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Toxicity profile of ethanolic extract of Azadirachta indica stem bark in male Wistar rats

Asian Pacific Journal of Tropical Biomedicine 2012年第10期2卷 811-817页

作者： Anofi Omotayo Tom Ashafal latifat olubukola orekoya Musa Toyin Yakubu Department of Plant Sciences University of the Free StateQwaqwa campus Deparment of Botany Lagos State UniversityBadagry Express Way Phytomedicine ToxicologyReproductive Biochemistry Research LaboratoryDepartment of BiochemistryUniversity of Ilorin

Objective:To investigate the loxic implications of ethanolic stem bark extract of Azadirachta indica(A-indica)at 50,100,200 and 300 mg/kg body weight in Wistar ***:Fifty male rats of Wistar strains were randomly grouped into five(A-F.)of ten animals *** in Group A(control)were orally administered 1 mL of distilled water on daily basis for 21 days while those in Groups B-E received same volume of the extract corresponding to 50,100,200 and 300mg/kg body ***:The extract did not significantly(P>0.05)alter the levels of albumin,total protein,red blood cells and factors relating to it whereas the white blood cell,platelets,serum triacylglycerol and high-density lipoprotein cholesterol decreased significantly(P<0.05).In contrast,the final body weights,absolute weights of the liver,kidney,lungs and heart as well as their organ-body weight ratios,serum globulins,total and conjugated bilirubin,serum cholesterol,low-density lipoprotein cholesterol and computed atherogenic index increased *** spleen-body weight ratio,alkaline phosphatase,alanine and aspartate transaminases,sodium,potassium,calcium,feed and water intake were altered at specific ***:Overall,the alterations in the biochemical parameters of toxicity have consequential effects on the normal functioning of the organs of the ***,the ethanolic extract of *** stem bark at the doses of 50,100,200 and 300 mg/kg body weight may not be completely safe as an oral remedy and should be taken with caution if absolutely necessary.

关键词： Azadirachta indica Feed intake Functional indices Haematological parameters Lipid profile Meliaceae

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