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RASSFIA Promoter Hypermethylation as a Prognosis and Diagnosis for Breast Cancer in Vietnamese Population

Journal of Life Sciences 2014年第4期8卷 316-321页

作者： Truong Kim Phuong lao duc thuan Doan Thi Phuong Thao Le Huyen Ai Thuy Falculty of Biotechnology Ho Chi Minh City Open University Ho Chi Minh City 70000 Vietnam Falculty of Medicine Ho Chi Minh City Medical University Ho Chi Minh City 70000 Vietnam

Aberrant tumor suppressor gene promoter methylation was associated with the several cancers, including breast cancer, which was the common female deaths in most countries involved in Vietnam. The methylation in tumor suppressor genes, including RASSFIA, were the key targets of establishing the potential biomarkers for prognosis and early diagnosis of breast cancer. In present study, with the aim towards using the hypermethylation at CpG islands of promoter of RASSFIA as the biomarker for breast cancer in Vietnamese population, MSP （methyl specific PCR） was carried out to analyze the hypermethylation status ofRASSFIA gene in 115 samples including 95 breast cancer specimens and 20 normal breast tissues from another disease （not breast cancer）. All samples were obtained from Ho Chi Minh City Medical Hospital, Vietnam. The known predictive and prognostic factors： HER2/neu overexpression was immunohistochemistry stained as input value for breast cancer specimens. For input value confirmed, the overexpression of p53 protein was also analyzed together with prior immunochemical assay. The results indicated that the hypermethylation of frequencies for methylation of given gene reached 42.1% （P 〈 0.05）. In addition, the DNA hypermethylation of RASSFIA gene increased the possibility to be breast cancer with high incidence via calculated of odd ratio （P 〈 0.05）. In conclusion, the hypermethylation of candidate genes could be used as the promising biomarkers applying in Vietnamese breast cancer patients.

关键词： RASSFIA hypermethylation MSP bisulfite modification breast cancer.

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Applying Wide & Deep Learning Model for Android Malware Classification

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Computer Systems Science & Engineering 2023年第6期45卷 2741-2759页

作者： Le duc thuan Pham Van Huong Hoang Van Hiep Nguyen Kim Khanh Ha Noi University of Science and Technology Ha Noi100000Viet Nam Academy of Cryptography Techniques Ha Noi100000Viet Nam

Android malware has exploded in popularity in recent years,due to the platform’s dominance of the mobile *** the advancement of deep learning technology,numerous deep learning-based works have been proposed for the classification of Android *** learning technology is designed to handle a large amount of raw and continuous data,such as image content ***,it is incompatible with discrete features,i.e.,features gathered from multiple ***,if the feature set is already well-extracted and sparsely distributed,this technology is less effective than traditional machine *** the other hand,a wide learning model can expand the feature set to enhance the classification *** maximize the benefits of both methods,this study proposes combining the components of deep learning based on multi-branch CNNs(Convolutional Network Neural)with wide learning *** feature set is evaluated and dynamically partitioned according to its meaning and generalizability to subsets when used as input to the model’s wide or deep *** proposed model,partition,and feature set quality are all evaluated using the K-fold cross validation method on a composite dataset with three types of features:API,permission,and raw *** accuracy with Wide and Deep CNN(WDCNN)model is 98.64%,improved by 1.38%compared to RNN(Recurrent Neural Network)model.

关键词： Wide and deep(W&D)learning convolutional neural network image feature raw features generalized features

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Embryonic, genetic and clinical outcomes of fresh versus vitrified oocyte: A retrospective cohort study

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Asian pacific Journal of Reproduction 2023年第6期12卷 266-272页

作者： Phuong Dao Thi Son Dang Truong thuan Nguyen duc Anh Pham Van Anh Do Tuan Van Hanh Nguyen HP Fertility-Hai Phong International Hospital of Obstetrics and Pediatrics Haiphong180000Vietnam Graduate University of Science and Technology Vietnam Academy of Science and TechnologyHanoi100000Vietnam Institute of Biotechnology Vietnam Academy of Science and TechnologyHanoi100000Vietnam

Objective:To compare embryonic development,ploidy status and clinical outcomes between fresh and frozen-thawed ***:This retrospective cohort study evaluated 83 fertilization cycles including both fresh and frozen oocytes from 79 patients at the HP Fertility Center of Hai Phong International Hospital of Obstetrics and Pediatrics in *** patient underwent several ovarian stimulation cycles to accumulate a certain number of oocytes that would be *** the last oocyte retrieval,all patient’s oocytes including both frozen and fresh would be *** outcomes included the rates of oocyte survival,cleavage embryo,blastocyst,ploidy status,pregnancy,biochemical pregnancy and clinical ***:The oocyte survival rate after thawing was 96.5%.No statistically significant difference was found when comparing fresh and frozen oocytes regarding fertilization rate(78.1%vs.75.5%,P=0.461),usable cleavage embryo rate(86.9%vs.87.2%,P=0.916)but usable blastocyst rate was found higher statistically in the frozen oocyte group(44.4%vs.54.0%,P=0.049).The percentages of euploid,aneuploid and mosaic embryos between the fresh group and the vitrified group had no significant differences(33.8%vs.31.6%,P=0.682;51.0%vs.54.2%,P=0.569;15.2%vs.12.4%,P=0.787;respectively).The rates of pregnancy,biochemical pregnancy and clinical pregnancy had no statistical difference(68.8%vs.64.8%,P=0.764;12.5%vs.3.6%,P=0.258;37.5%vs.46.4%,P=0.565).17 Mature oocytes are the minimum to have at least one euploid ***:Oocyte vitrification does not affect embryonic,genetic and clinical *** number of mature oocytes should be considered for fertilization in some cases.

关键词： Clinical outcomes Embryonic development Genetic outcomes Human oocyte Oocyte accumulation Oocyte cryopreservation Ploidy status Vitrified oocyte

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New Results on Stability and Stabilization of Delayed Caputo Fractional Order Systems with Convex Polytopic Uncertainties

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Journal of Systems Science & Complexity 2020年第3期33卷 563-583页

作者： DINH Cong Huong MAI Viet thuan DUONG Thi Hong Department for Management of Science and Technology Development Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Mathematics and Statistics Ton Duc Thang UniversityHo Chi Minh CityVietnam Department of Mathematics and Informatics Thainguyen University of SciencesThainguyenVietnam

In this paper,the problems of robust stability and stabilization,for the first time,are studied for delayed fractional-order linear systems with convex polytopic *** authors derive some sufficient conditions for the problems based on linear matrix inequality technique combined with fractional Razumikhin stability *** the results are obtained in terms of linear matrix inequalities that are numerically *** proposed results are quite general and improve those given in the literature since many factors,such as discrete and distributed delays,convex polytopic uncertainties,global stability and stabilizability,are *** examples and simulation results are given to illustrate the effectiveness of the effectiveness of our results.

关键词： Convex polytopic uncertainty delayed caputo fractional-order systems fractional Razumikhin theorem linear matrix inequality robust stability robust stabilization

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Imperfect Channel State Information of AF and DF Energy Harvesting Cooperative Networks

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China Communications 2016年第10期13卷 11-19页

作者： Hoang-Sy NGUYEN Anh-Hoa BUI Dinh-thuan DO Miroslav VOZNAK Wireless Communications Research Group Faculty of Electrical and Electronics Engineering Ton Duc Thang UniversityHo Chi Minh City Vietnam Eastern International University Binh Duong Province Vietnam Faculty of Electrical Engineering and Computer Science Technical University of Ostrava17. Listopadu 15/2172 70833 Ostrava Czech Republic

Wireless information and powered transfer networks(WIPT) has recently been implemented in 5th generation wireless networks. In this paper, we consider half-duplex relaying system in which the energy constrained relay node collects energy via radio frequency(RF) signals from the surrounding resources. Regarding energy harvesting protocol, we propose power time switching-based relaying(PTSR) architecture for both amplify-and-forward(AF) and decode-and-forward(DF). Especially, we reveal the analytical expressions of achievable throughput, ergodic capacity and energy-efficient in case of imperfect channel state information(CSI) for both AF and DF network. Through numerical analysis, we analyse the throughput performance, energy-efficient and ergodic capacity for different parameters, including power splitting ratio and energy harvesting time. Moreover, we also depict the performance comparison between AF and DF network with perfect and imperfect CSI. The results in numerical analysis reveal that the result of AF relaying network is less significant than DF relaying network in the various scenarios.

关键词： amplify-and-forward decode-and-forward energy harvesting throughput channel state information(CSI)

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Hydrodeoxygenation of Bio-Oil on Bimetallic Catalysts: From Model Compound to Real Feed

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Journal of Sustainable Bioenergy Systems 2015年第4期5卷 151-160页

作者： thuan Minh Huynh Udo Armbruster Luong Huu Nguyen duc Anh Nguyen Andreas Martin Leibniz Institute for Catalysis at University of Rostock Rostock Germany Vietnam Petroleum Institute Hanoi Vietnam

Two series of bimetallic Ni-Co catalysts and corresponding monometallic catalysts with ca. 20 wt% metal loading were evaluated in hydrodeoxygenation (HDO) of phenol as a model compound for bio-oil. The bimetallic catalysts outperformed the corresponding monometallic catalyst in terms of conversion and cyclohexane selectivity. This could be attributed to the formation of Ni-Co alloy, which caused a decrease in metal particle size and stabilized Ni active sites in the near surface region. The balanced combination of formed Ni-Co alloy with acidity from supports allowed performing all individual steps in the reaction network toward desired products at high rate. Consequently, the two best-performing catalysts were tested in HDO of wood based bio-oil, showing that the bimetallic catalyst 10Ni10Co/HZSM-5 was more effective than 20Ni/HZSM-5 in terms of degree of deoxygenation and upgraded bio-oil yield. These findings might open an opportunity for development of a novel cheap but effective catalyst for a key step in the process chain from biomass to renewable liquid fuels.

关键词： Bimetallic Catalysts Hydrodeoxygenation Phenol Bio-Oil Ni-Co Alloy

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New Results on H_(∞) Control for Nonlinear Conformable Fractional Order Systems

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Journal of Systems Science & Complexity 2021年第1期34卷 140-156页

作者： MAI Viet thuan NGUYEN Thi Huyen Thu NGUYEN Huu Sau NGUYEN Thi Thanh Huyen Department for Management of Science and Technology Development Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Mathematics and Statistics Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of General Science Hanoi University of Natural Resources and EnvironmentHanoiVietnam Faculty of Fundamental Science Hanoi University of IndustryHa NoiVietnam Department of Mathematics and Informatics Thainguyen University of SciencesThainguyenVietnam

This paper deals with H_(∞) control problem for nonlinear conformable fractional order systems. The authors first derive new sufficient condition for exponential stability of nonlinear conformable fractional order systems based on Lyapunov-like function method for conformable fractional order systems and linear matrix inequalities(LMIs) approach. Then, by introducing a new concepts of H_(∞) control problem for nonlinear conformable fractional order systems, the authors study H_(∞) performance analysis and H_(∞) state feedback controller design problems for the considered systems. In terms of LMIs, a sufficient condition is proposed to ensure the nonlinear conformable fractional order systems are not only exponentially stable, but also satisfy H_(∞) performance γ. An explicit expression for state feedback controllers is also designed to make the closed-loop system is exponentially stable with H_∞performance γ. Finally, numerical examples are given to illustrate the validity and effectiveness of the proposed results.

关键词： Conformable fractional-order H_(∞)control problems H_(∞)performance analysis linear matrix inequalities nonlinear systems

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Local Existence of Solution to a Class of Stochastic Differential Equations with Finite Delay in Hilbert Spaces

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Applied Mathematics 2013年第1期4卷 97-101页

作者： Le Anh Minh Hoang Nam Nguyen Xuan thuan Department of Natural Sciences Hong Duc University Thanh Hoa Vietnam

In this paper, we present a local Lipchitz condition for the local existence of solution to a class of stochastic differential equations with finite delay in a real separable Hilbert space which has the following form:

关键词： Stochastic Differential Equation Local Lipchitz Condition Strongly Semigroup

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Novel CagA ELISA exhibits enhanced sensitivity of Helicobacter pylori CagA antibody

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World Journal of Gastroenterology 2017年第1期23卷 48-59页

作者： Yuichi Matsuo Yasutoshi Kido Junko Akada Seiji Shiota Tran Thanh Binh Tran Thi Huyen Trang Ho DQ Dung Pham Huu Tung Tran Dinh Tri Ngo P Minh thuan Le Quang Tam Bui Chi Nam Vu Van Khien Yoshio Yamaoka Department of Environmental and Preventive Medicine Oita University Faculty of Medicine Department of General Medicine Oita University Faculty of Medicine Department of Endoscopy Cho Ray Hospital Department of Molecular Biology 108 Military Central Hospital Department of Endoscopy Daklak Hospital Department of Endoscopy Lao Cai Hospital Department of Hepatogastroentrology 108 Military Center Hospital Department of Medicine-Gastroenterology Baylor College of Medicine and Michael E.De Bakey Veterans Affairs Medical Center

AIMTo develop a novel Helicobacter pylori (H. pylori) CagA antibody enzyme-linked immunosorbent assay (ELISA) suitable for detecting serum anti-CagA antibodies with high *** East Asian-type CagA protein was purified and immobilized for ELISA. Serum samples from 217 Vietnamese individuals (110 H. pylori-infected and 107 uninfected individuals) were applied. Conventional ELISA from Western-type CagA and our East Asian-type CagA ELISA were evaluated by comparing 38 subjects with the Western-type genotype and 72 subjects with the East Asian-type cagA genotype. Histological scores of the gastric mucosa were determined using the updated Sydney System to examine the relationship with anti-CagA antibody *** 70-100 kDa fragments were immobilized on the ELISA plate. In ROC analysis, the area under the curve of our East Asian-type CagA ELISA was comparable to that of conventional CagA ELISA. The sensitivity of the two ELISAs differed depending on the cagA genotype. The sensitivity of East Asian-type CagA ELISA was higher for subjects infected with East Asian-type cagA H. pylori (P < 0.001), and the sensitivity of the conventional CagA ELISA tended to be higher for subjects infected with Western cagA H. pylori (P = 0.056). The titer of anti-CagA antibody tended to correlate with monocyte infiltration scores (r = 0.25, P = 0.058) and was inversely correlated with H. pylori density (r = -0.26, P = 0.043).CONCLUSIONThe novel ELISA is useful to detect anti-CagA antibodies in East Asian countries, and the titer may be a marker for predicting chronic gastritis.

关键词： Helicobacter pylori cagA genotype Anti-CagA antibody Enzyme-linked immunosorbent assay Inflammation Gastritis

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Assessment of Radiation Dose Caused by Radioactive Gaseous Effluent Released from Nuclear Power Plant Ninh thuan 1 under Scenario of Normal Working Conditions

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World Journal of Nuclear Science and Technology 2015年第3期5卷 183-191页

作者： Nguyen Tuan Khai Do Xuan Anh Le Dinh Cuong Duong duc Thang Vuong Thu Bac Nguyen Thi Thu Ha Nguyen Quang Long Trinh Van Giap Nguyen Hao Quang Institute for Nuclear Science and Technology (INST) Hanoi Vietnam Vietnam Atomic Energy Institute (VINATOM) Hanoi Vietnam

Based on guides RG 1.109, RG 1.111 published by United States Nuclear Regulatory Commission (USNRC), our research concentrates in assessing radiation doses caused by radioactive substances released from the nuclear power plant (NPP) Ninh thuan 1 under the scenario of normal operation using software package NRCDose72 provided by the USNRC. The database including the released radioactive nuclides, meteorology, terrain, population and agricultural production activities have been collected and processed to build the input data for the model calculation. The wind rose distribution obtained from the meteorological data in a five-year period from 2009-2013 showed that the radioactive nuclides released to environment spread in two main wind directions which are North East and South West. The X/Q (s/m3) and D/Q (s/m2) qualities which are, respectively, the ratio of activity concentration to release rate and that of deposition density of radioactive nuclides to release rate were calculated within an area of 80 km radius from the NPP site using XOQDOQ. Population doses were calculated using GASPAR. The XOQDOQ and GASPAR are two specific softwares in NRCDose72 package.

关键词： NPP Radioactive Release Radiation Dose Population Dose X/Q and D/Q

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