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Auranofin and its analogs as prospective agents for the treatment of colorectal cancer

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Cancer Drug Resistance 2022年第1期5卷 1-14页

作者： lara Massai Damiano Cirri Tiziano Marzo Luigi Messori Department of Chemistry University of FlorenceSesto Fiorentino 50019Italy Department of Chemistry and Industrial Chemistry University of PisaPisa 56124Italy Department of Pharmacy University of PisaPisa 56126Italy CISUP-Centre for Instrumentation Sharing(Centro per l’Integrazione della Strumentazione Scientifica) University of PisaPisa 56126Italy University Consortium for Research in the Chemistry of Metal ions in Biological Systems(CIRCMSB) Bari 70126Italy

Today colorectal cancer(CRC)is one of the leading causes of cancer death *** disease is poorly chemo-sensitive toward the existing medical treatments so that new and more effective therapeutic agents are urgently needed and intensely *** drugs,oxaliplatin in particular,were reported to produce some significant benefit in CRC treatment,triggering the general interest of medicinal chemists and oncologists for metal-based compounds as candidate anti-CRC *** this frame,gold compounds and,specifically,the established antiarthritic drug auranofin with its analogs,form a novel group of promising anticancer *** to its innovative mechanism of action and its favorable pharmacological profile,auranofin together with its derivatives are proposed here as novel experimental agents for CRC treatment,capable of overcoming resistance to platinum *** encouraging results in this direction have already been obtained.A few recent studies demonstrate that the action of auranofin may be further potentiated through the preparation of suitable pharmaceutical formulations capable of protecting the gold pharmacophore from unselective reactivity or through the design of highly synergic drug *** perspectives of the research in this field are outlined.

关键词： Auranofin CRC colorectal cancer metallodrugs anticancer agents gold gold-based drugs

Metastatic colorectal cancer-past,progress and future

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World Journal of Gastroenterology 2007年第28期13卷 3806-3815页

作者： Kathryn Field lara Lipton Department of Medical Oncology and Clinical Haematology Western HospitalFootscray 3011VictoriaAustralia

The clinical management of metastatic （stage IV） colorectal cancer （CRC） is a common challenge faced by surgeons and physicians. The last decade has seen exciting developments in the management of CRC, with significant improvements in prognosis for patients diagnosed with stage IV disease. Treatment options have expanded from 5-fluorouracil alone to a range of pharmaceutical and interventional therapies, improving survival, and providing a cure in selected cases. Enhanced understanding of the biologic pathways most important in colorectal carcinogenesis has led to a new generation of drugs showing promise in advanced disease. It is hoped that in the near future the treatment paradigm of metastatic CRC will be analogous to that of a chronic illness, rather than a rapidly terminal condition. This overview discusses the epidemiology of advanced CRC and currently available therapeutic options including medical, surgical, ablative and novel modalities in the management of metastatic colorectal cancer.

关键词： Colorectal cancer Metastases Chemotherapy Oncology Biological therapies

Carbon dioxide fixation into cyclic carbonates at room temperature catalyzed by heteroscorpionate aluminum complexes

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Green Chemical Engineering 2022年第3期3卷 280-287页

作者： Felipe de la Cruz-Martinez Jose A.Castro-Osma Agustin lara-Sanchez Universidad de Castilla-La Mancha Departamento de Quimica InorganicaOrganica y Bioquimica-Centro de Innovacion en Quimica Avanzada(ORFEO-CINQA)Facultad de Ciencias y Tecnologias QuimicasCiudad Real13071Spain Instituto de Investigaciones Quimicas(IIQ) Departamento de Quimica Inorganica and Centro de Innovacion en Quimica Avanzada(ORFEO-CINQA)Consejo Superior de Investigaciones Cientificas(CSIC)and University of SevillaSevilla41092Spain Universidad de Castilla-La Mancha Departamento de Quimica InorganicaOrganica y Bioquimica-Centro de Innovacion en Quimica Avanzada(ORFEO-CINQA)Facultad de FarmaciaAlbacete02071Spain

Novel mono-and bimetallic scorpionate aluminum compounds have been designed and characterized by spec-troscopic *** organometallics complexes,in combination with tetrabutylammonium bromide as cocatalyst,displayed good catalytic activity for the cycloaddition of styrene oxide and CO_(2) under ambient *** the compounds tested,monometallic complex 3 featuring diethylamino groups showed the highest catalytic *** catalytic system catalyzed the formation of cyclic carbonate products from their corresponding epoxides at room temperature and 1 bar of CO_(2) pressure in the absence of a solvent in good yields and excellent selectivities.

关键词： CO_(2) Epoxides Cyclic carbonates Aluminum complexes

Nitrate regulates rhizobial and mycorrhizal symbiosis in common bean(Phaseolus vulgaris L.)

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Journal of Integrative Plant Biology 2014年第3期56卷 281-298页

作者： Kalpana Nanjareddy Lourdes Blanco Manoj‐Kumar Arthikala Xochitl Alvarado Affantrange Federico Sánchez Miguel lara Genómica Funcional de Eucariotes Centro de Ciencias Genómicas Universidad Nacional Autónoma de México UNAM Apartado Postal 510‐3Cuernavaca Morelos 62271 México Escuela Nacional de Estudios Superiores‐UNAM León Blvd.UNAM 2011 Predio El Saucillo y El PotreroComunidad de los Tepetates León Gto.C.P.37684 Mexico Departamento de Biología Molecular de Plantas Instituto de BiotecnologíaUniversidad Nacional Autónoma de México UNAM Apartado Postal 510‐3 Cuernavaca Morelos 62271 México

Nitrogen-limited conditions are considered to be a prerequisite for legume-rhizobial symbiosis, but the effects of nitrate-rich conditions on symbiotic status remain poorly understood. We addressed this issue by examining rhizobial （Rhizobim tropici） and arbusclar mycorrhizal （Glomus intraradices） symbiosis in Phaseolus vulgaris L. cv. Negro Jamapa under nitrate pre-incubation and continuous nitrate conditions. Our results indicate that nitrate pre-incubation, independent of the concentration, did not affect nodule development. However, the continuous supply of nitrate at high concentrations impaired nodule maturation and nodule numbers. Low nitrate conditions, in addition to positively regulating nodule number, biomass, and nitrogenase activity, also extended the span of nitrogen-fixing activity. By contrast, for arbuscular mycorrhizae, continuous 1o and 50mmol/L nitrate increased the percent root length colonization, concomitantly reduced arbuscule size, and enhanced ammonia transport without affecting phosphate transport. Therefore, in this manuscript, we have proposed the importance of nitrate as a positive regulator in promoting both rhizobial and mycorrhizal symbiosis in the common bean.

关键词： Arbuscule common bean mycorrhiza nitrate nodule Rhizobium

Profiles of Entamoeba histolytica—specific imunoglobulins in human sera

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Asian Pacific Journal of Tropical Medicine 2012年第3期5卷 234-238页

作者： Windell L Rivera Herbert J Santos Vanissa A Ong lara Jessica G Murao Institute of Biology College of ScienceUniversity of the PhilippinesDilimanQuezon City 1101Philippines Molecular Protozoology Laboratory Natural Sciences Research InstituteUniversity of the PhilippinesDilimanQuezon City 1101Philippines

Objective:To determine the profdes of anti-Entamoeba histolytica(***) ***. and IgM in sera of diarrheic and non-diarrheic individuals and partially characterize target ***:Serum samples from thirty diarrheic and thirty non-diarrheic individuals were subjected to IgA,IgG,and IgM profiling through enzyme-linked immunosorbent assay (***),flow cytometry,and ***:ELBA titer results showed that both diarrheic and non-diarrheic individuals possess high levels of ***-specific IgG compared to IgA and *** cytometry data showed that diarrheic serum samples had higher mean reaction percentages against *** cells compared to non-diarrheic *** *** proteins with molecular weights ranging belween 7 kDa and 292 kDa were recognized by diarrheic serum IgG,and 170 kDa and 250 kDa by non-diarrheic serum IgG. Conclusions:Our findings suggest that serum *** IgG,compared with serum *** IgA and IgM responses,was generally high in both diarrheic and nondiarrheic sera,indicating a past exposure to the organism both in symptomatic patients as well as in asymptomatic carriers,*** addition,serum IgG from diarrheic and non-diarrheic patients were able to detect immunogenic *** proteins.

关键词： Entamoeba histolytica IgA IgG IgM ELISA immunoblot flow cytometry

Exercise training improves participation in persons with multiple sclerosis:A systematic review and meta-analysis

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Journal of Sport and Health Science 2022年第3期11卷 393-402页

作者： Thomas Edwards Anne Sophie Michelsen Afolasade O.Fakolade Ulrik Dalgas lara A.Pilutti School of Human Kinetics University of OttawaOttawaON K1N6N5Canada Department of Public Health-Exercise Biology Aarhus UniversityAarhus C 8000Denmark School of Rehabilitation Therapy Queens UniversityKingstonON K7L3N6Canada Interdisciplinary School of Health Sciences Brain and Mind Research InstituteUniversity of OttawaOttawaON K1N6N5Canada

Background Although previous studies have examined the effects of exercise training on other International Classification of Functioning,Disability and Health(ICF)component levels in persons with multiple sclerosis(MS),the effects of exercise training on participation remain *** objectives of this review were to:(1)characterize systematically the use of outcome measures that capture participation in exercise training studies;(2)quantify the effect of exercise training on participation in persons with *** A search of 6 electronic databases(CINAHL,SPORTDiscuss,Embase,MEDLINE,Cochrane Central,and Scopus)was conducted to identify controlled and noncontrolled trials involving exercise training and participation in persons with *** strings were built from Medical Subject Headings and CINAHL *** linking rules were used to identify participation chapters and categories ***-analysis was used to quantify the effect of exercise training on participation in randomized controlled trials comparing exercise effects to no intervention/usual *** We included 49 articles involving controlled and noncontrolled exercise trials in the systematic review of outcome *** captured 16 different outcome measures that captured all 9 participation chapters and identified 89 unique participation *** these 16 outcome measures,mobility was the most commonly represented participation chapter,with 108 items.A subsample of 23 randomized controlled trials was included in the *** overall effect of 0.60(standard error=0.12,95%confidence interval:0.36-0.84,z=4.9,p<0.001)was calculated,indicating a moderate,positive effect of exercise training on *** The current review provides information that can be used to guide the selection of outcome measures that capture participation in studies of exercise training in persons with *** training has a positive effect on outcomes that capture participation,p

关键词： Exercise training ICF framework Multiple sclerosis Participation

Traits of an invasive grass conferring an early growth advantage over native grasses

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Journal of Plant Ecology 2016年第6期9卷 672-681页

作者： lara G.Reichmann Susanne Schwinning H.Wayne Polley Philip A.Fay Department of Integrative Biology University of Texas at AustinAustinTX 78712USA USDA-ARS Grassland Soil and Water Research Laboratory808 E Blackland RoadTempleTX 76502USA Department of Biology Texas State UniversitySan MarcosTX 78666USA

Aims Invasive species often have higher relative growth rates(RGR)than their native *** use efficiency,total leaf area and specific leaf area(SLA)are traits that may confer RGR differences between natives and invasives,but trait differences are less prominent when the invasive species belongs to the same plant functional type as the dominant native ***,we test if traits displayed soon after germination confer an early size ***,we predicted that invasive species seedlings grow faster than the natives because they lack trade-offs that more strongly constrain the growth of native *** We quantified plant morphological and physiological traits and RGR during early seedling growth at high and low nutrient levels in three dominant perennial native C_(4) grasses:Panicum virgatum L.(switchgrass),Schizachyrium scoparium(Michx.)Nash(little bluestem)and Andropogon gerardii Vitman(big bluestem);and a perennial C_(4) exotic invasive grass,Sorghum halepense(L.)Pers.(Johnsongrass).Important Findings After 2 weeks of growth,Johnsongrass seedlings had greater biomass,SLA and photosynthetic nitrogen use efficiency,but lower leaf N concentrations(%leaf N)and root:shoot ratio than *** growth continued,Johnsongrass more quickly produced larger and thicker leaves than the natives,which dampened the growth advantage past the first 2 to 3 weeks of *** in carbon gain appears to be the best explanation for the early growth advantage of *** natives,growth was constrained by an apparent trade-off between allocation to root biomass,which reduced SLA,and production of leaves with high N content,which increased carbon *** Johnsongrass,root:shoot ratio did not interact with other traits,and%leaf N was decoupled from RGR as a result of a trade-off between the positive indirect association of%leaf N with RGR and the negative direct association of%leaf N with RGR.

关键词： biomass allocation invasive plants RGR Sorghum halepense trade-offs trait development

Design of microaerobically inducible miniR1 plasmids

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mLife 2023年第1期2卷 101-104页

作者： Fabiola Islas Andrea Sabido Juan-Carlos Sigala Alvaro R.lara Departamento de Procesos y Tecnología Universidad Autónoma MetropolitanaCiudad de MexicoMéxico

Plasmid DNA(pDNA)is the active pharmaceutical ingredient in the so-called DNA vaccines1 and in gene therapy *** first pDNA vaccine for use in humans,which has shown high protection against SARS-CoV-2,was recently appr... 详细信息

关键词： inducible products. template

Treatment of prolonged clonidine-induced autonomic instability with midodrine:a case report about a new approach or a cautionary tale?

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Emergency and Critical Care Medicine 2023年第4期3卷 194-197页

作者： Saada Malouf Catherine Henry lara Pemberton Joe-Anthony Rotella Department of Emergency Medicine Northern HealthEppingAustralia SPECTRE(Substance Use PsychiatryEnvenomationClinical Toxicologistand REcreational substances)UnitNorthern HealthEppingAustralia Melbourne Medical School University of MelbourneParkvilleAustralia

Background:Clonidine is a centrally acting a2 adrenergic and imidazoline-1 receptor agonist that can cause somnolence,bradycardia,and hypotension within several hours of *** well-described but observed by us locally is the observation that patients presenting after large overdoses including clonidine can have prolonged autonomic *** a result,they may require many days in hospital before *** have previously used midodrine as an indirect antagonist with good effect;however,there are no previous reports of its use for this *** presentation:We present the case of a young female patient who developed prolonged autonomic instability following a large overdose of clonidine(coingested with smaller doses of escitalopram+lisdexamfetamine)that was treated with midodrine but complicated by a type 2 non-ST segment elevated myocardial ***:Midodrine seems to ameliorate this protracted instability and may provide a means to decrease hospital length of stay in appropriate individuals.

关键词： Autonomic Case report Clonidine Instability Midodrine Overdose