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Characterization of gut microbiome and metabolome in Helicobacter pylori patients in an underprivileged community in the United States

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World journal of Gastroenterology 2021年第33期27卷 5575-5594页

作者： Brian White john D Sterrett Zoya Grigoryan Lauren Lally jared D Heinze Hyder Alikhan Christopher A Lowry lark j perez joshua DeSipio Sangita Phadtare Department of Biomedical Sciences Cooper Medical School of Rowan UniversityCamdenNJ 08103United States Department of Integrative Physiology University of Colorado BoulderBoulderCO 80309United States Department of Internal Medicine Lenox Hill HospitalNYCNY 10075United States Department of Internal Medicine Thomas Jefferson University HospitalPhiladelphiaPA 19107United States Department of Biological Sciences Rowan UniversityGlassboroNJ 08028United States Department of Chemistry and Biochemistry Rowan UniversityGlassboroNJ 08028United States Department of Gastroenterology Cooper University HospitalCamdenNJ 08103United States

BACKGROUND Helicobacter pylori(***),a bacterium that infects approximately half of the world’s population,is associated with various gastrointestinal diseases,including peptic ulcers,non-ulcer dyspepsia,gastric adenocarcinoma,and gastric *** the burden of antibiotic resistance increases,the need for new adjunct therapies designed to facilitate *** eradication and reduce negative distal outcomes associated with infection has become more *** of the interactions between ***,the fecal microbiome,and fecal fatty acid metabolism,as well as the mechanisms underlying these interactions,may offer new therapeutic *** To characterize the gut microbiome and metabolome in *** patients in a socioeconomically challenged and underprivileged inner-city *** Stool samples from 19 *** patients and 16 control subjects were analyzed.16S rRNA gene sequencing was performed on normalized pooled amplicons using the Illumina MiSeq System using a MiSeq reagent kit *** and beta diversity analyses were performed in QIIME ***-targeted fatty acid analysis of the samples was carried out using gas chromatography-mass spectrometry,which measures the total content of 30 fatty acids in stool after conversion into their corresponding fatty acid methyl ***-dimensional scaling(MDS)was performed on Bray-Curtis distance matrices created from both the metabolomics and microbiome datasets and a Procrustes test was performed on the metabolomics and microbiome MDS *** Fecal microbiome analysis showed that alpha diversity was lowest in *** patients over 40 years of age compared to control subjects of similar age *** diversity analysis of the samples revealed significant differences in microbial community structure between *** patients and control subjects across all ***-eight and six taxa had lower and higher relative abundance in *** patients,*** that were e

关键词： Gut microbiome Metabolome Helicobacter pylori Antibiotic resistance Dysbiosis Eradication

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