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Greenlight Photoselective Vaporisation of the Prostate in 133 High Surgical Risk Patients: A 5-Year Outcome Study

Open Journal of Urology 2013年第2期3卷 90-95页

作者： Ignacio Gómez García Marta Romero Molina Emilio Rubio Hidalgo Luis álvarez Buitrago Natanael García Betancourt larissa lara Pablo Gutierrez Antonio Sampietro Crespo Fernando álvarez Férnandez Antonio Gómez Rodríguez LMR Group Madrid Spain Urology Service Hospital Río Ortega Valladolid Spain Urology Service Hospital Virgen de la Salud Toledo Spain

Greenlight photoselective vaporisation of the prostate (GPVP) is progressively becoming an established treatment in patients with LUTS because it is a minimally invasive technique that achieves efficient haemostasis, making it the ideal technique for patients at high surgical risk. Material and Methods: To study of 133 patients with an ASA surgical risk score of 3 or 4, undergoing GPVP, with an analysis of perioperative outcome, IPSS, Qmax, IIEF-5 and complications during a five-year follow-up. Results: At 5 years the mean annual improvement in IPSS was stable, and at 5 years there was a 15.2 point improvement versus the preoperative score (p 0.05). The Qmax showed an improvement of 14.9 ml/sec and was maintained at five years after surgery (p 0.05). No patients were transfused or suffered urinary incontinence. 2.25% suffered major complications and there were no deaths. 3.1% of patients suffered de novo urgency. In the 5-year follow-up, five patients had to be reoperated. The quality of sexual health assessed by IIEF-5 before the procedure was scored at 14 points;the 5-year follow-up covering the preoperative period and all revisions did not show any worsening in the IIEF-5 score (p > 0.05). Conclusions: Due to its physical characteristics, in our opinion GPVP is now the treatment of choice in patients at high surgical risk. In our series, the risk of major/minor complications and transfusions was much lower than the same risks in conventional techniques. The objective results (Qmax and quality of life questionnaire) are equivalent to conventional techniques and persist over a 5-year follow-up.

关键词： Greenlight Vaporisation PVP High Risk ASA

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Effects of <i>Pereskia aculeata</i>Miller on the Biochemical Profiles and Body Composition of Wistar Rats

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Journal of Biosciences and Medicines 2015年第7期3卷 82-89页

作者： Maricelma da Silva Soares de Souza Sandra Maria Barbalho Elen Landgraf Guiguer Adriano Cressoni Araújo Patrícia Cincotto dos Santos Bueno Flávia Maria Vasquez Farinazzi-Machado larissa Maria de lara Lima Beatriz Clivati da Silva Claudemir Gregório Mendes Department of Biochemistry and Pharmacology School of Medicine University of Marília Marília Brazil Department of Biochemistry and Nutrition Faculty of Food Technology of Marília (FATEC) Marília Brazil

Pereskia aculeata Miller commonly known as “ora-pro-nobis” has been used extensively in folclore medicine. Plant belongs to the family Cactacea and it is found in the Brazil (reaching Bahia and Rio Grande do Sul states). The purpose was to evaluate the effects of plant on biochemical and corporal profiles of Wistar rats. The 80 animals were divided randomly into 4 groups by sex (n = 10 females and 10 males per group) as follows: G1 group (water/rat food ad libitum);G2 group (drink A: commercial condensed milk, sugar and water/rat food ad libitum);G3 group (drink B: P. aculeata juice/rat food ad libitum);G4 group (drink C: commercial condensed milk, sugar and P. aculeate juice/rat food ad libitum). After 35 days their biochemical and corporal profiles were analyzed (cholesterol, glycemia, triglycerides, HDL-c, AST, ALT, Lee Index, weight and visceral fat). Intake of the plant caused no changes in the lipid profile of Wistar rats. However, intake in male rats of the same prevented the increase in triglycerides front of a hypercaloric diet. There were significant changes in glycemic index due to the high carbohydrate content of the plant. The plant was effective in reducing the levels of AST and ALT in male rats and ALT only in females. The use of the plant did not cause significant changes in the index of Lee but the Pereskia aculeata Miller may reduce visceral fat gain in female with a regular diet.

关键词： Pereskia aculeata Wistar Rats Glycemia Lipids Visceral Fat

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Impact of SARS-CoV-2 infection during pregnancy on postnatal brain development:The potential role of glial cells

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BIOCELL 2022年第12期46卷 2517-2523页

作者： larissa DANIELE BOBERMIN lara SCOPEL MEDEIROS FERNANDA WEBER GIANCARLO TOMAZZONI DE OLIVEIRA LUCÉLIA SANTI WALTER ORLANDO BEYS-DA-SILVA CARLOS-ALBERTO GONÇALVES ANDRÉQUINCOZES-SANTOS Programa de Pós-Graduação emNeurociências Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do SulPorto Alegre90050170Brazil Departamento de Bioquímica Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do SulPorto Alegre90035003Brazil Faculdade de Farmácia Universidade Federal do Rio Grande do SulPorto Alegre90610000Brazil Hospital de Clínicas de Porto Alegre Porto Alegre90035903Brazil Programa de Pós-Graduação emBiologia Celular eMolecular Centro de BiotecnologiaUniversidade Federal do Rio Grande do SulPorto Alegre91501970Brazil Programa de Pós-Graduação em Ciências Biológicas:Bioquímica Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do SulPorto Alegre90035003Brazil

Glial cells are crucial for maintaining central nervous system(CNS)homeostasis.They actively participate in immune responses,as well as form functional barriers,such as blood-brain barrier(BBB),which restrict the entry of pathogens and inflammatory mediators into the CNS.In general,viral infections during the gestational period can alter the embryonic and fetal environment,and the related inflammatory response may affect neurodevelopment and lead to behavioral dysfunction during later stage of life,as highlighted by our group for Zika virus infection.Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)induces a cytokine storm and,during pregnancy,may be related to a more severe form of the coronavirus disease-19(COVID-19)and also to higher preterm birth rates.SARS-CoV-2 can also affect the CNS by inducing neurochemical remodeling in neural cells,which can compromise neuronal plasticity and synaptic function.However,the impact of SARS-CoV-2 infection during pregnancy on postnatal CNS,including brain development during childhood and adulthood,remains undetermined.Our group has recently highlighted the impact of COVID-19 on the expression of molecular markers associated with neuropsychiatric disorders,which are strongly related to the inflammatory response.Thus,based on these relationships,we discussed the impact of SARS-CoV-2 infection either during pregnancy or in critical periods of neurodevelopment as a risk factor for neurological consequences in the offspring later in life,focusing on the potential role of glial cells.Thus,it is important to consider future and long-term public health concerns associated with SARS-CoV-2 infection during pregnancy.

关键词： Brain development Glial cells Inflammation Pregnancy SARS-CoV-2

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Impact of Association between Functional Training and Respiratory Muscle Training in Elderly: A Randomized Controlled Trial

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Journal of Biomedical Science and Engineering 2023年第1期16卷 1-15页

作者： Guilherme Medeiros de Alvarenga Jessica Aline Zarantonello Sauer larissa de Almeida de lara Julio Cesar Francisco Humberto Remigio Gamba Department of Electrical and Computer Engineering Federal University of Technology CPGEI Curitiba Brazil Department of Physiotherapy Positivo University UP Curitiba Brazil Unicuritiba Curitiba Brazil

The elderly population in Brazil has been growing exponentially according to data presented by the IBGE. It is estimated that by 2025 the population will have reached 32 million, placing the country sixth in the world in the population of elderly people. To assess the results of respiratory training associated with functional training on respiratory muscle strength, lung function, and functionality of the elderly. The sample was composed of 40 elderlies, divided into four groups, the experimental group with functional training, one experimental group with functional training associated with respiratory training, one experimental group with respiratory training, and the fourth group, the control group. After the initial and final evaluations, the variables measured were: The Breathing Test, Sit to Stand Test, the SF-36 Quality of Life Questionnaire, and Spirometry. Twenty appointments were conducted twice a week. There were significant differences for variables maximum inspiratory and expiratory pressure;more accentuated in the associated group when compared to the respiratory group;forced vital capacity and forced expiratory volume in the first second/forced vital capacity were meaningful in the associated group;peak expiratory flow means values increased after the intervention;in the six-minute walk test, we noticed a trend to increase values after the intervention. Functional training as well as associated respiratory muscle training provide the most beneficial changes compared only to functional and respiratory training. Therefore, this may be an effective clinical training method for patients’ elderly.

关键词： Physiotherapy Elderly Respiratory Training Muscle Strength Gerontology

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