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Risk of post-operative complications associated with anti-TNF therapy in inflammatory bowel disease

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World Journal of Gastroenterology 2012年第3期18卷 197-204页

作者： Tauseef Ali laura Yun David T Rubin University of Oklahoma Health Sciences Center & VA Medical Center. Section of Digestive Diseases and Nutrition University of Chicago Inflammatory Bowel Disease Center

There have been increasing concerns regarding the safety of perioperative anti-tumour necrosis factor (anti-TNF) α agents. We performed a literature review to evaluate the post-operative complications associated with perioperative anti-TNF use in patients with inflammatory bowel disease. A comprehensive review was performed with a literature search utilizing Pub Med, Cochrane, OVID and EMBASE databases according to published guidelines. To date, there are only data for infliximab. There are three published studies which have assessed post-operative complications with perioperative infliximab use in patients with Crohn' s disease (CD), four studies in ulcerative colitis (UC) patients, and one study on both CD and UC patients. Two out of the three studies in CD patients showed no increased post-operative complications associated with perioperative infliximab. Two out of four studies in UC patients also did not show an increase in post-operative complications, and the combined study with CD and UC patients did not show an increased risk as well. Studyresults could not be combined secondary to significant differences in study designs, patient population and definition of their endpoints. There appears to be a risk of post-operative complications associated with TNF therapy in some patients. Based on these data, careful patient selection and prospective data collection should be performed.

关键词： Crohn's disease Ulcerative colitis Colectomy Post-operative complications

A qualitative correlation between friction coefficient and steel surface wear in linear dry sliding contact to polymers with SGF

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Friction 2014年第1期2卷 47-57页

作者： Dorin RUS Lucian CAPITANU Liliana-laura BADITA Mechanical Department Institute of Civil EngineeringBucharest050153Romania Tribology Department Institute of Solid Mechanics of the Romanian AcademyBucharest010141Romania National Institute of Research and Development in Mechatronics and Measurement Technique Bucharest 0211631Romania

In this paper we tried to present a qualitative correlation,based on extensive experimental determinations between the value and the evolution of the friction coefficient,wear,and contact temperature,in the case of linear dry contact,for thermoplastic material reinforced with short glass fibers(SGF)and various steel *** aim was to highlight the evolution of the wear process depending on the evolution of the friction *** a result,it was possible to graphically illustrate the evolution of the friction coefficient and the change of the wear process,emphasizing the abrasive,adhesive and corrosive *** evolution of the plastic material transfer function of the contact temperature,namely of the power lost by friction(product between the contact pressure and sliding speed,p and v)was aimed and it was *** has been demonstrated that in the case of a 30%SGF content it can reach and even exceed contact temperatures very close to the flow limit of the plastic *** tried,believing successfully,the graphic illustration of the evolution of the steel surface wear and of the contact temperature,depending on the friction *** influence of the normal load and sliding speed was evaluated in detail,but also the influence of the metallic surface roughness on the friction coefficient was discussed.

关键词： friction coefficient evolution steel surface wear contact temperature plastic material transfer hardness of steel surface influence

Potential roles of functional bacterial amyloid proteins,bacterial biosurfactants and other putative gut microbiota products in the etiopathogeny of Parkinson’s Disease

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BIOCELL 2021年第1期45卷 1-16页

作者： EMILIA MANOLE laura DUMITRESCU CRISTINA NICULIȚE BOGDAN OVIDIU POPESCU laura CRISTINA CEAFALAN Victor Babeș”National Institute of Pathology Bucharest050088Romania Colentina Clinical Hospital Bucharest020125Romania Carol Davila”University of Medicine and Pharmacy Bucharest020021Romania

An increasing number of studies provide evidence for the existence of a microbiota-gut-brain axis and its potential involvement in the development of sporadic Parkinson’s disease and other neurodegenerative *** neuropathologic hallmark of Parkinson’s disease is the presence of brain intraneuronal aggregates of misfolded alpha-synuclein,known as Lewy *** gut microbiota products may trigger alpha-synuclein conformational changes in the neurons of the enteric nervous system,which can then spread to the brain in a prion-like fashion through the vagus *** may interfere with neuroinflammatory pathways and susceptibility to *** this review,we assess the potential role of putative gut microbiota products in the etiopathogeny of Parkinson’s disease,with a special emphasis on functional bacterial amyloid proteins,bacterial biosurfactants,endotoxins and short-chain fatty *** possible roles of molecular hydrogen,a common byproduct of bacterial fermentation,are also addressed.

关键词： Alpha-synuclein Endotoxins Short-chain fatty acids

A modified intron of VRT2 drives glume and grain elongation in wheat

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Molecular Plant 2021年第9期14卷 1421-1423页

作者： laura E.Dixon Scott A.Boden Faculty of Biological Sciences University of LeedsLeeds LS29JTUK School of Agriculture Food and WineWaite Research InstituteUniversity of AdelaideGlen OsmondSA 5064Australia

Yield is a complex trait that is determined predominantly by the number,size,and weight of grain produced by a plant,which are all in fluenced by multiple genes and environ mental *** cereals,grain size is in flue need by envir on mental signals including nutrient availability and temperature,and by variation for genes that control the dimensions of a grain or the size of floral organs(e.g.,Heang and Sassa,2012;Brinton et al.,2017;Adamski et al.,2021;Liu et al.,2021;Xiao et al.,2021).Three recent studies have investigated subspecies of tetrapioid and hexapioid wheat that produce Ion ger grains,which form in florets that contain elongated floral structures(Adamski et al.,2021;Liu et al.,2021;Xiao et al.,2021);their findings provide new understanding of the genes controlling floret architecture,which could be used by breeders to enhance grain size and yield.

关键词： grain organs wheat

Oligodendrocytes in a dish for the drug discovery pipeline:the risk of oversimplification

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Neural Regeneration Research 2021年第2期16卷 291-293页

作者： Vito Antonio Baldassarro Luciana Giardino laura Calzà Health Science and Technologies Interdepartmental Center for Industrial Research(HST-ICIR) University of BolognaBolognaItaly Department of Veterinary Medical Sciences University of BolognaIRET FoundationBolognaItaly Department of Pharmacy and Biotechnology University of BolognaMontecatone Rehabilitation InstituteBolognaItaly

Myelination,remyelination and demyelination:modeling the in vitro drug discovery pipeline:Demyelination is a multifactorial event occurring in diseases primarily involving myelin forming cells(oligodendrocytes,OLs)and their precursors(oligodendrocyte precursor cells,OPCs)such as multiple sclerosis,but is also involved in the pathology of other central nervous system(CNS)injuries and diseases,such as neonatal encephalopathy。

关键词： cytes injuries diseases

Chloride Ion Critical Content in Reinforced Concrete

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Journal of Wuhan University of Technology(Materials Science) 2007年第4期22卷 737-740页

作者：李岩 laura STIRNEMANN Materials and Structural Engineering Department Nanjing Hydraulic Research Institute University of Missouri-Rolla St.LouisMO63109USA

Chloride ion critical content was studied under soaking and cycle of dry and wet conditions, with three electrochemical nondestructive measuring techniques, i e, half-cell potential, A C impedance, and time potential. The experimental results show that chloride ion critical content is primarily determined by the water cement ratio, while for the same concrete mixture the chloride ion critical content in soaking conditions is larger than that in a cycle of dry and wet conditions.

关键词： chloride ion cycle of dry and wet critical content A C impedance

Sensors, Biosensors, and Analytical Technologies for Aquaculture Water Quality

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Research 2020年第1期2020卷 1521-1535页

作者： Xiaodi Su laura Sutarlie Xian Jun Loh Institute of Materials Research and Engineering Agency for ScienceTechnology and Research2 Fusionopolis Way.Innovis#08-03Singapore 138634 Department of Chemistry National University of SingaporeBlock S8Level 33 Science Drive 3Singapore 117543

In aquaculture industry,fish,shellfish,and aquatic plants are cultivated in fresh,salt,or brackish *** increasing demand of aquatic products has stimulated the rapid growth of aquaculture *** to effectively monitor and control water quality is one of the key concerns for aquaculture industry to ensure high productivity and high *** are four major categories of water quality concerns that affect aquaculture cultivations,namely,(1)physical parameters,e.g.,pH,temperature,dissolved oxygen,and salinity,(2)organic contaminants,(3)biochemical hazards,e.g.,cyanotoxins,and(4)biological contaminants,i.e.,*** the physical parameters are affected by climate changes,the latter three are considered as environmental *** this review,we provide a comprehensive summary of sensors,biosensors,and analytical technologies available for monitoring aquaculture water *** include low-cost commercial sensors and sensor network setups for physical *** also include chromatography,mass spectrometry,biochemistry,and molecular methods(e.g.,immunoassays and polymerase chain reaction assays),culture-based method,and biophysical technologies(e.g.,biosensors and nanosensors)for environmental contamination *** to the different levels of sophistication of various analytical techniques and the information they can provide(either fine fingerprint,highly accurate quantification,semiquantification,qualitative detection,or fast screening),we will comment on how they may be used as complementary tools,as well as their potential and gaps toward current demand of real-time,online,and/or onsite detection.

关键词： qualitative latter Quality

Circadian rhythm disruption and retinal dysfunction:a bidirectional link in Alzheimer’s disease?

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Neural Regeneration Research 2024年第9期19卷 1967-1972页

作者： laura Carrero DesireéAntequera Cristina Municio Eva Carro Group of Neurodegenerative Diseases Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpainNetwork Center for Biomedical Research in Neurodegenerative Diseases(CIBERNED)ISCIIIMadridSpain PhD Program in Neuroscience Autonoma de Madrid UniversityMadridSpain Neurobiology of Alzheimer’s Disease Unit Functional Unit for Research into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpainNetwork Centre for Biomedical Research in Neurodegenerative Diseases(CIBERNED)ISCIIIMadridSpain

Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer’s disease.A predominant function of the retina is circadian synchronization,carrying information to the brain through the retinohypothalamic tract,which projects to the suprachiasmatic ***,Alzheimer’s disease hallmarks,including amyloid-β,are present in the retinas of Alzheimer’s disease patients,followed/associated by structural and functional ***,the mechanistic link between circadian dysfunction and the pathological changes affecting the retina in Alzheimer’s disease is not fully understood,although some studies point to the possibility that retinal dysfunction could be considered an early pathological process that directly modulates the circadian rhythm.

关键词： Alzheimer’s disease amyloid circadian rhythm neurodegeneration retina

Effect of insoluble materials on the volumetric behavior of rock salt

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第1期13卷 84-97页

作者： Mejda Azabou Ahmed Rouabhi laura Blanco-Martìn MINES ParisTech PSL Research UniversityCentre de Géosciences35 rue St HonoréFontainebleau77300France

This paper focuses on the presence of nodules of insoluble materials within salt specimens,and their effect on the volumetric strain measurements and the dilatancy *** analyzed experimental results of over 120 conventional triaxial compression tests,and found that in 20%of the cases,the volumetric strain measurements were *** also noted that the natural variability of the specimens can lead to a non-negligible data scattering in the volumetric strain measurements when different specimens are subjected to the same *** is expected given the small magnitude of those strains,but it occasionally implies that the corresponding specimens are not representative of the volumetric behavior of the studied *** order to understand these results,we numerically investigated salt specimens modeled as halite matrices with inclusions of *** of triaxial compression tests on these structures proved that such heterogeneities can induce dilatancy,and their presence can lead to the appearance of tensile zones which is physically translated into a micro-cracking *** modeling approach is validated as the patterns displayed in the numerical results are identical to that in the *** was then employed to explain the observed irregularities in experimental *** studied the natural variability effect as well and proposed a methodology to overcome the issue of specimen representativity from both deviatoric and volumetric perspectives.

关键词： Rock salt Dilatancy Material heterogeneity Natural variability Triaxial tests Virtual laboratory