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Journal of Integrative Medicine 2015年第6期13卷 353-355页

作者： lixing lao Zhipeng Ning School of Chinese Medicine Li Ka Shing Faculty of Medicinethe University of Hong Kong

The European Congress for Integrative Medicine 2015 Global Summit on Integrative Medicine and Healthcare in Greater Copenhagen has successfully promoted integrative medicine to the public once again. Integrative medicine, which is called the art and science of healthcare by Nordic Integrative Medicine, has been widely used in the world. In Hong Kong, integrated traditional Chinese and Western medicine, which is also known as the Chinese version of integrative medicine, provides a valuable reference for the development of integrative medicine in the world. In this article, we introduce the development of traditional Chinese medicine in Hong Kong and an integrated traditional Chinese and Western medicine model in the University of Hong Kong-Shenzhen Hospital.

关键词： integrative medicine traditional Chinese medicine Hong Kong

Clinical acupuncture research in the West

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Frontiers of Medicine 2011年第2期5卷 134-140页

作者： Xianze Meng Shifen Xu lixing lao Department of Traditional Chinese Medicine Shanghai Changzheng Hospitalthe Second Military Medical UniversityShanghai 200001China Shanghai Municipal Hospital of Traditional Chinese Medicine affiliated with Shanghai TCM University Shanghai 200071China Center for Integrative Medicine University of Maryland School of Medicine520 West Lombard StreetBaltimoreMD 21201USA

In recent years,acupuncture has rapidly become part of mainstream medicine in the West,where new developments in acupuncture clinical research show extensive progress in evaluating the efficacy and safety of the modality in many categories of disease,especially in pain *** challenges and difficulties remain,the acupuncture research community has matured and its past experience may lead to even better methods and more innovative research.

关键词： acupuncture clinical research research methodology the West

Remission of new-onset type 2 diabetes mellitus in an adolescent using an integrative medicine approach:A case report

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Journal of Integrative Medicine 2021年第1期19卷 85-88页

作者： Baoyi Shao Saiying Hou Yuenyan Chan Changchun Shao lixing lao Clinical Division Beijing Changchun Hospital of Traditional Chinese MedicineBeijing 100123China Virginia University of Integrative Medicine FairfaxVA 2203USA

Among adolescents,the incidence of type 2 diabetes mellitus(T2 DM)has recently increased.A 12-yearold Chinese boy with a one-year history of hyperphagia presented to our *** patient was diagnosed with T2 DM one month prior to visiting the clinic and reported undergoing no pharmacologic *** an integrative medicine approach,including Chinese herbal decoction,berberine hydrochloride tablets,physical exercise and diet control,the patient's fasting blood glucose(FBG)decreased from 8.3 mmol/L to 5.5 mmol/***,his glycated haemoglobin decreased from12.9%to 6.1%,indicating that without any Western medicine intervention his diabetes has been reversed after six months of *** FBG remained normal,and nine months after completion of treatment it was 4.9 mmol/L.A potential mechanism in this response may be related to improved insulin resistance and b-cell function,as indicated by observed changes in homeostasis model assessment of insulin resistance and b-cell ***,weight loss may also have contributed to the effectiveness of the *** case study is the first to present the innovative approach of integrative medicine to achieve remission of new-onset adolescent T2 DM.

关键词： Type 2 diabetes mellitus Integrative medicine Traditional Chinese medicine Case report

Which Research Is Needed to Support Clinical Decision-Making on Integrative Medicine?——Can Comparative Effectiveness Research Close the Gap?

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Chinese Journal of Integrative Medicine 2012年第10期18卷 723-729页

作者： Claudia M.Witt 黄文静 lixing lao Berman BM Charit University Medical Center Institute for Social MedicineEpidemiology and Health Economics University of Maryland School of Medicine Center for Integrative Medicine Chengdu University of Traditional Chinese Medicine The Institute for Integrative Health

In clinical research on complementary and integrative medicine, experts and scientists have often pursued a research agenda in spite of an incomplete understanding of the needs of end users. Consequently, the majority of previous clinical trials have mainly assessed the efficacy of interventions. Scant data is available on their effectiveness. Comparative effectiveness research （CER） promises to support decision makers by generating evidence that compares the benefits and harms of the best care options. This evidence, more generalizable than the evidence generated by traditional randomized controlled trials （RCTs）, is better suited to inform real-world care decisions. An emphasis on CER supports the development of the evidence base for clinical and policy decision-making. Whereas in most areas of complementary and integrative medicine data on comparative effectiveness is scarce, available acupuncture research already contributes to CER evidence. This paper wil introduce CER and make suggestions for future research.

关键词： comparative effectiveness research decision making integrative medicine Chinese medicine acupuncture

Mechanism of electroacupuncture on inflammatory pain: neural-immune-endocrine interactions

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Journal of Traditional Chinese Medicine 2019年第5期39卷 740-749页

作者： Li Yuan Yang Mingxiao Wu Fan Cheng Ke Chen Haiyong Shen Xueyong lao lixing School of Acupuncture Moxibustion and Tuina Shanghai University of Traditional Chinese MedicineShanghai 201203China School of Chinese Medicine The University of Hong KongHong KongChina

Nociceptive signals are transmitted by peripheral afferents to the central nervous system under pain condition, a process that involves various neurotransmitters and pathways. Electroacupuncture (EA) has been widely used as a pain management technique in clinical practice. Emerging studies have shown that EA can inhibit the induction and transmission of pain signals and, consequently, mediate anti-nociceptive and anti-inflammatory effects by rebalancing the neural-immune-endocrine interactions. This review summarizes the neural-immune- endocrine circuit including peripheral afferent and central efferent, contributing to EA-induced neuroimmune and neuroendocrine modulation in inflammatory pain models. The peripheral afferent circuit includes crosstalk among immune cells, inflammatory cytokines, peripheral nociceptors. In central efferent primarily involves the neuroinflammatory interactions between spinal nociceptive neurons and glial cells. Furthermore, the hypothalamic- pituitary-adrenal axis, sympathetic and vagal nervous may serve as an essential pathway involved in the mechanism of acupuncture-mediated analgesia within the interactions of the central, immune and endocrine systems. Overall, this review focuses on the interactions of neural-immune-endocrine in inflammatory pain, which may be underlying the mechanism of EA-induced anti-inflammatory and antinociceptive effect.

关键词： Electroacupuncture Analgesia Inflammatory pain Neural-immune-endocrine interactions Review

Chinese integrative medicine:inclusion of a Chinese medicine programme in a conventional medical institute

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Journal of Integrative Medicine 2014年第3期12卷 187-190页

作者： Hai-Yong Chen Yibin Feng lixing lao School of Chinese Medicine Li Ka Shing Faculty of MedicineThe University of Hong Kong Center for Integrative Medicine School of MedicineUniversity of Maryland

To meet community demands with optimal Chinese and conventional medical treatment, the University of Hong Kong is promoting integrative medicine by developing Chinese medicine programmes that train students of both Western and Chinese medicine. The programmes emphasize multi-disciplinary training and interaction between the two therapeutic approaches, enabling students to establish reliable, consistent, and respectful mutual cooperation in their future careers.

关键词： education, medical integrative medicine medicine, Chinese traditional TheUniversity of Hong Kong

Chinese medicines for prevention and treatment of human hepatocellular carcinoma: current progress on pharmacological actions and mechanisms

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Journal of Integrative Medicine 2015年第3期13卷 142-164页

作者： Xuanbin Wang Ning Wang Fan Cheung lixing lao Charlie Li Yibin Feng School of Chinese Medicine The University of Hong Kong Laboratory of Chinese Herbal Pharmacology Renmin Hospital Hubei Key Laboratory of Wudang Local Chinese Medicine Research School of Pharmacy Hubei University of Medicine California Department of Public Health

Hepatocellular carcinoma（HCC） is one of leading causes of death in the world. Although various treatments have been developed, the therapeutic side effects are far from desirable. Chinese medicines（CMs, including plants, animal parts and minerals） have drawn a great deal of attention in recent years for their potential in the treatment of HCC. Most studies have shown that CMs may be able to retard HCC progression with multiple actions, either alone or in combination with other conventional therapies to improve quality of life in HCC patients. Additionally, CMs are used for preventing HCC occurrence. The aim of this study is to review the potential prophylactic and curative effects of CMs on human HCC and the possible mechanisms that underlie these pharmacological actions. Publications were collected and reviewed from Pub Med and China National Knowledge Infrastructure from 2000 to 2014. Keywords for literature searches include ＂Chinese medicine＂, ＂Chinese herb＂, ＂traditional Chinese Medicine＂, ＂hepatocellular carcinoma＂ and ＂liver cancer＂. CMs in forms of pure compounds, isolated fractions, and composite formulas are included. Combination therapies are also considered. Both in vitro and in vivo efficacies of CMs are being discussed and the translational potential to bedside is to be discussed with clinical cases, which show the actions of CMs on HCC may include tumor growth inhibition, antimetastatic activities, anti-inflammation, anti-liver cancer stem cells, reversal on multi-drug resistance and induction/reduction of oxidative stress. Multiple types of molecules are found to contribute in the above actions. The review paper indicated that CMs might have potential to both prevent HCC occurrence and retard HCC progression with several molecular targets involved.

关键词： medicine,Chinese traditional liver neoplasms hepatocellular carcinoma recurrence disease treating & preventing molecular targets review

Acupuncture for low back pain:a clinical practice guideline from the Hong Kong taskforce of standardized acupuncture practice

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Journal of Traditional Chinese Medicine 2022年第1期42卷 140-147页

作者： CHEN Haiyong YEUNG Wing-Fai YANG Mingxiao MU Jinglan ZIEA Tat-Chi NG Bacon Fung-Leung lao lixing School of Chinese Medicine University of Hong KongHong Kong SARChina School of Nursing Hong Kong Polytechnic UniversityHong Kong SARChina Bendheim Integrative Medicine Center Memorial Sloan Kettering Cancer Center1429 First AvenueNew York 10021USA Department of Anesthesiology Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjing210008China Chinese Medicine Department Hong Kong Hospital AuthorityHong Kong SARChina Virginia University of Integrative Medicine FairfaxVA 22031USA

OBJECTIVE:To develop a clinical practice guideline to guide the treatment of low back pain by ***:An integrative approach of systematic review of literature,clinical evidence classification,expert opinion surveying,and consensus establishing via a Delphi program was utilized during the developing *** evidence-based practice standards and the personalized features of acupuncture were taken into ***:Based on clinical evidence and expert opinions,we developed a clinical practice guideline for the treatment of low back pain with *** recommendations have a wide coverage spanning from Western Medicine diagnosis and Traditional Chinese Medicine syndrome differentiation,to acupuncture treatment procedures,as well as post treatment care for rehabilitation and *** recommendations for acupuncture practice included treatment principles,therapeutic regimens,and operational *** levels of evidence and strength of recommendation were rated for each procedure of ***:A clinical practice guideline for acupuncture treating low back pain was developed based on contemporary clinical evidence and experts'consensus to provide best currently agreeable practice guideline for domestic and international stakeholders.

关键词： acupuncture low back pain diagnosis syndrome differentiation rehabilitation practice guideline

Can moxibustion, an ancient treatment modality, be evaluated in a double-blind randomized controlled trial? —— A narrative review

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Journal of Integrative Medicine 2014年第3期12卷 131-134页

作者： Bai-xiao Zhao Hai-Yong Chen Xue-yong Shen lixing lao School of Acupuncture Beijing University of Chinese Medicine School of Chinese Medicine The University of Hong Kong College of Acupuncture-Moxibustion and Tuina Shanghai University of Traditional Chinese Medicine Center for Integrative Medicine School of MedicineUniversity of Maryland

For thousands of years, moxibustion has been used for various diseases in China and other Asian countries. Despite the recent surge in Chinese herbal studies, few randomized controlled trials have been conducted on this modality, possibly due to the lacking of suitable double blinding methodology. This is a review of extant sham moxa devices and an introduction to a recently developed device that needs further validation.

关键词： moxibustion direct moxibustion indirect moxibustion randomized controlled trial reviews

Effects of the pestle needle therapy,a type of acupoint stimulation,on post-hemorrhoidectomy pain:A randomized controlled trial

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Journal of Integrative Medicine 2020年第6期18卷 492-498页

作者： Xian Wang Xuan Yin Xiu-tian Guo Yan Wang Wen-qi Jin Ai-jun Mao lixing lao Zhang-jin Zhang Jie Zhang Shi-fen Xu Department of Nursing Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 200071China Department of Acupuncture and Moxibustion Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 200071China Department of Proctology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 200071China School of Chinese Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Virginia University of Integrative Medicine FairfaxVA 22031USA

Background:Hemorrhoids are one of the most common conditions that lead to surgery,and until now surgical hemorrhoidectomy has been the major effective ***-operative pain from hemorrhoidectomy has been experienced by thousands of patients and remains a major inconvenience of the ***:This study evaluates the clinical efficacy of the pestle needle therapy,an acupoint stimulation method,for relief of post-hemorrhoidectomy ***,setting,participants and interventions:This was a single-center,patient-assessor-blinded and randomized controlled trial with 154 patients receiving Milligan hemorrhoidectomy *** patients were randomly assigned to either a treatment group or a control group at a ratio of 1:*** treatment group received the pestle needle therapy,with manual stimulation at Yaoshu(DU2),Mingmen(DU4),Changqiang(DU1),Chengshan(BL57),Erbai(EX-UE2)and the perianal points(1,3,5,7,9,and 11 o’clock around the lesion);while the control group received a sham treatment with very light *** sessions of treatment were performed at 30 min,4 h and 12 h after the surgery,and each lasted for 15 *** outcome measures:The primary outcome was post-operative pain measured with the visual analogue scale(VAS)at 12 h after *** secondary outcomes included the VAS scores measured at0.5,2,4,6,8,24 and 48 h after surgery,the analgesic dose,the time and the VAS score of the patients’first defecation after surgery,as well as the Hamilton Rating Scale for Anxiety(HAMA)evaluated before ***:The mean pain score of the treatment group was significantly lower than that of the control group(3.10±1.27 vs 4.82±1.29;P<0.001)at 12 h after *** with the control group,patients in the treatment group needed a smaller dose of analgesic within the first 24 hours after surgery(P=0.002);and their HAMA scores before discharge were lower(4.07±2.40 vs 5.10±2.45,P=0.009).Compared to the treatment group,patients in the contr

关键词： Pestle needle Acupoint stimulation Hemorrhoidectomy Post-operative pain Randomized controlled trial