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Force degradation behavior of glucocorticoid deflazacort by UPLC：isolation,identification and characterization of degradant by FTIR,NMR and mass analysis

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The Journal of Biomedical Research 2016年第2期30卷 149-161页

作者： Rajesh Deshmukh lata sharma Muktika Tekade Prashant Kesharwani Piyush Trivedi Rakesh K.Tekade Macleods Pharmaceuticals Ltd. Kachigam Daman 396320 India School of Pharmaceutical Science Rajiv Gandhi Prodyogiki Vishwavidyalaya Gandhi Nagar Bhopal 462036 India TIT College of Pharmacy Technocrats Institute of Technology Anand Nagar Bhopal 462021 India Department of Pharmaceutical Sciences Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University Detroit MI 48201 USA The University of Texas Southwestern Medical Center Advanced Imaging Research Center Dallas TX 75390 USA The International Medical University School of Pharmacy Department of Pharmaceutical Technology Kuala Lumpur57000 Malaysia

In this investigation,sensitive and reproducible methods are described for quantitative determination of deflazacort in the presence of its degradation *** method was based on high performance liquid chromatography of the drug from its degradation product on reverse phase using Acquity UPLC BEH C18columns（1.7 urn,2.1 mm ×150 mm） using acetonitrile and water（40：60 V/V） at a flow rate of 0.2 mL/minute in *** detection was performed at 240.1 *** was subjected to oxidative,acid,base,hydrolytic,thermal and photolytic *** drug was found to be stable in water and thermal stress,as well as under neutral stress ***,forced-degradation study performed on deflazacort showed that the drug degraded under alkaline,acid and photolytic *** degradation products were well resolved from the main peak,which proved the stability-indicating power of the *** developed method was validated as per ICH guidelines with respect to accuracy,linearity,limit of detection,limit of quantification,accuracy,precision and robustness,selectivity and *** from the aforementioned,the results of the present study also emphasize the importance of isolation characterization and identification of ***,an attempt was made to identify the degradants in *** of the degradation products of deflazacort was isolated and identified by the FTIR,NMR and LC-MS study.

关键词： Deflazacort forced degradation degradant characterization

Numerical simulation of square shaped particle sedimentation

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Particuology 2024年第1期84卷 107-116页

作者： Govind sharma Bahni Ray Department of Mechanical Engineering Indian Institute of Technology DelhiHauz KhasNew Delhi110016India

Direct numerical simulations of square particle sedimentation in a viscous incompressible fluid are presented to examine the effects of sharp edges for various particle-to-fluid density ratios and different initial inclination *** settling process exhibits four different motion regimes;non-oscillatory,non-uniform centered oscillatory,uniform off-centered oscillatory,and non-uniform off-centered(irregular)*** moderate density ratios,we observe that the rotational motion of settling square particle varies with the initial inclination *** employ Dynamic Time Warping and Fast Fourier Transform to analyze translational and angular *** systems are described using phase-space plots,and a chaotic phenomenon is observed at a higher density ratio.

关键词： Sedimentation Distributed Lagrangian multiplier Phase synchronization Oscillations

Sequential decay analysis of^(235)U(n^(th),f)reaction using fragmentation approach

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Chinese Physics C 2024年第6期48卷 145-154页

作者： Nitin sharma Ashutosh Kaushik Manoj K.sharma School of Physics and Materials Science Thapar Institute of Engineering&TechnologyPatiala-147004PunjabIndia

Numerous experimental and theoretical observations have concluded that the probability of the three fragment emission(ternary fission)or binary fission increases when one proceeds towards the heavy mass region of nuclear periodic *** factors affect fragment emission,such as the shell effect,deformation,orientation,and fissility *** and ternary fissions are observed for both ground and excited states of the *** collinear cluster tripartition(CCT)channel of the^(235)U(n^(th),f)reaction is studied,and we observe that the CCT may be a sequential or simultaneous emission *** date,different approaches have been introduced to study the CCT process as a simultaneous or sequential process,but the decay dynamics of these modes have not been not fully *** the three fragments of the sequential process and exploring their related dynamics using an excitation energy dependent approach would be of further ***,in this study,we investigate the sequential decay mechanism of the^(235)U(n^(th),f)reaction using quantum mechanical fragmentation theory(QMFT).The decay mechanism is considered in two steps,where initially,the nucleus splits into an asymmetric *** the second step,the heavy fragment obtained in the first step divides into two *** I analysis is conducted by calculating the fragmentation potential and preformation probability for the spherical and deformed choices of the decaying *** most probable fragment combination of stage I are identified with respect to the dips in the fragmentation structure and the corresponding maxima of the preformation probability(P0).The light fragments of the identified decay channels(obtained in step I)agree closely with the experimentally observed *** excitation energy of the decay channel is calculated using an iteration *** excitation energy is shared using an excitation energy dependent level density *** obtained excitation

关键词： fission cluster radioactivity ternary fission spontaneous fission cluster model total kinetic energy preformation probability

Updates on“Cancer Genomics and Epigenomics”

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World Journal of Clinical Oncology 2020年第11期11卷 890-897页

作者： Aarti sharma Kiran lata sharma Cherry Bansal Ashok Kumar Department of Surgical Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014India Department of Pathology Baylor College of MedicineHoustonTX 77030United States Department of Pathology Era’s Medical College and HospitalLucknow 226003India

The field of“Cancer Genomics and Epigenomes”has been widely investigated for their involvement in cancer to understand the basic processes of different *** aggregation of genetic and epigenetic alterations also displays a wide range of heterogeneity making it quite necessary to develop personalized treatment *** complex interplay between DNA methylation and chromatin dynamics in malignant cells is one of the major epigenetic mechanisms that lead to gene activation and ***,each tumor needs to be fully characterized to satisfy the ideas of personalized treatment *** present article addresses various aspects of genome characterization methods and their potential role in the field of cancer genomics and epigenomics.

关键词： Genetics Epigenetics Chromatin Cancer Copy number variations Transcription Histone-modifications

Study of plasma parameters of coaxial plasma source using triple Langmuir probe and Faraday cup diagnostics

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Plasma Science and Technology 2024年第4期26卷 94-100页

作者： Sunil KANCHI Rohit SHUKLA Archana sharma Pulsed Power and Electromagnetics Division Bhabha Atomic Research CentreVisakhapatnam 531011India Homi Bhabha National Institute Mumbai 400085India Beam Technology Development Group Bhabha Atomic Research CentreMumbai 400085India

Coaxial plasma guns are a type of plasma source that produces plasma which propagates radially and axially controlled by the shape of the ground electrode, which has attracted much interest in several applications. In this work, a 120° opening angle of CPG nozzle is used as a plasma gun configuration that operates at the energy of 150 J. The ionization of polyethylene insulator between the electrodes of the gun produces a cloud of hydrogen and carbon *** triple Langmuir probe and Faraday cup are used to measure plasma density and plasma temperature. These methods are used to measure the on-axis and off-axis plasma divergence of the coaxial plasma gun. The peak values of ion densities measured at a distance of 25 mm on-axis from the plasma gun are(1.6±0.5)×10^(19)m^(-3)and(2.8±0.6)×10^(19)m^(-3)for hydrogen and carbon plasma respectively and the peak temperature is 3.02±0.5 eV. The mean propagation velocity of plasma is calculated using the transit times of plasma at different distances from the plasma gun and is found to be 4.54±0.25 cm/μs and 1.81±0.18 cm/μs for hydrogen and carbon plasma respectively. The Debye radius is obtained from the measured experimental data that satisfies the thin sheath approximation. The shot-to-shot stability of plasma parameters facilitates the use of plasma guns in laboratory experiments. These types of plasma sources can be used in many applications like plasma opening switches, plasma devices, and as plasma sources.

关键词： coaxial plasma source triple Langmuir probe Faraday cup plasma density plasma temperature

Mitigating fire risks in hospitals:Are we primed and geared up?

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Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 141-142页

作者： Raman sharma Sruti sharma Department of Hospital Administration PGIMERChandigarhIndia Department of Hospital Administration Satellite CentreSangrurPGIMERChandigarhIndia

The recent incidents have confirmed that fires in COVID-19 hospitals have become a gruelling and nerve-testing challenge[1-3].The increased volumes of oxygen flow,abundance of inflammable alcohol sanitizers,wearing of inflammable kits,and abundance of equipment make it more acquiescent for such incidents and even difficult to *** density of equipment(especially ventilators)“enriches”air with oxygen,thereby increasing the“combustion risk”.

关键词： nit thereby control

Process engineering of demineralisation of moderate to high ash Indian coals through NaOH‑HCl leaching and HF leaching

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International Journal of Coal Science & Technology 2024年第2期11卷 111-122页

作者： Heena Dhawan D.K.sharma ANRF Ministry of ScienceNew DelhiIndia Department of Energy Science and Engineering Indian Institute of Technology DelhiNew Delhi 110016India

Chemical leaching of coals would be required to produce cleaner coals for some special applications where physical benefi-ciation may not be effective *** would also help in recovering Li and rare earth metals besides in the sequestration of CO_(2).About 20 Indian coals having complexly distributed moderate to high ash contents were sequentially treated with various alkali–acid such as NaOH-HCl,HF,HCl,HCl-HF,and NaOH-HCl-HF *** aimed to establish and design the best stepwise sequential process for the highest degree of demineralisation through a chemical leaching *** and process intensification studies were carried *** than 80%demineralisation of Madhaipur and Neemcha coals was observed using the best sequential treatment designed *** repeated stepwise treatment of the alkali and the acid was also studied,which was found to significantly enhance the degree of demineralisation of *** integrated process of alkali–acid leaching followed by solvent extraction(Organo-refining)and vice versa of the treated coal was also studied for producing cleaner coals.

关键词： Alkali–acid leaching Demineralisation Integrated process Rare earth elements

Optimizing sampling frequency of surface and downhole measurements for efficient stick-slip vibration detection

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Petroleum 2024年第1期10卷 30-38页

作者： Saket Srivastava Aditya sharma Catalin Teodoriu Mewbourne School of Petroleum and Geological Engineering The University of Oklahoma

Drilling vibrations significantly impact drilling operations with high costs due to early downhole equipment failure and loss of productive time. Stick-slip vibrations, a severe form of torsional vibrations,is known to be present up to 50% of total drilling time, making it a topic of immense concern and research. An ongoing discussion in the industry is regarding the reliability of surface measurements for early detection of severe downhole bit sticking. Moreover, most surface measurements are sampled at lower frequency rates closer to 1 Hz. Recently, the implementation of advanced data acquisition modules in downhole subs has greatly improved our understanding of drilling vibrations through high resolution data, sampled up to 10 kHz. However, with a wide range of sampling frequency to choose from different available tools, a critical question remains unanswered. What is an optimal and adequate sampling frequency for early detection of downhole vibrations using both surface and downhole measurements?The paper addresses the question with a focus on stick-slip vibrations through an experimental investigation. Stick slip tests are repeated for different sampling frequencies of surface and downhole measurements and the stick slip index for each case is calculated. The stick-slip index varies for different sampling frequency even though the vibration tests remain completely identical. It was inferred that sampling frequency of measurements greatly impact the detection of downhole vibrations. Even though stick-slip vibrations are characteristically low frequency vibrations(≤2Hz), a minimum of 10Hz sampling frequency is recommended for detection of stick-slip vibrations. Moreover, all characteristics of stick-slip vibrations including bit sticking, bit RPM peaks and negative bit RPMs are clearly observed at a minimum of 100Hz sampling rate.

关键词： Stick-slip

Numerical Analysis of Phase Change and Container Materials for Thermal Energy Storage in the Storage Tank of Solar Water Heating System

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Journal of Thermal Science 2024年第2期33卷 408-421页

作者： SINGH Shailendra ANAND Abhishek SHUKLA Amritanshu sharma Atul Non-Conventional Energy Laboratory Rajiv Gandhi Institute of Petroleum TechnologyJais Amethi229304India

This study evaluates the effectiveness of phase change materials(PCMs) inside a storage tank of warm water for solar water heating(SWH) system through the theoretical simulation based on the experimental model of *** et *** model is explained by five fundamental equations for the calculation of various parameters like the effectiveness of PCMs,the mass of hot water,total heat content,and duration of *** study simulated eleven PCMs to analyze their effectiveness like Sodium hydrogen phosphate dodecahydrate(SHPD),OM 37,N-Eicosane(NE),Lauric acid(LA),Paraffin wax(PW),OM 48,Paraffin wax C_(20-33)(PW-C20-33),Sodium acetate trihydrate(SAT),Palmitic acid(PA),Myristic acid(MA),and Stearic acid(SA).Among all PCMs,the SHPD has found the highest value of effectiveness factor of ***,it is the most recommended PCM for the storage tank of the SWH *** study also includes the melt fraction analysis of all enumerated PCMs corresponding to container materials of stainless steel,glass,aluminum mixed,tin,aluminum,and *** melt fraction analysis is performed by making a coding program in the FORTRAN programming *** the analysis,copper container material is found to have high melting rate for all PCMs so it is superior to other container materials.

关键词： theoretical model solar water heating system phase change material effectiveness factor melt fraction