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Systemic modulation of skeletal mineralization by magnesium implant promoting fracture healing: Radiological exploration enhanced with PCA-based machine learning in a rat femoral model

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Journal of Magnesium and Alloys 2024年第3期12卷 1009-1020页

作者： Yu Sun Heike Helmholz Regine Willumeit-Römer Institute of Metallic Biomaterials Helmholtz-Zentrum HereonGermany

The clinical application of magnesium(Mg)and its alloys for bone fractures has been well supported by in vitro and in vivo ***,there were studies indicating negative effects of high dose Mg intake and sustained local release of Mg ions on bone metabolism or repair,which should not be ignored when developing Mg-based ***,it remains necessary to assess the biological effects of Mg implants in animal models relevant to clinical treatment *** primary purpose of this study was to validate the beneficial effects of intramedullary Mg implants on the healing outcome of femoral fractures in a modified rat *** addition,the mineralization parameters at multiple anatomical sites were evaluated,to investigate their association with healing outcome and potential clinical *** to the control group without Mg implantation,postoperative imaging at week 12 demonstrated better healing outcomes in the Mg group,with more stable unions in 3D analysis and high-mineralized bridging in 2D *** bone tissue mineral density(TMD)was higher in the Mg group at the non-operated femur and lumbar vertebra,while no differences between groups were identified regarding the bone tissue volume(TV),TMD and bone mineral content(BMC)in *** the surgical femur,the Mg group presented higher TMD,but lower TV and BMC in the distal metaphyseal region,as well as reduced BMC at the osteotomy *** component analysis(PCA)-based machine learning revealed that by selecting clinically relevant parameters,radiological markers could be constructed for differentiation of healing outcomes,with better performance than 2D *** study provides insights and preclinical evidence for the rational investigation of bioactive materials,the identification of potential adverse effects,and the promotion of diagnostic capabilities for fracture healing.

关键词： Magnesium Implants Bone fracture Mineralization Systemic modulation Principal component analysis.

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Peri-implant gas accumulation in response to magnesium-based musculoskeletal biomaterials:Reframing current evidence for preclinical research and clinical evaluation

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Journal of Magnesium and Alloys 2024年第1期12卷 59-71页

作者： Yu Sun Heike Helmholz Regine Willumeit-Römer Institute of Metallic Biomaterials Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany

Historically,the rapid degradation and massive gas release from magnesium(Mg)implants resulted in severe emphysema and mechanical *** the advent of new alloys and surface treatment methods,optimized Mg implants have re-entered clinics since last decade with reliable ***,the optimization aims at slowing down the degradation process,rather than exemption of the gas *** study involved a systematic evaluation of current preclinical and clinical evidence,regarding the physical signs,symptoms,radiological features,pathological findings and complications potentially associated with peri±implant gas accumulation(PIGA)after musculoskeletal Mg *** literature search identified 196 potentially relevant publications,and 51 papers were enrolled for further analysis,including 22 preclinical tests and 29 clinical studies published from 2005 to *** Mg-based materials have been evaluated in animal research,and the application of pure Mg and Mg alloys have been reported in clinical follow-ups involving multiple anatomical sites and musculoskeletal *** tissue and intraosseous PIGA are common in both animal tests and clinical follow-ups,and potentially associated with certain adverse *** examinations especially micro-CT and clinical CT scans provide valuable information for quantitative and longitudinal *** according to simulation tests involving Mg implantation and chemical processing,tissue fixation could lead to an increase in the volume of gas cavity,thus the results obtained from ex vivo imaging or histopathological evaluations should be interpreted with *** still lacks standardized procedures or consensus for both preclinical and clinical evaluation of ***,by providing focused insights into the topic,this evidence-based study will facilitate future animal tests and clinical evaluations,and support developing biocompatible Mg implants for the treatment of musculoskeletal

关键词： Magnesium implant Degradation Hydrogen Gas release Postoperative follow-up

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Dielectric size optimization for high power density in large-scale triboelectric nanogenerators

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Nano Research 2024年第9期17卷 8455-8464页

作者： Abdulkerim Karabiber Ömer Dirik Feyyaz Koc Faruk Ozel Department of Electrical and Electronics Engineering Bingol UniversityBingol 12000Turkey Department of Metallurgical and Materials Engineering Karamanoglu Mehmetbey UniversityKaraman 70200Turkey

Triboelectric nanogenerators(TENGs)have emerged as a promising technology to harvest electrical energy from natural motions such as human movement,wind,and water *** TENGs show significant potential in small-scale applications,developing large-scale TENGs capable of generating high power remains a significant *** factors that can affect the performance of large-scale TENGs are being investigated to overcome this challenge,including the size and configuration of dielectric *** study optimizes dielectrics regarding surface area,thickness,and multicell configuration to improve harvested electrical power density in large-scale *** the studies,glass fiber was used as the positive dielectric,and multipurpose white silicone was used as the negative dielectric because of their high tribo-potential,durability,and easy *** the size optimization phase,dielectric thicknesses and surface areas that provide the maximum power density were ***,horizontal and vertical multicell configurations were examined to efficiently integrate size-optimized *** results reveal that large-scale TENGs with vertical multicell configurations can achieve high and usable energy density for *** findings provide valuable insight into the development of large-scale TENGs with advanced power generation capabilities.

关键词： triboelectric nanogenerator dielectric layer size optimization multi-cell structure high power density

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Device-measured physical activity and sedentary time in the Nordic countries:A scoping review of population-based studies

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Journal of Sport and Health Science 2024年第5期13卷 650-660页

作者： Ing-Mari Dohrn Jakob Tarp Jostein Steene-Johannessen Tommi Vasankari Maria Hagströmer Division of Physiotherapy Department of NeurobiologyCare Sciences and SocietyKarolinska Institutet14183 HuddingeSweden Department of Sports Medicine Norwegian School of Sports Sciences0806 OsloNorway UKK Institute for Health Promotion Research 33500 TampereFinland Faculty of Medicine and Health Technology Tampere University33100 TampereFinland Academic Primary Health Care Centre Region Stockholm13365 StockholmSweden

Purpose:The purpose of this scoping review was to summarize and describe the methodology and results from population-based studies of physical activity and sedentary time measured with devices in the Nordic countries(Denmark,Finland,Iceland,Norway,and Sweden)and published in 2000 or ***:A systematic search was carried out in PubMed and Web of Science in June 2023 using predefined search ***:Fourteen unique research projects or surveillance studies were ***,2 surveillance studies published by national agencies were included,resulting in a total of 16 studies for *** surveillance systems exist in Finland and Norway,with regular survey waves in school-aged children/adolescents and *** Denmark,recent nationally representative data have been collected in school children *** far,Sweden has no regular national surveillance system using device-based data *** studies were found from *** first study was conducted in 2001 and the most recent in 2022,with most data collected from 2016 to *** studies included children/adole scents 6-18 years,no study included *** total 11 studies included adults,of which 8 also covered older *** study focused specifically on older *** analytical sample size ranged from 205 to 27,*** methodology is presented,such as information on sampling strategy,device type and placement,wear protocols,and physical activity classification *** of physical activity and sedentary time in children/adolescents,adults,and older adults across the Nordic countries are ***:A growing implementation of device-based population surveillance of physical activity and sedentary behavior in the Nordic countries has been *** variety of devices,placement,and data procedures both within and between the Nordic countries highlights the challenges when it comes to comparing study outcomes as well as the need for more standa

关键词： Accelerometer Light intensity Moderate-vigorous intensity Surveillance Wearable devices

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Evaluation of crustal deformation and associated strong motions induced by the 2022 Paktika earthquake,Afghanistan

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Earthquake Science 2024年第6期37卷 546-557页

作者： A.Bari Jahed Ömer Aydan Takashi Ito Naoki Iwata University of Ryukyus Okinawa 903-0213Japan Chuden Engineering Consultants Hiroshima 734-8510Japan

The 2022 Paktika earthquake(moment magnitude:6.2) occurred on June 22,2022,near the border between the Khost and Paktika Provinces of Afghanistan,causing heavy damage and casualties in Paktika *** study evaluated the crustal deformation and associated strong motions induced by the Paktika *** deformations were determined using the Differential Interferometric Synthetic Aperture Radar(DInSAR) technique and three-dimensional finite element method(3DFEM) and the results were *** permanent ground displacements obtained from the DInSAR and 3D-FEM analyses were similar in terms of amplitude and areal *** motions were estimated using the 3D-FEM with and without considering regional *** estimations of maximum ground acceleration,velocity,and permanent ground deformations were compared among each other as well as with those inferred from failures of some simple structures in the Spera and Gayan *** inferred maximum ground acceleration and velocity from the failed adobe structures were more than 300 Gal and 50 cm/s,respectively,nearly consistent with the estimates obtained using empirical *** empirical method yielded a maximum ground acceleration of 347 Gal,whereas the maximum ground velocity was approximately50 cm/*** light of these findings,some surface expressions of crustal deformations and strong ground motions,such as failures of soil and rock slopes and rockfalls,have been *** rock slope failures in the epicentral area were consistent with those observed during various earthquakes in Afghanistan and worldwide.

关键词： Paktika earthquake FEM SAR Afghanistan fault rupture surface deformation slope rockfall

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Surgical treatment of a rare brachial artery aneurysm postarteriovenous fistula closure after kidney transplant:A case report

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World Journal of Clinical Cases 2024年第21期12卷 4755-4761页

作者： Nahit Arda Demirkan Yasemin Keskin Hakan Sevinç Ömer Arda Çetinkaya Department of General Surgery Ankara University School of MedicineAnkara 06100Türkiye Department of General Surgery Dr.Abdurrahman Yurtaslan Ankara Oncology Training and Research HospitalAnkara 06100Türkiye

BACKGROUND Brachial artery aneurysms are defined as dilations greater than 50%of the normal diameter,which are rare among all peripheral arterial *** they are often present as pseudoaneurysms,true brachial artery aneurysms are also detected *** this case report,the surgical repair method of true brachial artery aneurysms,which is a rare condition,is *** SUMMARY Herein,we present a 61-year-old male patient with complaints of swelling and pain in the right arm antecubital region that had been progressing over 6 *** the diagnosis of a true brachial artery aneurysm associated with arteriovenous fistula,the aneurysm was surgically repaired with an autologous saphenous vein *** patient was discharged without any neurovascular complications *** True brachial artery aneurysms are rare and there are not any recommendations for their management in the current *** though the treatment of true aneurysms in this artery is primarily based on a surgical treatment,endovascular repair also might be an option.

关键词： Brachial artery aneurysm Arteriovenous fistula Kidney transplantation Surgical repair Autologous vein interposition Case report

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C画幅变焦新兵适马18-50mm F2.8 DC DN| Contemporary佳能RF卡口镜头体验

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摄影之友 2024年第8期 130-131页

作者：芝麻mer(文/图) 不详

此前,适马已为多个卡口系统(如索尼E卡口、L卡口、富士X卡口、尼康Z卡口等)开发了镜头,此次针对佳能RF卡口系统发布的18-50mm F2.8 DC DN|Contemporary标志着适马进一步拓宽市场,满足使用佳能APS-C无反相机用户的需求。

关键词：变焦尼康 RF卡佳能 APS 镜头 DC 画幅

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Socio-Demographic and Occupational Aspects of HIV-HBV Co-Infection in Bangui, Central African Republic (CAR): Hospital-Based Cross-Sectional Study

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Advances in Infectious Diseases 2024年第2期14卷 310-321页

作者： Gaspard Tékpa Hermione Dahlia Mossoro-Kpinde Jessy Guylaine Nazilari Gertrude Komoyo Saint Calvaire Henri Diémer Centre Hospitalier Universitaire de lAmiti Bangui Central African Rpublic (CAR) Dpartement de Mdecine Facult des Sciences de la Sant Universit de Bangui Bangui Central African Republic (CAR) Direction de la Mdecine du Travail Ministre du Travail de lemploi et de la Protection Sociale Bangui Central African Rpublic (CAR) Dpartement de Sant Publique Facult des Sciences de la Sant Universit de Bangui Bangui Central African Rpublic (CAR)

Objective: HIV-HBV co-infection is a major public health problem that has not been sufficiently explored in the Central African workplace. The aim of this study was to assess the frequency of HIV-HBV co-infection among people who living with HIV (PLHIV) in the infectious and tropical diseases department of the Centre Hospitalier Universitaire de lAmiti Sino-Centrafricaine in Bangui. Methods: A retrospective study was carried out from January 1, 2010 to December 31, 2021 in the Infectious and Tropical Diseases Department at the Amiti Sino-Centrafricaine University Hospital. It included the files of all PLHIV, which included the results of HBV serology. A standardized form was used to collect socio-demographic and professional data by documentary review. Data was analysed using Epi-Info 7 software. Means, proportions were calculated as well as Chi square witch was significant if p-value was below 0.05. Results: The study included 265 patients, 188 were women (70.1%) and 77 men (29.1%), giving a sex ratio of 0.45. Mean age was 35.8 years, higher in men (40 years) than in women (35.8 years) (p 0.0001). The age groups 25 to 34 (37.7%) and 35 to 44 (33.6%) were in the majority (71.3%). The majority of PLHIV were unemployed (57.1%), including housewives (43.0%). HBV prevalence was 14.3%, including 7.2% among the unemployed, who account for half of all co-infections. The search for associations between HIV-HBV co-infection and all socio-demographic characteristics (age, sex, marital status) and socio-professional categories showed no significant difference (p 0.05). Conclusion: PLHIV were predominantly young adults, female, and unemployed;no occupation was significantly associated with co-infection. The vast majority of co-infected people were not covered by the occupational health system (unemployed or informal sector). Urgent action is needed to improve workers access to occupational medicine in CAR.

关键词： People Living with HIV HIV-HBV Co-Infection Occupation Informal Sector

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状腺肿高发病率与碘摄入量高地区年轻人的...：碘摄入量...

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国外医学（医学地理分册） 1992年第1期13卷 30-31页

作者： laur.,P 高嘉明

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综合基因组分析指导治疗对原发性不明癌症患者生存期影响的研究

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中国临床药理学杂志 2024年第18期40卷 2684-2684页

作者： KRÄmer A BOCHTLER T PAULI C 孟海峰

本研究为一项前瞻性、随机、开放标签、对照、多中心的Ⅱ期临床试验。在诱导期间,患者根据研究者的选择接受了3个初始周期的铂类化疗(卡铂-紫杉醇、顺铂-吉西他滨或卡铂-吉西他滨).在3个周期后重新分期,患者被分为2类:第1类,疾病得到控... 详细信息

本研究为一项前瞻性、随机、开放标签、对照、多中心的Ⅱ期临床试验。在诱导期间,患者根据研究者的选择接受了3个初始周期的铂类化疗(卡铂-紫杉醇、顺铂-吉西他滨或卡铂-吉西他滨).在3个周期后重新分期,患者被分为2类:第1类,疾病得到控制的患者(即完全缓解、部分缓解或疾病稳定的患者),第2类,疾病进展的患者。在3个周期的标准一线铂基化疗后达到疾病控制的患者通过阻滞分层随机化程序以3∶1的比例随机分为试验组[接受分子引导治疗(MGT)]与对照组(继续之前的化疗方案),2组均继续治疗3个周期。主要终点是研究者评估的意向性治疗人群的无进展生存期。

关键词： Ⅱ期临床试验吉西他滨疾病进展疾病控制铂类化疗基因组分析卡铂紫杉醇

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