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Corne.l Wave.ront Abe.rations in Patie.ts We.ring Multifocal Soft Contact Le.se. for Myopia Control

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Ope. Journal of Ophthalmology 2012年第3期2卷 45-53页

作者： Frank Spors Donald J. e.an Jie.She. lance e. mcnaughton Stuart Mann Ne.l M. Pate. Colle.e.of Optome.ry Pomona CA We.te.n Unive.sity of He.lth Scie.ce. Pomona CA

Purpose. The.purpose.of this study was to e.aluate.the.change.in corne.l wave.ront abe.rations in young adults who have.be.n fit with multifocal soft contact le.se. for myopia progre.sion control. Findings have.be.n analyze. for statistical significance.and clinical re.e.ance.and compare. to re.orte.ly succe.sful Orthoke.atology outcome.. Me.hods: The.dominant e.e.of 40 participants (27 wome., 13 me.;me.n age.27.3 ± 3.2 ye.rs;range.23 to 39 ye.rs) was fit with Procle.r Multifocal ce.te. distance.le.se. (Coope.vision, Ple.santon, USA) having a varie.y of distance.powe.s and re.ding additions. Re.ractive.e.rors we.e.limite. to a range.of –6.00 D up to +1.00 D of sphe.e. and no gre.te. than –1.00 D of cylinde.. Corne.l wave.ront me.sure.e.ts we.e.pe.forme. ove. 6 mm diame.e.s with a Ze.ss Atlas 9000 corne.l topographe. (Ze.ss Me.ite., Dublin, USA) prior to, and following le.s fitting. Data we.e.conve.te. into re.tangular Fourie. optics te.ms M, J0, J45 and RMS value. for e.ch re.ding addition we.e.statistically analyze.. Following e.aluation of statistical significance.and clinical re.e.ance. re.ults we.e.compare. to publishe. data from succe.sful Orthoke.atology tre.tme.ts. Re.ults: Statistically significant change. in highe. orde. abe.rations we.e.de.e.te. for le.se. of all re.ding additions. Le.s groups with highe. Add-powe.s de.onstrate. stronge. change. with incre.se. significance. Final RMS value. re.ating to 2nd, 3rd and 4th Ze.nike.Orde.s re.che. clinical significance.with a wave.ront e.ror of 0.10 μm, the.e.uivale.t of 0.25D. More.ve., as Add-powe.s incre.se., 3rd and 4th orde. abe.rations like.ise.showe. an incre.se. Pre.fitting astigmatism value. accounte. for the.highe.t re.orde. abe.rations and re.aine. pre.ominantly unchange.. Conclusion: Procle.r Multifocal ce.te.-distance.contact le.se. we.e.found to incre.se.highe. orde. wave.ront abe.rations in a manne. de.e.de.t on the.r Add-powe.. In comparison to succe.sful Orthoke.atology outcome., the.amounts of

关键词： Multifocal Soft Contact Le.se. Wave.ront Abe.rations Myopia Myopia Progre.sion Control Orthoke.atology Ze.nike Polynomials

e.porting China’s Succe.se. in Vaccine.Pre.e.table.He.atitis

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China CDC we.kly 2020年第30期2卷 575-576页

作者： lance e.Rode.ald National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina

Almost four de.ade. of scie.ce.innovation,and programmatic e.fort to control and pre.e.t vaccine.re.e.table.viral he.atitis have.paid off spe.tacularly we.l in *** the.pre.vaccine.e.a,ne.rly 10% of childre. we.e.infe.te. by he.atitis B virus(HBV)—e.pe.ially during childbirth—causing the. to be.life.ong carrie.s of HBV,able.to infe.t othe.s,and in gre.t dange. of live. cance. and cirrhosis as adults(1).

关键词： vaccine China. he.atitis

Forty and Twe.ty Ye.rs Ago and Now--Virus e.imination Succe.se. and Ne. Challe.ge.

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China CDC we.kly 2020年第50期2卷 953-954页

作者： lance e.Rode.ald National Immunization Program China CDC Immunization Se.vice. Division US CDC(2000-2012) WHO China Country Office.2012-2017)

Forty ye.rs ago,smallpox was de.lare. e.adicate. by the.World He.lth Organization(WHO).As ***,Dire.tor of the.Smallpox e.adication Programme.at the.WHO quote. from the.33^(rd) World He.lth Asse.bly(1980)(1),“...the.world and all its pe.ple. have.won fre.dom from smallpox...a most de.astating dise.se...since.e.rlie.t time.le.ving de.th,blindne.s,and disfigure.e.t in its wake.and which only a de.ade.ago was rampant in Africa,Asia and South Ame.ica.”

关键词： de.th Dire.tor dise.se.

Time.of Application of S-Me.olachlor Affe.ts Growth, Marke.able.Yie.d and Quality of Carrot and Re. Be.t

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Ame.ican Journal of Plant Scie.ce. 2012年第4期3卷 546-550页

作者： Darre. e. Robinson Kriste. e. mcnaughton De.artme.t of Plant Agriculture University of Guelph Ridgetown Campus Ridgetown Canada

Tole.ance.of carrot and re. be.t to s-me.olachlor at thre. application timings—pre.e.e.ge.ce.to crop (PRe., e.rly poste.e.ge.ce.(crop at two to four le.f stage.e.OST), and late.poste.e.ge.ce.(crop at five.to se.e. le.f stage.LPOST) —was de.e.mine. from 2008 to 2010. LPOST applications of s-me.olachlor re.uce. carrot above.ground plant dry we.ght, marke.able.yie.d and growe. payme.t, but did not affe.t carrot le.gth. PRe.and LPOST applications of s-me.olachlor re.uce. re. be.t above.ground plant dry we.ght, total marke.able.yie.d, yie.d of No. 2 and No. 3 re. be.t, and growe. payme.t. Our findings indicate.that while.carrot may be.tole.ant to PRe.applications of s-me.olachlor, applications made.afte. the.5 le.f stage.re.uce. plant dry we.ght e.ough to impact marke.able.yie.d and growe. payme.t. In re. be.t, the.pote.tial re.uction in growth, yie.d and grade.would not justify the.utility of a PRe.or LPOST applica- tion timing.

关键词： S-Me.olachlor Yie.d Quality Tole.ance Application Timing Re. Be.t Carrot

Tole.ance.of Winte. Whe.t (Triticum ae.tivumL.) and Unde. Se.de. Re. Clove. (Trifolium pre.e.se.lt;/i>L.) to Fall Applie. Post-e.e.ge.t Broadle.f He.bicide.

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Ame.ican Journal of Plant Scie.ce. 2014年第9期5卷 1265-1271页

作者： Kriste. e. mcnaughton Lyne.te.R. Brown Pe.e. H. Sikke.a Unive.sity of Gue.ph Ridgetown Campus Ridgetown Canada

The.fall application of post-e.e.ge.t (POST) he.bicide. on winte. whe.t provide. e.fe.tive.control of e.e.ge. winte. annual, bie.nial, and pe.e.nial broadle.f we.ds. In re.e.t ye.rs, whe.t produce.s have.se.n a shift to the.e.we.ds, due.in part, to the.adoption of re.uce.-and no-tillage.practice. and the.use.of non-re.idual he.bicide. such as glyphosate.in the.pre.e.ing soybe.n and corn crops. The.tole.ance.of winte. whe.t to te. he.bicide., applie. POST in the.fall, was e.aluate. be.we.n 2008 and 2011 at e.e.e. and Ridge.own, Ontario. Winte. whe.t yie.d was not re.uce. by applications of MCPA e.te., dicamba/ MCPA/ me.oprop, clopyralid, bromoxynil/ MCPA, thife.sulfuron /tribe.uron +MCPA e.te., fluroxypyr +MCPA e.te., and pyrasulfotole. bromoxynil. In contrast, 2,4-D e.te. and dichlorprop/2,4-D, cause. visible.injury in June.and July of the.following ye.r and consiste.tly de.re.se. winte. whe.t yie.d by at le.st 10%. Applications of 100 g a.i. ha-1 saflufe.acil also de.re.se. winte. whe.t yie.d in two of the.four harve.t ye.rs e.amine.. None.of the.he.bicide.options e.amine. we.e.safe.on re. clove. whe. it was unde. se.de. the.spring following winte. whe.t planting. All he.bicide. significantly de.re.se. re. clove. dry biomass one.month afte. whe.t harve.t.

关键词： 2 4-D Clopyralid Pyrasulfotole Saflufe.acil Winte. Whe.t

e.ficacy of POST glyphosate.applications in combination with othe. POST he.bicide. in glyphosate.re.istant corn (Ze. mays L.)

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Agricultural Scie.ce. 2014年第1期5卷 1-8页

作者： Kriste. e. mcnaughton Lyne.te.R. Brown Pe.e. H. Sikke.a Unive.sity of Gue.ph Ridgetown Campus Ridgetown Canada

The.use.of glyphosate.re.istant corn has facilitate. a shift from a re.iance.on pre.me.ge.ce.re.idual he.bicide. to poste.e.ge.ce.(POST) he.bicide., and in some.case. e.clusive.y glyphosate. Glyphosate.is a non-se.e.tive.he.bicide.that is re.ative.y slow-acting, which may allow we.ds to continue.to compe.e.with corn afte. application and pote.tially de.re.se.crop yie.d. The.addition of se.e.al POST corn he.bicide., with some.re.idual control, to an e.rly-se.son glyphosate.application was e.amine. to de.e.mine.if the.tankmix combination would improve.the.spe.d of we.d control compare. to glyphosate.applie. alone. Se.e. fie.d trials we.e.conducte. ove. thre. ye.rs (2009, 2010 and 2011) ne.r Ridge.own and e.e.e., Ontario. The.control of common ragwe.d was improve. 3 days afte. application (DAA) with thre. POST glyphosate.tankmixe. compare. to glyphosate.alone. Howe.e. control was still le.s than 55%. De.e.ding on the.we.d spe.ie. e.amine., at 28 DAA two of the.glyphosate.tankmix tre.tme.ts te.te. provide. be.te. common ragwe.d, common lambsquarte.s, or gre.n foxtail control than glyphosate.alone. Tre.tme.ts providing be.te. we.d control at 28 DAA also typically de.re.se. we.d de.sity compare. to glyphosate.alone.

关键词： Glyphosate We.d Control Glyphosate.Re.istant Corn POST Application

Acce.e.ating into Immunization Age.da 2030 with mome.tum from China’s succe.sful COVID-19 vaccination campaign during dynamic COVID Ze.o

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Infe.tious Dise.se. of Pove.ty 2023年第5期12卷 87-90页

作者： lance e.Rode.ald National Immunization Program China CDCDepartment of the National Immunization ProgramChinese Center for Disease Control and Prevention155 Changbai RoadBeijing 102206People’s Republic of China

China’s immunization programs conducte. a unifie.,tightly coordinate. COVID-19 vaccination campaign during the.dynamic COVID Ze.o pe.iod that re.che. we.l ove. 90%of the.population with vaccine. having>90%e.fe.tive.e.s against se.ious-to-fatal *** campaign was e.ght time. the.size.of the.annual routine.national immunization program,administe.ing 3.4 billion dose. of vaccine. while.monitoring vaccine.cove.age.acce.tability,safe.y,and *** asse. of the.routine.immunization program had to be.stre.gthe.e. and e.pande. to attain high cove.age.and re.ch hundre.s of millions of adults who had not be.n vaccinate. since.*** stre.gthe.ing and e.pansion we.e.in dire.tions aligne. with the.World He.lth Organization’s Immunization Age.da 2030,which has a vision that"e.e.yone.e.e.ywhe.e.at e.e.y age.fully be.e.its from vaccine. for good he.lth and we.l-be.ng"and re.uire. re.ching all childre.,adole.ce.ts,and adults with life.aving *** from this campaign should not be.lost but should be.inve.te. into achie.ing what is possible.with a prope.ly re.ource. national immunization program that is now prove. to be.capable.of re.ching e.e.yone.in the.world’s large.t country throughout the.life.course.and to do so with all vaccine. re.omme.de. by the.World He.lth Organization.

关键词： Vaccine. Immunization Immunization program Immunization Age.da 2030 COVID-19 Life.course.vaccination

Robust ge.ome.and RNA e.iting via CRISPR nucle.se. in PiggyBac syste.s

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Bioactive.Mate.ials 2022年第8期7卷 313-320页

作者： Yuqian Jiang Rache. Cathe.ine.Hoe.isch Yun Chang Xiaoping Bao Craig e.Came.on Xiaojun lance Lian De.artme.t of Biome.ical e.gine.ring Pennsylvania State UniversityUniversity ParkPA16802USA Huck Institute. of the.Life.Scie.ce. Pennsylvania State UniversityUniversity ParkPA16802USA De.artme.t of Biology Pennsylvania State UniversityUniversity ParkPA16802USA Davidson School of Che.ical e.gine.ring Purdue UniversityWest LafayetteIN47907USA De.artme.t of Microbiology and Immunology University of North Carolina School of MedicineChapel HillNC27599USA

CRISPR/Cas-me.iate. ge.ome.e.iting in human pluripote.t ste. ce.ls(hPSCs)offe.s unpre.e.e.te. opportunitie. for de.e.oping in vitro dise.se.mode.ing,drug scre.ning and ce.l-base. *** e.ficie.tly de.ive. the.CRISPR compone.ts,he.e.we.de.e.ope. two all-in-one.ve.tors containing Cas9/gRNA and inducible.Cas13d/gRNA casse.te. for robust ge.ome.e.iting and RNA inte.fe.e.ce.*** ve.tors utilize. the.PiggyBac transposon syste.,which allows stable.e.pre.sion of CRISPR compone.ts in *** Cas9 ve.tor PB-CRISPR e.hibite. high e.ficie.cy(up to 99%)of inducing ge.e.knockout in both prote.n-coding ge.e. and long non-coding *** othe. inducible.Cas13d ve.tor achie.e. e.tre.e.y high e.ficie.cy in RNA knockdown(98%knockdown for CD90)with optimize. gRNA *** toge.he.,our PiggyBac CRISPR ve.tors can se.ve.as powe.ful toolkits for studying ge.e.functions in hPSCs.

关键词： CRISPR-Cas9 Ge.ome.e.iting Cas13d RNA e.iting PiggyBac transposon Human pluripote.t ste. ce.ls

分子系统进化关系分析的一种新方法——贝叶斯法在硬蜱属中的应用

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动物学报 2003年第3期49卷 380-388页

作者：徐广方庆权 Jame. e. Ke.RANS lance A. DURDe. 南乔治亚大学生物系和美国国家蜱博物馆

距离矩阵邻接法、最大简约法和最大似然法是重建生物系统关系的 3种主要方法。普遍认为最大似然法在原理上优于前二种方法 ,但其计算复杂费时。由于现行计算机的能力尚达不到其要求而实用性差 ,特别是在处理大数据集样本 (即大于 2 5个... 详细信息

距离矩阵邻接法、最大简约法和最大似然法是重建生物系统关系的 3种主要方法。普遍认为最大似然法在原理上优于前二种方法 ,但其计算复杂费时。由于现行计算机的能力尚达不到其要求而实用性差 ,特别是在处理大数据集样本 (即大于 2 5个分类单元 )时 ,用此方法几乎不可能。新近提出的贝叶斯法 (Baye.ianme.hod)既保留了最大似然法的基本原理 ,又引进了马尔科夫链的蒙特卡洛方法 ,并使计算时间大大缩短。本文用贝叶斯法对硬蜱属 (Ixode.) 19个种的线粒体 16SrDNA片段进行了系统进化分析。从总体上看 ,分析结果与现有的基于形态学的分类体系基本吻合。但与现存的假说相反 ,莱姆病的主要宿主蓖籽硬蜱复合种组并非单系。通过比较贝叶斯法与其它三种方法的结果 ,我们认为贝叶斯法是一种系统进化分析的好方法 ,它既能根据分子进化的现有理论和各种模型用概率重建系统进化关系 ,又克服了最大似然法计算速度慢、不适用于大数据集样本的缺陷。贝叶斯法根据后验概率直观地表示系统进化关系的分析结果 ,不需要用自引导法进行检验。可以预料 ,贝叶斯法将会被广泛地应用到系统进化分析上.

关键词：分子系统进化贝叶斯法硬蜱属线粒体 16SrDNA