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Design of Multi-layered Protection Against Guided Mortar Threats Yhrough Numerical Modeling

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Defence Technology（防务技术） 2023年第11期29卷 55-65页

作者： Bonny Thawani Seng Kiat Lim laura brown Richard Critchley Rachael Hazael Cranfield Forensic Institute Cranfield UniversityDefence Academy of the United KingdomShrivenhamSN68LAUK

The trade—off between protection and weight is a constant consideration when designing a portable protective *** mobility is a desirable attribute and protection must therefore adapt,prompting a demand for lightweight,simple to construct,low-cost and effective ballistic protection *** strength and ductility,wave spreading capability and good energy absorption are key properties for ballistic *** materials,polycarbonate,Kevlar?-epoxy,polyurethane foam,and aluminium alloy,possess these properties and were selected for analysis by numerical *** configurations were proven to be an optimal solution,by exploiting the advantages of each material without having large penalties of mass and *** modelling using ANSYS AUTODYN?is used to simulate monolithic and multi-layered target configurations,to obtain the penetration mitigation *** results are analysed to select configurations based on different requirements,such as lowest cost,lowest mass,best performance,and optimal configuration which balanced the three key parameters *** optimal configuration of Aluminium,Kevlar-Epoxy,Polyurethane,and Polycarbonate has layers with thickness of 7,3,38,2 mm respectively with a total mass of 7.97 kg,total cost of$39.86 and penetration of 29.34%(14.67 mm).Polynomial relationships between performance and mass/cost are also determined.

关键词： Hydrocode Fragmentation High velocity Composite structures Foams

Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep

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Journal of Animal Science and Biotechnology 2015年第2期6卷 222-229页

作者： laura D brown Stephanie R Thorn Alex Cheung Jinny R Lavezzi Frederick C Battaglia Paul J Rozance Perinatal Research Center Division of Neonatology Department of Pediatrics University of Colorado Denver School of Medicine Center for Women’s Health Research University of Colorado Denver School of Medicine

Background： The importance of non-glucose carbohydrates, especially mannose and inositol, for normal development is increasingly recognized. Whether pregnancies complicated by abnormal glucose transfer to the fetus also affect the regulation of non-glucose carbohydrates is unknown. In pregnant sheep, maternal insulin infusions were used to reduce glucose supply to the fetus for both short （2-wk） and long （8-wk） durations to test the hypothesis that a maternal insulin infusion would suppress fetal mannose and inositol concentrations. We also used direct fetal insulin infusions （1-wk hyperinsulinemic-isoglycemic clamp） to determine the relative importance of fetal glucose and insulin for regulating non-glucose carbohydrates. Results： A maternal insulin infusion resulted in lower maternal （50%, P 〈 0.01） and fetal （35-45%, P 〈 0.01） mannose concentrations, which were highly correlated （r^2 = 0.69, P 〈 0.01）. A fetal insulin infusion resulted in a 50% reduction of fetal mannose （P 〈 0.05）. Neither maternal nor fetal plasma inositol changed with exogenous insulin infusions. Additionally, maternal insulin infusion resulted in lower fetal sorbitol and fructose （P 〈 0.01）. Conclusions： Chronically decreased glucose supply to the fetus as well as fetal hyperinsulinemia both reduce fetal non-glucose carbohydrates. Given the role of these carbohydrates in protein glycosylation and lipid production, more research on their metabolism in pregnancies complicated by abnormal glucose metabolism is clearly warranted.

关键词： Fructose Glucose Inositol Insulin Mannose Pregnancy

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傲放《唐顿庄园》的“新英伦玫瑰”

疯狂英语（阅读版） 2012年第12期 4-9页

作者： laura brown Mac

米歇尔·道克瑞正坐在汉普郡郊外一间极度奢华的酒店餐厅里，之所以选择这里进行采访，是因为此地距离《唐顿庄园》的拍摄地海科利尔城堡非常近。

关键词：庄园玫瑰唐酒店汉普城堡

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凯蒂·佩里:战无不胜的音乐女王

新东方英语（中学版） 2015年第1期 4-8页

作者： laura brown 张晓敏

颜色多变的头发、多彩甜蜜的服饰和一双迷人的电眼是她的标签;复古、性感、另类、时尚、无厘头,不论哪种造型她都能轻松驾驭;不管是颁奖仪式、走红毯还是街拍,她都是摄影师们追捧的焦点;生活上,她是一个坚强、风趣又温暖可人的邻家女孩... 详细信息

颜色多变的头发、多彩甜蜜的服饰和一双迷人的电眼是她的标签;复古、性感、另类、时尚、无厘头,不论哪种造型她都能轻松驾驭;不管是颁奖仪式、走红毯还是街拍,她都是摄影师们追捧的焦点;生活上,她是一个坚强、风趣又温暖可人的邻家女孩;事业上,她是野心勃勃、能撑起半边天的流行音乐天后;她是推特红人,却能一直坚持勇敢做自己。这位战无不胜的音乐女王就是让粉丝们爱到欲罢不能的"水果姐"凯蒂·佩里!

关键词：凯蒂佩里邻家女孩天后摇滚乐队燕麦粥 dress 勇敢无畏阿拉亚斯特拉

Accurate preterm labor diagnosis using a CD55-TLR4 combination biomarker model

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Journal of Biomedical Science and Engineering 2013年第3期6卷 253-257页

作者： Siddharth Pratap laura E. brown Michael G. Izban Stella Nowicki Bogdan J. Nowicki Department of Computer Science Michigan Technological University Houghton USA Department of Obstetrics & Gynecology Meharry Medical College Nashville USA Microarray & Bioinformatics Core Department of Microbiology and Immunology Meharry Medical College Nashville USA

We previously demonstrated immune activation in the maternal peripheral circulation associated with preterm labor (PTL). There was an elevation in WBC mRNA of anti-inflammatory complement decay-accelerating factor (CD55) and the innate-immune response activating toll-like receptor 4 (TLR4). These findings suggested that collectively, these two molecules might serve as useful biomolecules to aid in the diagnosis of PTL. In this study, we used a combined marker approach to determine whether a dual marker model utilizing both CD55 and TLR4 mRNA levels to classify PTL would increase diagnostic accuracy compared to either molecule alone. Two methods were evaluated;a linear discriminant (LD) method and a distribution free (DF) method, in order to find the optimal linear combination of TLR4 and CD55 data to diagnose PTL accurately. Our results indicated that a combined CD55-TLR4 dual marker model could provide statistically significant improve- ments compared to CD55 or TLR4 single marker models for PTL classification performance.

关键词： Preterm Labor (PTL) CD55 Decay Accelerating Factor (DAF) Toll-Like Receptor 4 (TLR4)

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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维普期刊数据库

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma L.Clayton UK Dementia Research Institute at King’s College London LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(ALS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and ALS affecting upper and lower motor neurons),these two diseases are complexly *** and ALS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Telencephalic stab wound injury induces regenerative angiogenesis and neurogenesis in zebrafish:unveiling the role of vascular endothelial growth factor signaling and microglia

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Neural Regeneration Research 2025年第10期20卷 2938-2954页

作者： Danielle Fernezelian Philippe Rondeau laura Gence Nicolas Diotel Universitéde La Réunion INSERMUMR 1188Diabète athérothrombose Thérapies Réunion Océan Indien(DéTROI)Saint PierreLa RéunionFrance

After brain damage,regenerative angiogenesis and neurogenesis have been shown to occur simultaneously in mammals,suggesting a close link between these ***,the mechanisms by which these processes interact are not well *** this work,we aimed to study the correlation between angiogenesis and neurogenesis after a telencephalic stab wound *** this end,we used zebrafish as a relevant model of neuroplasticity and brain repair ***,using the Tg(fli1:EGFP×mpeg1.1:mCherry)zebrafish line,which enables visualization of blood vessels and microglia respectively,we analyzed regenerative angiogenesis from 1 to 21 days *** parallel,we monitored brain cell proliferation in neurogenic niches localized in the ventricular zone by using *** found that after brain damage,the blood vessel area and width as well as expression of the fli1 transgene and vascular endothelial growth factor(vegfaa and vegfbb)were *** the same time,neural stem cell proliferation was also increased,peaking between 3 and 5 days post-lesion in a manner similar to angiogenesis,along with the recruitment of ***,through pharmacological manipulation by injecting an anti-angiogenic drug(Tivozanib)or Vegf at the lesion site,we demonstrated that blocking or activating Vegf signaling modulated both angiogenic and neurogenic processes,as well as microglial ***,we showed that inhibition of microglia by clodronate-containing liposome injection or dexamethasone treatment impairs regenerative neurogenesis,as previously described,as well as injury-induced *** conclusion,we have described regenerative angiogenesis in zebrafish for the first time and have highlighted the role of inflammation in this *** addition,we have shown that both angiogenesis and neurogenesis are involved in brain repair and that microglia and inflammation-dependent mechanisms activated by Vegf signaling are important contributors to

关键词： angiogenesis cerebral damage inflammation neurogenesis stab wound telencephalon vascular endothelial growth factor zebrafish

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot laura Reiche Andrew Chan Robert Hoepner Patrick Küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha J.Holdsworth Alistair J.Gunn laura Bennet Hamid Abbasi Mātai Medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia