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Recovery of a patient with severe COVID-19 by acupuncture and Chinese herbal medicine adjuvant to standard care

Journal of Integrative Medicine 2021年第5期19卷 460-466页

作者： Xin Yin Shu-bin Cai lan-ting tao Lu-ming Chen Zhong-de Zhang Su-hong Xiao Arthur Yin Fan Xu Zou Department of Critical Care Medicine Second Clinical CollegeGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of General Medicine No.3 Division Second Clinical CollegeGuangzhou University of Chinese Medicine.Guangzhou 510120Guangdong ProvinceChina Department of Emergency Medicine Second Clinical CollegeGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Second Clinical College Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina SH Clinic for Acupuncture&Chinese Medicine Indianapolis.IN 46268USA TCM American Alumni Association(TCMAAA) IndianapolisIN 46268USA American TCM Association(ATCMA) ViennaVA 22182USA McLean Center for Complementary and Alternative Medicine PLCViennaVA 22182USA

There is currently no drug or therapy that can cure the coronavirus disease 2019(COVID-19), which is highly contagious and can be life-threatening in severe cases. Therefore, seeking potential effective therapies is an urgent task. An older female at the Leishenshan Hospital in Wuhan, China, with a severe case of COVID-19 with significant shortness of breath and decrease in peripheral oxygen saturation(SpO_(2)),was treated using manual acupuncture and Chinese herbal medicine granule formula Fuzheng Rescue Lung with Xuebijing Injection in addition to standard care. The patient’s breath rate, SpO_(2), heart rate,ratio of neutrophil/lymphocyte(NLR), ratio of monocyte/lymphocyte(MLR), C-reactive protein(CRP),and chest computed tomography were monitored. Acupuncture significantly improved the patient’s breathing function, increased SpO_(2), and decreased her heart rate. Chinese herbal medicine might make the effect of acupuncture more stable;the use of herbal medicine also seemed to accelerate the absorption of lung infection lesions when its dosage was increased. The combination of acupuncture and herbs decreased NLR from 14.14 to 5.83, MLR from 1.15 to 0.33 and CRP from 15.25 to 6.01 mg/L. These results indicate that acupuncture and Chinese herbal medicine, as adjuvants to standard care, might achieve better results in treating severe cases of COVID-19.

关键词： COVID-19 Severe case Case report Acupuncture Chinese herbal medicine Integrative therapy

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Case of professor Xu ZOU’s acupuncture technique for“benefiting kidney and strengthening anti-pathogenic qi”in promoting the absorption of COVID-19

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World Journal of Acupuncture-Moxibustion 2020年第3期30卷 167-170页

作者： lan-ting tao tao-liang HUANG Dan-wen ZHENG Xu ZOU Second Clinical School Guangzhou University of Chinese MedicineGuangzhou 510405China

A case of the absorption of corona virus disease 2019(COVID-19)promoted by professor Xu ZOU’s acupuncture technique for"benefiting kidney and strengthening anti-pathogenic qi"is introduced.A female patient suffered from COVID-19,64 years old,had been treated with acupuncture and Chinese herb granules for 10 days on the base of the oral administration of *** the re-examination,the chest CT image indicated that the absorption of COVID-19 was obvious as compared with before,the nucleic acid test of novel corona virus was negative and the patient narrated no obvious *** therapy plays its active adjuvant effect in the whole process of the treatment of COVID-19.

关键词： Benefiting kidney and strengthening anti-pathogenic qi Acupuncture Chinese herbal granules Corona virus disease 2019(COVID-19)

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Physarum polycephalum-inspired adaptive optimization design of artificial microtubular networks

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Science China Chemistry 2025年

作者： Si-Min Zeng Di-Wei Zheng ting Pan Xing-lan Ding Yun Zhang Chi-Hui Yang Si-Xue Cheng Xian-Zheng Zhang Key Laboratory of Biomedical Polymers of Ministry of Education&Department of Chemistry Wuhan University

Natural biological microtubular networks have undergone adaptive evolutionary selection and may offer viable solutions to design challenges in artificial microtubular networks. The plasmodium of the slime mold Physarum polycephalum(P. polycephalum) extends continuously to form a protoplasmic microtubular network structure, directly connecting food *** simulations revealed that the formation of this adaptive P. polycephalum microtubular network could be captured by a mathematical algorithm. Inspired by the P. polycephalum microtubular networks, we propose an adaptive optimization design method for artificial microtubular networks. Specifically, we utilized hydrogels with biodegradable and tissue-adhesive properties to replicate the P. polycephalum microtubular networks via photomask. In Rhodamine B diffusion and glucosecatalyzed reaction experiments, we found that the P. polycephalum microtubular networks exhibited significantly enhanced efficiency compared to vascular and artificial networks. Furthermore, we demonstrated the potential for uric acid(UA) degradation of the hydrogels with a real P. polycephalum microtubular network loaded with urate oxidase(UOx) in a rodent model of hyperuricemia. And this network achieved more than double the effect of the artificial network. This underscores the potential of natural microtubular networks to replace artificial microtubular networks.

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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng lan Zheng Wu Wen-Jia Chen Xin-Ning Yu Hua-tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

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Metastable seed-crystals: epitaxial growth of branched-array organic heterostructure nanowires

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Science China Chemistry 2025年

作者： Jin Feng Zhen-Yu Geng ting-Yao Song Ying-Xin Ma Chuan-Zeng Wang Wei Zhang Hong-tao Lin Jin Zhou Shu-Ping Zhuo Shu-Hai Chen Xue-Dong Wang School of Chemistry and Chemical Engineering Shandong University of Technology Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & DevicesSoochow University College of Chemistry and Chemical Engineering Hunan Normal University

Tunable light–matter interactions are exhibited by organic low-dimensional crystals, making these crystals a promising platform for organic photonics. However, the precise synthesis of organic low-dimensional crystals remains challenging due to the stochastic nature of molecular nucleation processes. Herein, the directed nucleation process is driven by the introduction of metastable seed-crystals as the trunk, which ultimately leads to branched-array organic heterostructures. The successful formation of organic heterostructures with high-density branched arrays is attributed to the highest attachment energy (Eatt（023）=-104.25 kcal mol-1) of the exposed （023） crystal plane during the seed-crystal growth route. Significantly, these as-prepared heterostructures inherently have an ultralow lattice mismatch ratio η of 0.7%between trunk and branch, which contributes to the multi-channel photon transportation. Therefore, this work provides valuable insights into a versatile synthetic strategy for accessing low-dimensional heterostructures for integrated optoelectronics.

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基于SSR标记的澜沧江流域大理茶群体遗传多样性研究

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农业生物技术学报 2025年第1期33卷 68-78页

作者：黄利超陈洪宇罗义菊陶燕蓝蓝增全西南林业大学园林园艺学院西南林业大学古茶树研究中心

大理茶(Camellia taliensis)是茶的重要野生近缘种，是茶资源的重要组成部分，研究大理茶群体的遗传多样性和亲缘关系，对科学保护和合理利用大理茶种质资源至关重要。本研究应用SSR标记技术对澜沧江流域5个州市共45份大理茶种和5份普洱... 详细信息

大理茶(Camellia taliensis)是茶的重要野生近缘种，是茶资源的重要组成部分，研究大理茶群体的遗传多样性和亲缘关系，对科学保护和合理利用大理茶种质资源至关重要。本研究应用SSR标记技术对澜沧江流域5个州市共45份大理茶种和5份普洱茶(C. sinensis var. assamica)种的种质资源进行遗传多样性和亲缘关系分析。结果显示，15对有效引物共检测到55个多态性位点，每对引物平均扩增3.67个位点；大理茶资源的平均期望杂合度(epected heterozygosity, He)为0.346；多态信息含量(polymorphism information content, PIC)变化范围是0.024～0.661，平均值为0.381；香农指数变化范围是0.067～1.321，平均值为0.669；多态性引物比例为60.0%，多态性引物占有效引物的比例为75.0%。聚类分析结果显示，澜沧江流域大理茶树种质分类与地理区域具有相关性，地理位置较远的大理茶树居群间的遗传距离较远，但居群内遗传距离较近。以上结果表明，澜沧江流域大理茶资源具有中等遗传多样性和中等丰富度。本研究为大理茶种质资源的保护开发及遗传图谱构建提供参考。

关键词：大理茶遗传多样性 SSR

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Lignin in Marine Environment and Its Analysis-A Review

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Journal of Ocean University of China 2012年第4期11卷 501-506页

作者： LI Xianguo ZHANG ting SUN Shuwen lan Haiqing YU tao Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100P.R.China

Lignin is a group of phenolic polymers which is abundant in the woody tissues of vascular plants,and is essentially absent from all other living *** has therefore been accepted as a tracer for terrestrial organic carbon(TOC) in marine environment since the *** polymers are not amenable to direct chemical analysis without prior *** review focused on the methods of chemical decomposition,extraction,derivatization and detection of lignin in marine *** described and compared several chemical decomposition methods,including nitrobenzene oxidation,alkaline cupric oxide(CuO) oxidation and thermochemolysis,and detection methods such as gas chromatography(GC),gas chromatography-mass spectrometry(GC-MS),high performance liquid chromatography(HPLC) and so *** improvement of lignin analysis and the application prospects of this tracer were also discussed.

关键词： lignin in marine environment decomposition extraction derivatization detection

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Fructus Zanthoxyli extract improves glycolipid metabolism disorder of type 2 diabetes mellitus via activation of AMPK/PI3K/Akt pathway:Network pharmacology and experimental validation

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Journal of Integrative Medicine 2022年第6期20卷 543-560页

作者： ting Zhang Qing Zhang Wei Zheng ting tao Ruo-lan Li Li-yu Wang Wei Peng Chun-jie Wu School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina

Objective:This study investigated the potential mechanisms behind the beneficial effects of Fructus Zanthoxyli(FZ)against type 2 diabetes mellitus(T2DM)based on network pharmacology and experimental ***:Ultra-high-performance liquid chromatography coupled with hybrid quadrupole-orbitrap high-resolution mass spectrometry,and gas chromatography-mass spectrometry were used to identify the constituents of ***,the differentially expressed genes linked to the treatment of diabetes with FZ were screened using online databases(including Gene Expression Omnibus database and Swiss Target Prediction online database),and the overlapping genes and their enrichment were analyzed by Kyoto Encyclopedia of Genes and Genomes(KEGG).Finally,the pathway was verified by in vitro experiments,and cell staining with oil red and Nile red showed that the extract of FZ had a therapeutic effect on ***:A total of 43 components were identified from FZ,and 39 differentially expressed overlapping genes were screened as the possible targets of FZ in *** dug component-target network indicated that PPARA,PPARG,PIK3R3,JAK2 and GPR88 might be the core genes targeted by FZ in the treatment of ***,the enrichment analysis of KEGG showed that effects of FZ against T2DM were closely correlated with the adenosine monophosphate-activated protein kinase(AMPK)and phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt)signaling *** vitro experiments further confirmed that FZ significantly inhibited palmitic acid-induced lipid formation in Hep G2 ***,FZ treatment was able to promote the AMPK and PI3K/Akt expressions in Hep G2 ***:Network pharmacology combined with experimental validation revealed that FZ extract can improve the glycolipid metabolism disorder of T2DM via activation of the AMPK/PI3K/Akt pathway.

关键词： Fructus Zanthoxyli Zanthoxylum bungeanum Maxim Type 2 diabetes mellitus Network pharmacology Glucose and lipid metabolism Phosphatidylinositol-3-kinase AMPK/PI3K/Akt

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宫颈癌筛查妇女高危型人乳头瘤病毒感染现状及影响因素研究:基于成都市45万人群

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中国全科医学 2025年第2期28卷 213-219页

作者：舒婷兰志鹏巫霞罗映娟杨柳电子科技大学医学院附属妇女儿童医院·成都市妇女儿童中心医院保健部四川省成都市611731

背景宫颈癌是女性常见恶性肿瘤之一,其病因明确,通过规范筛查可以有效降低宫颈癌发病率。人乳头瘤病毒(HPV)检测是WHO推荐的首选宫颈癌筛查方法,了解成都市高危型人乳头瘤病毒(hrHPV)感染状况,对优化成都市宫颈癌筛查方案具有重要意义... 详细信息

背景宫颈癌是女性常见恶性肿瘤之一,其病因明确,通过规范筛查可以有效降低宫颈癌发病率。人乳头瘤病毒(HPV)检测是WHO推荐的首选宫颈癌筛查方法,了解成都市高危型人乳头瘤病毒(hrHPV)感染状况,对优化成都市宫颈癌筛查方案具有重要意义。目的分析成都市35~64岁参加宫颈癌筛查人群的hrHPV感染现状和宫颈病变患者的hrHPV亚型感染分布情况,探讨hrHPV阳性检出率的相关影响因素。方法从“成都市育龄妇女生殖健康数据库”收集2023年参加成都市免费宫颈癌筛查的459433例个案数据,分析不同hrHPV基因型感染总体分布情况以及宫颈病变患者的hrHPV亚型感染分布情况,比较不同特征人群hrHPV感染情况,并构建多水平Logistic回归模型分析hrHPV检出阳性情况的相关因素。结果459433例中,hrHPV阳性检出率为11.65%(53509/459433),hrHPV感染随年龄的增长呈上升趋势(χ_(趋势)^(2)=1501.082,P<0.001)。82.39%(131/159)的宫颈癌患者感染HPV 16或18亚型,以单纯感染HPV 16亚型为主(52.20%,83/159)。多水平Logistic回归分析结果显示,年龄、文化程度、婚姻状况、绝经状态、避孕方式、妊娠次数、分娩次数为hrHPV阳性检出情况的影响因素(P<0.05)。结论成都市女性hrHPV阳性检出率略低于全国平均水平。在筛查过程中,要重视健康教育与随访工作,特别是对HPV 16或18亚型阳性者的后续随访工作。开展宫颈癌筛查宣传工作时应特别关注年长者、文化程度较低者、未婚或离异/丧偶者、已绝经者、未避孕或采用避孕套外的其他避孕方式者、妊娠或分娩2次以上者等重点人群,加强宫颈癌防治核心知识、生殖健康知识等的宣传,提高妇女健康素养。

关键词：宫颈癌乳头状瘤病毒感染高危型人乳头瘤病毒筛查影响因素分析

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Growth, Zeros and Fixed points of Differences of Meromorphic Solutions of Difference Equations

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Applied Mathematics(A Journal of Chinese Universities) 2020年第1期35卷 16-32页

作者： lan Shuang-ting CHEN Zong-xuan School of Mathematics and Systems Science Guangdong Polytechnic Normal UniversityGuangzhou 510665China School of Mathematical Sciences South China Normal UniversityGuangzhou 510631China

In this paper,we study the di erence equation a1(z)f(z+1)+a0(z)f(z)=0;where a1(z)and a0(z)are entire functions of nite *** some conditions,we obtain some properties,such as xed points,zeros etc.,of the di erences and ... 详细信息

关键词： Difference equation forward difference fixed point

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