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第九届全国免疫学学术大会

作者： Ying Zhao Jun Wang laura calpe-berdiel Amanda C.Foks Bart Lammers Johan Kuiper Theo J.C.Van Berkel Miranda Van Eck Department of Pathology and Pathophysiology Soochow University Division of Biopharmaceutics Leiden/Amsterdam Center for Drug ResearchLeiden University Institute of Biology and Medical Sciences Soochow University

Background:LDL receptor(LDLr)and ABC-transporter A1(ABCA1)are two distinct players in cellular cholesterol *** recognizes apoprotein B100 and apoE in lipoproteins to mediate the uptake of cholesterol,while ABCA1 promotes excess cholesterol efttux to apoprotein ***:The present study aims to investigate whether LDLr deficiency influences the atheroprotective effects of leukocyte ABCA1 in *** and Results:LDLr-/-mice were transplanted with bone marrow from LDLr/ABCA1mice,LDLr/ABCA1/-mice,and their respective *** leukocyte ABCA1 deficiency reduced plasma cholesterol levels,after 8weeks of Western-type diet feeding,animals transplanted with LDLr/ABCA1and LDLr/ABCA1bone marrow developed 1.6-fold(p<0.01)and 1.4-fold(p<0.05)larger lesions,compared to their respective *** clearly indicates that the atheroprotection of leukocyte ABCA1 is not affected by ***-way ANOVA analysis also demonstrated that deletion of the leukocyte LDLr reduced lesion development(p<0.001),especially in the absence of leukocyte ***,leukocyte LDLr deficiency did not affect monocytosis,recruitment of moncocytes and macrophage foam cell ***,the deletion of leukocyte ABCA1 did reduce lymphocytosis and recruitment of T cells into the adventitia of lesions,associated with smaller lesion size in LDLr/ABCA1transplanted mice,indicating the potential contribution of lymphocytosis and recruitment ofT cells to ***:Leukocyte LDLr deficiency does not affect the atheroprotective effects of leukocyte ***,suppression of lymphocytosis and recruitment of T cells in the adventitia could contribute to the atheroprotection of Leukocyte LDLr deficiency and ABCA1.

关键词： LDL receptor ABCA1 lymphocytosis T lymphocytes atherosclerosis

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Leukocyte ABC-transporter A1 and LDL Receptor Play Independent Roles in Atherosclerosis： the Potential Contribution of T Cells

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中国动脉硬化杂志 2013年第9期21卷 I0075-I0075页

作者： Ying Zhao Jun Wang laura calpe-berdiel Amanda C. Foks Bart Lammers Johan Kuiper Theo J.C. Van Berkel Miranda Van Eck Department of Pathology and Pathophysiology Soochow University Suzhou Jiangsu 215123 China Division of Biopharmaeeutics leiden~Amsterdam Center for Drug Research leiden University leiden 2333 CCThe Netherlands Institute of Biology and Medical Sciences Soochow University Suzhou Jiangsu 215123 China

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Leukocyte ABCA1 is atheroprotective in absence of ApoAI

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中国病理生理杂志 2012年第11期 2009-2009页

作者： laura calpe-berdiel Josep JULVE Joan Carles ESCOL-GIL Amanda FOKS Ronald J.VAN DER SLUIS Johan KUIPER Francisco BLANCO-VACA Theo J.C.VAN BERKEL Jan-Albert KUIVENHOVEN Miranda VAN ECK Department of Pathophysiology School of Biology and Basic Medical SciencesSoochow UniversitySuzhou 215123China IIB Sant Pau and CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEMBarcelonaSpain 3. Division of BiopharmaceuticsLeiden/Amsterdam Center for Drug ResearchGorlaeus LaboratoriesLeiden UniversityLeidenNetherlands Departament de Bioquímicali Biologia Molecular Universitat Autònoma de BarcelonaBarcelonaSpain Department of Vascular Medicine Academic Medical CenterUniversity of AmsterdamAmsterdamNetherlands

AIM:ABC-transporter A1(ABCA1)facilitates cellular cholesterol efflux to lipid-free/poor apolipoproteins,including apolipoprotein AI(ApoAI).The aim of the present study was to investigate the importance of ApoAI for AB... 详细信息

关键词： Leukocyte ABCA1 is atheroprotective in absence of ApoAI

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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma L.Clayton UK Dementia Research Institute at King’s College London LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(ALS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and ALS affecting upper and lower motor neurons),these two diseases are complexly *** and ALS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

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Telencephalic stab wound injury induces regenerative angiogenesis and neurogenesis in zebrafish:unveiling the role of vascular endothelial growth factor signaling and microglia

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Neural Regeneration Research 2025年第10期20卷 2938-2954页

作者： Danielle Fernezelian Philippe Rondeau laura Gence Nicolas Diotel Universitéde La Réunion INSERMUMR 1188Diabète athérothrombose Thérapies Réunion Océan Indien(DéTROI)Saint PierreLa RéunionFrance

After brain damage,regenerative angiogenesis and neurogenesis have been shown to occur simultaneously in mammals,suggesting a close link between these ***,the mechanisms by which these processes interact are not well *** this work,we aimed to study the correlation between angiogenesis and neurogenesis after a telencephalic stab wound *** this end,we used zebrafish as a relevant model of neuroplasticity and brain repair ***,using the Tg(fli1:EGFP×mpeg1.1:mCherry)zebrafish line,which enables visualization of blood vessels and microglia respectively,we analyzed regenerative angiogenesis from 1 to 21 days *** parallel,we monitored brain cell proliferation in neurogenic niches localized in the ventricular zone by using *** found that after brain damage,the blood vessel area and width as well as expression of the fli1 transgene and vascular endothelial growth factor(vegfaa and vegfbb)were *** the same time,neural stem cell proliferation was also increased,peaking between 3 and 5 days post-lesion in a manner similar to angiogenesis,along with the recruitment of ***,through pharmacological manipulation by injecting an anti-angiogenic drug(Tivozanib)or Vegf at the lesion site,we demonstrated that blocking or activating Vegf signaling modulated both angiogenic and neurogenic processes,as well as microglial ***,we showed that inhibition of microglia by clodronate-containing liposome injection or dexamethasone treatment impairs regenerative neurogenesis,as previously described,as well as injury-induced *** conclusion,we have described regenerative angiogenesis in zebrafish for the first time and have highlighted the role of inflammation in this *** addition,we have shown that both angiogenesis and neurogenesis are involved in brain repair and that microglia and inflammation-dependent mechanisms activated by Vegf signaling are important contributors to

关键词： angiogenesis cerebral damage inflammation neurogenesis stab wound telencephalon vascular endothelial growth factor zebrafish

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Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot laura Reiche Andrew Chan Robert Hoepner Patrick Küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

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Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha J.Holdsworth Alistair J.Gunn laura Bennet Hamid Abbasi Mātai Medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

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Identification and evaluation of antioxidant activity of bioactive casein-derived peptides during in vitro digestion and transepithelial transport in Caco-2 cells

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Food Bioscience 2023年第3期53卷 2427-2439页

作者： Victor D’Opazo Jorge calpe laura Escrivá Tiago Melo Nazareth Giuseppe Meca Carlos Luz Laboratory of Food Chemistry and Toxicology Faculty of PharmacyUniversity of Valencia46100BurjassotSpain

Dairy products are important sources of bioactive(antibacterial,antithrombotic,antihypertensive,immuno-modulatory,and antioxidative)peptides,that need to be released from the target *** the present study,bovine milk casein protein was hydrolyzed by pancreatin and trypsin(4 and 24 h)to evaluate the hydrolyses efficiency(ninhydrin reaction);to elucidate the sequence of casein-derived peptides(SDS-PAGE,LC-ESI-TOF-MS);and to assess the peptides antioxidant activity(DPPH and ORAC),bioactivity in silico,bioaccessibility after in vitro digestion,and bioavailablility by transepithelial transport in Caco-2 *** hydrolysis degree increased with the incubation time,with evident degradation of casein-derived proteins into low molecular weight peptides(<5 kDa)after 4 and 24 h *** showed higher hydrolysis degree(91%)than trypsin(21%).An increase in antioxidant activity was observed with increasing incubation time,with higher antioxidant effect observed for trypsin derived peptides(47%reduction of free radicals;32112μM Trolox equivalents)than pancreatin derived peptides(15%reduction;2862μM Trolox equivalents).A total of 69 ca-seins derived peptides were identified after trypsin(33 peptides)and pancreatin(36 peptides)hydrolysis for 24 h;with 26 peptides released fromβ-casein,21 fromα-s1-casein,15 fromα-s2-casein,and 7 from k-casein *** of these peptides were described as antioxidant,anti-inflammatory,and *** in vitro digestion 123 peptides were found in gastric(56 peptides),duodenal(43 peptides)and colonic(24 peptides)fraction;while five peptides were bioavailable by crossing the intestinal barrier,with increased peptides’abundance after trypsin hydrolysis treatment.

关键词： Casein Bioactive peptides Antioxidant activity In vitro digestion Bioaccessibility Bioavailability

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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk laura Nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

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