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Numerical Simulation of the Genesis of Typhoon Durian (2001) over the South China Sea:the Effect of Sea Surface Temperature

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Journal of Ocean University of China 2010年第2期9卷 99-115页

作者： WANG Lei lau kai-hon FUNG Chi-Hung Department of Mathematics Hong Kong University of Science and Technology Hong Kong P. R. China Institute for the Environment Hong Kong University of Science and Technology Hong Kong P. R. China

Typhoon Durian (2001),which formed over the South China Sea (SCS),was simulated by using the Weather Research and Forecasting (WRF) model. The genesis of typhoon Durian which formed in the monsoon trough was reproduced by numerical simulations. The simulated results agree reasonably well with observations. Two numerical experiments in which the sea surface temperature (SST) was either decreased or increased were performed to investigate the impact of the SST on the genesis of the ty-phoon. When the SST was decreased by 5℃ uniformly for all grids in the model,the winds calculated became divergent in the lower troposphere and convergent in the upper troposphere,creating conditions in which the amount of total latent heat release (TLHR) was low and the tropical cyclone (TC) could not be formed. This simulation shows the importance of the convergence in the lower tropo-sphere and the divergence in the upper troposphere for the genesis of the initial vortex. When the SST was increased by 1℃ uni-formly for all grids,a stronger typhoon was generated in the results with an increase of about 10 m s-1 in the maximum surface wind speed. Only minor differences in intensity were noted during the first 54 h in the simulation with the warmer SST,but apparent dif-ferences in intensity occurred after 54 h when the vortex began to strengthen to typhoon strength. This experiment shows that warmer SST will speed the strengthening from tropical storm strength to typhoon strength and increase the maximum intensity reached,while only minor impact can be seen during the earlier stage of genesis before the TC reaches the tropical storm strength. The results sug-gest that the amount of TLHR may be the dominant factor in determining the formation and the intensification of the TC.

关键词： tropical cyclone WRF numerical simulation cyclone genesis

The Upper Ocean Thermal Structure and the Genesis Locations of Tropical Cyclones in the South China Sea

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Journal of Ocean University of China 2007年第2期6卷 125-131页

作者： WANG Lei Fung Chi-Hung lau kai-hon Department of Mathematics Hong Kong University of Science and Technology Hong Kong SAR P. R. China Institute for the Environment Hong Kong University of Science and TechnologyHong Kong SAR P. R. China

The relationship between the upper ocean thermal structure and the genesis locations of tropical cyclones (TCs) in the South China Sea (SCS) is investigated by using the Joint Typhoon Warning Center (JTWC) best-track archives and high resolution (1/4 degree) temperature analyses of the world's oceans in this paper. In the monthly mean genesis positions of TCs from 1945 to 2005 in the SCS, the mean sea surface temperature (SST) was 28.8℃ and the mean depth of 26℃ water was 53.1 m. From the monthly distribution maps of genesis positions of TCs, SST and the depth of 26℃ water in the SCS, we discovered that there existed regions with SST exceeding 26℃ and 26℃ water depth exceeding 50 m where no tropical cyclones formed from 1945 to 2005 in the SCS, which suggests that there were other factors unfavorable for TC formation in these regions.

关键词： tropical cyclone ocean thermal structure South China Sea

Features of Ocean Surface Winds Observed by the QuikSCAT Satellite Before Tropical Cyclogenesis over the South China Sea

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Journal of Ocean University of China 2008年第3期7卷 241-245页

作者： WANG Lei lau kai-hon FUNG Chi-Hung ZHANG Qinghong Department of Mathematics Hong Kong University of Science and Technology Hong Kong P. R. China Institute for the Environment Hong Kong University of Science and Technology Hong Kong P. R. China Department of Atmospheric Sciences Peking University Beijing 100871 P. R. China

Ocean surface winds observed by the Quick Scatterometer(QuikSCAT) satellite prior to the geneses of 36 tropical cy-clones(TCs) in the South China Sea(SCS) are investigated in this paper. The results show that there are areas with negative mean horizontal divergence around the TC genesis locations three days prior to TC formation. The divergence term [-(f+ζ)(u/x+v/y) ] in the vorticity equation is calculated based upon the QuikSCAT ocean surface wind data. The calculated mean divergence term is about 10.3 times the mean relative vorticity increase rate around the TC genesis position one day prior to TC genesis,which shows the important contributions of the divergence term to the vorticity increase prior to TC formation. It is suggested that criteria related with the divergence and divergence term be applied in early detections of tropical cyclogenesis using the QuikSCAT satellite data.

关键词： tropical cyclone QuikSCAT South China Sea cyclone genesis

Comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department

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World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui Kin Lam Zonglin Dai Eric Ho Yin lau Carrie Yuen Ting Ip Ho Ching Chan Lingyun Zhao Tat ChiTsang Matthew Sik hon Tsui Timothy Hudson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores(EWSs)and three shock indices in early sepsis prediction in the emergency department(ED).METHODS:We performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in hong *** primary outcome was sepsis(Sepsis-3 definition)within 48 h of ED *** c-statistics and the DeLong test,we compared 11 EWSs,including the National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worthing Physiological Scoring System(WPS),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),with Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qSOFA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of whom 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROC]0.75,95%CI 0.70-0.79)and was significantly better than SIRS,qSOFA,other EWSs and shock indices,except WPS,at predicting the primary ***,the pooled sensitivity and specificity of NEWS2≥5 for the prediction of sepsis were 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all EWSs and shock indices declined when used to predict mortality at a more remote time ***:NEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early warning score Shock index

The Impact of Medical Resources and Oral Antiviral Drugs on SARS-CoV-2 Mortality—hong Kong SAR,China,2022

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China CDC weekly 2024年第21期6卷 469-477,I0001-I0005页

作者： Zhiqi Zeng Jingyi Liang Zhijie Lin Wenda Guan Wei He Qianying Li Lixi Liang Weiqi Pan Zige Liu Guibin Lu Xiaoyan Deng Eric HY lau Chitin hon Zifeng Yang Guangzhou key laboratory for clinical rapid diagnosis and early warning of infectious diseases KingMed School of Laboratory MedicineGuangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Macao Institute of Systems Engineering Macao University of Science and TechnologyMacao SARChina Respiratory Disease AI Laboratory on Epidemic Intelligence and Medical Big Data Instrument Applications Faculty of Innovative EngineeringMacao University of Science and TechnologyMacao SARChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina School of Public Health The University of Hong KongHong Kong SARChina Laboratory of Data Discovery for Health Hong Kong SARChina Guangzhou Laboratory Guangzhou CityGuangdong ProvinceChina

Introduction:The Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)demonstrates increased transmissibility compared to earlier strains,contributing to a significant number of fatalities in hong Kong Special Administrative Region(HKSAR),*** medical resources and medications are essential in mitigating these *** study evaluates the effects of supplementary resources from the Chinese mainland during the fifth wave of the pandemic in ***:Vector autoregression(VAR)was employed to analyze data from the Oxford coronavirus disease 2019(COVID-19)Government Response Tracker to assess the effectiveness of control measures during five waves of the pandemic in ***,a transmission dynamics model was created to investigate the influence of supplementary medical resources from the Chinese mainland and oral medications on ***:In the initial four waves,workplace closures,restrictions on public events,international travel bans,and shielding the elderly significantly influenced pandemic ***,during the fifth wave,these measures showed no notable *** comparing a situation without extra medical resources or COVID-19 oral medication,there was a 17.7%decrease in COVID-19 fatalities with mainland medical resources and an additional 10.2%reduction with oral ***,they contributed to a 26.6%decline in ***:With the rapid spread of the virus,regional reallocation of medical resources may reduce mortality even when the local healthcare system is overstretched.

关键词： mainland Impact travel

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台风Maggie路径异常的数值研究

热带气象学报 2006年第1期22卷 55-59页

作者：张中锋刘启汉拓瑞芳民航北京气象中心北京100621 香港科技大学海岸与大气研究中心

台风Maggie(1999年)是近年来比较特殊的一个台风,所有台风预报中心均未能准确预报其登陆前的异常路径。通过两个数值试验揭示了台风Maggie路径异常的原因。即Maggie路径异常的主要原因是它与邻近的一个热带气旋相互作用的结果。

关键词：台风路径异常数值试验

Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben Chung-Lap Chan Grace Gar-Lee Yue LI Pei-ting Sharon Sze-Man hon HUANG Dan-qi Miranda Sin-Man Tsang Clara Bik-San lau Ping-Chung Leung Chun-Kwok Wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(P<0.05),altered the hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(P<0.05).4HF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

Material characterization and inter/intra-particle validation for DEM simulation of urea coating process

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Particuology 2024年第5期88卷 32-48页

作者： Salma A.Nouh KuZilati KuShaari lau Kok Keong Shafirah Samsuri Chemical Engineering Department Universiti Teknologi PETRONAS32610 Seri IskandarPerak Darul RidzuanMalaysia

Particle coating is a common operation in the controlled-release fertilizer (CRF) industry,where a coating layer is appliedto the urea cores.A discrete element method (DEM) computer simulation was applied to model the coating process for the urea granules using measured model *** accuracy of DEM input parameters for the coating material properties and the physical and mechanical characterizations of urea granules are crucial to the study of particle coating ***,to enhance the simulation accuracy,information on the material properties (urea granules) is *** this study,the elasticity parameters,shear modulus ,coefficient of restitution (CoR),and coefficient of rolling and static friction (CoRF) and (CoSF) of urea granules are estimated experimentally in addition to the physical *** sensitivity of the angle of repose of the urea bed was investigated at different coefficients of *** to the obtained experimental value of the angle of repose,values of 0.2 and 0.3 for CoRF and CoSF,respectively,were adjusted to obtain consistent urea granules’ motion for simulation and the ***,the spray droplet sizes and velocity distributions were estimated using the video-imaging process *** on this experimental characterization,elasticity parameters and spray properties were integrated into DEM simulation software as input data to perform numerical analysis of the coating process to compare simulation and experimental results,which show uniformity at three different pan speeds with a maximum deviation of 0.033 at 5 ***,consistency between DEM and experiment results was achieved in terms of average coating thickness (μm) of the selected samples and average intra-particle thickness variation ( CoV intra ).These results revealed that the coating film thickness is proportional to the rotation speed for the experiment and *** enhance the inter-particle coating uniformity,the effects of the

关键词： Contact model Discrete element method Urea fertilizer Coating process

Wan-Yee Joseph lau:the promoter of modernization and internationalization of Chinese surgery

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Oncology and Translational Medicine 2024年第1期10卷 1-3页

作者： Wan-Yee Joseph lau Faculty of Medicine The Chinese University of Hong KongHong KongChina

To my knowledge,there have been 3 books[1–3]and 2 book chapters written about me.[4–5]For those who are interested in the details of my life,please refer to these books/book *** title of this article is an English translation of the title of the book I refer to as reference 1,which I find appropriate to describe the role that I play in China.

关键词： please details translation