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内脏高敏感性消化不良患者的痛觉过敏:疼痛特异性通路抑或多模式通路的致敏作用?

世界核心医学期刊文摘（胃肠病学分册） 2005年第10期1卷 31-31页

作者： Vandenberghe j. vos R. Persoons P. j. Tack 赵菊辉 Department of Internal Medicine Division of Gastraenterology University Hospital Gasthuisberg Herestraat 49 B-3000 Leuven Belgium Dr.

Background and aims: Patients with functional dyspepsia who have hypersensitivity to gastric distension have more prevalent pain, suggesting the presence of hyperalgesia. It is unclear whether this reflects activation of pain specific afferent pathways or multimodal afferent pathways that also mediate non-painful sensations. In the former case, hyperalgesia should occur when intensity of non-painful sensations is still low. The aim of the study was to analyse whether the symptom profile during gastric dissentions in functional dyspepsia patients with hyperalgesia reflects sensitisation of pain specific or multimodal pathways. Methods: Forty eight consecutive dyspeptic patients (35 female) underwent gastric sensitivity testing with a barostat balloon using a double random staircase protocol. At the end of every distending step, patients scored perception of upper abdominal sensations on a graphic 0-6 rating scale and completed visual analogue scales (VAS 0-100 mm) for pain, nausea, satiety, and fullness. The end point was a rating scale of 5 or more. Results: Hypersensitivity was present in 20 patients (40%); gastric compliance did not differ between normo-and hypersensitive patients. At maximal distension (score 5 or more), hypersensitive patients had significantly lower distending pressures and intra-balloon volumes, but similar VAS scores for pain, nausea, satiety, and fullness compared with normosensitive patients. In both normosensitive and hypersensitive patients, elevation of pain VAS scores with increasing distending pressures paralleled the elevation in VAS scores for nausea, satiety, and fullness. Conclusions: Hypersensitive dyspeptic patients reach the same intensity of painful and non-painful sensations as normosensitive patients but at lower distending pressures. Hyperalgesia occurs in hypersensitive dyspeptic patients at distending pressures that also induce intense non-painful sensations. These findings argue against isolated upregulation of pain speci

关键词：痛觉过敏致敏作用高敏感性特异性敏感性试验上腹部试验方案顺应性大时

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描述流行病学Meta回归框架

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中国医院统计 2019年第5期 401-401页

作者： Abraham D.Flaxman Theo vos Christopher j.L.Murray 宇传华周脉耕华盛顿大学健康测量与评价研究中心

1990年初世界银行和世界卫生组织联合倡导发起全球疾病负担(global burden of disease,GBD)研究。Christopher Murray教授(华盛顿大学健康测量与评价研究中心主任)和Alan Lopez教授(澳大利亚墨尔本大学人口与全球健康学院全球健康与疾... 详细信息

1990年初世界银行和世界卫生组织联合倡导发起全球疾病负担(global burden of disease,GBD)研究。Christopher Murray教授(华盛顿大学健康测量与评价研究中心主任)和Alan Lopez教授(澳大利亚墨尔本大学人口与全球健康学院全球健康与疾病负担测量组组长)作为GBD项目主要带头人,创建了伤残调整寿命年(DALY)和健康期望寿命(HALE)等指标,通过综合死亡率、患病率、发病率、缓解率等多种数据,全面评价致死和非致死性疾病和伤害所导致的疾病负担。目前正在进行GBD 2019的研究。随着大数据时

关键词：描述流行病学疾病负担

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Prospective study of Centurion~？ versus Infiniti~？ phacoemulsification systems： surgical and visual outcomes

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International journal of Ophthalmology(English edition) 2017年第11期10卷 1698-1702页

作者： Lawrence j.Oh Chu Luan Nguyen Eugene Wong Samuel S.Y.Wang Ian C.Francis University of New South Wales Sydney 2000 Australia Department of Ophthalmology Prince of Wales Hospital Sydney 2031 Australia Chatswood Private Hospital Chatswood Sydney 2067 Australia

AIM： To evaluate surgical outcomes（SOs） and visual outcomes（vos） in cataract surgery comparing the Centurion？ phacoemulsification system（CPS） with the Infiniti？ phacoemulsification system（IPS）.METHODS： Prospective, consecutive study in a singlesite private practice. Totally 412 patients undergoing cataract surgery with either the CPS using the 30-degree balanced？ tip（n=207） or the IPS using the 30-degree Kelman？ tip（n=205）. Intraoperative and postoperative outcomes were documented prospectively up to one month follow-up. Nuclear sclerosis（NS） grade, cumulated dissipated energy（CDE）, preoperative corrected distance visual acuity（CDVA）, and CDVA at one month were recorded. RESULTS： CDE was 13.50% less in the whole CPS compared with the whole IPS subcohort. In eyes with NS grade III or greater, CDE was 28.87% less with CPS（n=70） compared with IPS（n=44）（P=0.010）. Surgical complications were not statistically different between the two subcohorts（P=0.083）, but in the one case of vitreous loss using the CPS, CDVA of 6/4 was achieved at one month. The mean CDVAs（vos） at one month for NS grade III and above cataracts were-0.17 log MAR（6/4.5） in the CPS and-0.15 log MAR（6/4.5） in the IPS subcohort respectively（P=0.033）.CONCLUSION： CDE is 28.87% less, and vos are significantly improved, in denser cataracts in the CPS compared with the IPS. The authors recommend the CPS for cases with denser nuclei.

关键词： phacoemulsification Infiniti Centurion cumulated dissipated energy visual and surgical outcomes

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α2-Heremans-schmid glycoprotein(fetuin A)downregulation and its utility in inflammatory bowel disease

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World journal of Gastroenterology 2017年第3期23卷 437-446页

作者： Anastassios C Manolakis Gregory Christodoulidis Andreas N Kapsoritakis Panagiotis Georgoulias Elisavet K Tiaka Kostas Oikonomou Varvara j Spyros P Potamianos Department of Gastroenterology University of ThessalySchool of Medicine41110 LarissaGreece Department of Surgery University of ThessalySchool of Medicine41110 LarissaGreece Laboratory of Nuclear Medicine University of ThessalySchool of Medicine41110 LarissaGreece

AIM To investigate the impact of inflammatory bowel disease (IBD) on α2-Heremans-Schmid Glycoprotein(AHSG/fetuin A) and potential associations with disease and patient *** AHSG serum levels were determined in treatment-na?ve newly-diagnosed patients, 96 with ulcerative colitis(UC), 84 with Crohn's disease (CD), 62 with diarrheapredominant or mixed irritable bowel syndrome (IBS, D- and M- types) and 180 healthy controls (HC), by an enzyme linked immunosorbent assay (ELISA).All patients were followed for a minimum period of 3 years at the Gastroenterology Department of the University Hospital of larissa, Greece. C-reactive protein(CRP), anti-glycan antibodies, anti-Saccharomyces cerevisiae mannan antibodies Ig G, anti-mannobioside carbohydrate antibodies Ig G, anti-laminariobioside carbohydrate antibodies Ig G and anti-chitobioside carbohydrate antibodies Ig A were also determined via immunonephelometry and ELISA, *** The mean ± SE of serum AHSG, following adjustment for confounders, was 0.32 ± 0.02 g/L in IBD, 0.32 ± 0.03 g/L in CD and 0.34 ± 0.03 g/L in UC patients, significantly lower than in IBS patients(0.7 ± 0.018 g/L) and HC (0.71 ± 0.02 g/L) (P justed analysis verified the inverse association between AHSG and penetrating, as well as stricturing CD (partial correlation coefficient: -0.45 and -0.33, respectively) (P justing for confounding factors, inverse correlations between AHSG and CRP and the need for anti-TNFα therapy or surgery, were found (partial correlation coefficients:-0.31,-0.33,-0.41, respectively, P < 0.05, in all cases). Finally, IBD individuals who were seropositive, for at least one marker, had AHSG levels falling within the two lower quartiles (OR = 2.86, 95%CI: 1.5-5.44, P < 0.001) while

关键词： Inflammatory bowel disease Irritable bowel syndrome Fetuin A

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1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)

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伤害医学（电子版） 2020年第2期9卷 52-59页

作者：林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng juanita A Haagsma jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L james Theo vos Christopher j L Murray 汕头大学医学院伤害预防研究中心汕头515041 不详

伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶... 详细信息

伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币.

关键词：直接医疗费用呼吸系统疾病心脑血管疾病公共卫生心肌梗死恶性肿瘤致死原因人口老龄化趋势

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Prevention,diagnostic evaluation,management and prognostic implications of liver disease in critically ill patients with COVID-19

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World journal of Clinical Cases 2023年第3期11卷 514-527页

作者： Asimina Valsamaki Maria Xanthoudaki Katerina G Oikonomou Panagiotis j Vlachostergios AntoniosPapadogoulas Periklis Katsiafylloudis Ioanna Voulgaridi Apostolia-Lemonia Skoura Apostolos Komnos Panagiotis Papamichalis Intensive Care Unit General Hospital of LarissaLarissa 41221Greece Division of Hematology and Medical Oncology Department of MedicineWeill Cornell MedicineNew YorkNY 10065United States Department of Microbiology General Hospital of LarissaLarissa 41221Greece Transfusion Medicine Department University Hospital of LarissaLarissa 41110Greece

Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2,broke out in December 2019 in Wuhan city of China and spread rapidly ***,by March 2020,the World Health Organization declared the disease a global *** from the respiratory system,various other organs of the human body are also seriously affected by the *** injury in patients with a severe form of COVID-19 is estimated to be 14.8%-53.0%.Elevated levels of total bilirubin,aspartate aminotransferase and alanine aminotransferase and low levels of serum albumin and prealbumin are the main laboratory *** with pre-existing chronic liver disease and cirrhosis are much more prone to develop severe liver *** literature review presented the recent scientific findings regarding the pathophysiological mechanisms responsible for liver injury in critically ill patients with COVID-19,the various interactions between drugs used to treat the disease and the function of the liver and the specific tests providing the possibility of early diagnosis of severe liver injury in these ***,it highlighted the burden that COVID-19 put on health systems worldwide and its effect on transplant programs and the care provided to critically ill patients in general and particularly to those with chronic liver disease.

关键词： Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 Liver disease Intensive care unit Liver unit Prealbumin

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Neuroendocrine differentiation and the ubiquitinproteasome system in cancer:Partners or enemies?

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World journal of Experimental Medicine 2011年第1期1卷 7-9页

作者： Panagiotis j Vlachostergios Christos N Papandreou Department of Medical Oncology University of Thessaly School of MedicineUniversity Hospital of LarissaBiopolis 41110LarissaGreece

Neuroendocrine(NE)differentiation of cancer and deregulation of the ubiquitin-proteasome system(UPS)are two processes that have been independently linked to the development of aggressive and treatment-resistant *** data suggest a plausible interconnection between these two mechanisms,based on indirect evidence of neuropeptide-induced effects on UPS,reversed by proteasome inhibition and deubiquitinaselike properties of NE *** the model of their exact interactions is one of the keys to targeting the NE malignant phenotype more effectively.

关键词： Neuroendocrine differentiation Ubiquitin Proteasome Cancer

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前列腺7 T MR T2WI的影像质量及其对前列腺癌的显示能力

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国际医学放射学杂志 2014年第5期 507-507页

作者： E.K.vos M.W.Lagemaat j.O.Barentsz j.j.Fütterer P.Zámecnik H.Roozen 吴寒 Department of Radiology Radboud University Medical Centre

摘要目的评价前列腺7 T MR T2WI的影像质量及前列腺癌的可见性。方法在7 T条件下采用单一的体外发射/接收线圈对17例前列腺癌病人行MR T2WI检查。由3名放

关键词：前列腺癌可见性接收线圈病人 T MR T2WI 影像质量 MR

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眼咽肌营养不良患者的上睑下垂加重其吞咽困难

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世界核心医学期刊文摘（神经病学分册） 2006年第6期2卷 37-37页

作者： De Swart B.j.M. Van Der Sluijs B.M. vos A.M.C. 王孝文 304 Neuromuscular Centre Nijmegen Institute of Neurology Radboud University Nijmegen Medical Centre PO Box 9101 6500 HB Nijmegen Netherlands

Background: Ptosis and dysphagia are important features in oculopharyngeal muscular dystrophy (OPMD). Objective: Retroflexion of the head is a well known compensatory mechanism for ptosis, but generally retroflexion has a negative effect on swallowing. We hypothesised that severity of ptosis is related to degree of retroflexion and that this compensation is responsible for deteriorating dysphagia. Methods: Nine OPMD patients were examined in the conditions “head position adapted to ptosis" and “head position slightly flexed". Ptosis was quantified by photogrammetry and retroflexion of the head by digital photographs. The severity of dysphagia was measured using visual analogue scales (VAS) and by calculating swallowing volumes and oropharyngeal swallow efficiency (OPSE) based on videofluoroscopy. Results: Statistical analyses show a significant relationship between ptosis and degree of retroflexion. The degree of retroflexion of the head correlated significantly with VAS scores and with the maximum swallowing volume. The slightly flexed head position significantly improved VAS scores as well as swallowing volumes and OPSE. Conclusion: In OPMD patients, ptosis significantly correlates with retroflexion of the head, which has a negative effect on swallowing. Subjective and objective reduction of swallowing problems was found when patients were instructed to eat and drink with a slightly flexed head position.

关键词：吞咽困难上睑下垂肌营养不良患者视频荧光造影检查头部位置 VAS评分视觉模拟量表严重程度

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Gastroenterology and liver disease during COVID-19 and in anticipation of post-COVID-19 era: Current practice and future directions

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World journal of Clinical Cases 2021年第19期9卷 4918-4938页

作者： Katerina G Oikonomou Panagiotis Papamichalis Tilemachos Zafeiridis Maria Xanthoudaki Evangelia Papapostolou Asimina Valsamaki Konstantinos Bouliaris Michail Papamichalis Marios Karvouniaris Panagiotis j Vlachostergios Apostolia-Lemonia Skoura Apostolos Komnos Intensive Care Unit General Hospital of LarissaLarissa 41221ThessalyGreece Surgical Department General Hospital of LarissaLarissa 41221ThessalyGreece Department of Cardiology University Hospital of LarissaLarissa 41110ThessalyGreece Intensive Care Unit University Hospital of LarissaLarissa 41110ThessalyGreece Division of Hematology and Medical Oncology Department of MedicineWeill Cornell MedicineNew YorkNY 10065United States Transfusion Medicine Department University Hospital of LarissaLarissa 41110ThessalyGreece

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has emerged as a major threat to global public *** virus causes the clinical syndrome known as coronavirus disease 2019(COVID-19),in which multiple organs can get *** from manifestations of the respiratory system,which predominate,its clinical presentation is frequently accompanied by symptoms of the gastrointestinal(GI)tract and liver *** correlation of symptoms and abnormalities with disease severity is discussed,leading to ambiguous results from international ***,the disease infects patients with coexisting liver and GI disorders affecting both their health status and the availability of healthcare services provided to *** risk of transmission of the disease during aerosol-generating procedures has changed the diagnostic approach and follow-up algorithms for liver and GI *** the safety of both doctors and patients,telemedicine and distant evaluation have become everyday practice,whereas several routines and emergency visits at outpatient and emergency departments have been postponed or *** against SARS-CoV-2 is underway,providing hope to humanity and the expectation that the post-COVID-19 era is *** review aims to update knowledge about the manifestations of COVID-19 related to liver and GI diseases and the effect of the pandemic on the diagnostic and therapeutic procedures for these diseases with a special focus on how current practices have changed and what changes will possibly remain in the future.

关键词： COVID-19 SARS-CoV-2 Liver disease Gastroenterology practice Endoscopy

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