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Low-intensity walking as mild medication for pressure control in prehypertensive and hypertensive subjects:how far shall we wander?

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Acta Pharmacologica Sinica 2019年第8期40卷 1119-1126页

作者： Qin Lu Sheng-ming Wang Yi-xiao Liu Hong Chen Rui Zhang Wen-hui Zhang Yuan-yuan Zou jia-wei Zhou Xin-yi Guo Ying Zhang Teng-Li Huang Yu-hang Liu Si-qi Zhang Kyosuke Yamanishi Hiromichi Yamanishi Hideaki Higashino Haruki Okamura Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of Medicine Hirakata Ryoikuen

Successful prevention and treatment of hypertension depend on the appropriate combination of antihypertensive drug therapy and nondrug lifestyle *** most hypertension guidelines recommend moderate-to high-intensity exercise,we decided to explore a mild yet effective type of exercise to add to hypertension management,especially in populations with complications or *** comparing the short-term cardiovascular effects of low-speed walking versus high-speed walking for 3 kilometers(km)(3 km/h versus 6 km/h)in young,healthy volunteers,we delivered low-speed walking(low-intensity walking,2.5 metabolic equivalents of task,METs)as exercise therapy in 42.prehypertensive and 43 hypertensive *** found that one session of 3 km low-intensity walking exerted a transient pressure-lowering effect as well as a mild negative chronotropic effect on heart rate in both the prehypertensive and hypertensive subjects;these short-term benefits on blood pressure and heart rate were accompanied by a brief increase in urine β-endorphin *** we prescribed regular low-intensity walking with a target exercise dose(exercise volume)of 500-1000 METs-min/week(50-60 min/day and 5-7 times/week)in hypertensive subjects in addition to their daily *** low-intensity walking also showed mild but significant blood pressure-lowering and heart rate-reducing effects in 7 hypertensive subjects within two *** is hypothesized that regular low-intensity exercise of the necessary dose could be taken as a pragmatic and supplementary medication for hypertension management.

关键词： hypertension prehypertension exercise medication low-intensity walking metabolic equivalent of task blood pressure heart rate urine β-endorphin

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DCK confers sensitivity of DCTD-positive cancer cells to oxidized methylcytidines

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Protein & Cell 2023年第7期14卷 534-539页

作者： Ya-Hui Zhao wei jiang Hai Gao Guo-Zheng Pang Yu-Shuang Wui Yuan-Xian Wang Meng-Yao Sheng jia-Ying Xie Wan-Ling Wu Zhi-jian Ji Ya-Rui Du Lei Zhang Xiao-Qin Wang Colum P.Walsh Hai jiang Guo-Liang Xu Dan Zhou Shanghai Key Laboratory of Medical Epigenetics Laboratory of Cancer EpigeneticsInstitutes of Biomedical SciencesMedical College of Fudan UniversityChinese Academy of Medical Sciences(RU069)Shanghai 200032China State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai200031China Center for Medical Research and Innovation Shanghai Pudong HospitalFudan UniversityShanghai 201399China Department of Hematology Huashan Hospital of Fudan UniversityShanghai 200040China Department of Chemistry and Institutes of Biomedical Science Shanghai Medical CollegeFudan UniversityShanghai 200032China Genomic Medicine Research Group Biomedical SciencesUlster UniversityColeraine BT521SAUnited Kingdom Centre for Research and Development Region Gavleborg/Uppsala UniversityGavle SE-80187Sweden

Dear Editor,Cytidine analogs,such as decitabine(DAC)and cytarabine(ara-C),have been widely used in the clinical treatment for several cancer types,including myelodysplastic syndrome and acute myeloid leukemia(AML;Appelbaum et al.1999;Saba 2.07).However,drug resistance causing treatment failure and disease relapse is an unresolved problem to *** cancer cells rely on the salvage enzymes cytidine deaminase(CDA)and dCMP deaminase(DCTD)to inactivate these cytidine derivative drugs by deamination(Jamieson et al.1987;Ebrahem et al.2.12..It is imperative to develop new categories of chemotherapeutic nucleosides to overcome the drug resistance caused by such increased cellular deamination activity.

关键词： cancer drugs

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The Coude Echelle Spectrograph for the Lijiang 1.8 m telescope

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Research in Astronomy and Astrophysics 2020年第3期20卷 76-83页

作者： Xiao-Li Wang Liang Chang Lei Wang Hang-Xin Ji Hao Xian Zhen Tang Yu-Xin Xin Chuan-Jun Wang Shou-Sheng He Ju-jia Zhang Bao-Li Lun Kai wei Xi-Qi Li Xiao-Jun jiang Hui-Juan Wang Hong-Bin Li Ji-Rong Mao yunnan Observatories Chinese Academy of SciencesKunming 650216China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China Nanjing Institute of Astronomical Optics&Technology National Astronomical ObservatoriesChinese Academy of SciencesNanjing 210042China The Institute of Optics and Electronics Chinese Academy of SciencesChengdu 610209China Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of ScienccsBeijing 100101China University of chinese academy of sciences Beijing 100049China

The Coude Echelle Spectrograph(CES)was originally mounted on Xinglong 2.16 m telescope in *** the High Resolution Fiber-fed Spectrograph(HRS)was commissioned at Xinglong 2.16 m telescope,the red path of CES was moved to Lijiang 1.8 m telescope,following some redesign and *** CES of Lijiang 1.8 m telescope has the spectral resolution(R=λ/?λ)ranging from 2.000 to 50000 corresponding to different slit *** a 2.k×2.k PI CCD,CES has a wavelength coverage between 570 nm to 1030 *** particular,the resolution of 37000 at 0.5 mm slit corresponds to 1.3′′on the *** limiting magnitude is V=11.5 with the use of the tip-tilt feedback system,and the S/N is about 40 for 1 hour exposure at 600 nm(R=37000).During the installation of CES,the tip-tilt mirror technology had successfully fulfilled high precision guiding and tracking for high resolution spectral observation and significantly improved the observation efficiency.

关键词： Instrumentation:spectrographs methods:observational techniques:spectroscopic

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Influence of Sn addition on mechanical properties of gas tungsten arc welded AM60 Mg alloy sheets

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Transactions of Nonferrous Metals Society of china 2016年第8期26卷 2051-2057页

作者： Jun GOU Ai-tao TANG Fu-sheng PAN jia SHE Su-qin LUO Jun-hua YE Da-wei SHI College of Materials Science and Engineering Chongqing University Chongqing 400044 China national Engineering Research Center for Magnesium Alloys Chongqing University Chongqing 400044 China Chongqing academy of Science and Technology Chongqing 401123 China Science and Technology on Reactor System Design Technology Laboratory College of Materials Science and Engineering Guilin University of Technology Guilin 541004 China

The effects of Sn addition on the microstructure and mechanical properties of gas tungsten arc butt-welded Mg?6Al?0.3Mn (AM60) (mass fraction, %) alloy sheets were investigated by optical microscopy, scanning electron microscopy, X-ray diffraction, transmission electron microscopy, and microhardness and tensile tests. The results indicate that both the average microhardness and joint efficiency of AM60 are improved by the addition of 1% Sn (mass fraction). The ultimate tensile strength of Mg?6Al?1Sn?0.3Mn (ATM610) reaches up to 96.8% of that of base material. Moreover, fracture occurs in the fusion zone ofATM610 instead of in the heat-affected zone of AM60 welded joint. The improvement in the properties is mainly attributed to the formation of Mg2.n, which effectively obstructs the grain coarsening in the heat-affected zone, resulting in a relatively finemicrostructure. The addition of 1% Sn improves the mechanical properties of AM60 welded joint

关键词： AM60 Mg alloy ATM610 Mg alloy gas tungsten arc welding mechanical properties

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Effects analysis on catalytic combustion characteristic of hydrogen/air in micro turbine engine by fuzzy grey relation method

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Journal of Central South University 2019年第8期26卷 2214-2223页

作者： E jia-qiang WU jiang-hua LIU Teng CHEN Jing-{2. DENG Yuan-wang PENG Qing-guo College of Mechanical and Vehicle Engineering Hunan University Changsha 410082 China Institute of New Energy and Energy-Saving & Emission-Reduction Technology Hunan University Changsha 410082 China

In order to enhance catalytic combustion efficiency, a premixed hydrogen /air combustion model of the micro turbine engine is established under different excess air ratio, inlet velocity and heat transfer coefficient. And effects of inlet velocity, excess air coefficient and heat transfer coefficient on the catalytic combustion efficiency of the hydrogen have been analyzed by the FLUENT with CHEMKIN reaction mechanisms and the fuzzy grey relation theory. It is showed that inlet velocity has a more intuitive influence on the catalytic combustion efficiency of the hydrogen. A higher efficiency can be obtained with a lower inlet velocity. The optimum excess air coefficient is in the range of 0.94 to 1.0, the catalytic combustion efficiency of the hydrogen will be declined if the excess air coefficient exceeded 1.0. The effect of heat transfer coefficient on the catalytic combustion efficiency of the hydrogen mainly embodies in the case of the excess air coefficient exceeded 1.0, however, the effect will be declined if the heat transfer coefficient exceeded 4.0. The fuzzy grey relation degrees of the inlet velocity, heat transfer coefficient and excess air coefficient on the catalytic combustion efficiency of the hydrogen are 0.640945, 0.6332.4 and 0.547892.respectively.

关键词： micro turbine engine catalytic combustion hydrogen fuzzy grey relation theory

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Coupling of a T12.a2.aCu2.8 Thin Film Intrinsic Josephson Junction and a Fabry-Perot Resonator

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chinese Physics Letters 2011年第3期28卷 195-198页

作者： FAN Bin WANG Zheng YUE Hong-wei YAN Shao-Lin JI Lu HE Ming SONG Feng-Bin FANG lan ZHAO Xin-Jie Department of Electronics Nankai UniversityTianjin 300071

We study the electromagnetic coupling mechanism of a T1_(2.Ba_(2.CaCu_(2.O_(8)(TI-2.12.thin film intrinsic Josephson junction to a hemispherical Fabry-Perot *** effective model to analyze coupling mechanism is put *** dielectric substrate is used as a dielectric resonator antenna and the Josephson junction,and a superconducting film is used as the feed line to excite a resonance mode inside the dielectric resonator *** confirm this method,two Josephson junction samples with different dimensions of substrate and shapes of superconducting film are fabricated and tested under microwave *** the same time,numerical simulations of the antenna characteristics and the field distribution of these samples are performed by numerical *** different coupling intensities of the two samples with the Fabry Perot resonator fit well with the numerical simulation *** proposed model is important for Josephson junctions used in the microwave field.

关键词： field Josephson dielectric

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MicroRNA-145 suppresses uveal melanoma angiogenesis and growth by targeting neuroblastoma RAS viral oncogene homolog and vascular endothelial growth factor

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chinese Medical Journal 2020年第16期133卷 1922-1929页

作者： Jing-Yan Yang Yang Li Qian Wang Wen-jia Zhou Yan-Ni Yan Wen-Bin wei Beijing Tongren Eye Center Beijing Tongren HospitalBeijing Ophthalmology and Visual Science Key LabBeijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentCapital Medical UniversityBeijing 100730China

Background:Uveal melanoma(UM)is the most common primary intraocular malignancy in *** has been demonstrated that microRNA-145(miR-145)is correlated with the progression of various cancers by regulating the expression of multiple target genes,especially a number of genes that regulate angiogenesis and ***,the underlying mechanisms of miR-145 in tumor angiogenesis of UM are still not well ***,we aimed to explore the potential target genes or pathways regulated by miR-145 in UM and the effect of miR-145 on invasion and ***:Totally,2. choroid samples were collected in our study,including 12.UM samples and 12.normal uveal *** expression of neuroblastoma RAS viral oncogene homolog(N-RAS),phosphorylated protein kinase B(p-AKT),and vascular endothelial growth factor(VEGF)in UM tissues and normal uveal tissues was analyzed using Western blotting *** expression system was used to construct MUM-2. and OCM-1 cell lines with stable overexpression of *** and endothelial cell tube formation assay were used to measure the effects of miR-145 on the invasion and angiogenesis of UM in *** downstream target genes of miR-145 were predicted by bioinformatics and confirmed using a luciferase ***/c nude mice models were established to investigate the mechanisms of miR-145 on tumor growth and angiogenesis in *** data comparisons were performed using analysis of Student’s t test.A two-tailed P2.,p-AKT(1.16±0.2. vs.0.57±0.03,t=7.05,P=0.001),and VEGF(0.97±0.32.vs.0.45±0.2.,t=3.314,P=0.008)inUMtumor tissues were significantly higher than those in normal uveal *** assay demonstrated N-RAS and VEGF as downstream targets of ***,tube formation assay revealed that miR-145-transfected human

关键词： Uveal melanoma Vascular endothelial growth factor A Neuroblastoma RAS viral oncogene homolog microRNA-145 Angiogenesis

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Preparation of semiconductor zinc telluride by photoelectrochemical deposition

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Journal of Central South University 2022年第9期29卷 2899-2910页

作者： LUO Miao-si MA Zi-wei ZHANG Zong-liang WANG Zhi-jian jiaNG Liang-xing jia ming LIU Fang-yang School of Metallurgy and Environment Central South UniversityChangsha 410083China Department of Material Science&Engineering University of UtahSalt Lake CityUtah84112USA Hunan Rare Earth Metal Materials Research Institute Hunan Key Laboratory for Rare Earth Functional MaterialsChangsha 410126China

With the continuous development of electronic industry, people’s demand for semiconductor materials is also increasing. How to prepare semiconductor materials with low cost, low energy consumption and high yield has become one of the hot spots of research. ZnTe is commonly used in the semiconductor industry due to its superior optoelectronic properties. Electrochemical deposition is one of the most frequently used methods to prepare ZnTe thin films. However,the traditional electrochemical deposition technology has many shortcomings, such as slow deposition rate and poor film quality. These hinder the large-scale promotion of zinc telluride electrochemical deposition technology. To solve the problems encountered in the preparation of semiconductor thin films by conventional electrochemical deposition, and based on the photoconductive properties of semiconductor materials themselves, the basic principles of photoelectrochemistry of semiconductor electrodes, and some characteristics of the electrochemical deposition process of semiconductor materials, the use of photoelectrochemical deposition method for the preparation of semiconductor materials was proposed. Firstly, the electrochemical behaviors(electrode reactions, nucleation growth and charge transport process) of the ZnTe electrodeposition under illumination and dark state conditions were studied. Then, the potentiostatic deposition of ZnTe was carried out under light and dark conditions. The phase structure, morphology and composition of the sediments were studied using X-ray diffractometer, scanning electron microscope and other testing methods. Finally, the photoelectrochemical deposition mechanisms were analyzed. Compared with conventional electrochemical deposition, photoelectrochemical deposition increases the current density during deposition and reduces the charge transfer impedance during ZnTe deposition process. In addition, since light illumination promotes the deposition of the difficult-to-deposit el

关键词： photoelectrochemical deposition zinc telluride semiconductors photogenerated electron-hole pairs thin film

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土壤中酚类化合物降解菌筛选及应用

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环境工程技术学报 2018年第4期8卷 449-455页

作者：孟宪荣许伟魏蓝贾超蒋村苏州市环境科学研究所江苏苏州215007 苏州科技大学环境工程学院江苏苏州215009

以苏州某化工场地污染土壤为菌源,以目标污染物为唯一碳源,通过连续培养、分离纯化筛选出高效酚类化合物降解菌。利用16S r DNA基因测序、构建基因树等分子生物学技术手段确定菌株种属,并研究了菌株对酚类化合物耐受性和降解效果。结果... 详细信息

以苏州某化工场地污染土壤为菌源,以目标污染物为唯一碳源,通过连续培养、分离纯化筛选出高效酚类化合物降解菌。利用16S r DNA基因测序、构建基因树等分子生物学技术手段确定菌株种属,并研究了菌株对酚类化合物耐受性和降解效果。结果表明:以4-甲基苯酚(4-MP)和4-氯-3-甲基苯酚(4-C-3-MP)为唯一碳源筛选出了2.菌,分别为嗜麦芽窄食单胞菌(NM)和香茅醇假单胞菌(NCM)。菌株NM对4-MP耐受性良好,4-MP浓度为400 mg/L时仍能生长繁殖;菌株NCM对4-C-3-MP耐受性较差,4-C-3-MP浓度≥2.0 mg/L时,菌株NCM受到完全抑制,停止生长。菌株NM不能降解土壤中苯酚,对4-MP和4-C-3-MP去除效果良好,第2.天时去除率分别达到43%和2.%;菌株NCM对土壤中苯酚、4-MP和4-C-3-MP均有降解效果,第2.天时苯酚、4-MP和4-C-3-MP去除率分别为2.%、2.%和2.%,较第15天时去除率分别提高了18、3和6个百分点。

关键词：土壤微生物修复酚类化合物高效降解菌

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散结镇痛胶囊对缩宫素诱导小鼠痛经的作用机制

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中成药 2021年第8期43卷 2030-2035页

作者：孙兰李家春刘莉娜皇立卫魏天杨王振中江苏食品药品职业技术学院江苏淮安223003 江苏财经职业技术学院江苏淮安223003 江苏康缘药业股份有限公司江苏连云港222001 中药制药过程新技术国家重点实验室江苏连云港222001

目的研究散结镇痛胶囊对缩宫素诱导小鼠痛经模型的镇痛机制。方法将60只ICR雌性小鼠按体质量随机分为正常组、模型组、阳性组(布洛芬缓释胶囊,0.10 g/kg),散结镇痛胶囊高、中、低剂量组(1.80、0.90、0.45 g/kg)组。采用注射苯甲酸雌二... 详细信息

目的研究散结镇痛胶囊对缩宫素诱导小鼠痛经模型的镇痛机制。方法将60只ICR雌性小鼠按体质量随机分为正常组、模型组、阳性组(布洛芬缓释胶囊,0.10 g/kg),散结镇痛胶囊高、中、低剂量组(1.80、0.90、0.45 g/kg)组。采用注射苯甲酸雌二醇和缩宫素复制小鼠痛经模型,注射激素的同时开始每天灌胃给药,连续7 d。末次灌胃1 h后,除正常组外,其余组各鼠腹部注射缩宫素2.IU,并记录30 min内小鼠扭体反应次数。小鼠取血后颈椎脱臼处死,分离子宫组织,检测血清中E2.NO水平及子宫组织PGF_(2.)(前列腺素F2.)、Ca^(2.)水平和P⁃MLC2.(磷酸化肌球蛋白轻链)、COX⁃2.环氧合酶⁃2.、ERα(雌激素受体)蛋白表达。结果与模型组比较,散结镇痛胶囊抑制缩宫素诱导的小鼠扭体反应(P2.平及升高NO水平(P2.)、Ca^(2.)水平升高(P2.、COX⁃2.白表达增加(P2.)、Ca^(2.)水平(P2.、COX⁃2.白表达(P2.)、Ca^(2.)水平(P2.白表达(P2.、COX⁃2.ERα蛋白表达,降低PGF_(2.)、Ca^(2.)、E2.平相关。

关键词：散结镇痛胶囊缩宫素痛经前列腺素F_(2.)

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