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Decision-Making and Management of Sel.-Care in Persons with Traumatic Spinal.Cord Injuries: A Prel.minary Study

Journal.of Behavioral.and Brain Science 2024年第2期14卷 47-63页

作者： Paul.E. Pl.nski Jasmin Vassil.va Ryan Shahidi Paul.B. Perrin Wil.iam Carter lance l. goetz Amber Brochetti James M. Bjork Institute for Drug and Al.ohol.Studies Virginia Commonwealth University Richmond VA USA Richmond Veterans Affairs Medical.Center Richmond VA USA Department of Psychiatry Virginia Commonwealth University Richmond VA USA Department of Psychol.gy Virginia Commonwealth University Richmond VA USA Department of Physical.Medicine and Rehabil.tation Virginia Commonwealth University Richmond VA USA Department of Spinal.Cord Injury Cleveland Veterans Affairs Medical Center Cleveland OH USA Department of Pharmacol.gy and Toxicol.gy Virginia Commonwealth University Richmond VA USA

Patients and physicians understand the importance of sel.-care fol.owing spinal.cord injury (SCI), yet many individual. with SCI do not adhere to recommended sel.-care activities despite l.gistical.supports. Neurobehavioral.determinants of SCI sel.-care behavior, such as impul.ivity, are not widel. studied, yet understanding them coul. inform efforts to improve SCI sel.-care. We expl.red associations between impul.ivity and sel.-care in an observational.study of 35 US adul.s age 18 - 50 who had traumatic SCI with parapl.gia at l.ast six months before assessment. The primary outcome measure was sel.-reported sel.-care. In l.SSO regression model. that incl.ded al. neurobehavioral.measures and demographics as predictors of sel.-care, dispositional.measures of greater impul.ivity (negative urgency, l.ck of premeditation, l.ck of perseverance), and reduced mindful.ess were associated with reduced sel.-care. Outcome (magnitude) sensitivity, a l.tent decision-making parameter derived from computational.y model.ng successive choices in a gambl.ng task, was al.o associated with sel.-care behavior. These resul.s are prel.minary;more research is needed to demonstrate the util.ty of these findings in cl.nical.settings. Information about associations between impul.ivity and poor sel.-care in peopl. with SCI coul. guide the devel.pment of interventions to improve SCI sel.-care and hel. patients with el.vated risks rel.ted to sel.-care and secondary heal.h conditions.

关键词： Spinal.Cord Injury Sel.-Care Decision-Making Parapl.gia Impul.ive Behavior Heal.h Care

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The accel.ration of a high-charge el.ctron bunch to 10 GeV in a 10-cm nanoparticl.-assisted wakefiel. accel.rator

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Matter and Radiation at Extremes 2024年第1期9卷 15-24页

作者： Constantin Anicul.esei Thanh Ha Samuel.Yoffe lance l.bun Stephen Mil.on Edward McCary Michael.M.Spinks Hernan J.Quevedo Ou Z.l.bun Ritwik Sain Andrea Hannasch Rafal.Zgadzaj Isabel.a Pagano Jose A.Franco-Al.amirano Martin l.Ringuette Erhart Gaul.Scott V.l.edtke Ganesh Tiwari Bernhard Ersfel. Enrico Brunetti Hartmut Ruhl.Todd Ditmire Sandra Bruce Michael.E.Donovan Michael.C.Downer Dino A.Jaroszynski Bjorn Manuel.Hegel.ch University of Texas at Austin AustinTexas 78712USA SUPA Department of Physics University of StrathclydeGlasgowScotland G4 ONGUnited Kingdom Tau Systems Inc.AustinTexas 78701USA l.wrence l.vermore National.l.boratory LivermoreCalifornia 94550USA l.s Al.mos National.l.boratory Los AlamosNew Mexico 87545USA Brookhaven National.l.boratory UptonNew York 11973USA l.dwig-Maximil.ans-Universität MunichGermany

An intense l.ser pul.e focused onto a pl.sma can excite nonl.near pl.sma *** appropriate conditions,el.ctrons from the background pl.sma are trapped in the pl.sma wave and accel.rated to ul.ra-rel.tivistic *** scheme is cal.ed a l.ser wakefiel. *** this work,we present resul.s from a l.ser wakefiel. accel.ration experiment using a petawatt-cl.ss l.ser to excite the wakefiel.s as wel. as nanoparticl.s to assist the injection of el.ctrons into the accel.rating phase of the *** find that a 10-cm-l.ng,nanoparticl.-assisted l.ser wakefiel. accel.rator can generate 340 pC,10±1.86 GeV el.ctron bunches with a 3.4 GeV rms convol.ed energy spread and a 0.9 mrad rms *** can al.o produce bunches with l.wer energies in the 4–6 GeV range.

关键词： accel.ration nanoparticl. charge

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Quick l.ok drug book /. 2003.

Quick look drug book /. 2003.

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2003年

作者： lance l.onard l.

来源：畅想之星图书光盘版（南... 评论

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Robust genome and RNA editing via CRISPR nucl.ases in PiggyBac systems

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Bioactive Material. 2022年第8期7卷 313-320页

作者： Yuqian Jiang Rachel.Catherine Hoenisch Yun Chang Xiaoping Bao Craig E.Cameron Xiaojun lance l.an Department of Biomedical.Engineering Pennsylvania State UniversityUniversity ParkPA16802USA Huck Institutes of the l.fe Sciences Pennsylvania State UniversityUniversity ParkPA16802USA Department of Biol.gy Pennsylvania State UniversityUniversity ParkPA16802USA Davidson School.of Chemical.Engineering Purdue UniversityWest LafayetteIN47907USA Department of Microbiol.gy and Immunol.gy University of North Carolina School of MedicineChapel HillNC27599USA

CRISPR/Cas-mediated genome editing in human pl.ripotent stem cel.s(hPSCs)offers unprecedented opportunities for devel.ping in vitro disease model.ng,drug screening and cel.-based *** efficientl. del.ver the CRISPR components,here we devel.ped two al.-in-one vectors containing Cas9/gRNA and inducibl. Cas13d/gRNA cassettes for robust genome editing and RNA interference *** vectors util.zed the PiggyBac transposon system,which al.ows stabl. expression of CRISPR components in *** Cas9 vector PB-CRISPR exhibited high efficiency(up to 99%)of inducing gene knockout in both protein-coding genes and l.ng non-coding *** other inducibl. Cas13d vector achieved extremel. high efficiency in RNA knockdown(98%knockdown for CD90)with optimized gRNA *** together,our PiggyBac CRISPR vectors can serve as powerful.tool.its for studying gene functions in hPSCs.

关键词： CRISPR-Cas9 Genome editing Cas13d RNA editing PiggyBac transposon Human pl.ripotent stem cel.s

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Heart regeneration with human pl.ripotent stem cel.s: Prospects and chal.enges

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Bioactive Material. 2020年第1期5卷 74-81页

作者： Yuqian Jiang Xiaojun lance l.an Department of Biomedical.Engineering Pennsylvania State UniversityUniversity ParkPA16802USA Huck Institutes of the l.fe Sciences Pennsylvania State UniversityUniversity ParkPA16802USA Department of Biol.gy Pennsylvania State UniversityUniversity ParkPA16802USA

Cardiovascul.r disease,ranging from congenital.heart disease to adul. myocardial.infarction,is the l.ading cause of death *** pursuit of rel.abl. cardiovascul.r regenerative medicine,human pl.ripotent stem cel.s(hPSCs),incl.ding human embryonic stem cel.s(hESCs)and human induced pl.ripotent stem cel.s(hiPSCs),offer pl.nty of potential.cel.-based *** are capabl. of prol.ferating indefinitel. in an undifferentiated state,and are al.o pl.ripotent,being abl. to differentiate into virtual.y any somatic cel. types given specific stepwise cues,thus representing an unl.mited source to generate functional.cardiovascul.r cel.s for heart *** we recapitul.ted current advances in devel.ping efficient protocol. to generate hPSCderived cardiovascul.r cel. l.neages,incl.ding cardiomyocytes,endothel.al.cel.s,and epicardial.*** al.o discussed appl.cations of hPSC-derived cel.s in combination with compatibl. bioactive material.,promising trial. of cel. transpl.ntation in animal.model. of myocardial.infarction,and potential.hurdl.s to bring us cl.ser to the ul.imate goal.of cel.-based heart repair.

关键词： Human pl.ripotent stem cel.s Cardiovascul.r cel.s Tissue engineering

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Engineered human pl.ripotent stem cel.-derived natural.kil.er cel.s with PD-l. responsive immunol.gical.memory for enhanced immunotherapeutic efficacy

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Bioactive Material. 2023年第9期27卷 168-180页

作者： Yun Chang Gyuhyung Jin Weichuan l.o Qian l.o Juhyung Jung Sydney N.Hummel.Sandra Torregrosa-Al.en Bennett D.El.ey Phil.p S.l.w Xiaojun lance l.an Xiaoping Bao Davidson School.of Chemical.Engineering Purdue UniversityWest LafayetteIN47907USA Purdue University Institute for Cancer Research West LafayetteIN47907USA Department of Comparative Pathobiol.gy Purdue UniversityWest LafayetteIN 47907USA Department of Chemistry Purdue UniversityWest LafayetteIN47907USA Department of Biomedical.Engineering The Huck Institutes of the Life SciencesDepartment of BiologyThe Pennsylvania State UniversityUniversity ParkPA16802USA

Adoptive chimeric antigen receptor(CAR)-engineered natural.kil.er(NK)cel.s have shown promise in treating various ***,l.mited immunol.gical.memory and access to sufficient numbers of al.ogenic donor cel.s have hindered their broader precl.nical.and cl.nical.***,we first assess eight different CAR constructs that use an anti-PD-l. nanobody and/or universal.anti-fl.orescein(FITC)singl.-chain variabl. fragment(scFv)to enhance antigen-specific prol.feration and anti-tumor cytotoxicity of NK-92 cel.s against heterogenous sol.d *** next genetical.y engineer human pl.ripotent stem cel.s(hPSCs)with optimized CARs and differentiate them into functional.dual.CAR-NK *** tumor microenvironment responsive anti-PD-l. CAR effectivel. promoted hPSC-NK cel. prol.feration and cytotoxicity through antigen-dependent activation of phosphoryl.ted STAT3(pSTAT3)and pSTAT5 signal.ng pathways via an intracel.ul.r truncated Il.2 receptorβ-chain(ΔIl.2Rβ)and STAT3-binding tyrosine-X-X-gl.tamine(YXXQ)***-tumor activities of PD-l.-induced memory-l.ke hPSC-NK cel.s were further boosted by administering a FITC-fol.te bi-specific adapter that bridges between a programmabl. anti-FITC CAR and fol.te receptor al.ha-expressing breast tumor ***,our hPSC CAR-NK engineering pl.tform is modul.r and coul. constitute a real.stic strategy to manufacture off-the-shel. CAR-NK cel.s with immunol.gical.memory-l.ke phenotype for targeted immunotherapy.

关键词： Natural.kil.er cel.s Human pl.ripotent stem cel.s Immunol.gical.memory Immunotherapy Chimeric antigen receptor

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Three potential.l.vel. for the Bashkirian/Moscovian boundary in the Naqing section based on conodonts

Three potential levels for the Bashkirian/Moscovian boundary...

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中国古生物学会第26届学术年会

作者： lance l. l.mbert James E. Barrick Department of Geol.gical.Sciences of the University of Texas at San Antonio San Antonio TX 78249 USA Department of Geosciences of Texas Tech University Lubbock TX 79409 USA

In the Carboniferous,the endemism of biota,the strong gl.cial.eustatic control.over sedimentation and consequent widespread disconformities hamper the sel.ction of acceptabl. GSSPs for the Carboniferous stages,incl.ding the Serpukhovian,Moscovian,Kasimovian and *** rel.tivel. deeper-water,carbonate-sl.pe and basinal.sections can be served as

关键词： Bashkirian/Moscovian boundary conodont Naqing section South China

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OBSERVING THE HEAT EQUATION ON A TORUS Al.NG A DENSE GEODESIC

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Systems Science and Mathematical.Sciences 1991年第2期4卷 186-192页

作者： lance D.Drager Robert l.Foote Cl.de F.Martin Department of Mathematics Texas Tech.University.LubbockTX 79409USA Department of Mathematics Wabash CollegeCrawfordsvilleIN 47933USA Department of Mathematics Texas Tech.UniversityLubbockTX 79409USA

Several.authors have considered observabil.ty probl.ms for the heat equation and rel.tedpartial.differential.equations.A basic probl.m is to determine what kinds of sampl.ng providesufficient information to uniquel. determine the initial.heat *** address the case wherethe temperature is measured whil. travel.ing al.ng a *** consider the special.case where the space is a fl.t torus(of arbitrary dimension)and thecurve is a *** is shown that,in this case,the observed temperature is sufficient informationto uniquel. determine the initial.heat distribution if and onl. if the geodesic is dense in the *** the case of a torus,Fourier anal.sis techniques can be used to write down the sol.tion of theheat *** al.ows us to derive an expl.cit representation of the observed temperature interms of the initial.*** use this representation and some ideas from the theory ofal.ost periodic functions to show that the Fourier coefficients of the initial.distribution can berecovered from the observation.

关键词： Observabil.ty heat equation inverse probl.ms

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Autotrophic Biofil.ers for Oxidation of Nitric Oxide

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Chinese Journal.of Chemical.Engineering 2004年第1期12卷 113-117页

作者：陈建孟陈浚 lance Hershman 王家德 Daniel.P.Y.Chang Col.ege of Biol.gical.and Environmental.Engineering Zhejiang University of Technology Hangzhou 310032 China Department of Civil.and Environmental.Engineering University of California Davis California 95616 USA

Carbon foam—a kind of new engineering material.as packing material.was adopted in three biofil.ers with different pore dimensions and adapted autotrophic nitrite nitrobacteria to investigate the purification of nitric oxide (NO) in a gas stream. The biofil. was devel.ped on the surface of carbon foams using nitrite as its onl. nitric source. The moisture in the fil.er was maintained by ul.rasonic aerosol.equipment which can minimize the thickness of the l.quid fil.. The l.quid phase nitrification test was conducted to determine the variabil.ty and the potential.of performance among the three carbon foam biofil.ers. The investigation showed that during the NO2^-—N inl.t concentration of 200 g·l.-1·min^-1 to 800 g·l.-1·min^-1, the 24PPC (pores per centimeter) carbon foam biofil.er had the greatest potential. achieving the NO2^-—N removal.efficiency of 94% to 98%. The 8PPC and 18PPC carbon foam biofil.ers achieved the NO2^-—N removal.efficiency of 15% to 21% and of 30% to 40%, respectivel.. The potential.for this system to remove NO from a gas stream was shown on the basis of a steady removal.efficiency of 41% to 50% which was attained for the 24PPC carbon foam biofil.er at specified NO inl.t concentration of 66.97 mg·m^-3 to 267.86mg·m^-3 and an empty-bed residence time of 3.5 min.

关键词：一氧化氮净化细菌过滤器硝化细菌亚硝酸盐

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Effectiveness of DTaP Against Pertussis in≤2-Year-Ol. Chil.ren—l.nyi Prefecture,Shandong Province,China,2017–2019

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China CDC weekl. 2023年第17期5卷 374-378,I0006-I0009页

作者： Pinpin Zhu Dan Wu Yan Wang Xiaoxue l.u lance ERodewal. Yixing l. Hui Zheng l.i Cao Yifan Song l. Song Xiaodong Zhao Jianyi Yao Fuzhen Wang Mingshuang l. Qian Zhang Tingting Yan Zundong Yin National.Immunization Program Chinese Center for Disease Control and PreventionBeijingChina l.nyi Center for Disease Control.and Prevention Linyi CityShandong ProvinceChina Jinan Center for Disease Control.and Prevention Jinan CityShandong ProvinceChina Heal.h Communication Center Chinese Center for Disease Control and PreventionBeijingChina

Summary What is al.eady known about this topic?Vaccine effectiveness(VE)is positivel. correl.ted with the number of administered co-purified diphtheria,tetanus,and acel.ul.r pertussis vaccine(DTaP)doses.A matched case-control.study conducted in Zhongshan City reveal.d that the co-purified DTaP VE against pertussis-rel.ted il.nesses in chil.ren aged 4–11 months was 42%for one dose,88%for two doses,and 95%for three doses,*** is added by this report?The resul.s of this study contribute to the current body of *** found that the VE of co-purified DTaP against pertussis-rel.ted il.ness and hospital.zation increased substantial.y,ranging from 24%–26%after one dose to 86%–87%after four doses.

关键词： doses DTaP vaccine

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