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Visual ＂playback＂ of colorful signals in the field supports sensory drive for signal detectability

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Current Zoology 2018年第4期64卷 493-498页

作者： Alex R. gunderson Leo J. FLEIShMAN Manuel LEAL Department of Integrative Biology University of California Berkeley CA 94720 USA Department of Biology Union College Schenectady NY 12308 USA Division of Biological Sciences University of Missouri 105 Tucker Hall Columbia MO 65211 USA

Colorful visual signals are important systems for investigating the effects of signaling environ ments and receiver physiology on signal evolution as predicted by the sensory drive hypothesis. Support for the sensory drive hypothesis on color signal evolution is mostly based on document ing correlations between the properties of signals and habitat conditions under which the signals are given （i.e., a correlational approach） and less commonly on the use of mathematical models that integrate representations of visual environments, signal properties, and sensory systems （i.e., a functional approach）. here, we used an experimental approach in the field to evaluate signal efficacy of colorful lizard throat fans called dewlaps that show geographic variation in the lizard Anolis cristatellus. We used a remote controlled apparatus to display ＂fake dewlaps＂ to wild lizards to test for adaptive divergence in dewlap brightness （i.e., perceived intensity） among populations in situ. We found evidence of local adaptation in dewlap brightness consistent with the sensory drive hypothesis. Specifically, dewlaps that had the brightness characteristics of local lizards were more likely to be detected than those with the brightness characteristics of nonlocal lizards. Our findings indicate that simplified mathematical representations of visual environments may allow robust estimates of relative detectability or conspicuousness in natural habitats. We have shown the feasibility of evaluating color signal efficacy experimentally under natural conditions and dem onstrate the potential advantages of presenting isolated components of signals to an intended re ceiver to measure their contribution to signal function.

关键词： Anolis color signal sensory drive signal evolution

Essential neural anatomy for creating a clinically translatable osseointegrated neural interface for prosthetic control in sheep

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Plastic and Aesthetic Research 2023年第1期10卷 600-614页

作者： Kirsten A.gunderson Scott K.Odorico Zeeda h.Nkana Lucas Sears Grant Seils Rashea L.Minor Weifeng Zeng Samuel O.Poore Aaron M.Dingle Division of Plastic Surgery University of Wisconsin School of Medicine and Public HealthMadisonWI 53792USA University of Wisconsin-Madison School of Veterinary Medicine MadisonWI 53706USA

Aim:Ovine models for osseointegrated prosthetics research are well established,but do not consider neural control of advanced *** validity of interfacing technologies,such as the Osseointegrated Neural Interface(ONI),in their ability to provide communication between native nerves and advanced prosthetics is required,necessitating a stable,longitudinal large animal model for *** objective of this study is to provide a detailed anatomic description of the major nerves distal to the carpal and tarsal joints,informing the creation of a chronic ONI for prosthetic control in ***:Six pelvic and six thoracic cadaveric limbs from mature female,non-lactating sheep were *** were obtained to determine average bone length,medullary canal diameter,and cortical bone *** dissection was performed to discern topographical neuroanatomy and average circumferences of the major nerves of the pelvic and thoracic *** analysis was performed.A surgical approach for the creation of ONI was ***:Average metacarpal and metatarsal length was 15.0 cm(±0.0)and 19.7 cm(±1.0),*** intramedullary canal diameter was 12.91 mm(±3.69)for forelimbs and 12.60 mm(±3.69)for *** thoracic limb nerves consisted of one dorsal and three ventral nerves,with an average circumference of 5.14 mm(±2.00)and 5.05 mm(±1.06),*** limb nerves consisted of two dorsal and one ventral nerve with an average circumference of 6.27 mm(±1.79)and 5.40 mm(±0.53),***:These anatomic data inform the surgical approach and manufacture of a sensory ONI for chronic testing in awake,freely ambulating animals for future clinical translation.

关键词： Amputation prosthesis prostheses neural interface clinical translation large animal osseointegration neuroprosthesis

Synthesis and Characterization of Naproxen-Salicylate Derivatives as Potential Dual-Targeted Inhibitors of Dihydrofolate Reductase

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Advances in Biological Chemistry 2024年第4期14卷 87-102页

作者： Syon Schlecht Emily gunderson Ruthie Fowler Takara Aguilar Biotechnology Research and Development Empower College and Career Center Jefferson Georgia

Dihydrofolate reductase (DhFR) is an enzyme that catalyzes the reduction of dihydrofolate (DhF) to tetrahydrofolate (ThF). Chemotherapy drugs such as methotrexate help to slow the progression of cancer by limiting the ability of dividing cells to make nucleotides by competitively inhibiting DhFR. Nonsteroidal anti-inflammatory drugs (NSAIDs) have been previously reported to exhibit competitive inhibition of DhFR, in addition to their primary action on cyclooxygenase enzymes. This interaction interferes with the enzymatic reduction of dihydrofolate to tetrahydrofolate, thereby impeding the folate metabolism pathway essential for nucleotide synthesis and cell proliferation. This activity stems from their structural resemblance to the p-aminobenzoyl-l-glutamate (pABG) moiety of folate, a substrate of DhFR. It has been established that NSAIDs containing a salicylate group (which has structural similarities to pABG), such as diflunisal, exhibit stronger DhFR-binding activity. In this study, we synthesized salicylate derivatives of naproxen with the aim of exploring their potential as inhibitors of DhFR. The interactions between these derivatives and human DhFR were characterized using a combination of biochemical, biophysical, and structural methods. Through polyacrylamide gel electrophoresis (PAGE) analysis, enzymatic assays, and quantitative ELISA, we investigated the binding affinity and inhibitory potency of the synthesized salicylate derivatives towards DhFR. The findings of this study suggest the potential of salicylate derivatives of naproxen as promising candidates for the inhibition of DhFR, thereby offering novel therapeutic opportunities for modulating the inflammatory process through multiple pathways. Further optimization of these derivatives could lead to the development of more efficacious dual-targeted analogs with enhanced therapeutic benefits.

关键词： Dihydrofolate Reductase DhFR Chemotherapy Nonsteroidal Anti-Inflammatory Drugs NSAIDs Folate Metabolism Pathway Anti-Folate Novel Therapeutic Development

Numerical Study of the Impact of Wake Surfing on Inland Bodies of Water

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Journal of Water Resource and Protection 2022年第3期14卷 238-272页

作者： Endicott M. Fay Andrew gunderson Arden Anderson Cotty Fay Marine Design Inc. Bainbridge Island WA USA Mercury Marine Fond du Lac WI USA

In many areas around the world, wake surfing has been cited as one of the major causes of lakeshore erosion and turbidity. This paper quantifies the impact related to turbidity and erosion with the use of computational fluid dynamics (CFD) of boat wakes in shallow water and the build-up of wind driven waves. The energy, type and direction of the boat’s wake are described quantitatively and a table for predicting wind driven waves over varying fetches, depth and wind speeds is provided. The CFD simulation shows that if a wake surf boat is operated 200 ft from shore and in at least 10 ft of water, the environmental impact is minimal.

关键词： CFD Erosion Waves Wakes Wind Driven Waves

Burden of bone disease in chronic pancreatitis:A systematic review and meta-analysis

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World Journal of Gastroenterology 2023年第8期29卷 1374-1394页

作者： Ankit Chhoda Maria Jose hernandez-Woodbine Nana Afua Akkya Addo Syed Alishan Nasir Alyssa Grimshaw Craig gunderson Awais Ahmed Steven D.Freedman Sunil G.Sheth Department of Gastroenterology Beth Israel Deaconess Medical CenterBostonMA 02215United States Department of Medicine Norwalk HospitalYale School of MedicineNorwalkCT 06850United States Cushing/Whitney Medical Library Yale UniversityNew HavenCT 06510United States General Internal Medicine Yale School of MedicineNew HavenCT 06510United States

BACKGROUND Bone disease is an under-recognized cause of morbidity in chronic pancreatitis(CP).Over the past decade,publications of original studies on bone disease in CP has warranted synthesis of the evidence to ascertain the true burden of the *** To quantify the prevalence of osteopenia,osteoporosis,and fragility fractures in CP patients and investigate the associated clinical features and *** A systematic search identified studies investigating bone disease in CP patients from Cochrane Library,Embase,Google Scholar,Ovid Medline,PubMed,Scopus,and Web of Science,from inception until October *** outcomes included prevalence of osteopenia,osteoporosis,and fragility fractures,which were metaanalyzed using a random-effects model and underwent metaregression to delineate association with baseline clinical *** Twenty-one studies were included for systematic review and 18 studies were included for *** pooled prevalence of osteopenia and osteoporosis in CP patients was 41.2%(95%CI:35.2%-47.3%)and 20.9%(95%CI:14.9%-27.6%),*** pooled prevalence of fragility fractures described among CP was 5.9%(95%CI:3.9%-8.4%).Metaregression revealed significant association of pancreatic enzyme replacement therapy(PERT)use with prevalence of osteoporosis[coefficient:1.7(95%CI:0.6-2.8);Ph mean age,sex distribution,body mass index,alcohol or smoking exposure,diabetes with prevalence of osteopenia,osteoporosis or fragility *** of data on systemic inflammation,CP severity,and bone mineralization parameters precluded a formal *** This meta-analysis confirms significant bone disease in patients with *** than PERT use,we observed no patient or study-specific factor to be significantly associated with CP-related bone *** studies are needed to identify confounders,at-risk population,and to understand the mechanisms of CP-related bone disease an

关键词： Chronic pancreatitis Fractures Osteoporosis Osteopenia Bone disease

恢复力与可持续发展:在瞬息万变的世界中增强适应能力

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AMBIO－人类环境杂志 2002年第5期31卷 437-440页

作者： Carl Folke Steve Carpenter Thomas Elmqvist lance gunderson C.S.holling Brian Walker 刘林群瑞典斯德哥尔摩大学系统生态学系美国麦迪逊市的威斯康星大学美国佐治亚州亚特兰大市Emory大学环境研究系佛罗里达大学恢复力联盟计划部

由于在以往的自然资源政策上逐渐暴露出了两个带根本性的错误,人们开始意识到在环境管理理论和实践方面需要进行一场全球性的重大改革。第一个错误是毫无保留地假定生态系统对人类利用所作出的反应是呈线性关系、是可以预测和控制的。... 详细信息

由于在以往的自然资源政策上逐渐暴露出了两个带根本性的错误,人们开始意识到在环境管理理论和实践方面需要进行一场全球性的重大改革。第一个错误是毫无保留地假定生态系统对人类利用所作出的反应是呈线性关系、是可以预测和控制的。第二个错误是认定人娄社会与天然系统可以分别对待,不必联系在一起进行考虑。然而,从世界各地收集到的证据表明,天然系统和人类社会系统是以非线性方式运行的,在其动态运行过程中均有其显著的极限,而且,人类社会与生态系统表现为一种紧密相联的、复杂的且不断演变的综合系统。本文是代表瑞典政府环境咨询委员会编写的一份报告的摘要,这份报告是作为向2002年8月26日～9月4日在南非约翰内斯堡召开的可持续发展世界首脑会议献礼的论文而撰写的。从概念上说,恢复力是一种能缓冲变化所带来的影响、学习知识和求得发展的能力,我们将它作为在一个纷纭复杂、快速变化的世界中,是否真正懂得如何维护和提高适应能力的一种参照标准来使用。在社会、生态综合系统中,有两种有用的工具可用来提高恢复力,一种是结构严谨的工作方案,另一种是积极的适应力管理。这两种工具都需要而且有助于形成这样一种社会环境:具有灵活开放的组织机构和多层次的监管体制,允许学习适应力方面的知识和提高适应力但又不妨碍对来来的发展作出选择。

关键词：恢复力可持续发展生态系统生态恢复适应力管理适应能力

Go to the back before going forward:Addressing psychological responses in anterior cruciate ligament reconstruction rehabilitation

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Journal of Sport and health Science 2024年第5期13卷 666-669页

作者： Terese L.Chmielewski Adam Meierbachtol Rick Aberman Travis gunderson Jonathon Sikorski Kathleen Cummer TRIA Orthopedic Center BloomingtonMN 55431USA Rehabilitation Science Graduate Program Department of Family Medicine and Community HealthMedical SchoolUniversity of MinnesotaMinneapolisMN 55455USA Optum Inc. Clinical OperationsPhysical Health DivisionEden PrairieMN 55344USA Dr.Rick Aberman Consulting MinnetonkaMN 55305USA Department of Rehabilitation Medicine Division of Physical TherapyUniversity of WashingtonSeattleWA 98195USA

helping athletes return to sports participation is a primary goal of anterior cruciate ligament(ACL)reconstruction *** facilitate the achievement of this goal,decades of research studies have sought to identify knee impairments that reduce knee function as well as interventions to resolve them.1Yet,over the past 10 years,research pertaining to psychological responses(i.e.,cognitions and emotions)after ACL reconstruction has grown exponentially—a phenomenon that can be visualized by entering the search terms"psychological"and"anterior cruciate ligament reconstruction"into the PubMed search engine.

关键词： ligament return psychological