d how to obtain more.re.re.e.tative.sample. and pre.tre.tme.t prognostic information in orde. to individualize.the.tre.tme.t strate.y as e.rly as frontline.the.apy.

关键词： Follicular lymphoma POD24 targe. the.apie. che.o-immunothe.apy biological he.e.oge.e.ty

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Dual e.zyme.activate. fluore.ce.n base. fluore.ce.t probe

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Frontie.s of Che.ical Scie.ce.and e.gine.ring 2020年第1期14卷 117-121页

作者： Maria L.Odynie. Jordan e.gardiner Adam C.Se.gwick Xiao-Pe.g He.Ste.e. D.Bull Tony D.Jame. De.artme.t of Che.istry University of BathBathBA27AYUK De.artme.t of Che.istry University of Texas at AustinAustinTX 78712-1224USA Ke. Laboratory for Advance. Mate.ials&Fe.inga Nobe. Prize.Scie.tist Joint Re.e.rch Ce.te. East China University of Science and TechnologyShanghai 200237China

A simple.dual analyte.fluore.ce.n-base. probe.PF3-Glc)was synthe.ise. containingβ-glucosidase.β-glc)and hydroge. pe.oxide.H2O2)trigge. *** pre.e.ce.ofβ-glc,re.ulte. in fragme.tation of the.pare.t mole.ule.re.e.sing glucose.and the.slightly fluore.ce.t mono-boronate.fluore.ce.n(PF3).Subse.ue.tly,in the.pre.e.ce.of glucose.oxidase.GOx),the.re.e.se. glucose.was catalytically conve.te. to D-glucono-δ-lactone.which produce. H2O2 as a *** GOx-produce. H2O2,re.ulte. in classic H2O2-me.iate. boronate.oxidation and the.re.e.se.of the.highly e.issive.fluorophore.*** unique.cascade.re.ction le.d to an 80-fold incre.se.in fluore.ce.ce.inte.sity.

关键词： che.ose.sors dual-activation GOx fluore.ce.ce β-glucosidase mole.ular logic

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An augme.te. and inte.active.e.hibition of an archive. mode. for Fre.e.ick Kie.le.'s e.dle.s House. 1959

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Frontie.s of Archite.tural Re.e.rch 2022年第6期11卷 993-1006页

作者： Chante.le.Niblock laura McGuire.John Harding Ge.d Zillne. Chris Hamill Andre. Whitne. School of Natural and Built e.vironme.t Queens University of BelfastNorthern IrelandBT71NNUK School of Archite.ture University of Hawaii at MānoaHonoluluHI96822USA School of Archite.ture University of ReadingReadingBerkshireRG66URUK Austrian Fre.e.ick and Lillian Kie.le. Private.Foundation Mariahilfer Straße1060WienAustria Hotknife.Digital Me.ia NottinghamNG13HDUK

This re.e.rch e.plore. the.pote.tial of an imme.sive.and inte.active.online.archive.to e.hance.our unde.standing of historic archite.ture.through the.study of *** re.orts on imple.e.ting an augme.te. re.lity mobile.application that e.hibits a mode. for the.unbuilt e.dle.s House.1959,by Fre.e.ick Kie.le..A re.le.tive.critique.from the.re.e.rche.’s point of vie.,and initial fe.dback from a small sample.of archite.ture.stude.ts,provide. an insight into use.s’e.pe.ie.ce.of the.e.hibition,its value.as a re.e.rch tool,and as an e.ucational *** on e.isting te.hnologie. and e.tablishe. re.e.rch me.hods,we.pre.e.t an alte.native.way of e.hibiting a large.scale. mode. for public e.gage.e.t and re.e.rch collaboration be.we.n acade.ics,archivists,and *** discuss the.de.e.opme.t of the.mobile.application with inte.active.fe.ture. spe.ifically de.igne. for an archite.tural *** touche. on issue. associate. with docume.ting,inte.pre.ing,and e.hibiting archite.tural mode.s,e.phasizing acce.sibility,accuracy,e.gage.e.t,combining 3D and 2D digital asse.s,and use. *** was found that the.inte.active.and imme.sive.fe.ture. of the.e.hibition e.hance. the.re.e.rche.s’scope.to spatially inspe.t the.mode.,visually e.pe.ie.ce.it,collaborate.with othe.s,and stre.gthe. conne.tions be.we.n the.mode. and othe. e.ample. of Kie.le.’s te.tual and visual archival mate.ials.

关键词： Augme.te. mode. Unbuilt archite.ture Fre.e.ick Kie.le. Inte.active.e.hibition e.dle.s house

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Forage.offe.ing and se.sonal intake.comparisons to e.aluate.e.rope.n rabbit thre.t in Nothofagus fore.ts of southe.n Patagonia

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e.ological Proce.se. 2022年第1期11卷 604-617页

作者： Ale.andro Hue.tas He.re.a Mónica Toro‑Manríque. laura Borre.li María Vane.sa Le.cinas Guille.mo Martíne. Pastur Ce.tro de.Inve.tigación e. e.osiste.as de.la Patagonia(CIe.) Camino Baguales s/n Km 4CoyhaiqueChile Ulte.arius Consultore. Ambie.tale. y Cie.tíficos Ltda. Ignacio Serrano 420CoyhaiqueChile Instituto Nacional de.Te.nología Agrope.uaria(INTA) EEA BarilocheModesta Victoria 44508400 San Carlos de BarilocheRío NegroArgentina Laboratorio de.Re.ursos Agrofore.tale. Centro Austral de Investigaciones Científicas(CADIC)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Houssay 2009410 UshuaiaTierra del FuegoArgentina.

Background:The.e.rope.n rabbit(Oryctolagus cuniculus L.1758)was introduce. into diffe.e.t re.ions of the.world,ge.e.ating significant trade.offs that critically impacte. native.***,we.e.aluate.the.rabbit’s forage.intake. in thre. ve.e.ation type.(fore.ts,shrublands,and grasslands)along the.four se.sons in a te.pe.ate.fore.t landscape.in Southe.n Patagonia and discuss the.pote.tial thre.ts ove. native.*** formulate. the.following que.tions:(i)what is the.forage.offe. at e.ch ve.e.ation type.(ii)what is the.rabbit’s forage.intake.and how it varie. across the.se.sons along the.ye.r?and(iii)which ve.e.ation type. and plant life.forms we.e.more.use. according to the.rabbit’s forage.intake.?Me.hods:We.ce.suse. unde.story ve.e.ation to characte.ize.the.forage.offe. at e.ch ve.e.ation type.and de.e.mine. se.sonal die.ary intake. using microhistological analysis of *** plant spe.ie. ide.tifie. in the.fie.d we.e.groupe. according to life.form classe.(tre. re.e.e.ation,shrubs,forbs,graminoids,orchids,fe.ns,bryophyte.,and he.iparasite.).Data we.e.analyse. through uni‑and multi‑variate.analyse.,de.e.mining re.ationships be.we.n forage.offe. and the.rabbit’s forage.***:Forage.intake. re.e.le. change. in plant life.form consumption across ve.e.ation type.,whe.e.intake.pre.sure.was conside.ably diffe.e.t for tre. re.e.e.ation(p=0.001),graminoids(p=0.001),and he.iparasite.(p=0.001).Be.ide.,significant change. in consumption among se.sons we.e.de.e.te. for shrubs(p=0.001),fe.ns(p=0.030),and he.iparasite.(p=0.002).Although many spe.ie. play an important role.in the.rabbit’s forage.intake.ne.works(e.g.,Chiliotrichum diffusum,Holcus lanatus),the.stronge.t intake.linkage. we.e.found in e.otic grasse.(e.g.,Poa prate.sis and Fe.tuca sp.),native.he.iparasite.(e.g.,Misode.drum sp.),native.shrubs(e.g.,e.pe.rum rubrum),and native.tre.s(e.g.,Nothofagus sp.).The.summe. and autumn se.sons pre.e.te. highe. intake.compare. to the.winte. and spring se.sons.F

关键词： Fore.t e.ology Oryctolagus cuniculus Plant-animal inte.action Ve.e.ation type He.bivory Habitat use

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The.multiface.e. pote.tial of the.lipid transmitte. ole.yle.hanolamide.to tre.t alcohol-induce. ne.roinflammation and alcohol use.disorde.s

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Ne.ral Re.e.e.ation Re.e.rch 2020年第1期15卷 71-72页

作者： laura Orio De.artme.t of Psychobiology and Me.hods in Be.avioural Scie.ce. Complutense University of Madrid

Is the.e.a ne.d for ne. pharmacothe.apie. to tre.t alcohol use.disorde.s(AUDs)?AUD is a highly pre.ale.t condition in the.world population that cause. me.ical,psychological,pe.sonal,social and e.onomic *** most se.e.e.dime.sion of AUDs is alcohol de.e.de.ce.a condition in which individuals lose.control ove. alcohol intake.de.pite.the.ne.ative.*** some.me.ications have.be.n approve. for this purpose.e.isting pharmacothe.apie. are.not e.fe.tive.for all pe.ple.due.to the.he.e.oge.e.ty of *** approve. me.ications include.Disulfiram(Antabuse.?),which induce. an ave.sion to drink by incre.sing alcohol me.abolism-de.ive. ace.alde.yde.Naltre.one.Re.ia^?,Vivitrol^?),a compe.itive.opioid antagonist forμ-re.e.tors that de.re.se. he.vy drinking and pre.e.ts re.apse.Acamprosate.Campral^?),an indire.t partial agonist at N-me.hyl-D-aspartic acid glutamate.re.e.tors and antagonist at me.abotropic glutamate.re.e.tors that is use. to pre.e.t re.apse.in de.oxifie. alcoholics.

关键词： me.abolism inflammation alcohol

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