检索结果-南通市图书馆

Cluster analysis reveals a homogeneous subgroup of PCOS women with metabolic disturbance associated with adverse reproductive outcomes

引用

Chinese Medical Journal 2024年第5期137卷 604-612页

作者： Hanxiao Chen Rujun Zeng Xun Zeng lang qin The Reproductive Medical Center Department of Obstetrics and GynecologyWest China Second University HospitalSichuan UniversityChengduSichuan 610041China Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education West China Second University HospitalSichuan UniversityChengduSichuan 610041China

Background:Polycystic ovarian syndrome(PCOS)is a heterogeneous and complex reproductive endocrinological disease that could lead to infertility.There were many attempts to classify PCOS but it remains unclear whether there is a specific subgroup of PCOS that is associated with the best or worst reproductive outcomes of assisted reproductive techniques(ART).Methods:Infertile PCOS patients who underwent their first cycle of in vitro fertilization(IVF)in West China Second University Hospital,Sichuan University from January 2019 to December 2021 were included.Basic clinical and laboratory information of each individual were extracted.Unsupervised cluster analysis was performed.Controlled ovarian stimulation parameters and reproductive outcomes were collected and compared between the different clusters of PCOS.Results:Our analysis clustered women with PCOS into"reproductive","metabolic",and"balanced"clusters based on nine traits.Reproductive group was characterized by high levels of testosterone(T),sex hormone-binding globulin(SHBG),follicular stimulation hormone(FSH),luteinizing hormone(LH),and anti-Müllerian hormone(AMH).Metabolic group was characterized by high levels of body mass index(BMI),fasting insulin,and fasting glucose.Balanced group was characterized by low levels of the aforementioned reproductive and metabolic parameters,except for SHBG.Compared with PCOS patients in reproductive and balanced clusters,those in metabolic cluster had lower rates of good quality day 3 embryo and blastocyst formation.Moreover,PCOS patients in the reproductive cluster had greater fresh embryo transfer(ET)cancelation rate and clinical pregnancy rate after fresh ET than metabolic cluster(odds ratio[OR]=3.37,95%confidence interval[CI]:1.77-6.44,and OR=6.19,95%CI:1.58-24.24,respectively).And compared with PCOS of metabolic cluster,PCOS of balanced cluster also had higher chance for fresh ET cancelation(OR=2.83,95%CI:1.26-6.35).Conclusion:Our study suggested that PCOS patients in metabolic cluster may be associated with adverse re

关键词： Polycystic ovarian syndrome Assisted reproductive techniques Clustering analysis Metabolic disturbance Clinical pregnancy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Trial characteristics and treatment effect estimates in randomized controlled trials of Chinese herbal medicine: A meta-epidemiological study

引用

Journal of Integrative Medicine 2024年第3期22卷 223-234页

作者： Betty H.Wang Ya-li Lin Yin-yan Gao Jin-lu Song lang qin Ling-qi Li Wen-qi Liu Claire C.W.Zhong Mary Y.Jiang Chen Mao Xiao-bo Yang Vincent C.H.Chung Irene X.Y.Wu Jockey Club School of Public Health and Primary Care the Chinese University of Hong KongHong Kong 999077China Xiangya School of Public Health Central South UniversityChangsha 410006Hunan ProvinceChina School of Chinese Medicine the Chinese University of Hong KongHong Kong 999077China School of Public Health Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Chinese Medicine Syndrome Research Team the Second Affiliated HospitalGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou 510120Guangdong ProvinceChina Hunan Provincial Key Laboratory of Clinical Epidemiology Central South UniversityChangsha 410006Hunan ProvinceChina

Background:Previously published meta-epidemiological studies focused on Western medicine have identified some trial characteristics that impact the treatment effect of randomized controlled trials(RCTs).Nevertheless,it remains unclear if similar associations exist in RCTs on Chinese herbal medicine(CHM).Further,Chinese medicine-related characteristics have not been explored yet.Objective:To investigate trial characteristics related to treatment effect estimates on CHM RCTs.Search strategy:This meta-epidemiological study searched 5 databases for systematic reviews on CHM treatment published between January 2011 and July 2021.Inclusion criteria:An eligible systematic review should only include RCTs of CHM and conduct at least one meta-analysis.Data extraction and analysis:Two reviewers independently conducted data extraction on general characteristics of systematic reviews,meta-analyses and included RCTs.They also assessed the risk of bias of RCTs using the Cochrane risk of bias tool.A two-step approach was used for data analyses.The ratio of odds ratios(ROR) and difference in standardized mean differences (dSMD) with 95%confidence interval (CI) were applied to present the difference in effect estimates for binary and continuous outcomes,respectively.Results:Ninety-one systematic reviews,comprising 1338 RCTs were identified.For binary outcomes,RCTs incorporated with syndrome differentiation (ROR:1.23;95%CI:[1.07,1.39]),adopting Chinese medicine formula (ROR:1.19;95%CI:[1.03,1.34]),with low risk of bias on incomplete outcome data (ROR:1.29;95%CI:[1.06,1.52]) and selective outcome reporting (ROR:1.12;95%CI:[1.01,1.24]),as well as a trial size≥100 (ROR:1.23;95%CI:[1.04,1.42]) preferred to show larger effect estimates.As for continuous outcomes,RCTs with Chinese medicine diagnostic criteria (dSMD:0.23;95%CI:[0.06,0.41]),judged as high/unclear risk of bias on allocation concealment (dSMD:-0.70;95%CI:[-0.99,-0.42]),with low risk of bias on incomplete outcome data (dSMD:0.30;95%CI:[0.18,0.43]),conducted at a single center

关键词： Chinese herbal medicine Randomized controlled trial Risk of bias Meta-epidemiological study Effect estimates

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chain Extender-induced Hydrogen Bonding Organization Determines the Morphology and Properties of Thermoplastic Polycarbonate Polyurethane

引用

Chinese Journal of Polymer Science 2024年第1期42卷 87-96,I0009页

作者： Yi-lang qin Ping Zhu Chen-Xi Ouyang Xia Dong Fuwai Hospital Chinese Academyof Medical Sciences&Peking Union Medical College/National Center for Cardiovascular DiseasesBejing 100037China CASKey Laboratoryof Engineering Plastics CAS Research/Education Centerfor Excellence in Molecular SciencesInstitute ofChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Thermoplastic polycarbonate polyurethanes(PCUs) are multiblock copolymers that have been applied for medical devices for long time. Aliphatic diols are common chain extenders(CE) involved in the composition of the hard segments of PCU. However, limited knowledge was discovered about how the chemical structure of CE affects the hydrogen bonding organization within PCUs and their mechanical properties.To investigate this problem, a group of PCUs were synthesized respectively by extending the polymer chain with 1,4-butanediol(BDO),aminoethanol(MEA), ethanediol(EO) as three kinds of chain extenders. Tiny differences in the CE chemical structure results in remarkable variations in phase separation, condensed morphologies, thermal and mechanical properties, which are characterized by Fourier transform infrared spectrometer, atomic force microscopy, small-angle X-ray scattering, differential scanning calorimetry, and tensile tests. The microstructural evolution during unilateral deformation and the different mechanism induced by the different CEs was probed and unveil by in situ wide-and small-angle X-ray diffraction. Symmetry of CE can improve the organization of the hydrogen bonding. The coherence strength of the urethane/urea group also plays a key role by comparing the two PCUs with ethanediol and aminoethanol.

关键词： Thermoplastic polycarbonate polyurethane Chain extender Hydrogen bonding Mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An AIEgen nano-assembly for simultaneous detection of ATP and H_(2)S

引用

Chinese Chemical Letters 2024年第6期35卷 376-379页

作者： Jia-Mei qin Xue Li Wei lang Fu-Hao Zhang Qian-Yong Cao School of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330031China

A new aggregation-induced emission(AIE)-based fluorescence sensor,TPEPy-SS-C14,for simultaneous recognition of adenosine triphosphate(ATP)and hydrogen sulfide(H_(2)S)has been reported via the aggregation-disaggregation mechanism.The probe self-assembles nano-structure aggregations in aqueous solution.It shows fluorescence turn-on response toward ATP for the complexation-enhanced aggregation,but leads to fluorescence quenching of H_(2)S for cleavage the aggregations.

关键词： AIE-based ATP detection H_(2)S detection Fluorescent sensor Cell imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

产科抗磷脂综合征的诊治原则与热点问题述评

引用

四川大学学报（医学版） 2024年第3期55卷 513-520页

作者：高睿秦朗四川大学华西第二医院妇产科生殖医学中心成都610041 出生缺陷与相关妇儿疾病教育部重点实验室(四川大学) 成都610041

产科抗磷脂综合征(obstetric antiphospholipid syndrome, OAPS)是一种与多种病理妊娠事件相关的自身免疫疾病,严重威胁我国育龄期女性生育健康。OAPS的具体发病机制尚不明确,可能与局部微血栓形成及炎症反应有关,全孕期低分子肝素联合... 详细信息

产科抗磷脂综合征(obstetric antiphospholipid syndrome, OAPS)是一种与多种病理妊娠事件相关的自身免疫疾病,严重威胁我国育龄期女性生育健康。OAPS的具体发病机制尚不明确,可能与局部微血栓形成及炎症反应有关,全孕期低分子肝素联合阿司匹林治疗是OAPS的标准治疗方案。及时、准确地诊断OAPS是规范化治疗的基础,然而,全世界对OAPS的诊断标准尚未形成共识,这导致诊治不规范的现象普遍存在。本文旨在总结OAPS的诊治原则,并对非标准OAPS的概念、抗磷脂抗体(antiphospholipid antibody, aPL)的检测方法选择、非标准aPL解读与应用、基于aPL的风险分层等热点问题进行述评,为该病的临床管理提供借鉴与参考。

关键词：抗磷脂综合征抗磷脂抗体产科诊断治疗综述

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Systemic autoimmune diseases and recurrent pregnancy loss:research progress in diagnosis and treatment

引用

Chinese Medical Journal 2021年第17期134卷 2140-2142页

作者： Rui Gao Xun Zeng lang qin Department of Obstetrics and Gynecology The Reproductive Medical CenterWest China Second University HospitalSichuan UniversityChengdu 610041China West China School of Medicine Sichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education West China Second University HospitalSichuan UniversityChengdu 610041China

To the Editor:Recurrent pregnancy loss(RPL)is defined as the loss of two or more pregnancies before 24 weeks of gestation,and it affects about 1%to 2%of couples.[1]The etiology of RPL includes metabolic/endocrinological abnormalities,genetic factors,anatomical factors,immune disorders,thrombophilia,male factors,and psychological factors.[1,2]Systemic autoimmune diseases like antiphospholipid syndrome(APS),[3]undifferentiated connective tissue disease(UCTD),[4]and systemic lupus erythematosus(SLE)[5]have been found to be important causes of RPL in recent years.Understanding the associations between different systemic autoimmune diseases and RPL,as well as being able to provide suitable diagnoses and treatments,is of great significance.

关键词： diagnosis pregnancy treatment Systemic erythematosus lupus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

胆甾相液晶微球光子禁带的动态调控及其应用

引用

物理化学学报 2024年第5期40卷 10-30页

作者：刘晓珺秦朗俞燕蕾复旦大学材料科学系聚合物分子工程国家重点实验室复旦大学义乌研究院

胆甾相液晶微球是空间结构高度对称的三维光子晶体,能够全方位地选择性反射特定波长的圆偏振光,具有无角度依赖性的光子禁带,作为一种新兴的光学材料在全向激光器、反射式显示和微传感器等领域展现出广阔的应用前景。近年来,毛细管微流... 详细信息

胆甾相液晶微球是空间结构高度对称的三维光子晶体,能够全方位地选择性反射特定波长的圆偏振光,具有无角度依赖性的光子禁带,作为一种新兴的光学材料在全向激光器、反射式显示和微传感器等领域展现出广阔的应用前景。近年来,毛细管微流控技术的蓬勃发展为连续、可控、高通量地制备结构复杂且分子规则取向的单分散胆甾相液晶微球提供了强有力的支持。本综述重点关注利用毛细管微流控技术制备胆甾相液晶微球的相关研究工作,首先分析了毛细管微流控装置在设计微球结构中的决定性作用,阐明了溶液体系的选择与液晶分子取向间的关系以及边界效应对微球尺寸的影响;随后,从胆甾相液晶微球的光学特性切入,介绍了利用温度、溶剂和光等外界刺激调控螺旋结构自组装的原理和策略以及微球之间独有的“光子交叉通讯”现象;最后,总结了现阶段胆甾相液晶微球的潜在应用方向并讨论了该材料体系未来面临的挑战。

关键词：胆甾相液晶结构色微流控微球光子器件

来源：

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

New avenues for functional neuroimaging:ultra-high field MRI and OPM-MEG

引用

Psychoradiology 2021年第4期1卷 165-171页

作者： lang qin Jia-Hong Gao Center for MRI Research Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China McGovern Institute for Brain Research Peking UniversityBeijing 100871China Beijing City Key Laboratory for Medical Physics and Engineering School of PhysicsPeking UniversityBeijing 100871China National Biomedical Imaging Center Peking UniversityBeijing 100871China

Functional brain imaging technology has developed rapidly in recent years.On the one hand,high-field 7-Tesla magnetic resonance imaging(MRI)has excelled the limited spatial resolution of 3-Tesla MRI,allowing us to enter a new world of mesoscopic imaging from the macroscopic imaging of human brain functions.On the other hand,novel optical pumping magnetometer-magnetoencephalography(OPM-MEG)has broken down the technical barriers of traditional superconducting MEG,which brings imaging of neuronal electromagnetic signals from cortical imaging to whole-brain imaging.This article aims to present a brief introduction regarding the development of conventional MRI and MEG technology,and,more importantly,to delineate that high-field MRI and OPM-MEG complement each other and together will lead us into a new era of functional brain imaging.

关键词： ultra-high field MRI OPM-MEG neuroimaging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Collagen-based materials in reproductive medicine and engineered reproductive tissues

引用

Journal of Leather Science and Engineering 2022年第1期4卷 37-51页

作者： Hanxiao Chen Luqi Xue Guidong Gong Jiezhou Pan Xiaoling Wang Yaoyao Zhang Junling Guo lang qin Department of Obstetrics and Gynecology The Reproductive Medical CenterWest China Second University HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education West China Second University HospitalSichuan UniversityChengdu 610041China West China School of Medicine Sichuan UniversityChengdu 610041China BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniversityChengdu 610065SichuanChina State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065SichuanChina.

Collagen,the main component of mammal skin,has been traditionally used in leather manufacturing for thousands of years due to its diverse physicochemical properties.Collagen is the most abundant protein in mammals and the main component of the extracellular matrix(ECM).The properties of collagen also make it an ideal building block for the engineering of materials for a range of biomedical applications.Reproductive medicine,especially human fertility preservation strategies and reproductive organ regeneration,has attracted significant attention in recent years as it is key in resolving the growing social concern over aging populations worldwide.Collagen-based biomaterials such as collagen hydrogels,decellularized ECM(dECM),and bioengineering techniques including collagen-based 3D bio-printing have facilitated the engineering of reproductive tissues.This review summarizes the recent progress in apply-ing collagen-based biomaterials in reproductive.Furthermore,we discuss the prospects of collagen-based materials for engineering artificial reproductive tissues,hormone replacement therapy,and reproductive organ reconstruction,aiming to inspire new thoughts and advancements in engineered reproductive tissues research.

关键词： Collagen-based biomaterials Leather and collagen Leather tanning process Reproductive medicine Reproductive tissues

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New Insight into the Development of Oxygen Carrier Materials for Chemical Looping Systems

引用

Engineering 2018年第3期4卷 343-351页

作者： Zhuo Cheng lang qin Jonathan A. Fan Liang-Shih Fan William G. Lowrie Department of Chemical and Biomolecular Engineering The Ohio State University Columbus OH 43210 USA Department of Electrical Engineering Ginzton Laboratory Stanford University Stanford CA 94305 USA

化学链燃烧(CLC)和化学链重整(CLR)是通过循环氧化还原反应,清洁高效地将烃类转化为动力、燃料和化学品的创新技术。金属氧化物材料在化学链氧化还原过程中起着至关重要的作用。在还原过程中,氧载体为烃类的转化和产物合成提供所需的氧... 详细信息

化学链燃烧(CLC)和化学链重整(CLR)是通过循环氧化还原反应,清洁高效地将烃类转化为动力、燃料和化学品的创新技术。金属氧化物材料在化学链氧化还原过程中起着至关重要的作用。在还原过程中,氧载体为烃类的转化和产物合成提供所需的氧离子量。在氧化步骤中,耗尽的金属氧化物氧载体从空气中补充分子氧,同时释放热量。近年来,用于各种化学链应用的氧载体材料已经取得了较大进展。在这些金属氧化物材料中,铁基氧载体由于其高携氧能力、显著的成本效益,以及化学链反应在实际应用方面的多功能性而具有吸引力。它们的反应性也可以通过结构设计和改性进一步得到增强。本文综述了氧载体材料的发展及其在这些材料上的烃类转化机制的最新进展。这些进展将有助于氧载体材料的开发,以实现更有效的化学链技术应用。

关键词：化学链氧载体烃类转化离子扩散机制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：