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Type 1 diabetes and associated autoimmune diseases

World Journal of Diabetes 2020年第11期11卷 527-539页

作者： lara frommer George J Kahaly Department of Medicine I Johannes Gutenberg Medical CenterMainz 55131Germany

BACKGROUND Common autoimmune diseases(AID)tend to occur together in the same individual and *** 1 diabetes(T1D)is caused by an autoimmuneinduced inflammatory destruction of the pancreatic tissue and clusters with several other *** To compare the demographic,clinical,and serological features of patients with single T1D vs those with T1D and associated *** From October 1999 to February 2020,a total of 665 patients with T1D and their first-degree relatives were *** Compared to patients with isolated T1D,those with T1D+AID were older and had a higher female:male *** patient age and age at disease onset were higher in T1D+AID vs T1D *** average time interval between T1D onset and the onset of a second glandular AID was markedly shorter than the time interval between T1D and the occurrence of a non-endocrine AID.T1Dspecific autoantibodies were more frequent in patients with T1D+AID and relatives vs those with T1D ***,the prevalence of AID and autoantibodies against various tissues were found to be higher in relatives of patients with T1D only compared to relatives of patients with T1D+*** Annual serological and subsequent functional screening for AID in patients with T1D and their first-degree relatives is recommended.

关键词： Type 1 diabetes Autoimmunity Serology Antibodies Autoimmune endocrine diseases Autoimmune non-endocrine disorders

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