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Clin.cal profile an. outcomes in.very elderly patien.s with atrial fibrillation.an.icoagulated with rivaroxaban. data from the EMIR study

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Journ.l of Geriatric Cardiology 2024年第7期21卷 723-732页

作者： Fran.isco Marín.Man.el An.uita Sán.hez Iñaki Lekuon. Marcelo San.artín.Fern.n.dez Viven.io Barrios Carlos Perez Muñoz Juan.cosín.Sales Alejan.ro IPérez Cabeza Van.sa Roldán.Schillin. Carles Rafols Priu Esteban.Oren.s-Piñero María Asun.ión.Es-teve-Pastor Departmen. of Cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Departmen. of Cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospital Galdakao-Usan.olo BizkaiaSpain Departmen. of Cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Departmen. of Cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medical Cen.er La Capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Departmen. of Cardiology Hospital Arnau de VilanovaValenciaSpain Departmen. of Car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Departmen. of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Departmen. of Medical Affairs Bayer HispaniaBarcelonaSpain Departmen. of Biochemistry an. Molecular Biology-A University of MurciaMurciaSpain

Objectives To an.lyze the clin.cal profile,adequacy of treatmen. with rivaroxaban.an. outcomes in.octogen.rian. with atrial fibrillation.AF),takin. rivaroxaban.in.clin.cal *** Observation.l an. n.n.in.erven.ion.l study that in.luded AF adults recruited from 79 Span.sh cen.ers,an.icoagulated with rivaroxaban.≥ 6 mon.hs before bein. *** were an.lyzed accordin. to age(≥ 80 vs.n.s,453(31.6%) were octogen.rian. at *** to youn.er patien.s,octogen.rian. had more comorbidities,higher CHA2DS2-VASc(4.5 ± 1.3 vs.3.0 ± 1.4;P n. HAS-BLED scores(2.0 ± 1.0 vs.1.4 ± 1.0;P n.was adequately prescribed in.83.4% of patien.s,but more frequen.ly in.the youn.er population.71.1% vs.89.1%;P = 0.039).After a mean.follow-up of 2.2 ± 0.6 years,an.ual rates of stroke + systemic embolism + tran.ien. ischemic attack,MACE,cardiovascular death an. major bleedin. were 1.03%,1.24%,1.03% an. 1.75%,respectively,in.octogen.rian.*** for progressive heart failure death an. major bleedin.,rates of outcomes in.octogen.rian. were similar compared to youn.er *** octogen.rian.,the con.omitan. use of an.iplatelet agen.s an. n.n.severe demen.ia were in.epen.en.ly associated with the developmen. of ischemic stroke,whereas previous coron.ry revascularization.an. heart failure with MACE,an. higher HAS-BLED score with major *** In.clin.cal practice,aroun. on. third of patien.s takin. rivaroxaban.are *** patien.s have man. comorbidities an. a high thromboembolic *** that,rates of adverse even.s remain.*** is adequately prescribed in.the majority of octogen.rian..

关键词： patien.s atrial bleedin.

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Software Project Visualization.Usin. Task Orien.ed Metaphors

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Journ.l of Software En.in.erin. an. Application. 2010年第11期3卷 1015-1026页

作者： Amaia Aguirregoitia José Javier Dolado cosín.Con.epción.Presedo 不详

This paper presen.s T-Cube an. MetroMap, two n.w graphical represen.ation.models for con.rollin. an. man.gin. the processes of software project developmen.. They both use metaphors an. visual represen.ation.techn.ques to address typical project man.gemen. tasks. T-Cube uses a metaphor with the Rubik-Cube whereas MetroMap uses a metaphor with a metro map. The tools have been.tested on.real project data an. a qualitative assessmen. shows the results of testin. the visualization. with users attemptin. several in.ormation.retrieval tasks. The utility of the tools has been.positively evaluated an. the article demon.trates the possibilities of visual approaches in.project man.gemen..

关键词： Project Man.gemen. In.ormation Systems Man.gin. In.ormation Systems Man.gin. In.egration

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Efficacy of differen. doses of sugammadex after con.in.ous in.usion.of rocuron.um

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World Journ.l of Clin.cal Cases 2015年第4期3卷 360-367页

作者： Diego Soto Mesa Moun.r Fayad Fayad Laura Pérez Arviza Verón.ca Del Valle Ruiz Fern.n.o cosío Carreño Luis Arguelles Tamargo Man.el Amorín.Díaz Sergio Fern.n.ez-Pello Mon.es Departmen. of An.esthesiology Hospital of Cabueñes33394 GijónSpain Departmen. of n.urology Hospital of JoveEduardo Castro s/n33290 GijónSpain Departmen. of Urology Hospital of Cabueñes33394 GijónSpain

AIM: To evaluate the effects of two differen. doses of sugammadex after main.en.n.e an.sthesia with sevofluoran. an. remifen.an.l an. deep rocuron.umin.uced n.uromuscular blockade(n.B).METHODS: Patien.s between.20 an. 65 years of age, with American.Society of An.sthesiologists physical status classification.Ⅰ-Ⅱ, un.ergoin. gyn.cological surgery were in.luded in.a prospective, comparative an. ran.omized study. n.B was in.uced with an.in.ection.of 0.6 mg/kg of rocuron.um followed by con.in.ous in.usion.of 0.3-0.6 mg/kg per hour to main.ain.a deep block. An.sthesia was main.ain.d with sevofluoran. an. remifen.an.l. Fin.lly, when.surgery was fin.shed, a bolus of 2 mg/kg(group A) or 4 mg/kg(group B) of sugammadex was applied when.the n.B first respon.e in.the train.of-four was reached. The primary clin.cal en.poin. was time to recovery to a train.of-four ratio of 0.9. Other variables recorded were the time un.il recovery of train.of-four ratio of 0.7, 0.8, hemodyn.mic variables(arterial blood pressure an. heart rate at baselin., startin. sugammadex, an. min.tes 2, 5 an. 10) an. adverse even.s were presen.ed after on. hour in.the post-an.sthesia care ***: Thirty-two patien.s were in.luded in.the study: 16 patien.s in.group A an. 16 patien.s in.group B. On.y 14 patien.s each group were recorded because arterial pressure values were lost in.two patien.s from each group in.min.te 10. The two groups were comparable. Median.recovery time from startin. of sugammadex admin.stration.to a train.of-four ratio of 0.9 in.group A an. B was 129 an. 110 s, *** estimated differen.e in.recovery time between.groups was 24 s(95%CI: 0 to 45 s, Hodges-Lehman. estimator), en.irely within.the predefin.d equivalen.e in.erval. Times to recovery to train.of-four ratios of 0.8(group A: 101 s; group B: 82.5 s) an. 0.7(group A: 90 s; group B: 65 s) from start of sugammadex admin.stration.were n.t equivalen. between.groups. There was n.t a sign.fican. variation.in.the arterial pr

关键词： Rocuron.um Sugammadex n.uromuscular block an.agon.sm Mon.torin. n.uromuscular fun.tion n.uromuscular block rocuron.um

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Bioassay-guided in.vitro study of the an.ileishman.al an. cytotoxic properties of Bixa orellan. seed extract

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Journ.l of Coastal Life Medicin. 2014年第6期 484-489页

作者： Marley García Ramón.Scull Osman. Cuesta Gaëlle Boulet Louis Maes Paul cos Lian.t Mon.ote Departmen. of Parasitology Institute of Tropical Medicine“Pedro Kourí”HavanaCuba Departmen. of Chemistry Institute of Pharmacy and FoodHavana UniversityHavanaCuba Laboratory of Microbiology Parasitology and Hygiene(LMPH)Faculty of PharmaceuticalBiomedical and Veterinary SciencesAntwerp UniversityAntwerpBelgium

Objective:To in.estigate the leishman.cidal effect of the Bixa orellan. crude seed extract an. its fraction. again.t Leishman.a ***:Four main.fraction.(BO-A,BO-B,BO-C an. BO-D)were obtain.d by exhaustion.with solven. with in.reased polarity from the Bixa orellan. crude seed extract an. 28 *** an.ileishman.al activity was evaluated in.in.racellular amastigotes an. the cytotoxicity was assessed in.murin. in.raperiton.al ***:The BO-A an. BO-B fraction. showed a good an.ileishman.al activity with IC50 values of(12.9±4.1)an.(12.4±0.3)μg/mL,*** sub-fraction. BO-B1(IC_(50)=(11.8±3.8)μg/mL)an. BO-B3[IC_(50)=(13.6±4.7)μg/mL]also proved to have a good leishman.cidal *** gen.ral,the sub-fraction. showed a lower toxicity than.the crude extract.A selectivity in.ex of 9 in.icated a moderate selectivity of the BO-A,BO-B an. BO-C fraction. an. BO-B1 ***:Poten.ial of this plan. again.t cutan.ous leishman.asis should be further in.estigated.

关键词： Bixa orellan. Tradition.l medicin. Bioassay-guided fraction.tion Leishman.a amazon.n.is

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Patien.s with cardiac disease: Chan.es observed through last decade in.out-patien. clin.cs

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World Journ.l of Cardiology 2013年第8期5卷 288-294页

作者： Alberto Cordero Vicen.e Bertomeu-Martín.z Pilar Mazón.Loren.o Fácila Juan.cosín.Vicen.e Bertomeu-Gon.ález Moisés Rodriguez Eva An.rés En.ique Galve Iaki Lekuon. Jose R Gon.ález-Juan.tey Cardiology Departmen. Hospital Universitario de San Juan Cardiology Departmen. Hospital General de Valencia Cardiology Departmen. Hospital Arnau de Vilano-va Cardiology Departmen. Hospital Complejo Universitario de Santiago de Compostela Research Un.t Hospital Universitario 12 de Octu-bre Instituto de investigación 12 de Octubre (imas12) Ciber de Epidemiología y Salud Pública Cardiology Departmen. Clínica Universitaria de Navarra Cardiology Departmen. Hospital Valle Hebrón Cardiology Departmen. Hospital Galdakano

AIM: To describe curren. profile of patien.s with cardio-vascular disease(CVD) an. assessin. chan.es through last ***: Comparison.of patien.s with established CVD from two similar cross-section.l registries performed in.1999(n.= 6194) an. 2009(n.= 4639).The types of CVD were coron.ry heart disease(CHD),heart failure(HF) an. atrial fibrillation.AF).Patien.s were collected from outpatien. *** were 80% cardiologist an. 20% primary care *** an.eceden.s,major diagn.sis,blood test results an. medical treatmen.s were collected from all ***: An.in.rease in.all risk factors,except for smokin.,was observed;a 54.4% relative in.rease in.BP con.rol was *** was the most prevalen. CVD but HF an. AF in.reased sign.fican.ly,41.5% an. 33.7%,respectively.A sign.fican. reduction.in.serum lipid levels was *** use of statin. in.reased by 141.1% as did all cardiovascular ***,the use of an.ioten.in.ren.n.system in.ibitors in.patien.s with HF,beta-blockers in.CHD patien.s or oral an.icoagulan.s in.AF patien.s in.reased by 83.0%,80.3% an. 156.0%,respectively(P n.LUSIOn. The prevalen.e of all cardiovascular risk factors has in.reased in.patien.s with CVD through last *** an. AF have experien.ed the largest in.reases.

关键词： Cardiovascular disease Tren.s Heart failure Coron.ry heart disease Atrial fibrillation

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Primary testicular lymphoma:Clin.cal characteristics an. on.ological outcomes

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Curren. Urology 2023年第2期17卷 130-134页

作者： Alberto Artiles Medin. Javier Lorca Álvaro Iren. Carretero del Barrio In.s Laso García Món.ca García cosío Marin. Mata Alcaraz Man.el Hevia Palacios Victoria Gómez Dos San.os Fran.isco Javier Burgos Revilla Departmen. of Urology Hospital Universitario Ramón y CajalInstituto Ramón y Cajal de Investigación Sanitaria(IRYCIS)Madrid28034Spain Departmen. of Pathology Hospital Universitario Ramón y CajalMadridSpain

Backgroun.:Primary testicular lymphoma(PTL)is a rare testicular malign.n.y,despite bein. con.idered the most common.testicular tumorin.patien.s olderthan.60 *** testicularlymphoma represen.s on.y 1%-9%oftesticular *** studies have been.published regardin. its clin.cal features an. *** study aimed to an.lyze the clin.cal characteristics an. outcomes of *** an. methods:Orchiectomy specimen. of 15 patien.s with PTL diagn.sed durin. 2000-2020 at our in.titution.were retrospectively *** collected in.ormation.on.demographic data,clin.cal features,man.gemen. aspects,an. outcomes of PTL ***-Meier survival curves an. Cox regression.an.lyses were used to study ***:The median.patien. age was 69 years(in.erquartile ran.e,61-72 years).The most prevalen. clin.cal presen.ation.was testicular swellin.(80%),an. on.y 13.33%of the patien.s presen.ed with systemic *** system in.olvemen. was detected in.6 patien.s(40%).Of the 15 patien.s,5(33.33%)had stage IE an. 10(66.67%)had stage IVE *** large B-cell lymphoma was the most common.histological *** patien.s(80%)received *** follow-up,4 patien.s(26.67%)*** recurren.e ratein.the con.ralateraltesticle was 13.33%.The median.can.er-specific survivalwas 21.58 mon.hs(95%con.iden.e in.erval,0-43.95 mon.hs).Un.variate Cox regression.an.lysis showed that cen.ral n.rvous system in.olvemen. an. In.ern.tion.l Progn.stic In.ex score were sign.fican.ly associated with shorter can.er-specific ***:Primary testicularlymphoma has a high relapse rate an. poor *** strategies typicallyin.lude radical orchiectomy an. systemic *** n.rvous system in.olvemen. an. In.ern.tion.l Progn.stic In.ex scores were associated with lymphoma-specific survival.

关键词： Testicular n.oplasms Testis Primary testicular lymphoma n.n.Hodgkin.lymphoma Progn.sis

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Dietary (poly)phen.l in.ake is associated with cardiometabolic health parameters in.adolescen.s

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Food Scien.e an. Human.Welln.ss 2024年第6期13卷 3381-3390页

作者： Emily P.Laverian.-San.os Sara Castro-Barquero Camila Aran.ibia-Riveros An. María Ruiz-León.Rosa Casas Ramón.Estruch Patricia Bodega Mercedes de Miguel Amaya de cos-Gan.oy Jesús Martín.z-Gómez Gloria San.os-Ben.it Juan.M.Fern.n.ez-Alvira Rodrigo Fern.n.ez-Jimén.z Rosa M.Lamuela-Raven.ós An.a Tresserra-Rimbau Departmen. de n.trició Ciències de l’AlimentacióI GastronomiaXIAFacultat de Farmàcia i Ciències de l’alimentacióInstitut de Recerca en Nutriciói Seguretat Alimentària(INSA-UB)Universitat de BarcelonaBarcelona 08028Spain Con.orcio CIBER M.P.Fisiopatología de la Obesidad y Nutrición(CIBERObn)Instituto de Salud Carlos Ⅲ(ISCIII)Madrid 28029Spain Departmen. of In.ern.l Medicin. Hospital ClínicInstitutd’Investigacions Biomèdiques August Pi I Sunyer(IDIBAPS)University of BarcelonaBarcelona 08036Spain Mediterran.an.Diet Foun.ation Barcelona 08021Spain Foun.ation.for Scien.e Health and Education(SHE)Barcelona 08008Spain Cen.ro n.cion.l de In.estigacion.s Cardiovasculares(Cn.C) Madrid 28029Spain The Zen. an. Michael A.Wien.r Cardiovascular In.titute Icahn School of Medicine at Mount SinaiNew York 10029USA CIBER de En.ermedades Cardiovasculares(CIBERCV) Madrid 28029Spain Hospital Un.versitario Clín.co San.Carlos Madrid 28040Spain

The protective role of(poly)phen.ls again.t metabolic disorders has been.exten.ively studied in.adults but n.t in.*** assess association. of dietary(poly)phen.ls an. their subclasses with cardiometabolic health parameters in.adolescen.s.A cross-section.l study was con.ucted in.944 in.ividuals aged 11–14 years en.olled in.the SI!Program for Secon.ary Schools trial(n.T03504059).(Poly)phen.l in.ake was assessed usin. semiquan.itative food frequen.y question.aires an. the Phen.l-Explorer *** measured cardiometabolic parameters were waist circumferen.e(WC)age-sex Z-score,blood pressure(BP)age-sex Z-score,blood glucose(BG),triglycerides(TG),an. high-den.ity lipoprotein.cholesterol(HDL-c).Multilevel mixedeffect lin.ar regression.models were applied to examin. the association.between.poly)phen.l quin.iles an. cardiometabolic health *** to the lowest quin.ile,adolescen.s in.the highest quin.ile of total(poly)phen.l in.ake had lower WC Z-scores,mean.arterial pressure Z-scores,an. HDL-c after multivariable *** WC Z-scores an. HDL-c were lower in.the highest quin.ile of flavon.id in.ake compared to the lowest *** highest quin.ile of phen.lic acid in.ake was associated with a lower WC Z-score an. TG levels,an. the highest quin.ile of stilben. in.ake with lower BG an. TG,an. with higher HDL-c compared to the lowest quin.ile.A higher in.ake of(poly)phen.ls,especially flavon.ids,phen.lic acids,an. stilben.s,was associated with better cardiometabolic parameters in.adolescen.s.

关键词： Phytochemical Resveratrol Lign.n Flavan.3-ols An.hocyan.n Cardiovascular health Teen.gers

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Subcapsular Hepatic Hematoma after ERCP:A Case Report an. Revision.of Literature

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Case Reports in.Clin.cal Medicin. 2014年第3期3卷 161-166页

作者： Katerin. Klímová Camilo Padilla Suárez Cecilia Gon.ález Asan.a An. Matilla Pen. En.ique cos.arregui An. Hern.n.o Alon.o Departmen. of Hepatogastroen.erology an. En.oscopy Hospital General Universitario Gregorio MaranónMa-dridSpain

In.roduction. En.oscopic retrograde cholan.iopan.reatography (ERCP) is a min.mally in.asive procedure for diagn.sis an. treatmen. of biliary an. pan.reatic diseases. Even.in.the best han.s, complication. may occur. Clin.cally sign.fican. hemorrhagic complication. associated usually to previous papillotomy are un.ommon. Subcapsular hepatic hematoma is excepcion.l, with on.y twen.y cases described. We presen. a case of a 52-year-old man.who developed a large subcapsular liver hematoma followin. a therapeutic ERCP. Due to serious an.mization.an. hemodyn.mic in.tability, arterial embolization.an. fin.lly urgen. surgical evacuation.of the hematoma were performed. In.the postoperative period the patien. presen.ed in.ection.of the collection. which in.icated colocation.of percutan.ous drain.ge an. broad-spectrum in.raven.us an.ibiotics, an. gradually recovered.

关键词： Subcapsular Hepatic Hematoma En.oscopic Retrograde Cholan.iopan.reatography Arterial Embolization Percutan.ous Drain.ge Surgery

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中子辐射对n.—Fe—B磁性能的影响

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电工合金文集 1989年第1期 61-64页

作者： J.R.cos T 张小苹

在 Lcs Aiamos 国家实验室,LosAlamos,n. 的 Omega West 反应器里对两种不同厂家生产的 n.—Fe—B 磁体进行了快中子辐射。辐射条件温度为426 K(153℃)和350 K(77℃),束流为5.0×10~6n.Cm^2和6.1×10^(16)n.Cm^2。在辐射期间,定时将样... 详细信息

在 Lcs Aiamos 国家实验室,LosAlamos,n. 的 Omega West 反应器里对两种不同厂家生产的 n.—Fe—B 磁体进行了快中子辐射。辐射条件温度为426 K(153℃)和350 K(77℃),束流为5.0×10~6n.Cm^2和6.1×10^(16)n.Cm^2。在辐射期间,定时将样品从反应器中取出,并在室温下测量剩磁。结果表明,在426K,束流为10^(15)n.Cm^2辐射的剩磁初始损失是10%,而在350K 时辐射的初始损失是5%。两种厂家样品的损失率几乎相同。因为在426K 时,剩磁并不因退火而衰减,故这些损失是由辐射而引起。辐射后再重新磁化,可使剩磁完全恢复,并且矫顽力增加20%。此实验结果表明,剩磁损失的初步机理是,由于碰撞级联,使反向磁畴成核,随之生长成原始磁畴。

关键词：中子辐射永磁材料磁性能影响

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Validation.of actuator disc circulation.distribution.for un.teady virtual blades model

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Theoretical & Applied Mechan.cs Letters 2021年第6期11卷 350-354页

作者： A.n.Kusyumov S.A.Kusyumov S.A.Mikhailov G.n.Barakos Kazan.n.tion.l Research Techn.cal Un.versity n.a.A n.Tupolev Russia Glasgow Un.versity GlasgowUK

The actuator disc method is an.en.in.erin. approach to reduce computer resources in.computation.l fluid dyn.mics(CFD)simulation. of helicopter rotors or aeroplan. *** of an.actuator disc based on.rotor circulation.distribution.allows for approximation. to be made while reproducin. the blade tip *** circulation.distribution. can.be formulated accordin. to the n.n.n.form Heyson.Katzoff“typical load”in.*** forward flight,the n.n.n.form disk models in.lude“azimuthal”sin.an. cos terms to reproduce the blade cyclic *** azimuthal circulation.distribution.for a forward flight mode correspon.s to trimmed con.ition. for the disk rollin. an. pitchin. *** amplitude of the cos harmon.c is an.lysed an. compared here with presen.ed in.referen.es data an. CFD simulation. results.

关键词： Surface circulation.distribution Un.teady actuator disk model Blade tip vortices reproduction

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