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Systematic Screening of the Serotonin Receptor 1A (5-HT1A) Gene in Chronic Tinnitus

Journal of Otology 2006年第2期1卷 83-85页

作者： Kleinjung T langguth b Fischer b Hajak G Eichhammer P Sand PG Departments of Otorhinolaryngology University of Regensburg Departments of Psychiatry University of Regensburg

Objective Chronic tinnitus is a highly prevalent condition and has been hypothesized to result from an innate disturbance in central nervous serotonergic transmission. Given the frequent comorbidity with major depression and anxiety, we argue that candidate genes for these disorders are likely to overlap. The present study addresses the gene encoding for the 5-HT1A receptor as a putative risk factor for tinnitus. Methods In 88 subjects with a diagnosis of chronic subjective tinnitus who underwent a detailed neurootological examination, the entire 5-HT1A gene was amplified using overlapping PCR products. Amplicons were custom sequenced bidirectionally and were screened for variants in multiple alignments against the human genome reference. Results We identified a synonymous C > T exchange at residue 184 (Pro) in 7/88 subjects, but detected no missense variants in the population under study. Specifically, the following residues were fully conserved: 16 (Pro), 22(Gly), 28(Ile), 98 (Val), 220(Arg), 267 (Val), 273 (Gly), and 418 (Asn). Discussion The present data count against the causation of chronic tinnitus by a change in the 5-HT1A receptor’s amino acid sequence. However, the allele frequency for the 184Pro minor allele (0.04) reached twice the frequency reported in control cohorts from the same ethnicity. Additional investigations are invited to clarify the role of the 5-HT1A polymorphism in larger samples, and to control for comorbid affective disorders.

关键词： 5-HT1A Gene Tinnitus

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Pediatric Nd:YAG laser capsulotomy in the operating room: review of 87 cases

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International Journal of Ophthalmology(English edition) 2019年第5期12卷 779-783页

作者： Michael Kinori Narasimhan Jagannathan Anne M langguth Marjorie A Sasso Marilyn b Mets bahram Rahmani Hawke Yoon Rebecca Mets-Halgrimson Sudhi P Kurup Janice L Zeid The Goldschleger Eye Institute Sheba Medical CenterTel Ha ShomerAffiliated to the Sackler Faculty of MedicineTel Aviv University Department of Pediatric Anesthesiology Ann & Robert H.Lurie Children's Hospital of Chicago Division of Ophthalmology Ann & Robert H.Lurie Children's Hospital of Chicago Department of Ophthalmology Northwestern University Feinberg School of Medicine Department of Surgical Services Ann & Robert H.Lurie Children's Hospital of Chicago

AIM: To report a large series of children having Nd:YAG laser capsulotomy in the operating room using the lateral decubitus position. METHODS: Medical records of children who underwent Nd:YAG laser capsulotomy in the operating room at Ann & Robert H. Lurie Children's Hospital of Chicago between September 2008 and April 2017 were reviewed. Induction of general anesthesia and intubation was performed in the supine position after which the patient was placed in lateral decubitus position. The Nd:YAG laser capsulotomy was performed using a standard protocol. At the completion of the procedure, the patient was turned back into the supine position and extubated. RESULTS: This study included 87 eyes of 60 patients. Patient's age ranged from 1 to 18 y(mean 6.4±4.1 y). In most cases(84/87, 97%), the procedure was performed under general anesthesia. In all cases, good focus on the membrane was achieved, and the procedure was performed successfully. There were no intraoperative ocular or anesthesia-related complications. CONCLUSION: When performing Nd:YAG laser capsulotomy in the operating room, the lateral decubitus position allowsan easy and safe approach without the risk of potentially devastating complications that have been associated with the previously described sitting and prone positions.

关键词： posterior capsular opacification YAG capsulotomy general anesthesia pediatric cataract

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1.5 T和3 T环境下具有自动MRI检查模式的MR条件起搏系统的安全性和效能

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国际医学放射学杂志 2023年第6期 753-753页

作者： J.N.Dacher P.langguth D.Adam W.b.Winkler M.A.Julio G.Prenner 王倩

摘要目的在1.5 T和3 T MRI环境下，评估具有自动开启MRI检查模式注册商标ENO?、TEO?或OTO?的起搏系统的安全性和效能，以及非增强MR检查的影像质量。方法

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