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g.protein-mediated sig.al transduction: a molecular choreog.aphy of g.protein activation after g.P binding

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Sig.al Transduction and Targ.ted Therapy 2024年第8期9卷 3155-3157页

作者： Evi Kostenis lars Jurg.nliemke Judith Alenfelder Department of Molecular- Cellular-and PharmacobiologyInstitute of Pharmaceutical BiologyUniversity of BonnBonnGermany g.aduate Training.g.oup RTg.873 University of BonnBonnGermany

A recent report from the Skiniotis g.oup,'published in Nature,provides fascinating.insig.t into the molecular choreog.aphy underlying.a quintessential cellular sig.aling.mechanism:g.protein-mediated sig.al *** time-resolved cryo-EM,the authors pieced tog.ther many sequential structural snapshots to visualize how a trimeric aβy g.protein-after being.convinced by its activated g.protein-coupled receptor(g.CR)to release g.P-picks up g.P,to set in motion finely tuned conformational transitions that lead to the conversion into the active state and,finally,subunit dissociation as well as diseng.g.ment from the receptor.

关键词： Skin activation finally

Foam rolling.and stretching.do not provide superior acute flexibility and stiffness improvements compared to any other warm-up intervention: A systematic review with meta-analysis

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Journal of Sport and Health Science 2024年第4期13卷 509-520页

作者： Konstantin Warneke g.rit Plöschberg.r lars H.Lohmann Eric Lichtenstein Daniel Jochum Stanislav D.Sieg.l Astrid Zech David g.Behm Institute of Sport Science University of KlagenfurtKlagenfurt am Wörthersee 9020Austria Department of Human Motion Science and Exercise Physiolog. Friedrich Schiller UniversityJena 07749Germany Department Sport Exercise and HealthUniversity of BaselBasel 4052Switzerland Department of Health Sciences and Technolog. ETH ZurichZurich 8092Switzerland School of Human Kinetics and Recreation Memorial University of NewfoundlandSt.JohnsNL A1C 5S7Canada

Backg.ound:Acute improvement in rang. of motion(ROM)is a widely reported effect of stretching.and foam rolling.which is commonly explained by chang.s in pain threshold and/or musculotendinous ***,these effects were also reported in response to various other active and passive interventions that induce responses such as enhanced muscle ***,we hypothesized that acute ROM enhancements could be induced by a wide variety of interventions other than stretching.or foam rolling.that promote an increase in muscle ***:After a systematic search in PubMed,Web of Science,and SPORTDiscus databases,38 studies comparing.the effects of stretching.and foam rolling.with several other interventions on ROM and passive properties were *** studies had 1134 participants in total,and the data analysis resulted in 140 effect sizes(ESs).ES calculations were performed using.robust variance estimation model with ***:Study quality of the included studies was classified as fair(PEDro score=4.58)with low to moderate certainty of *** showed no sig.ificant differences in ROM(ES=0.01,p=0.88),stiffness(ES=0.09,p=0.67),or passive peak torque(ES=-0.30,p=0.14)between stretching.or foam rolling.and the other identified *** plots revealed no publication ***:Based on current literature,our results challeng. the established view on stretching.and foam rolling.as a recommended component of warm-up *** lack of sig.ificant difference between interventions sug.ests there is no need to emphasize stretching.or foam rolling.to induce acute ROM,passive peak torque increases,or stiffness reductions.

关键词： Rang. of motion Passive properties Muscletendon unit Muscle tissue

Revisiting.the stretch-induced force deficit:A systematic review with multilevel meta-analysis of acute effects

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Journal of Sport and Health Science 2024年第6期13卷 805-819页

作者： Konstantin Warneke lars Hubertus Lohmann Institute of Human Movement Science Sport and HealthUniversity of GrazGraz 8010Austria Institute of Sport Science Alpen-Adria University of KlagenfurtKlagenfurt am Worthersee 9020Austria Institute of Human Movement and Exercise Physiolog. University of JenaJena 07749Germany

Backg.ound:When recommending.avoidance of static stretching.prior to athletic performance,authors and practitioners commonly refer to available systematic ***,effect sizes(ES)in previous reviews were extracted in major part from studies lacking.control conditions and/or prepost testing.***,currently available reviews conducted calculations without accounting.for multiple study outcomes,with ES:0.03 to 0.10,which would commonly be classified as ***:Since new meta-analytical software and controlled research articles have appeared since 2013,we revisited the available literatures and performed a multilevel meta-analysis using.robust variance estimation of controlled prepost trials to provide updated ***,previous research described reduced electromyog.aphy activity—also attributable to fatig.ing.training.routines—as being.responsible for decreased subsequent *** second part of this study opposed stretching.and alternative interventions sufficient to induce g.neral fatig.e to examine whether static stretching.induces hig.er performance losses compared to other exercise ***:Including.83 studies with more than 400 ES from 2012 participants,our results indicate a sig.ificant,small ES for a static stretch-induced maximal streng.h loss(ES=0.21,p=0.003),with hig. mag.itude ES(ES=0.84,p=0.004)for stretching.durations≥60 s per bout when compared to passive *** opposed to active controls,the maximal streng.h loss rang.s between ES:0.17 to0.28,pg.did not neg.tively influence athletic performance in g.neral(when compared to both passive and active controls);in fact,a positive effect on subsequent jumping.performance(ES=0.15,p=0.006)was found in ***:Reg.rding.streng.h testing.of isolated muscles(e.g.,leg.extensions or calf raises),our results confirm previous ***,since no(or even positive)e

关键词： Static stretching Maximal streng.h Athletic performance Performance testing

Identification of dig.tal technolog.es and dig.talisation trends in the mining.industry

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International Journal of Mining.Science and Technolog. 2020年第6期30卷 747-757页

作者： lars Barnewold Bernd g.Lottermoser Institute of Mineral Resources Eng.neering RWTH Aachen University52062 AachenGermany

Dig.talisation in mining.refers to the use of computerised or dig.tal devices or systems and dig.tised data that are to reduce costs,improve business productivity,and transform mining.***,it remains increasing.y difficult for mining.companies to decide which dig.tal technolog.es are most relevant to their needs and individual *** paper provides an overview of dig.tal technolog.es currently relevant to mining.companies as presented and discussed by mining.journals,the media and insig.t reports of leading.consultancy *** technolog.es were systematically identified using.text-mining.techniques,and network analyses established the relations between sig.ificant *** demonstrated that currently 107 different dig.tal technolog.es are pursued in the mining.***,an analysis of the actual implementation of dig.tal technolog.es in 158 active surface and underg.ound mines reveals a limited uptake of dig.tal technolog.es in g.neral and that the uptake increases with the run-of-mine ***-scale mining.operations appear to select and apply dig.tal technolog.es suitable to their needs,whereas operations with lower production rates do not implement the currently available dig.tal technolog.es to the same *** minor producers may require other dig.tal transformation solutions tailored to their capabilities and needs and applicable to their scale of operations.

关键词： Diffusion of dig.tal technolog.es Automation Internet of thing. Big.data Machine learning Artificial intellig.nce

Production of hybrid aspen on ag.icultural land during.one rotation in southern Sweden

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Journal of Forestry Research 2021年第1期32卷 181-189页

作者： Nils Fahlvik lars Rytter lars-g.ran Stener The Forestry Research Institute of Sweden(Skog.orsk) Ekebo 225026890 SvalovSweden

Hig. potential productivity tog.ther with short rotation periods have made hybrid aspen an interesting.option for wood production on former arable land in Nordic *** this study,some of the oldest active experimental plots with hybrid aspen in Sweden were remeasured at 23–30 years of ag..A main aim was to assess ag. and productivity at the time of maximum mean annual volume *** addition,the infl uence of commercial thinning.on stand development and diff erences in g.netic g.in among.clones were *** from fi ve experiments in southern Sweden were used,including.three g.netic trials,one demonstration stand with a clone mixture and one stand reg.nerated from root *** three g.netic trials were treated as sing.e plot experiments,subject to a standard thinning.*** the remaining.experiments,diff erent thinning.strateg.es were tested in a balanced block *** g.owth had culminated or was close to maximum at ag. 25–30 *** annual stem volume increment at culmination was 20–22 m 3 ha^−1 a^−*** heig.t reached 30–35 m at 28–30 years of *** diameter at breast heig.t was 27–29 cm after 29–30 years in the g.netic *** ranking.based on diameter at ag. 7–9 years was positively correlated with the ranking.at the fi nal measurement in the g.netic trials,20 years *** indicates that clones can be selected for superior g.owth based on results from young.*** intense thinning.prog.ams increased the mean diameter compared to lig.t *** study indicates that one or two early and relatively heavy thinning. can promote the development of crop trees,without jeopardizing.total volume production during.a rotation of 25–30 years.

关键词： Populus tremula×Populus tremuloides Rotation leng.h Thinning Biomass

Confirmation of a Sub-Saturn-size Transiting.Exoplanet Orbiting.a g.Dwarf:TOI-1194 b and a Very Low Mass Companion Star: TOI-1251 B from TESS

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Research in Astronomy and Astrophysics 2024年第3期24卷 129-143页

作者： Jia-Qi Wang.Xiao-Jun Jiang.Jie Zheng.Hanna Kellermann Arno Riffeser Liang.Wang.Karen A.Collins Allyson Bieryla lars A.Buchhave Steve B.Howell Elise Furlan Eric g.rardin Joao g.eg.rio Eric Jensen Felipe Murg.s Mesut Yilmaz Sam Quinn Xing.g.o Ruo-Yu Zhou Frank g.upp Hui-Juan Wang CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy Of SciencesBeijing 10010China University of Chinese Academy of Sciences Beijing 100049China University Observatory Munich Scheinertrsse 1.D-81679 MunichGemany Max Planck Institute for Extraterrestrial Physics Giessenbachstr.1D-85748 GarchingGermany National Astronomical Observatories/Nanjing.Institute of Astronomical Optics&Technolog. Chinese Academy of SciencesNanjing210042China CAS Key Laboratory of Astronomical Optics&Technolog. Nanjing Institute of Astronomical Optics&TechnologyNanjing 210042China Center for Astrophysics Harvard&Smithsonian60 Garden Street.CambridgeMA 02138USA National Space Institute Technical University of DenmarkElektrovejDK-2800 KgsLyngbyDenmark NASA Ames Research Center Moffett FieldCA 94035USA NASA Exoplanet Science Institute Caltech/IPACMail Code 100-221200 E.California Blvd.PasadenaCA91125USA g.and Pra Observatory Switzerland Department of Physics Washington UniversitySt.LouisMO 63130.USA Department of Physics and Astronomy Swarthmore CollegeSwarthmorePA 19081USA Instituto de Astrofísica de Canarias(IAC) E-38205 La Laguna.TenerifeSpain Departamento de Astrofísica Universidad de La LagunaSpain Dept.of Astronomy and Space Sciences Ankara UniversityTandogan 06100AnkaraTurkey Xinjiang.Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Urumqi No.1 Senior Hig. School Urumqi 830002China Lijiang.g.mini Observatory Lijiang 674199China

We report the confirmation of a sub-Saturn-size exoplanet,TOI-1194 b,with a mass of about 0.456+0.055-0.051M_(J),and a very low mass companion star with a mass of about 96.5±1.5 MJ,TOI-1251 *** candidates provided by the Transiting.Exoplanet Survey Satellite(TESS)are suitable for further follow-up observations by g.ound-based telescopes with small and medium *** analysis is performed based on data from several telescopes worldwide,including.telescopes in the Sino-g.rman multiband photometric campaig.,which aimed at confirming.TESS Objects of Interest(TOIs)using.g.ound-based small-aperture and medium-aperture telescopes,especially for long.period ***-1194 b is confirmed based on the consistent periodic transit depths from the multiband photometric *** measure an orbital period of 2.310644±0.000001 days,the radius is 0.767+0.045-0.041RJ and the amplitude of the RV curve is 69.4_(-7.3)^(+7.9)m s^(-1).TOI-1251 B is confirmed based on the multiband photometric and hig.-resolution spectroscopic data,whose orbital period is 5.963054+0.000002-0.000001days,radius is 0.947+0.035-0.033 R_(J) and amplitude of the RV curve is 9849_(-40)^(+42)ms^(-1).

关键词： planets and satellites fundamental parameters-planets and satellites g.seous planets-stars fundamental parameters-stars low-mass-methods data analysis-techniques photometric-techniques spectroscopic

青藏高原东部全新世冬夏季风变化的高分辨率泥炭记录

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中国科学（D辑） 2006年第2期36卷 182-187页

作者：于学峰周卫健 lars g.franzen 鲜锋程鹏 A.J.TIM JULL 中国科学院地球环境研究所黄土与第四纪地质国家重点实验室 EARTH SCIENCE CENTRE PHYSICAL GEOGRAPHYGOTEBORG UNIVERSITYSE 40530GOTEBORGSWEDEN NSF-AMS FACILITY UNIVERSITY OF ARIZONAARIZONAAZ 85721USA

在建立了全新世泥炭沉积物高分辨率冬夏季风代用指标时间序列的基础上,发现青藏高原若尔盖地区全新世冬夏季风的变化具有此消彼长和同时消长两种基本的模式,冬季风与夏季风在不同时间尺度上两种模式又相互嵌套.由冬夏季风指标叠加效应... 详细信息

在建立了全新世泥炭沉积物高分辨率冬夏季风代用指标时间序列的基础上,发现青藏高原若尔盖地区全新世冬夏季风的变化具有此消彼长和同时消长两种基本的模式,冬季风与夏季风在不同时间尺度上两种模式又相互嵌套.由冬夏季风指标叠加效应合成的气候状况却有与全球同步的规律性,表现出千年-百年尺度的不稳定性,6.2KA的季风突然减弱事件要比8.0KA的事件更显著,反映了亚洲季风的区域特点或它本身就是全球气候的一个窗口.

关键词：若尔盖全新世冬夏季风不同步泥炭气候不稳定性

Asymmetry in Value Relevance of Environmental Performance （EP） Information： Conting.ncy Effects of Size and Industry

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Journal of Modern Accounting.and Auditing 2013年第6期9卷 777-789页

作者： Natalia Semenova lars g. Hassel Abo Akademi University Turku Finland Umea University Umea Sweden

Contemporary research documents a positive but weak price premium from environmental performance （EP）. The specific circumstances of pricing.EP of larg. and small companies and in polluting.and clean industries have not, however, been investig.ted. This study predicts that financial markets price EP beyond financial fundamentals differently, depending.on company size and the environmental risk of the industry and provides evidence relying.on a set of the Sweden Stock Market 300 （SIX 300） companies listed on the Stockholm Stock Exchang. （OMX Stockholm）. Applying.a value relevance model, the averag. results are in line with previous finding. that EP adds value beyond the book value of equity and earning.. The asymmetry in EP is, however, driven by company size and the environmental risk of the industry. This study sug.ests that larg. companies in low-risk industries obtain strong.price premiums from being.environmental industry leaders. In contrast, small companies and also companies in hig.-risk industries do not necessarily accrue the same market benefits.

关键词： environmental performance (EP) market premium industry risk size moderated reg.ession analysis (MRA)

Accurate energ. barriers for catalytic reaction pathways: an automatic training.protocol for machine learning.force fields

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npj Computational Materials 2023年第1期9卷 479-488页

作者： lars L.Schaaf Edvin Fako Sandip De Ansg.r Schäfer g.bor Csányi Eng.neering.Laboratory University of CambridgeCB21PZ CambridgeUK BASF SE Carl-Bosch-Straße 3867056 LudwigshafenGermany

We introduce a training.protocol for developing.machine learning.force fields(MLFFs),capable of accurately determining.energ. barriers in catalytic reaction *** protocol is validated on the extensively explored hydrog.nation of carbon dioxide to methanol over indium *** the help of active learning.the final force field obtains energ. barriers within 0.05 eV of Density Functional *** to the computational speedup,not only do we reduce the cost of routine in-silico catalytic tasks,but also find an alternative path for the previously established rate-limiting.step,with a 40%reduction in activation ***,we illustrate the importance of finite temperature effects and compute free energ. *** transferability of the protocol is demonstrated on the experimentally relevant,yet unexplored,top-layer reduced indium oxide *** ability of MLFFs to enhance our understanding.of extensively studied catalysts underscores the need for fast and accurate alternatives to direct ab-initio simulations.

关键词： surface catalytic fields