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Circulating tumor DNAs and non-coding RNAs as potential biomarkers for hepatocellular carcinoma diagnosis, prognosis and response to therapy

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Hepatoma Research 2019年第2期5卷 12-33页

作者： Paola Guerriero Farzaneh Moshiri laura lupini Silvia Sabbioni Massimo Negrini Elisa Callegari Department of Morphology Surgery and Experimental MedicineUniversity of FerraraFerrara 44121Italy Department of Molecular Medicine School of Advanced Technologies in MedicineTehran University of Medical SciencesTehran 11369Iran Department of Life Sciences and Biotechnologies University of FerraraFerrara 44121Italy

Hepatocellular carcinoma(HCC)is the second leading cause of cancer-related deaths worldwide and despite improvement in therapeutic approaches,prognosis remains *** can be partly attributed to the fact that the majority of HCCs are diagnosed at intermediate or advanced *** of circulating biomarkers able to detect HCC at early stages could improve patients'*** present,however,alpha fetoprotein or des-g-carboxyprothrombin are unable to reliably detect HCC at early stages and better circulating biomarkers are *** tumor DNA(ctDNA)and non-coding RNAs(ncRNAs)are emerging as promising biomarkers to achieve the *** and epigenetic alterations in ctDNA allow to pinpoint tumor-specific biomarkers,reveal tumor heterogeneity,help monitor tumor evolution over time and assess therapy *** remains to be fully evaluated the possibility of detecting these biomarkers at early tumor *** ncRNAs are quantitative biomarkers with potential use in diagnostic,prognostic and predictive clinical *** may help to reveal HCC at early ***,because of heterogeneous and sometimes conflicting reported results,they still require validation and standardization of pre-analytical and analytical approaches before clinical applications could be envisaged.

关键词： Liquid biopsy hepatocellular carcinoma circulating tumor DNA non-coding RNA diagnosis prognosis therapy response

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Genetic variation in eggplant for Nitrogen Use Efficiency under contrasting NO3^- supply

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Journal of Integrative Plant Biology 2020年第4期62卷 487-508页

作者： Antonio Mauceri laura Bassolino Antonio lupini Franz Badeck Fulvia Rizza Massimo Schiavi laura Toppino Maria Rosa Abenavoli Giuseppe L.Rotino Francesco Sunseri Dipartimento Agraria University degli Studi M editerranea di Reggio CalabriaI-89124Reggio CalabriaItaly CREA Centro di ricerca Genomica e Bioinformatica I-26836Montanaso LombardoItaly CREA Centro d i「icerca Genomicae Bioinformatica I-29017Fiorenzuolad’ArdaItaly

Eggplant(Solanum melongena L.) yield is highly sensitive to N fertilization, the excessive use of which is responsible for environmental and human health *** N input together with the selection of improved Nitrogen-Use-Efficiency(NUE) genotypes, more able to uptake, utilize, and remobilize N available in soils, can be challenging to maintain high crop yields in a sustainable agriculture. The aim of this study was to explore the natural variation among eggplant accessions from different origins, in response to Low(LN) and High(HN)Nitrate(NO3^-) supply, to identify NUE-contrasting genotypes and their NUE-related traits, in hydroponic and greenhouse pot experiments. Two eggplants, AM222 and AM22, were identified as N-use efficient and inefficient,respectively, in hydroponic, and these results were confirmed in a pot experiment, when crop yield was also evaluated. Overall, our results indicated the key role of Nutilization component(NUt E) to confer high NUE. The remobilization of N from leaves to fruits may be a strategy to enhance NUt E, suggesting glutamate synthase as a key enzyme. Further, omics technologies will be used for focusing on C-N metabolism interacting networks. The availability of RILs from two other selected NUE-contrasting genotypes will allow us to detect major genes/quantitative trait loci related to NUE.

关键词： fir Efficiency utilize

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