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Unsteady Flow and Structural Behaviors of Centrifugal Pump under Cavitation Conditions

Chinese Journal of Mechanical Engineering 2019年第1期32卷 127-141页

作者： Denghao Wu Yun Ren Jiegang Mou Yunqing Gu lanfang jiang College of Mechanical Engineering Zhejiang University of Technology Zhijiang College Zhejiang University of Technology

Cavitation has a significant e ect on the flow fields and structural behaviors of a centrifugal pump. In this study, the unsteady flow and structural behaviors of a centrifugal pump are investigated numerically under di erent cavitation conditions. A strong two-way coupling fluid-structure interaction simulation is applied to obtain interior views of the e ects of cavitating bubbles on the flow and structural dynamics of a pump. The renormalization-group k-ε turbulence model and the Zwart–Gerbe–Belamri cavitation model are solved for the fluid side, while a transient structural dynamic analysis is employed for the structure side. The di erent cavitation states are mapped in the head-net positive suction head(H-NPSH) curves and flow field features inside the impeller are fully revealed. Results indicate that cavitating bubbles grow and expand rapidly with decreasing NPSH. In addition, the pressure fluctuations, both in the impeller and volute, are quantitatively analyzed and associated with the cavitation states. It is shown that influence of the cavitation on the flow field is critical, specifically in the super-cavitation state. The e ect of cavitation on the unsteady radial force and blade loads is also discussed. The results indicate that the averaged radial force increased from 8.5 N to 54.4 N in the transition progress from an onset cavitation state to a super-cavitation state. Furthermore, the structural behaviors, including blade deformation, stress, and natural frequencies, corresponding to the cavitation states are discussed. A large volume of cavitating bubbles weakens the fluid forces on the blade and decreases the natural frequencies of the rotor system. This study could enhance the understanding of the e ects of cavitation on pump flow and structural behaviors.

关键词： Centrifugal pump Cavitation Unsteady flow Structural behaviors Fluid-structure interaction

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Downregulation of miR-503 Promotes ESCC Cell Proliferation,Migration,and Invasion by Targeting Cyclin D1

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Genomics, Proteomics & Bioinformatics 2017年第3期15卷 208-217页

作者： lanfang jiang Zitong Zhao Leilei Zheng Liyan Xue Qimin Zhan Yongmei Song State Key Laboratory of Molecular Oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Esophageal squamous cell carcinoma （ESCC） is one of the most aggressive cancers in China, but the underlying molecular mechanism of ESCC is still unclear. Involvement of micro- RNAs has been demonstrated in cancer initiation and progression. Despite the reported function of miR-503 in several human cancers, its detailed anti-oncogenic role and clinical significance in ESCC remain undefined. In this study, we examined miR-503 expression by qPCR and found the downregulation of miR-503 expression in ESCC tissue relative to adjacent normal tissues. Fur- ther investigation in the effect of miR-503 on ESCC cell proliferation, migration, and invasion showed that enhanced expression of miR-503 inhibited ESCC aggressive phenotype and overexpres- sion of CCND1 reversed the effect of miR-503-mediated ESCC cell aggressive phenotype. Our study further identified CCND1 as the target gene of miR-503. Thus, miR-503 functions as a tumor suppressor and has an important role in ESCC by targeting CCND1.

关键词： Esophageal squamous cellcarcinoma miR-503 Cyclin D1 Proliferation Migration and invasion

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miR-503-3p promotes epithelialemesenchymal transition in breast cancer by directly targeting SMAD2 and E-cadherin

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Journal of Genetics and Genomics 2017年第2期44卷 75-84页

作者： Zitong Zhao Xinyi Fan lanfang jiang Zhongqiu Xu Liyan Xue Qimin Zhan Yongmei Song State Key Laboratory of Molecular Oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union MedicalCollegeBeijing 100021China Qiqihar Medical University Qiqihar 161000China

Although progress in clinical and basic research has significantly increased our understanding of breast cancer, little is known about the molecular mechanism underlying breast cancer metastasis. Identification of effective therapeutic targets to prevent breast cancer metastasis is urgently needed. The function of mi R-503-3p has been investigated in other cancers, but its role in breast cancer remains ***, we found that mi R-503-3p was overexpressed in breast cancer tissue and plasma compared with adjacent normal breast tissue and with plasma from healthy individuals. Moreover, we identified mi R-503-3p to be an oncogene of breast cancer cell proliferation, migration and invasion. Upregulation of mi R-503-3p in breast cancer cells inhibited expression of epithelialemesenchymal transition（EMT）-related protein SMAD2 and the epithelial marker protein E-cadherin by directly binding to their m RNA30 untranslated region, whereas increased expression of mesenchymal marker proteins, including vimentin and N-cadherin. Taken together, our findings support a critical role for mi R-503-3p in induction of breast cancer EMT and suggest that plasma mi R-503-3p may be a useful diagnostic biomarker for breast cancer.

关键词： Breast cancer miR-503-3p Plasma miRNA SMAD2 E-cadherin

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考虑气动特性的汽车前照灯造型参数化方法

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计算机辅助设计与图形学学报 2010年第2期22卷 293-298页

作者：蒋兰芳刘红柴国钟浙江工业大学机械制造及自动化教育部重点实验室杭州310032

为研究汽车前照灯造型对汽车气动阻力的影响并指导车灯造型设计,提出一种车灯造型参数化方法.结合美学、考虑汽车空气动力学,在分析汽车前部和车灯造型的基础上,总结出车灯造型的3类设计参数;建立了由"考虑美学与气动阻力的车灯造型汽... 详细信息

为研究汽车前照灯造型对汽车气动阻力的影响并指导车灯造型设计,提出一种车灯造型参数化方法.结合美学、考虑汽车空气动力学,在分析汽车前部和车灯造型的基础上,总结出车灯造型的3类设计参数;建立了由"考虑美学与气动阻力的车灯造型汽车外流场数值分析简化模型"和正交实验优化算法组成的车灯造型参数设计平台.实例的数值计算和风洞实验验证了文中方法的有效性及参数优化组合的效果.该方法对丰富汽车造型设计和车灯设计、促进其工程化很有意义.

关键词：汽车前照灯参数化方法气动阻力优化

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Nip promotes autophagy through facilitating the interaction of Rab7 and FYCO1

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1559-1572页

作者： Wenchang Xiao Danna Yeerken Jia Li Zhangfu Li lanfang jiang Dan Li Ming Fu Liying Ma Yongmei Song Weimin Zhang Qimin Zhan State Key Laboratory of Molecular Oncology National Cancer center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Biomedical Engineering College of Life Science and TechnologyHuazhong University of Science and Technology(HUST)WuhanChina Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital&InstituteBeijingChina Department of Hepato-Pancreato-Biliary Surgery Peking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhenChina Research Unit of Molecular Cancer Research Chinese Academy of Medical SciencesBeijingChina Institute of Cancer Research Shenzhen Bay LaboratoryShenzhenChina

Autophagy is the main degradation pathway to eliminate long-lived and aggregated proteins,aged or malfunctioning organelles,which is essential for the intracellular homeostasis and prevention of malignant *** the processes of autophagosome biogenesis have been well illuminated,the mechanism of autophagosome transport remains largely *** this study,we demonstrated that the ninein-like protein(Nip),a well-characterized centrosomal associated protein,was able to modulate autophagosome transport and facilitate *** autophagy,Nip colocalized with autophagosomes and physically interacted with autophagosome marker LC3,autophagosome sorting protein Rab7 and its downstream effector ***,Nip enhanced the interaction between Rab7 and FYC01,thus accelerated autophagic flux and the formation of ***,compared to the wild-type mice,NLP deficient mice treated with chemical agent DMBA were prone to increased incidence of hepatomegaly and liver cancer,which were tight associated with the hepatic autophagic *** together,our findings provide a new insight for the first time that the well-known centrosomal protein Nip is also a new regulator of autophagy,which promotes the interaction of Rab7 and FYC01 and facilitates the formation of autophagolysosome.

关键词： prevention DMBA interaction

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注塑件残余应力的载荷测量法

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上海交通大学学报 2016年第2期50卷 241-245,250页

作者：刘红蒋兰芳陈先立浙江工业大学机械工程学院杭州310014 浙江工业大学之江学院杭州310024

基于线性迭加原理提出了一种非破坏性的表面残余应力测量方法——载荷测量法,通过以一定的方式在注塑件上施加载荷来检测表面测点的应变,并计算出注塑件的加载应力和残余应力.结果表明:与工程上常用的钻孔法及剥层法相比,载荷测量法具... 详细信息

基于线性迭加原理提出了一种非破坏性的表面残余应力测量方法——载荷测量法,通过以一定的方式在注塑件上施加载荷来检测表面测点的应变,并计算出注塑件的加载应力和残余应力.结果表明:与工程上常用的钻孔法及剥层法相比,载荷测量法具有不破坏被测构件且检测成本较低的优点;在保证被测构件的受力状态处于弹性范围内的基础上,所提出的载荷测量法具有足够的检测精度.

关键词：注塑件残余应力有限元法载荷测量法

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Method of Lamp Fogging Discrimination

Method of Lamp Fogging Discrimination

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2012 International Conference on Mechanical Materials and Manufacturing Engineering(ICMMME 2012)

作者： Hong Liu lanfang jiang Changguo Hu Xianli Chen Jiaodi Lin College of Mechanical Engineering Zhejiang University of Technology Zhijiang college of Zhejiang University of Technology

This paper discussed the mechanism of internal fogging in automotive lamp based on the principle of water vapor condensation, and put forward the concept of the critical fogging humidity of lamp according to the structure and engineering characteristics. It given out a simple way to judge lamp fogging on the base of lamp temperature field, and verified the existence of the critical fog humidity by the test. All of these are very meaningful on the evaluation of the lamp’s structure and raise the level of lamp design

关键词： Lamp Fogging Critical Fogging Humidity Temperature Field

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离心泵内部不稳定流动的PIV测试

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农业机械学报 2015年第2期46卷 46-51页

作者：任芸吴登昊刘厚林蒋兰芳浙江工业大学之江学院杭州310024 江苏大学流体机械工程技术研究中心镇江212013

以一台比转数为74的离心泵为研究对象,首先通过外特性试验发现当流量约低于18 m3/h后,泵的扬程随流量变化非常小,然后采用PIV技术探索了该扬程曲线下叶轮流道内不稳定流动涡的发生、发展规律。试验结果表明:不稳定流动在0.6QBEP工况开... 详细信息

以一台比转数为74的离心泵为研究对象,首先通过外特性试验发现当流量约低于18 m3/h后,泵的扬程随流量变化非常小,然后采用PIV技术探索了该扬程曲线下叶轮流道内不稳定流动涡的发生、发展规律。试验结果表明:不稳定流动在0.6QBEP工况开始产生,直到0.4QBEP工况得到发展,最后在0.1QBEP时几乎扩展到整个叶轮流道;叶轮旋转过程中,靠近蜗壳隔舌处的叶轮流道内流动最不稳定,也是最先出现分离涡的流道;随着流量的降低,附着于叶片工作面的分离涡逐渐增多、汇聚,不断发展的漩涡向流道出口移动的同时,也偏向于流道中心。

关键词：离心泵不稳定流动外特性分离涡PIV

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大功率集成封装LED路灯透镜的光学设计

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光学技术 2010年第6期36卷 820-824页

作者：刘红胡立大蒋兰芳赵芹浙江工业大学机械学院浙江杭州310014 浙江工业大学之江学院浙江杭州310024

为了实现道路照明所要求的矩形光斑分布,以满足LED路灯照明系统的要求,依据光源特性和路面的光斑分布,通过折射定律建立透镜母线的斜率方程,根据该方程设计了用于矩形光斑分布的LED路灯透镜,采用正交优化方法,利用LightTools软件对所设... 详细信息

为了实现道路照明所要求的矩形光斑分布,以满足LED路灯照明系统的要求,依据光源特性和路面的光斑分布,通过折射定律建立透镜母线的斜率方程,根据该方程设计了用于矩形光斑分布的LED路灯透镜,采用正交优化方法,利用LightTools软件对所设计的透镜光学系统进行仿真比较研究,得到了一个矩形光斑分布的光学透镜。仿真结果表明,该透镜光学系统在高度为10m的照射条件下,照射面积为40m×10m的矩形光斑,均匀度为0.31。对有光斑尺寸要求的LED路灯透镜来说,该方法提供了一种简单有效的设计途径。

关键词：应用光学自由曲面透镜 LED路灯优化分析

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幼儿个性和谐发展的内涵、途径与模式

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学前教育研究 2010年第5期 69-72页

作者：姜兰芳许丽萍江苏省张家港市花园浜幼儿园张家港215600

幼儿和谐个性的发展对于幼儿形成良好的人际关系,实现全面协调的发展至关重要。充分利用幼儿的多种自主活动,确立科学的幼儿和谐个性发展目标,拓展幼儿个性和谐发展的自主空间,建构有利于幼儿个性和谐发展的教育模式,对于幼儿的全面发... 详细信息

幼儿和谐个性的发展对于幼儿形成良好的人际关系,实现全面协调的发展至关重要。充分利用幼儿的多种自主活动,确立科学的幼儿和谐个性发展目标,拓展幼儿个性和谐发展的自主空间,建构有利于幼儿个性和谐发展的教育模式,对于幼儿的全面发展具有非常重要的价值。

关键词：自主活动个性儿童发展

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