检索结果-南通市图书馆

Genetic association of rs7754840 and rs7756992 polymorphisms in the CDKAL1 gene and gestational diabetes mellitus in selected Filipino pregnant women

引用

Asian pacific Journal of Reproduction 2021年第4期10卷 155-161页

作者： Maria Ruth B.Pineda-Cortel Karlo Baybayan Peter Louie Bello latiffa lois camenforte Stefany Jane Ching Kathleen Conti Jeremiah Jose Ignacio Jiovanni Diaz Adrian Villavieja Jefferyl Kae Pandac Emilyn U.Alejandro Department of Medical Technology Faculty of PharmacyUniversity of Santo TomasManilaPhilippines The Graduate School University of Santo TomasManilaPhilippines Institute of Clinical Laboratory Sciences Silliman UniversityDumaguete CityPhilippines Research Center for the Natural and Applied Sciences University of Santo TomasManilaPhilippines Department of Integrative Biology and Physiology University of MinnesotaUSA

Objective:To investigate the possible association between rs7754840 and rs7756992 polymorphisms of CDKAL1 gene and susceptibility to gestational diabetes mellitus(GDM)in a Filipino pregnant ***:A total of 101 patients with GDM and 99 women without GDM were *** CDKAL1 gene single nucleotide polymorphisms(SNPs),namely rs7754840 and rs7756992,were genotyped by using TaqMan allelic discrimination ***-Whitney U test,median and interquartile range were used to describe physical and biochemical *** differences in the genotype and allele distribution of the target genetic variants among the two groups of participants were assessed by using Chi-square *** to Hardy-Weinberg equilibrium was tested prior to conducting further *** logistic regression model was used to investigate the effects of the genotype models on GDM ***:There was no observed correlation between the genotypes of the rs7754840 SNP and oral glucose tolerance test ***,there was no significant association between genetic models of the rs7754840 SNP and GDM risk(additive OR 1.43,95%CI 0.82-2.50,P=0.21;dominant OR 1.21,95%CI 0.57-2.59,P=0.62;recessive OR 1.63,95%CI 0.86-3.09,P=0.13).Conclusions:The results of this study suggest no association between CDKAL1 gene variant rs7754840 and GDM development in Filipino pregnant *** studies with a larger population should be performed to validate our findings.

关键词： Gestational diabetes mellitus GDM Single nucleotide polymorphism SNP Genetic association rs7756992 rs7754840 CDKAL1 Filipino pregnant women

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：