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Particuology 2024年第8期91卷 260-267页

作者： Tom lang Jens Bartsch Laboratory of Solids Process Engineering Department of Biochemical and Chemical EngineeringTU Dortmund University44227DortmundGermany

In comparison to the established twin-screw machines,the application of a planetary roller granulator for continuous operation of melt granulation is a promising alternative based on the unique process *** initial study focused on the material transport during processing as a key driver for the overall ***,the impact of direct process parameters on the residence time distribution was the main *** investigations are complemented in this study by considering the free processing volume,which is defined by the number of planetary spindles applied within a *** impact on the processing conditions is evaluated with respect to the process setting in terms of feed rate and rotation *** results highlight the potential of altering the underlying transport function in planetary roller melt granulation(PRMG)via the investigated direct process and equipment *** impact of the feed rate is lower in comparison,while a higher rotation speed as well as a higher free processing volume promote material ***,a normalization of the determined residence time distribution(RTD)model data was feasible with respect to the process settings and the number of applied planetary spindles in the processing *** demonstrates the key role of the free processing volume in the fundamental mechanisms of material transport and mixing during PRMG.

关键词： Continuous manufacturing Melt granulation Planetaryroller granulator Quality-by-Design Residence time Material mixing

Three-dimensional finite element simulation and reconstruction of jointed rock models using CT scanning and photogrammetry

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1348-1361页

作者： Yingxian lang Zhengzhao Liang Zhuo Dong State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian116024China School of Energy Science and Engineering Henan Polytechnic UniversityJiaozuo454003China

The geometry of joints has a significant influence on the mechanical properties of *** simplify the curved joint shapes in rocks,the joint shape is usually treated as straight lines or planes in most laboratory experiments and numerical *** this study,the computerized tomography (CT) scanning and photogrammetry were employed to obtain the internal and surface joint structures of a limestone sample,*** describe the joint geometry,the edge detection algorithms and a three-dimensional (3D) matrix mapping method were applied to reconstruct CT-based and photogrammetry-based jointed rock *** comparison tests,the numerical uniaxial compression tests were conducted on an intact rock sample and a sample with a joint simplified to a plane using the parallel computing *** results indicate that the mechanical characteristics and failure process of jointed rocks are significantly affected by the geometry of *** presence of joints reduces the uniaxial compressive strength (UCS),elastic modulus,and released acoustic emission (AE) energy of rocks by 37%–67%,21%–24%,and 52%–90%,*** to the simplified joint sample,the proposed photogrammetry-based numerical model makes the most of the limited geometry information of *** UCS,accumulative released AE energy,and elastic modulus of the photogrammetry-based sample were found to be very close to those of the CT-based *** UCS value of the simplified joint sample (i.e.38.5 MPa) is much lower than that of the CT-based sample (i.e.72.3 MPa).Additionally,the accumulative released AE energy observed in the simplified joint sample is 3.899 times lower than that observed in the CT-based *** scanning provides a reliable means to visualize the joints in rocks,which can be used to verify the reliability of photogrammetry *** application of the photogrammetry-based sample enables detailed analysis for estimating the mechanical properties of jointed rocks.

关键词： X-ray computerized tomography(CT)scanning Photogrammetry Parallel computing Numerical simulation Uniaxial compression test Digital image processing

Side-Channel Leakage Analysis of Inner Product Masking

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Computers, Materials & Continua 2024年第4期79卷 1245-1262页

作者： Yuyuan Li lang Li Yu Ou College of Computer Science and Technology Hengyang Normal UniversityHengyang421002China Hunan Provincial Key Laboratory of Intelligent Information Processing and Application Hengyang Normal UniversityHengyang421002China

The Inner Product Masking(IPM)scheme has been shown to provide higher theoretical security guarantees than the BooleanMasking(BM).This scheme aims to increase the algebraic complexity of the coding to achieve a higher level of *** previous work unfolds when certain(adversarial and implementation)conditions are met,and we seek to complement these investigations by understanding what happens when these conditions deviate from their expected *** this paper,we investigate the security characteristics of IPM under different *** adversarial condition,the security properties of first-order IPMs obtained through parametric characterization are preserved in the face of univariate and bivariate *** implementation condition,we construct two new polynomial leakage functions to observe the nonlinear leakage of the IPM and connect the security order amplification to the nonlinear *** observe that the security of IPMis affected by the degree and the linear component in the leakage *** addition,the comparison experiments from the coefficients,signal-to-noise ratio(SNR)and the public parameter show that the security properties of the IPM are highly implementation-dependent.

关键词： Side-channel analysis inner product masking mutual information nonlinear leakage

Dynamic Analysis of Incentive Policy Impacts on Recycling of Retired Batteries for Electric Vehicles

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Journal of Systems Science and Information 2024年第4期12卷 491-514页

作者： Cuixia WANG lang WEI School of Information Management Jiangxi University of Finance and EconomicsNanchang 330032China School of Economics and Management Hunan College of InformationChangsha 410200China

Electric Vehicles(EVs),as a low-carbon means of transportation,have promptly become popular worldwide in the past *** the lifespan of batteries is limited,massive of Electric Vehicle Batteries(EVBs)are being retired,resulting in a rapid increase in the demand for the recycling of retired EVBs in recent ***,due to high recycling costs and immature recycling technologies,EV manufacturers are facing significant challenges in recycling retired ***,as the country with the largest number of EV users in the world,is exploring effective incentive policies for the recycling of retired *** this context,we developed a system dynamics model to analyze the impact of incentive polices such as,recycling subsidies,technological progress,and carbon trading on the retired EVBs *** show that:1)recycling subsidies can improve the recycling ratios quickly in the short term,and dynamic subsidies are more efficient than static subsidies;2)the policy of technological advancement can reduce the recovery and cascade utilization cost,thus having a positive impact on battery recycling,but the policy effect has a time-delay;3)the carbon trading policy is unable to promote efficient recycling due to the current low carbon prices;4)dynamic subsidy and technological advancement policies complement each other,therefore,the combination of these two policies is the best way to promote the recycling of retired EVBs and reduce carbon *** is hoped that this study will contribute to the ongoing debate on policies for the industrialization of retired EVBs recycling.

关键词： electric vehicles retired battery recycling policy impact system dynamics

Targeted drug approvals in 2023:breakthroughs by the FDA and NMPA

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Signal Transduction and Targeted Therapy 2024年第3期9卷 813-821页

作者： lang Zheng Wenjing Wang Qiu Sun Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China West China Medical Publishers West China HospitalSichuan UniversityChengdu 610041China

According to the official website of China’s National Medicines and Pharmaceutical Administration(NMPA),a total of 87 novel drugs were approved in China in 2023,with targeted drugs accounting for 67.8%of the total,amounting to 59 drugs(Fig.1a;Table 1)[https://***/yaopin/ypjgdt/***].Notably,domestic innovation is flourishing,with five first-in-class drugs,including Glumetinib,a c-Met inhibitor from Haihe Biopharma;Leritrelvir,a 3CL protease inhibitor from Raynovent;Anaprazole,a proton pump inhibitor from Xuanzhu Biopharm;Pegol-Sihematide,an EPO drug from Hansoh Pharma;and Zuberitamab from BioRay Biopharmaceutical Co.,***,the world’s first allosteric inhibitor targeting TYK2,Sotyktu(deucravacitinib),has been approved for the treatment of psoriasis and Selumetinib,a MEK inhibitor co-developed by AstraZeneca and Merck Sharp&Dohme(MSD),became the first approved drug in China for the treatment of neurofibromatosis type I(NF1).Beyond these drugs,the approval of novel drug types such as CAR-T cell products,siRNA,monoclonal antibodies,dual antibodies,and ADCs in China is a significant development in the country’s pharmaceutical industry(Fig.1a).

关键词： drugs Merck approval

Robust-augmentation nonlinear dynamic inversion control of over-actuated coaxial high-speed helicopter in transition mode

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Chinese Journal of Aeronautics 2024年第8期37卷 404-420页

作者： Yuqing QIU Yan LI Jinxi lang Yuxian LIU Zhong WANG School of Automation Northwestern Polytechnical UniversityXi’an 710129China

As the elevator and rudder can be used actively for control,in addition to the rotors,Coaxial High-speed Helicopters(CHHs)have the problems of control redundancy and changing control authority in the transition *** paper presents a robust-augmentation transitioning flight control design for a CHH under the adverse conditions of parametric uncertainties and external ***,based on control characteristic analysis,an Adaptive Filtered Nonlinear Dynamic Inversion(AFNDI)controller is proposed for the angular rate to handle the effect of unknown unstructured uncertainties and external *** analysis proves that the presented angular rate controller can guarantee steady-state and transient ***,the attitude angle and velocity controllers are also ***,an Incremental-based Nonlinear Prioritizing Control Allocation(INPCA)method is designed to take into account control surface transition and changing control authority,which efficiently distributes the required moments between coaxial rotors and aero-surfaces,and avoids the control reversal problem of the yaw *** the proposed control architecture,the low-pass filter is introduced to alleviate the adverse influence of time delay and measurement ***,the effectiveness of the proposed controller is demonstrated through nonlinear numerical simulations,and is compared with existing *** results show that the proposed control law can improve both capabilities of disturbance rejection and fast response,and works satisfactorily for the CHH transitioning control characteristic.

关键词： Coaxial high-speed helicopter Transition mode Attitude control Control allocation Robust adaptive control

Tensile strength behavior of cement-stabilized dredged sediment reinforced by polypropylene fiber

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 380-392页

作者： Lei lang Jiangshan LI Xin CHEN Lijun HAN Ping WANG State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicChinese Academy of SciencesWuhan 430071China Hubei Provincial Key Laboratory of Contaminated Sludge and Soil Science and Engineering Wuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

This study evaluated the feasibility of using polypropylene fiber(PF)as reinforcement in improving tensile strength behavior of cement-stabilized dredged sediment(CDS).The effects of cement content,water content,PF content and length on the tensile strength and stress–strain behavioral evolutions were evaluated by conducting splitting tensile strength ***,the micro-mechanisms characterizing the tensile strength behavior inside PF-reinforced CDS(CPFDS)were clarified via analyzing macro failure and microstructure *** results indicate that the highest tensile strengths of 7,28,60,and 90 d CPFDS were reached at PF contents of 0.6%,1.0%,1.0%,and 1.0%,exhibiting values 5.96%,65.16%,34.10%,and 35.83%higher than those of CDS,***,3 mm,PF of showed the best reinforcement *** CPFDS exhibited obvious tensile strain-hardening characteristic,and also had better ductility than *** mix factor(C_(C)^(a)/C_(w)^(b))and time parameter(q_(t0)(t))of CDS,and the reinforcement index(k_(t-PF))of CPFDS were used to establish the tensile strength prediction models of CDS and CPFDS,considering multiple *** PF“bridge effect”and associated cementation-reinforcement coupling actions inside CPFDS were mainly responsible for tensile strength behavior *** key findings contribute to the use of CPFDS as recycled engineering soils.

关键词： dredged sediment chemical stabilization fiber reinforcement splitting tensile strength micro-mechanisms

Chain Extender-induced Hydrogen Bonding Organization Determines the Morphology and Properties of Thermoplastic Polycarbonate Polyurethane

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Chinese Journal of Polymer Science 2024年第1期42卷 87-96,I0009页

作者： Yi-lang Qin Ping Zhu Chen-Xi Ouyang Xia Dong Fuwai Hospital Chinese Academyof Medical Sciences&Peking Union Medical College/National Center for Cardiovascular DiseasesBejing 100037China CASKey Laboratoryof Engineering Plastics CAS Research/Education Centerfor Excellence in Molecular SciencesInstitute ofChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Thermoplastic polycarbonate polyurethanes(PCUs) are multiblock copolymers that have been applied for medical devices for long time. Aliphatic diols are common chain extenders(CE) involved in the composition of the hard segments of PCU. However, limited knowledge was discovered about how the chemical structure of CE affects the hydrogen bonding organization within PCUs and their mechanical *** investigate this problem, a group of PCUs were synthesized respectively by extending the polymer chain with 1,4-butanediol(BDO),aminoethanol(MEA), ethanediol(EO) as three kinds of chain extenders. Tiny differences in the CE chemical structure results in remarkable variations in phase separation, condensed morphologies, thermal and mechanical properties, which are characterized by Fourier transform infrared spectrometer, atomic force microscopy, small-angle X-ray scattering, differential scanning calorimetry, and tensile tests. The microstructural evolution during unilateral deformation and the different mechanism induced by the different CEs was probed and unveil by in situ wide-and small-angle X-ray diffraction. Symmetry of CE can improve the organization of the hydrogen bonding. The coherence strength of the urethane/urea group also plays a key role by comparing the two PCUs with ethanediol and aminoethanol.

关键词： Thermoplastic polycarbonate polyurethane Chain extender Hydrogen bonding Mechanical properties

SFGA-CPA: A Novel Screening Correlation Power Analysis Framework Based on Genetic Algorithm

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Computers, Materials & Continua 2024年第6期79卷 4641-4657页

作者： Jiahui Liu lang Li Di Li Yu Ou College of Computer Science and Technology Hengyang Normal UniversityHengyang421002China Hunan Provincial Key Laboratory of Intelligent Information Processing and Application Hengyang Normal UniversityHengyang421002China

Correlation power analysis(CPA)combined with genetic algorithms(GA)now achieves greater attack efficiency and can recover all subkeys ***,two issues in GA-based CPA still need to be addressed:key degeneration and slow evolution within *** challenges significantly hinder key recovery *** paper proposes a screening correlation power analysis framework combined with a genetic algorithm,named SFGA-CPA,to address these ***-CPA introduces three operations designed to exploit CPA characteris-tics:propagative operation,constrained crossover,and constrained ***,the propagative operation accelerates population evolution by maximizing the number of correct bytes in each ***,the constrained crossover and mutation operations effectively address key degeneration by preventing the compromise of correct ***,an intelligent search method is proposed to identify optimal parameters,further improving attack *** were conducted on both simulated environments and real power traces collected from the SAKURA-G *** the case of simulation,SFGA-CPA reduces the number of traces by 27.3%and 60%compared to CPA based on multiple screening methods(MS-CPA)and CPA based on simple GA method(SGA-CPA)when the success rate reaches 90%.Moreover,real experimental results on the SAKURA-G platform demonstrate that our approach outperforms other methods.

关键词： Side-channel analysis correlation power analysis genetic algorithm crossover mutation

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无血清法培养新生和成年雪旺细胞

中华手外科杂志 2001年第Z1期17卷 56-57页

作者：沈尊理,Berger Alfred,Hierner Robert,lang sabina 上海市第一人民医院整形科 Clinic of Plastic Hand and Reconstructive Surgery Hannover Medical School!30659 Hannover Germany Clinic of Plastic Hand and Reconstructive Surgery Hannover Medical School!30659 Hannover Germany Clinic of Plastic Hand and Reconstru

目的　探索应用“M”无血清培养液培养新生和成年鼠雪旺细胞的可行性。方法　取新生(出生 1～ 3d)和成年 (3～ 4个月 )Lewis鼠的坐骨神经 ,分别经差速贴壁法和 3周体外变性法获取雪旺细胞 ,然后采用“M”无血清培养液培养 1周。用S 10 ... 详细信息

目的　探索应用“M”无血清培养液培养新生和成年鼠雪旺细胞的可行性。方法　取新生(出生 1～ 3d)和成年 (3～ 4个月 )Lewis鼠的坐骨神经 ,分别经差速贴壁法和 3周体外变性法获取雪旺细胞 ,然后采用“M”无血清培养液培养 1周。用S 10 0和 5 溴化鸟嘧啶 (BrdU)免疫组化法分别鉴定雪旺细胞的纯度和增殖率。结果　新生和成年鼠雪旺细胞培养后 1周 ,其纯度分别达 95 %和 93% ,增殖率分别达 73.8%和 38.3%。大多数污染的成纤维细胞处于DNA合成静止期。结论　应用“M”无血清培养液简化了雪旺细胞的培养技术 ,有效地控制了成纤维细胞的污染。

关键词：许旺氏细胞细胞培养成纤维细胞无血清培养液