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Minimally invasive surgery vs laparotomy in patients with colon cancer residing in high-altitude areas

World Journal of Clinical Cases 2021年第35期9卷 10919-10926页

作者： Duo-Ji Suo lang Yang-Zhen Ci Ren zha-Xi Bian Ba Department of General Surgery People’s Hospital of Tibet Autonomous RegionLasa 850000Tibet Autonomous RegionChina Department of Internal Medicine The Tibet Autonomous Region Centers for Disease Control and PreventionLasa 850000Tibet Autonomous RegionChina

BACKGROUND Colon cancer is associated with a higher incidence among residents in highaltitude *** environment at high altitudes inhibits the phagocytic and oxygen-dependent killing function of phagocytes,thereby increasing the inflammatory factors,inhibiting the body’s innate immunity and increasing the risk of colon *** To examine the effect of minimally invasive surgery vs laparotomy in patients with colon cancer residing in high-altitude *** Ninety-two patients with colon cancer in our hospital from January 2019 to February 2021 were selected and divided into the minimally invasive surgery and laparotomy groups using the random number table method,with 46 patients in each *** invasive surgery was performed in the minimally invasive group and laparotomy in the laparotomy *** conditions,inflammatory index pre-and post-surgery,immune function index and complication probability were *** Operative duration was significantly longer and intraoperative blood loss and recovery time of gastrointestinal function were significantly less(all P<0.05)in the minimally invasive group than in the laparotomy *** number of lymph nodes dissected was not significantly *** surgery,there were no significant differences in serum C-reactive protein,interleukin-6 and tumor necrosis factor-αlevels between the groups,whereas after surgery,the levels were significantly higher in the minimally invasive group(26.98±6.91 mg/L,146.38±11.23 ng/mL and 83.51±8.69 pg/mL vs 41.15±8.39 mg/L,186.79±15.36 ng/mL and 110.65±12.84 pg/mL,respectively,P<0.05).Furthermore,before surgery,there were no significant differences in CD3+,CD4+and CD4+/CD8+levels between the groups,whereas after surgery,the levels decreased in both groups,being significantly higher in the minimally invasive group(55.61%±4.39%,35.45%±3.67%and 1.30±0.35 vs 49.68%±5.33%,31.21%±3.25%and 1.13±0.30,respectively,P<0.05).Complication probability was significant

关键词： Minimally invasive surgery Laparotomy High-altitude area Colon cancer Surgical trauma Immune dysfunction

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森林转换对土壤氮相关水解酶活性的影响

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亚热带资源与环境学报 2024年第3期19卷 68-75页

作者：陈秋雯杜暄瑜查满丽郞彩芳郭剑芬福建师范大学地理研究所福州350117 福建师范大学福建省植物生理生态重点实验室福州350117

森林转换会对土壤生态过程产生显著影响,其中土壤酶是土壤系统不可缺少的重要组成部分,能表征土壤C,N,P等养分的循环状况,因此研究森林转换对土壤酶活性的影响具有重要意义。此外,不同底物浓度下酶活性差异大,底物浓度如何影响不同森林... 详细信息

森林转换会对土壤生态过程产生显著影响,其中土壤酶是土壤系统不可缺少的重要组成部分,能表征土壤C,N,P等养分的循环状况,因此研究森林转换对土壤酶活性的影响具有重要意义。此外,不同底物浓度下酶活性差异大,底物浓度如何影响不同森林土壤酶活性越来越受到关注。以福建省顺昌县武坊林场常绿阔叶天然林和杉木人工林为研究对象,采用96微孔酶标板荧光分析法,通过设置2种底物浓度研究与氮循环有关的2种水解酶(β-1,4-N-乙酰葡糖氨糖苷酶和亮氨酸氨基肽酶)活性在不同土层(0~10、10~20和20~40 cm)的分布规律及对森林转换的响应。研究表明:(1)在天然林中高浓度(400μM)和低浓度(200μM)下β-1,4-N-乙酰葡糖氨糖苷酶(NAG)与亮氨酸氨基肽酶(LAP)活性随土层加深呈现先减小后增加的趋势,提高底物浓度后,表层和深层土壤NAG酶活性以及深层土壤LAP酶活性增大。(2)在人工林中2种底物浓度下NAG酶活性随着土层的加深而逐渐减少,土层对低浓度(200μM)NAG酶有显著影响(P人工林,不同林分对高浓度(400μM)LAP酶有显著影响(P<0.05)。(4)土壤理化性质(pH、粒径、全碳和全氮)与不同浓度下NAG和LAP酶活性无显著相关,200μM浓度下LAP活性与不同浓度NAG酶活性呈显著负相关(P<0.05)。

关键词：水解酶活性底物浓度森林转换土壤深度

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针刺治疗对颈椎间盘突出症微创手术后疗效的影响

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中国疼痛医学杂志 2024年第6期30卷 424-431页

作者：查紫璐计忠伟万权胡佳琦张南南茹彬徐郎海许运蔡文君李顺浙江省人民医院(杭州医学院附属人民医院)疼痛科杭州310014

目的:探讨针刺治疗对颈椎间盘突出症(cervical disc herniation,CDH)微创手术(minimally invasive surgery,MIS)后疗效的影响。方法:回顾性分析2019年1月1日至2020年12月31日浙江省人民医院疼痛科住院行MIS的CDH病人。采用视觉模拟评分... 详细信息

目的:探讨针刺治疗对颈椎间盘突出症(cervical disc herniation,CDH)微创手术(minimally invasive surgery,MIS)后疗效的影响。方法:回顾性分析2019年1月1日至2020年12月31日浙江省人民医院疼痛科住院行MIS的CDH病人。采用视觉模拟评分法(visual analogue scale,VAS)评分、颈椎功能障碍指数(neck disability index,NDI)评分和改良MacNab标准分别评估术后1个月、6个月和1年的疼痛程度、颈椎功能和临床疗效。比较接受针刺治疗和未接受针刺治疗病人的临床特点。结果:211名病人被纳入队列,其中102人接受针刺治疗,未接受针刺治疗病人109例。针刺治疗的病人较未接受针刺治疗的病人术后1个月、6个月和1年的VAS和NDI评分更低(P<0.001)。针刺治疗与治疗后6个月和1年时更低的改良MacNab标准评分相关(P<0.001)。多因素logistic回归显示,针刺治疗是MIS术后1年良好结果的独立因素(P<0.001,OR=9.282,95%CI:3.469-24.836)。结论:针刺治疗对MIS后CDH病人的临床结果有益,是MIS后CDH病人的一种有效的辅助治疗方法。

关键词：针刺治疗颈椎间盘突出症微创手术临床结果疼痛功能

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Glucose-responsive,antioxidative HA-PBA-FA/EN106 hydrogel enhanced diabetic wound healing through modulation of FEM1b-FNIP1 axis and promoting angiogenesis

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Bioactive Materials 2023年第12期30卷 29-45页

作者： Wenqian zhang Kangkang zha Yuan Xiong Weixian Hu lang Chen Ze Lin Chenyan Yu Wu Zhou Faqi Cao Hankun Hu Bobin Mi Guohui Liu Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan430022China Department of Pharmacy Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Hubei Micro-explore Innovative Pharmaceutical Research Co LtdWuhanHubei430071PR China Suzhou Organ-on-a-Chip System Science and Technology Co LtdSuzhouJiangsu215000PR China

The diabetic wounds remain to be unsettled clinically,with chronic wounds characterized by drug-resistant bacterial infections,compromised angiogenesis and oxidative damage to the *** ameliorate oxidative stress and applying antioxidant treatment in the wound site,we explore the function of folliculininteracting protein 1(FNIP1),a mitochondrial gatekeeper protein works to alter mitochondrial morphology,reduce oxidative phosphorylation and protect cells from unwarranted ROS *** our in vitro experiments showed the effects of FNIP1 in ameliorating oxidative stress and rescued impaired angiogenesis of HUVECs in high glucose *** realize the drug delivery and local regulation of FNIP1 in diabetic wound sites,a novel designed glucose-responsive HA-PBA-FA/EN106 hydrogel is introduced for improving diabetic wound *** to the dynamic phenylboronate ester structure with a phenylboronic acid group between hyaluronic acid(HA)and phenylboronic acid(PBA),the hydrogel is able to realize a glucose-responsive release of *** acid(FA)is added in the hydrogel,which not only severs as crosslinking agent but also provides antibacterial and anti-inflammatory ***,the release of FEM1b-FNIP1 axis inhibitor EN106 ameliorated oxidative stress and stimulated angiogenesis through FEM1b-FNIP1 axis *** in vivo and in vitro results demonstrated that accelerated diabetic wounds repair with the use of the HA-PBA-FA/EN106 hydrogel,which may provide a promising strategy for chronic diabetic wound repair.

关键词： FNIP1 Wound healing Hydrogel Antioxidant Glucose-responsive

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Content Determination of Astragaloside Ⅳ in Astragalus from Three Different Regions by HPLC

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Medicinal Plant 2018年第6期9卷 15-18,22页

作者： Wei XIN Jiangli NIE Ye HAN Yi PEI Nan YANG Yujie lang Xi zha College of Horticulture and Landscape Architecture Tianjin Agricultural University

[Objectives] The content of astragaloside in Astragalus membranaceus(Fisch.) ***(Bge.) Hisao from three different regions was determined.[Methods] Referring to the method recorded in the Chinese Pharmacopoeia(2015 edition),the content of astragaloside IV in *** was determined by HPLC.[Results] There were great differences in the astragaloside IV content of *** among different *** content of astragaloside IV in *** cultivated in Inner Mongolia was highest(0.155%),followed by that(0.143%) in *** cultivated in Gansu,and the content of astragaloside IV in *** cultivated in Shanxi was lowest(0.080%).The contents of astragaloside IV in *** from different regions were all in line with the standard(not less than 0.040%) of Chinese Pharmacopoeia(2015 edition).[Conclusions]The content of astragaloside IV in *** cultivated in three different regions met the medicinal standards.

关键词： Astragalus membranaceus(Fisch.)Bge.var.mongholicus(Bge.)Hisao Astragaloside IV HPLC Content determination

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Theoretical analysis and experimental verification of thermal decomposition mechanism of CuSe

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Transactions of Nonferrous Metals Society of China 2022年第10期32卷 3478-3486页

作者： Huan LUO Heng XIONG Wen-long JIANG lang LIU Guo-zheng zha Tian-tian ZHEN Bin YANG Bao-qiang XU National Engineering Research Center of Vacuum Metallurgy Kunming University of Science and TechnologyKunming 650093China Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093China Yunnan Provincial Key Laboratory for Nonferrous Vacuum Metallurgy Kunming University of Science and TechnologyKunming 650093China State Key Laboratory of Complex Non-Ferrous Metal Resources Clean Utilization Kunming University of Science and TechnologyKunming 650093China

Experiments on the thermal decomposition of CuSe were carried out by using a thermogravimetric analyzer(TGA)at different heating *** kinetic parameters and mechanisms were discussed based on model-free and model-based *** decomposition rate and decomposition behavior of CuSe were investigated by using a vacuum thermogravimetric *** results showed that the R3 model was identified as the most probable mechanism function under the present experimental *** average values of activation energy and the pre-exponential factor were 12.344 J/mol and 0.152 s^(−1),*** actual decomposition rate of CuSe was found to be 0.0030 g/(cm^(2)·min).

关键词： CuSe thermal decomposition non-isothermal kinetics mechanism

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Large-scale multiferroic complex oxide epitaxy with magnetically switched polarization enabled by solution processing

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National Science Review 2020年第1期7卷 84-91页

作者： Cong Liu Feng An Paria S.M.Gharavi Qinwen Lu Junkun zha Chao Chen Liming Wang Xiaozhi zhan Zedong Xu Yuan zhang Ke Qu Junxiang Yao Yun Ou Zhiming zhao Xiangli Zhong Dongwen zhang Nagarajan Valanoor lang Chen Tao Zhu Deyang Chen Xiaofang zhai Peng Gao Tingting Jia Shuhong Xie Gaokuo Zhong Jiangyu Li Shenzhen Key Laboratory of Nanobiomechanics Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences School of Materials Science and Engineering Xiangtan University School of Materials Science and Engineering University of New South Wales Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemical Physics University of Science and Technology of China Institute for Advanced Materials and Guangdong Provincial Key Laboratory of Optical Information Materials and Technology South China Academy of Advanced Optoelectronics South China Normal University Dongguan Neutron Science Center Department of Physics Southern University of Science and Technology International Center for Quantum Materials and Electron Microscopy Laboratory School of Physics Peking University Hunan Provincial Key Laboratory of Health Maintenance for Mechanical Equipment Hunan University of Science and Technology Department of Physics College of Science National University of Defense Technology Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Songshan Lake Materials Laboratory Dongguan Neutron Science Center

Complex oxides with tunable structures have many fascinating properties, though high-quality complex oxide epitaxy with precisely controlled composition is still out of reach. Here we have successfully developed solution-based single-crystalline epitaxy for multiferroic（1-x）BiTi;/;Fe;Mg;/;O;–（x）CaTiO;（BTFM–CTO） solid solution in large area, confirming its ferroelectricity at the atomic scale with strong spontaneous polarization. Careful compositional tuning leads to a bulk magnetization of 0.07 ± 0.035 μB/Fe at room temperature, enabling magnetically induced polarization switching exhibiting a large magnetoelectric coefficient of 2.7–3.0 × 10;s/m. This work demonstrates the great potential of solution processing in large-scale complex oxide epitaxy and establishes novel room-temperature magnetoelectric coupling in epitaxial BTFM–CTO film, making it possible to explore a much wider space of composition,phase, and structure that can be easily scaled up for industrial applications.

关键词： complex oxide solution method epitaxy multiferroic

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新“举国体制”下竞技体育人才培养体系的构建

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北京师范大学学报（自然科学版） 2015年第2期51卷 217-220页

作者：王长权查萍郎健北京师范大学体育与运动学院北京100875

采用文献资料法、计算和科学预测的方法,对我国竞技体育可持续发展及人才培养体系进行了研究.认为中国竞技体育应回归教育,以形成新的"举国体制";在教育系统内部应以四级"任务学校"的形式构建竞技体育人才培养体系,并对各级"任务学校"... 详细信息

采用文献资料法、计算和科学预测的方法,对我国竞技体育可持续发展及人才培养体系进行了研究.认为中国竞技体育应回归教育,以形成新的"举国体制";在教育系统内部应以四级"任务学校"的形式构建竞技体育人才培养体系,并对各级"任务学校"的数量进行了可行性测算.

关键词：竞技体育举国体制培养体系任务学校

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Role of the immune microenvironment in bone,cartilage,and soft tissue regeneration:from mechanism to therapeuticopportunity

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军事医学研究:英文版 2023年第4期10卷 499-528页

作者： Yuan Xiong Bo‑Bin Mi Ze Lin Yi‑Qiang Hu Le Yu Kang‑Kang zha Adriana CPanayi Tao Yu lang Chen Zhen‑Ping Liu Anish Patel Qian Feng Shuan‑Hu Zhou Guo‑Hui Liu Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan 430022China Department of Chemical and Biomolecular Engineering Ohio UniversityAthensOH 45701USA Key Laboratory of Biorheological Science and Technology Ministry of Education College of BioengineeringChongqing UniversityShapingbaChongqing 400044China Department of Plastic Surgery Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02152USA Department of Orthopaedics Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Physics Center for Hybrid Nanostructure(CHyN)University of HamburgHamburg 22761Germany Joint Laboratory of Optofluidic Technology and System National Center for International Research on Green OptoelectronicsSouth China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China Skeletal Biology Laboratory Department of Orthopedic SurgeryBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02120USA Harvard Stem Cell Institute Harvard UniversityCambridgeMA 02138USA.

Bone,cartilage,and soft tissue regeneration is a complex spatiotemporal process recruiting a variety of cell types,whose activity and interplay must be precisely mediated for effective healing *** extensive strides have been made in the understanding of the immune microenvironment processes governing bone,cartilage,and soft tissue regeneration,effective clinical translation of these mechanisms remains a *** of the immune microenvironment is increasingly becoming a favorable target for bone,cartilage,and soft tissue regeneration;therefore,an in-depth understanding of the communication between immune cells and functional tissue cells would be ***,we review the regulatory role of the immune microenvironment in the promotion and maintenance of stem cell states in the context of bone,cartilage,and soft tissue repair and *** discuss the roles of various immune cell subsets in bone,cartilage,and soft tissue repair and regeneration processes and introduce novel strategies,for example,biomaterial-targeting of immune cell activity,aimed at regulating *** the mechanisms of the crosstalk between the immune microenvironment and regeneration pathways may shed light on new therapeutic opportunities for enhancing bone,cartilage,and soft tissue regeneration through regulation of the immune microenvironment.

关键词： Immune microenvironment Regeneration Cell-cell interaction Tissue engineering Biomaterials

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大孔树脂对玉米花粉黄酮类的吸附分离特性研究

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河南工业大学学报（自然科学版） 2007年第1期28卷 21-24页

作者：查磊任顺成罗浪峰河南工业大学粮油食品学院河南郑州450052

选择8种大孔吸附树脂,比较其对玉米花粉黄酮类的吸附率和解吸率,筛选较优的玉米花粉黄酮类吸附剂,并对其动态吸附性能进行了考察.结果表明:AB-8树脂对玉米花粉黄酮类有较好的吸附和解吸效果.

关键词：玉米花粉黄酮类大孔吸附树脂静态吸附动态吸附

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