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comSeedling growth of five tropical dry forest tree species in relation to light and nitrogen gradients

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Journal of Plant Ecology 2014年第3期7卷 250-263页

作者： S.n.Tripathi A.S.Raghubanshi Ecosystems Analysis Laboratory Department of BotanyBanaras Hindu UniversityVaranasiUttar Pradesh 221005India Deen Dayal Upadhyaya College University of DelhiShivaji MargKarampuraNew Delhi 110015India Institute of Environment and Sustainable Development Banaras Hindu UniversityVaranasiUttar Pradesh 221005India

Aims Increasing anthropogenic nitrogen(n)deposition has been claimed to induce changes in species composition and community dynamics.A greenhouse experiment was conducted to examine the effect of increased n availability on growth and functional attributes of seedlings of five tree species with different life history characteristics under varying *** following questions have been addressed:(i)how do the pioneer and non-pioneer species respond in absolute growth and relative growth rate(RGR)to the interaction of light and nitrogen?(ii)how does the interaction between irradiance and nitrogen availability modulate growth attributes(*** attributes)?(iii)is there any variation in growth responses between leguminous and non-leguminous species along the light and nitrogen gradients?Methods Seedlings of five tree species(Acacia catechu,Bridelia retusa,Dalbergia sissoo,Lagerstroemia parviflora and Terminalia arjuna)were subjected to twelve combinations of irradiance and n *** growth traits,including height(HT),basal area(BA),whole plant dry biomass(MD),leaf mass per unit area(LMA),leaf area ratio(lar),net assimilation rate(nAR),RGR,biomass fractions,root-toshoot ratio(R:S)and leaf nitrogen content,were studied to analyse intra-and inter-specific responses to interacting light and n *** Findings Significant interactions for irradiance and n availability for majority of growth attributes indicates that growth and biomass allocation of seedlings were more responsive to n availability under high ***,species responded differentially to n addition and they did not follow successional *** growers(***,a shade-tolerant species and ***,a light demander)exhibited greater response to n enrichment than the fast growers(***,*** and ***).However,n-mediated increment in growth traits was greater in non-legumes(***,*** and ***)compared with that of legumes(*** and D

关键词： tropical dry forest irradiance nitrogen biomass allocation relative growth rate net assimilation rate

高血压人群中的肾功能和心血管疾病:ERIC-HTA研究

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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 48-49页

作者： Redón J. Cea-Calvo L. Lozano J.V. 朱冰坡 Unidad de Hipertension Arterial Hospital ClinicoUniversidad de ValenciaAvda.Blasco Ibáez 1746010-ValenciaSpain

Background and objectives: Epidemiological data on the incidence and prevalenc e of cardiovascular disease in chronic renal failure are scant. The objective of the present study is to assess the relationship between renal function, measure d by the estimated glomerular filtration rate, and the presence of early or esta blished cardiovascular disease, in a population of hypertensives from primary ca re. Patients and methods: Cross-sectional, multicentre study carried out in primary care c entres all over Spain. Hypertensive subjects, older than 55 years, were included . In all of them a structured interview including cardiovascular risk factors or disease was performed. Blood pressure was measured following a standard procedu re, and serum biochemistry and an electrocardiogram were obtained. Renal functio n was estimated using the abbreviated MDRD(Modification of Diet in Renal Disease Study Group) equation. For each glomerular filtration rate stratum the odds rat io and 95%confidence interval(CI) of left ventricular hypertrophy or cardiovasc ular disease were calculated, adjusted by confounding variables. Results: A tota l of 13 687 patients(mean age 68.1 years, women 55.4%, diabetics 30.6%, body m ass index 28.6 kg/m2) were included. Of these, 26.4%had established cardiovascu lar diseases and 20.3%electrocardiographic left ventricular hypertrophy. The av erage serum creatinine was 1.01 mg/dl, creatinine clearance 70.0 ml/min, and glo merular filtration rate 74.0 ml/min per 1.73 m2. Thirty-three patients(0.24%) had glomerular filtration raten per 1.73 m2; 89(0.65%) from 15 to 29; 3745(27.36%) from 30 to 59; 7798(56.97%) from 60 to 89; and 2019(14.75%) high er than 89 ml/min per 1.73 m2. In a multiple regression analysis, after adjustin g by age, sex, body mass index, diabetes, systolic and diastolic blood pressure, and smoking, a lower glomerular filtration rate was associated with a higher pr evalence of left ventricular hypertrophy. Likewise, a reduction i

关键词：心血管疾病高血压人群肾功能 ERIC 肾小球滤过率 HTA 心血管危险因素心电图检查

基于SOX9的生物学研究及其在肝癌干细胞中的研究进展

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中国临床医学 2016年第6期23卷 838-840页

作者：王孟超黄罡周伟平第二军医大学东方肝胆外科医院肝外三科上海200433

肿瘤干细胞是指在肿瘤组织中高度恶性的细胞亚群,具有高侵袭性、易转移性、多耐药性特点,与肿瘤复发密切相关。因此,肿瘤干细胞可能成为未来肿瘤治疗的靶点。目前发现的肿瘤干细胞标志物包括CD133、CD90、CD44等。SOX9(sex determining ... 详细信息

肿瘤干细胞是指在肿瘤组织中高度恶性的细胞亚群,具有高侵袭性、易转移性、多耐药性特点,与肿瘤复发密切相关。因此,肿瘤干细胞可能成为未来肿瘤治疗的靶点。目前发现的肿瘤干细胞标志物包括CD133、CD90、CD44等。SOX9(sex determining region y box-9)除了参与多个器官的生长发育外,还与组织纤维化及肿瘤的发生有着密切关系,尤其在多种肿瘤干细胞中高表达。SOX9亦在肝癌干细胞中高表达,并通过相关信号通路影响肝癌干细胞的自我更新、增殖以及耐药,因此成为肝癌潜在的预后判断指标和治疗靶点。

关键词：肿瘤干细胞肝细胞肝癌 SOX9

丹麦úrhus县2型糖尿病随机人群中视网膜病变的患病率

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 8-9页

作者： Hove M.n. Kristensen J.K. Lauritzen T. Bek T. 杨建刚 Department of Ophtha lmology úrhus University Hospital DK-8000 úrhus C Denmark

Purpose: To determine the prevalence of diabetic retinopathy and the causes of visual impairment in an unselected population of type 2 diabetes patients, and to describe the risk factors for developing diabetic retinopathy in this populat ion. Methods: A total of 10851 type 2 diabetes patients were identified in the c ounty of úrhus. A representative sample of 378 patients underwent a routine ocu lar examination, including fundus photography. Blood pressure and serum haemoglo bin A1c, total cholesterol, high density lipoprotein cholesterol, triglyceride a nd apolipoprotein a were measured. Results: The prevalence of diabetic retinopat hy in the type 2 diabetes population was 31.5%. In all, 2.9%had proliferative diabetic retinopathy and 5.3%had clinically significant macular oedema. Of the latter, 8/20 (40%) were newly identified and had not yet been lasertreated. The re was a positive correlation between severity of retinopathy and duration of di abetes, HbA1c, systolic blood pressure and treatment with insulin. none of the p atients had social blindness (visual acuitynt (VA nclusion: The prevalence of diabetic retinop athy and visual impairment in this unselected type 2 diabetes population was low er than anticipated from the existing literature,and causes other than diabetic retinopathy contributed significantly to the occurrence of visual loss. A substa ntial number of the patients with vision-threatening diabetic maculopathy had n ot been referred for timely photocoagulation treatment.

关键词：视网膜病变 rhus 眼底照相视力损害黄斑水肿眼科常规检查光凝治疗高密度脂蛋白载脂蛋白总胆固醇

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口腔原发性恶性黑色素瘤:1例报道

世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 16-17页

作者： Ortega K.L. de Araú jo n.S. de Souza F.B. Magalh.aes M.H.C.G. 刘超 Faculdade de Odontologia Departamento de Patologia Bucal Cidade Un iversitá ria Lineu Prestes 2227 05508- 900 S.ao Paulo SP BrazilDr.

A 43-year-old white man was referred to the Special Care Dentistr y Center of the School of Dentistry,University of Sao Paulo, Brazil, for the diagnosis o f an extensive nodular lesion of the maxillary gingiva. The patient complained t hat his left maxilla had swollen over the last 4 months, with some exudation fro m the gingival crevice, sporadic bleeding, and slight tooth mobility, but no pai n. An extra-oral examination confirmed expressive swelling of the left side of the face (Fig. 1A). Palpation disclosed bilateral enlargement of the submandibu lar lymph nodes. An intra-oral examination showed an extensive, reddish, nodul ar mass (around 11 cm in diameter) that extended from the last left maxillary mo lar to the right maxillary incisor, covered by a mucosa that was ulcerated in so me areas (Fig. 1B,C). Palpation revealed a painless, soft, bleeding tissue that seemed to arise in the periodontal ligaments, extending to the palate and vestibular area. A small pigmented spot was found in the palat al mass. Histopathologically, the biopsy revealed a proliferation of neoplastic cells that exhibited a wide variety of shapes, including spindle, plasmacytoid, and epithelioid forms. The atypical cells showed enlarged and pleomorphic nuclei . Mitotic activity and pigmented areas were observed (Fig. 2A,B). Immunohistoche mistry was used to establish the final diagnosis. The tumor cells strongly expre ssed S100 protein, gp100 (HMB- 45), melan A, and tyrosine antibodies (Fig. 2C,D ). With the diagnosis of malignant melanoma, the patient was referred to an onco logist for treatment. As computed tomography revealed that the lesion was deeply inserted into the skull surface (Fig. 1D), surgical intervention was not possib le. The patient underwent radiotherapy, but died 14 months later.

关键词：恶性黑色素瘤牙龈裂多形性核分裂前庭区病理检查血组织肿大淋巴结免疫组化检查瘤细胞

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视网膜病变与充血性心力衰竭风险研究

世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 3-3页

作者： Wong T.y. Rosamond W. 张磊

Context: Congestive heart failure (CHF) affects a substantial proportion of ad ults including those without preexisting coronary heart disease. The pathogenesi s of CHF is uncertain, but microvascular disease has been hypothesized as a poss ible factor. Objective: To determine the relationship of retinopathy, a marker o f systemic microvascular disease, to risk of CHF. Design, Setting, and Participa nts: Populationbased, prospective 7-year cohort study in 4 US communities usi ng the Atherosclerosis Risk in Communities Study database. Participants (n=1 161 2, aged 49 to 73 years) had retinal photographs taken between 1993 and 1995. The photographs were graded according to a standardized protocol for the presence o f retinopathy (eg, microaneurysms, retinal hemorrhages, soft exudates), arteriov enous nicking, focal arteriolar narrowing, and generalized arteriolar narrowing. Main Outcome Measures: Association between retinopathy and incident CHF, identi fied from hospitalization and death records. Results: The 7-year cumulative inc idence of CHF was 5.4%(492 events). Participants with retinopathy had a higher incidence of CHF compared with those without retinopathy (15.1 %vs 4.8%, Pntrolling for age, sex, race, preexisting coronary heart disease, m ean arterial blood pressure, diabetes, glucose level, cholesterol level, smoking , body mass index, and study site, the presence of retinopathy was associated wi th a 2-fold higher risk of CHF (relative risk, 1.96; 95%confidence interval, 1 .51-2.54). Among participants without preexisting coronary heart disease, diabe tes, or hypertension, retinopathy was associated with a 3-fold higher risk of C HF (relative risk, 2.98; 95%confidence interval, 1.50-5.92). Conclusions: Reti nopathy is an independent predictor of CHF, even in persons without preexisting coronary heart disease, diabetes, or hypertension. This suggests that microvascu lar disease may play an important role in the development of heart failure

关键词：视网膜病变充血性心力衰竭视网膜照片视网膜出血动脉狭窄冠心病病史微动脉瘤患病风险微血管病软性渗出

冠状动脉钙化的高血压患者左心室肥厚可预测心血管事件

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中华高血压杂志 2019年第1期27卷 98-98页

作者： Grossman C Levin M Koren-Morag n Bornstein G Lei-bowitz A Ben-Zvi I Shemesh J Grossman E 陈云叶鹏

冠状动脉钙化(coronary artery calcification,CAC)与心血管病风险增加有关。左心室肥厚(left ventricular hypertrophy,LVH)是心血管事件的独立危险因素。本研究目的是评估在CAC存在的情况下LVH的相对心血管病风险。

关键词：心血管病 CAC 冠状动脉 LVH 左心室肥厚

EVALUATIOn OF CIRCADIAn InTRAOCU-lar PRESSURE In PATIEnTS WITH GLAUCOMA OR OCUlar HyPERTEn-SIOn: THE BEHAVIOUR OF DIFFEREnT AnTIGLAUCOMATOUS DRUGS

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国际眼科杂志 2003年第1期3卷 94-94页

作者： n.Orzalesi L.Rossetti A.Bottoli P.Fogagnolo E.Fumagalli.Eye Clinic San Paolo Hospital ItalySan Paolo Hospital ItalySan Paolo Hospital ItalySan Paolo Hospital ItalySan Paolo Hospital Italy

Purpose: In 3 cross-over clinical trials we compared around-the-clock intraocular pressure (IOP) reduction induced by timolol, latanoprost, dorzolamide, brimonidine, a fixed combination of timolol and dorzolamide, bimatoprost and travoprost in patients with open-angle glaucoma or ocular hypertension. Methods: Each trial included 20 patients who were all

关键词：青光眼高眼压眼压昼夜变化抗青光眼药物药动学

在特殊类型锥细胞营养不良患者的锥细胞cGMP磷酸二脂酶γ亚基因中发现一种G替代C的替代物

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 60-60页

作者： Piri n. Danciger M. 邢咏新

To identify genes responsible for cone dystrophies and determine the functiona l consequences of their underlying mutations. Case-control study. Two hundred f orty unrelated patients diagnosed with cone dystrophy, cone-rod dystrophy, macu lar dystrophy, macular degeneration, or Stargardt disease, 95 control individual s, and 2 unrelated families with a distinctive type of cone dystrophy. The DnAs of the 240 probands were screened for sequence variants in the PDE6H gene (that encodes the inhibitory γ-subunit of cone cyclic guanosine monophosphate [cGMP ] -phosphodiesterase [PDE]) by single-strand conformation polymorphism electro ph oresis. The effect of a nucleotide substitution in the DnA of a patient on gene expression efficiency was analyzed by in vitro transcrip-tion/translation. Cone -specific gene variants, fundus, visual field and electroretinogram (ERG) findi ngs, and protein synthesis efficiency. We found a heterozygous G to C substituti on in the 5′untranslated region (UTR) of the PDE6H gene in the DnA of a patient with a distinctive form of cone dystrophy, her sibling, and their father. This rare form of disease is very different in manifestation from other cone dystroph ies and has been described as “cone dystrophy with nyctalopia and supernormal r od responses,”“cone dystrophy with supernormal scotopic ERGs”and “supernorma l and delayed rod ERG syndrome.”Among the 240 patients that we studied, only 1 proband had the G to C variant. Furthermore, none of the 95 controls used in thi s study had this nucleotide change. We also determined that the PDE6H variant wa s not present in another family affected with this particular type of cone dystr ophy. Because the 5’UTR of mRnAs plays a critical role in the regulation of pro tein synthesis, we determined the effect of the G to C change in this process. B y use of in vitro transcription/translation experiments, we demonstrated that th is substitution could lead to an increase in PDE6H gene expression. Our result

关键词：磷酸二脂酶 γ亚基营养不良患者黄斑营养不良黄斑变性基因突变光感受器体外观察先证者视网膜电图