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Cryogenian and Ediacaran integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 919-949页

作者： lang sun Malik Muhammad Saud Sajid KHAN Chuan YANG Zhixin sun Bing PAN Shehryar AHMED Lanyun MIAO Weichen sun Chunlin HU Xiaojuan sun Cui LUO Bo CHEN Zongjun YIN Fangchen ZHAO Guoxiang LI Maoyan ZHU State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

The complex evolutionary history of the Qinghai-Tibetan Plateau and its surrounding areas,including the continental blocks(Indian,Lhasa,South Qiangtang,Tarim,Olongbuluk,Central Qilian,Alxa,North China,Yangtze,Central Iran and Oman)and the orogenic belts between them,has long been the frontier in Earth science research.The Cryogenian and Ediacaran strata are extensively distributed in these blocks.Specifically,relatively complete Cryogenian and Ediacaran successions have been discovered in Oman,Indian,Yangtze,and Tarim blocks,while only the Ediacaran successions have been reported in Iran,the South Qiangtang,Central Qilian,Alxa,and North China blocks.Based on previous studies together with the integration of new materials and advancement obtained through the Second Tibetan Plateau Scientific Expedition and Research,this review aims to synthesize a correlative stratigraphic framework of the representative Cryogenian and Ediacaran sequences from the Qinghai-Tibetan Plateau and its surrounding areas.Furthermore,the Cryogenian and Ediacaran biotas and major geological events in these areas are comprehensively discussed in aspects of current research status.The results indicate that,in general,Ediacaran fossils of each area exhibit distinct features in preservation and assemblage composition,but the typical late Ediacaran fossils Cloudina and Shaanxilithes have been reported from most of these areas.In addition to the two global Cryogenian glaciations,late Ediacaran glaciogenic deposits are extensively recorded in the areas within and around the northern QinghaiTibetan Plateau(including the North China,Alxa,Central Qilian,Olongbuluk,and Tarim blocks,and the North Qilian Accretionary Belt),as well as central and southern Iran.However,further research is required to determine the age,distribution,and origin of these late Ediacaran glaciogenic deposits.Meanwhile,the middle Ediacaran DOUNCE/Shuram Excursion is widely documented in the Qinghai-Tibetan Plateau and its surrounding areas.The available data show that,after the

关键词： Qinghai-Tibetan Plateau Cryogenian Ediacaran Stratigraphy Palaeogeography Biota Gondwana

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Cambrian integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 950-970页

作者： Zhixin sun lang sun Fangchen ZHAO Bing PAN Malik Muhammad Saud Sajid KHAN Shehryar AHMED Chuan YANG Lanyun MIAO Zongjun YIN Guoxiang LI Maoyan ZHU State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

The Qinghai-Tibetan Plateau and its surrounding areas have a long and complex tectonic evolutionary history.Cratons and blocks,such as northern India,Lhasa,Qiangtang,Qaidam and Central Qilian,and their in-between orogenic belts constitute the main part of the Qinghai-Tibetan Plateau.During the Cambrian Period,most of these cratons and blocks were on the northwestern periphery of Gondwana,and were associated with the surrounding blocks,e.g.Arabian,Central Iran,Afghanistan,Tarim,Alxa,North China,South China and Sibumasu through the Proto-Tethys Ocean.The Cambrian stratigraphic sequences on these stable blocks are composed of mixed siliciclastic and carbonate rocks deposited in the shallow-water marine environments,and contain the trilobite assemblages of shelf facies.The Cambrian stratigraphic sequences in the Qilian tectonic belts,however,are characterized by the intermediate-basic igneous rocks and silicates formed in the Proto-Tethys Ocean,and contain the trilobite assemblages of deep-water slope facies.Combining with previous data,field observations and newly discovered fossils through funding by the Second Tibetan Plateau Scientific Expedition and Research,the general characteristics of the Cambrian strata in different tectonic units of the Qinghai-Tibetan Plateau and its surrounding areas have been summarized in this paper.Furthermore,efforts have been made to subdivide and correlate the Cambrian strata across these areas by utilizing available biostratigraphic and geochronological data.As a result,a comprehensive litho-and biostratigraphy chart has been compiled.Finally,from the biogeographic perspective,this paper also provides a brief overview of the Cambrian paleogeographical reconstruction of the major tectonic blocks,and discusses the problems associated with the evolution of the ProtoTethys tectonic belt.

关键词： Qinghai-Tibetan Plateau Cambrian Stratigraphy Paleogeography Biota Gondwana Proto-Tethys Ocean

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Cryogenian and Ediacaran integrative stratigraphy, biotas, and palaeogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年

作者： lang sun Malik Muhammad Saud Sajid KHAN Chuan YANG Zhixin sun Bing PAN Shehryar AHMED Lanyun MIAO Weichen sun Chunlin HU Xiaojuan sun Cui LUO Bo CHEN Zongjun YIN Fangchen ZHAO Guoxiang LI Maoyan ZHU State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences

The complex evolutionary history of the Qinghai-Tibetan Plateau and its surrounding areas, including the continental blocks (Indian, Lhasa, South Qiangtang, Tarim, Olongbuluk, Central Qilian, Alxa, North China, Yangtze, Central Iran and Oman) and the orogenic belts between them, has long been the frontier in Earth science research. The Cryogenian and Ediacaran strata are extensively distributed in these blocks. Specifically, relatively complete Cryogenian and Ediacaran successions have been discovered in Oman, Indian, Yangtze, and Tarim blocks, while only the Ediacaran successions have been reported in Iran,the South Qiangtang, Central Qilian, Alxa, and North China blocks. Based on previous studies together with the integration of new materials and advancement obtained through the Second Tibetan Plateau Scientific Expedition and Research, this review aims to synthesize a correlative stratigraphic framework of the representative Cryogenian and Ediacaran sequences from the Qinghai-Tibetan Plateau and its surrounding areas. Furthermore, the Cryogenian and Ediacaran biotas and major geological events in these areas are comprehensively discussed in aspects of current research status. The results indicate that, in general,Ediacaran fossils of each area exhibit distinct features in preservation and assemblage composition, but the typical late Ediacaran fossils Cloudina and Shaanxilithes have been reported from most of these areas. In addition to the two global Cryogenian glaciations, late Ediacaran glaciogenic deposits are extensively recorded in the areas within and around the northern QinghaiTibetan Plateau (including the North China, Alxa, Central Qilian, Olongbuluk, and Tarim blocks, and the North Qilian Accretionary Belt), as well as central and southern Iran. However, further research is required to determine the age, distribution, and origin of these late Ediacaran glaciogenic deposits. Meanwhile, the middle Ediacaran DOUNCE/Shuram Excursion is widely documented in the Qinghai-Tibetan Plateau and its surrounding

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An ultra-sensitive metasurface biosensor for instant cancer detection based on terahertz spectra

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Nano Research 2023年第5期16卷 7304-7311页

作者： Peiliang Wang Jing Lou Yun Yu lang sun Lan sun Guangyou Fang Chao Chang Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China Innovation Laboratory of Terahertz Biophysics National Innovation Institute of Defense TechnologyBeijing 100071China The Key Laboratory of Electromagnetic Radiation and Sensing Technology Chinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China Air and Missile Defense College Air Force Engineering UniversityXi’an 710051China Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100007China School of Psychological and Cognitive Sciences Beijing Key Laboratory of Behavior and Mental HealthPeking UniversityBeijing 100871China School of Life Science and Technology Xi’an Jiaotong UniversityXi’an 710049China

Metasurface biosensors have become the core label-free and rapid-detection technology in bioanalysis.Lung cancer and brain cancer are the first leading causes of cancer death among adults and adolescents,respectively,where poor early diagnosis results from expensive detection costs and time consumption.To tackle the above problems,here,we introduce a terahertzdomain metasurface biosensor for cancer diagnosis,relying on a perfectly symmetrical periodic surface structure,which significantly exhibits polarization-insensitivity at 2.05 THz and the high-sensitivity of 504 GHz/RIU(RIU=refractive index unit).According to the frequency shifts and transmittance variations,four cell types are successfully distinguished from each other.The minimum number of cells is required for thousands of cells to display the differences of spectra,which is 1/30 of clinical methods.Furthermore,the results were consistent with pathological results(the gold standard in clinic)by Gaussian curve fitting.The proposed biosensor has really achieved the characterization of cells in normal and cancerous state.This detection strategy dramatically reduced the cost of detection by reuse and time consumption was reduced to 1/20 of the pathology testing.In addition,it is flexible to set samples and easy to realize automatic operation due to the great polarization-insensitivity of the proposed biosensor,which can further reduce labor costs in the future.It is envisioned that the proposed biosensor will present immense potential in the fields of cancer detection,distinguishing different cancers,identifying primary lesion cancer or metastatic cancer.

关键词： terahertz metasurface biosensor cancer detection

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Polymyxin resistance caused by large-scale genomic inversion due to IS26 intramolecular translocation in Klebsiella pneumoniae

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药学学报:英文版 2023年第9期13卷 3678-3693页

作者： Haibin Li lang sun Han Qiao Zongti sun Penghe Wang Chunyang Xie Xinxin Hu Tongying Nie Xinyi Yang Guoqing Li Youwen Zhang Xiukun Wang Zhuorong Li Jiandong Jiang Congran Li Xuefu You Beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100050China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100050China

Polymyxin B and polymyxin E(colistin)are presently considered the last line of defense against human infections caused by multidrug-resistant Gram-negative organisms such as carbapenemase-producer Enterobacterales,Acinetobacter baumannii,and Klebsiella pneumoniae.Yet resistance to this last-line drugs is a major public health threat and is rapidly increasing.Polymyxin S2(S2)is a polymyxin B analogue previously synthesized in our institute with obviously high antibacterial activity and lower toxicity than polymyxin B and colistin.To predict the possible resistant mechanism of S2for wide clinical application,we experimentally induced bacterial resistant mutants and studied the preliminary resistance mechanisms.Mut-S,a resistant mutant of K.pneumoniae ATCC BAA-2146(Kpn2146)induced by S2,was analyzed by whole genome sequencing,transcriptomics,mass spectrometry and complementation experiment.Surprisingly,large-scale genomic inversion(LSGI)of approximately 1.1 Mbp in the chromosome caused by IS26mediated intramolecular transposition was found in Mut-S,which led to mgrB truncation,lipid A modification and hence S2resistance.The resistance can be complemented by plasmid carrying intact mgrB.The same mechanism was also found in polymyxin B and colistin induced drug-resistant mutants of Kpn2146(Mut-B and Mut-E,respectively).This is the first report of polymyxin resistance caused by IS26 intramolecular transposition mediated mgrB truncation in chromosome in K.pneumoniae.The findings broaden our scope of knowledge for polymyxin resistance and enriched our understanding of how bacteria can manage to survive in the presence of antibiotics.

关键词： Klebsiella pneumoniae Polymyxin resistance mgrB IS26 Whole genome sequencing Structural variation Inversion

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煤矸石精确产酸潜力评价方法对比研究

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矿业科学学报 2024年第1期9卷 13-21页

作者：孙红福阴祥诚孙朗赵峰华朱孟浩范紫仪中国矿业大学(北京)地球科学与测绘工程学院北京100083

为有效避免重大酸性水污染事故,需提高矿山岩石产酸潜力评价的精度。通过全面阐述矸石中常见含硫矿物的产酸潜力计算方法,采用三步连续提取法测定了多个矿石和煤矸石中产酸矿物的硫含量,对比分析了精确产酸潜力和最大产酸潜力。结果表明... 详细信息

为有效避免重大酸性水污染事故,需提高矿山岩石产酸潜力评价的精度。通过全面阐述矸石中常见含硫矿物的产酸潜力计算方法,采用三步连续提取法测定了多个矿石和煤矸石中产酸矿物的硫含量,对比分析了精确产酸潜力和最大产酸潜力。结果表明:煤矸石的产酸潜力值取决于各产酸硫的质量分数和单位硫产酸值;对大部分样品,用产酸硫含量计算的产酸潜力值不同程度地低于用全硫预测的产酸潜力值;样品SC中的硫成分主要为砷黄铁矿硫,相比黄铁矿的单位硫产酸值更高,导致SC样品计算的精确产酸潜力相比全硫预测的产酸潜力更高;三步连续提取法适用于以铁和铜的硫化物为主要含硫矿物的煤矸石;当矿石中其他硫化物成分增多和空白样品混合不均匀都会对结果产生一定干扰。研究结果为准确评价矿区煤矸石精确产酸潜力提供了依据。

关键词：产酸潜力含硫矿物煤矸石三步连续提取法酸性水预测

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Targeted drug approvals in 2023:breakthroughs by the FDA and NMPA

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Signal Transduction and Targeted Therapy 2024年第3期9卷 813-821页

作者： lang Zheng Wenjing Wang Qiu sun Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China West China Medical Publishers West China HospitalSichuan UniversityChengdu 610041China

According to the official website of China’s National Medicines and Pharmaceutical Administration(NMPA),a total of 87 novel drugs were approved in China in 2023,with targeted drugs accounting for 67.8%of the total,amounting to 59 drugs(Fig.1a;Table 1)[https://***/yaopin/ypjgdt/index.html].Notably,domestic innovation is flourishing,with five first-in-class drugs,including Glumetinib,a c-Met inhibitor from Haihe Biopharma;Leritrelvir,a 3CL protease inhibitor from Raynovent;Anaprazole,a proton pump inhibitor from Xuanzhu Biopharm;Pegol-Sihematide,an EPO drug from Hansoh Pharma;and Zuberitamab from BioRay Biopharmaceutical Co.,Ltd.Additionally,the world’s first allosteric inhibitor targeting TYK2,Sotyktu(deucravacitinib),has been approved for the treatment of psoriasis and Selumetinib,a MEK inhibitor co-developed by AstraZeneca and Merck Sharp&Dohme(MSD),became the first approved drug in China for the treatment of neurofibromatosis type I(NF1).Beyond these drugs,the approval of novel drug types such as CAR-T cell products,siRNA,monoclonal antibodies,dual antibodies,and ADCs in China is a significant development in the country’s pharmaceutical industry(Fig.1a).

关键词： drugs Merck approval

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泵车臂架油缸护套疲劳强度计算与分析

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液压气动与密封 2024年第1期44卷 93-97页

作者：郭彦斌陈希孙朗朗马军杰张强邓乃川徐州徐工液压件有限公司江苏徐州221004

臂架油缸作为泵车臂架机构的执行元件,承受臂架带来的交变载荷,由于泵车工作的特殊性,对油缸的安全性要求非常高。以具体产品为例,对泵车臂架油缸脆弱点进行疲劳强度理论计算,并用有限元分析对结果进行验证,形成理论计算方法,为类似产... 详细信息

臂架油缸作为泵车臂架机构的执行元件,承受臂架带来的交变载荷,由于泵车工作的特殊性,对油缸的安全性要求非常高。以具体产品为例,对泵车臂架油缸脆弱点进行疲劳强度理论计算,并用有限元分析对结果进行验证,形成理论计算方法,为类似产品的疲劳强度计算提供参考,提高分析计算的效率。

关键词：泵车臂架油缸护套疲劳强度

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Zeolite templated carbon nanodots for broadband ultrafast pulsed fiber laser generation

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Photonics Research 2019年第10期7卷 1182-1187页

作者： XINTONG XU JIAQI CHEN WENTAO SHI DALIN sun SHAOWEN CHU lang sun WENFEI ZHANG YANPING CHEN JIANPANG ZHAI SHUANGCHEN RUAN ZIKANG TANG Center for Advanced Material Diagnostic Technology College of Engineering PhysicsShenzhen Technology UniversityShenzhen 518118China Shenzhen Key Laboratory of Laser Engineering Shenzhen UniversityShenzhen 518060China College of New Materials and New Energies Shenzhen Technology UniversityShenzhen 518118China Institute of Applied Physics&Materials Engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina

Carbon nanodots(C-dots) with a uniform size of about 2 nm are synthesized via in situ pyrolysis of n-propylamine that is confined in the nanochannels of zeolite Linde Type A(LTA). The as-synthesized C-dots@LTA composite shows nonlinear optical saturable absorption properties in a broad wavelength band and can be used as saturable absorber(SA) to generate ultrafast pulsed fiber lasers. By inserting a zeolite LTA single crystal hosting C-dots into the fiber laser cavity, mode-locked fiber lasers with long-term operation stability at 1.5 μm and 1 μm are achieved. These results show that the C-dots@LTA are a promising SA material for ultrafast pulsed fiber laser generation in a broad wavelength band. To the best of our knowledge, this is the first demonstration of a C-dots@LTA-based mode-locked fiber laser.

关键词： fiber laser zeolite

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Stress Concentration Effect in Interface Between Conductor and Epoxy Resin in Coaxial Components of Power Equipment

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 412-420页

作者： Chuang Wang Kang Lei Qing sun Hui Li Jiawei Zhang lang Zhao Zongren Peng School of Electrical Engineering Xi’an University of TechnologyXi’an 710054China Xi’an Power Supply Company State Grid Shaanxi Electric Power CompanyXi’an 710032China State Key Laboratory of Electrical Insulation and Power Equipment Xi’an Jiaotong UniversityXi’an 710049China

The spacer used in gas insulated switchgear(GIS)plays a vital role in its safe operation.The mismatch of mechanical properties between conductor and insulating material in spacers results in stress concentration at the interface between them.During a hydrostatic test,mechanical damages are often initiated from the interface.In this paper,the stress between aluminum conductors and epoxy resin is studied by using a simplified coaxial structure specimen.The measurement system and finite element simulation are used to explore the generation of stress and strain during curing and shrinkage.The real-time measurement of strain at the interface shows that the residual strain in the entire process is primarily generated during the cooling stage.Consequently,the temperature and stress/strain distribution at the interface during the cooling stage are further studied,and combined with experiments and simulations.The consistency between the finite element simulation and the experimental measurement results verifies the validity of the simulation method used.The results show that the maximum of the first principal stress generated during the cooling stage of the production process is concentrated on the upper and lower edges of the interface which is critical to the impact of the production quality of the spacer.

关键词： Epoxy resin GIS interface stress/strain distribution

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