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Unveiling quality of clinical trial in China:from concern to confirmation

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Cancer Communications 2024年第5期44卷 576-579页

作者： Huiyao Huang Yiru Hou Hong fang Ling Xu Yue Yu Huifang Zhang Jing Zhang Yu Tang Gongtao lan Wenbao Zhang Ning Li Clinical Trials Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjingJiangsuP.R.China Department of Quality Medicine Boehringer Ingelheim(China)Investment Co LtdShanghaiP.R.China Department of Clinical Development Quality Pfizer Research and Development(China)BeijingP.R.China Department of Drug Registration National Medical Products AdministrationBeijingP.R.China Bureau of Medical Administration National Health CommissionBeijingP.R.China

The cornerstone of scientifically valid and ethically sound clinical trials is in compliance with established global quality *** China has made significant progress over the past 20 years in terms of the clinical trial quantity[1],quality and participation in multiregional trials[2],there still remain concerns regarding the trial quality,which could be associated with the self-inspection initiative in 2015[3].

关键词： clinical corners confirmation

Characteristics of early gastric tumors with different differentiation and predictors of long-term outcomes after endoscopic submucosal dissection

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World Journal of Gastroenterology 2024年第14期30卷 1990-2005页

作者： Hong-Yi Zhu Jie Wu Yuan-Miao Zhang fang-lan Li Jin Yang Bin Qin Jiong Jiang Ning Zhu Meng-Yao Chen Bai-Cang Zou Department of Gastroenterology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Pathology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Gastroenterology Xianyang Hospital of Yan'an UniversityXianyang 712000Shaanxi ProvinceChina Department of Gastroenterology The First Hospital of Xi'anXi'an 710000Shaanxi ProvinceChina

BACKGROUND Gastric cancer is a common malignant tumor of the digestive tract,and endosco-pic submucosal dissection(ESD)is the preferred treatment for early-stage gastric *** analysis of the epidemiological characteristics of gastric mucosal tumors with different differentiation degrees and the influencing factors of long-term ESD efficacy may have certain significance for revealing the development of gastric cancer and *** To analyze the features of gastric mucosal tumors at different differentiation levels,and to explore the prognostic factors of *** We retrospectively studied 301 lesions in 285 patients at The Second Affiliated Hospital of Xi'an Jiaotong University from 2014 to 2021,according to the latest Japanese guidelines(sixth edition),and divided them into low-grade intrae-pithelial neoplasia(LGIN),high-grade intraepithelial neoplasia(HGIN),and computed tomography at 3,6 and 12 months after *** compared clinicopathologic characteristics,ESD efficacy,and complications with different degrees of differentiation,and analyzed the related factors associated with *** HGIN and differentiated carcinoma patients were significantly older compared with LGIN patients(P<0.001)and accounted for more 0-IIc(P<0.001),atrophic gastritis was common(P<0.001),and irregular microvascular patterns(IMVPs)and demarcation lines(DLs)were more obvious(P<0.001).There was more infiltration in the undifferentiated carcinoma tissue(P<0.001),more abnormal folds and poorer mucosal peristalsis(P<0.001),and more obvious IMVPs,irregular microsurface patterns and DLs(P<0.05)than in the LGIN and HGIN *** disease-free survival rates at 2,5,and 8 years after ESD were 95.0%,90.1%,and 86.9%,***-tiated lesions(HR 5.066),white moss(HR 7.187),incomplete resection(HR 3.658),and multiple primary cancers(HR 2.462)were significantly associated with poor *** Differentiations of gastric mucosal tumors have different epidemiological and

关键词： Gastric mucosal epithelial neoplasia Differentiated early gastric cancer Undifferentiated early gastric cancer Endoscopic submucosal dissection Long-term outcomes

Reinforced concrete-like Na_(3.5)V_(1.5)Mn_(0.5)(PO_(4))_(3)@graphene hybrids with hierarchical porosity as durable and high-rate sodium-ion battery cathode

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Chinese Chemical Letters 2024年第4期35卷 214-219页

作者： Tao Long Peng Chen Bin Feng Caili Yang Kairong Wang Yulei Wang Can Chen Yaping Wang Ruotong Li Meng Wu Minhuan lan Wei Kong Pang Jian-fang Wu Yuan-Li Ding College of Materials Science and Engineering Hunan UniversityChangsha 410082China Department of Physics Xiamen UniversityXiamen 361005China College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Institute for Superconducting&Electronic Materials Faculty of EngineeringUniversity of WollongongWollongongNSW 2522Australia

Realizing high-rate capability and high-efficiency utilization of polyanionic cathode materials is of great importance for practical sodium-ion batteries(SIBs) since they usually suffer from extremely low electronic conductivity and limited ionic diffusion kinetics. Herein, taking Na_(3.5)V_(1.5)Mn_(0.5)(PO_(4))_(3)(NVMP) as an example, a reinforced concrete-like hierarchical and porous hybrid(NVMP@C@3DPG) built from 3D graphene(“rebar”) frameworks and in situ generated carbon coated NVMP(“concrete”) has been developed by a facile polymer assisted self-assembly and subsequent solid-state method. Such hybrids deliver superior rate capability(73.9 m Ah/g up to 20 C) and excellent cycling stability in a wide temperature range with a high specific capacity of 88.4 m Ah/g after 5000 cycles at 15 C at room temperature, and a high capacity retention of 97.1% after 500 cycles at 1 C(-20 ℃), and maintaining a high reversible capacity of 110.3 m Ah/g in full cell. This work offers a facile and efficient strategy to develop advanced polyanionic cathodes with high-efficiency utilization and 3D electron/ion transport systems.

关键词： Sodium-ion battery Polyanionic cathode Hybrid structure Interconnected structure Energy storage

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基层卫生健康事业高质量发展内涵与路径分析

中国卫生政策研究 2024年第1期17卷 17-23页

作者：刘兰芳姚岚华中科技大学同济医学院医药卫生管理学院湖北武汉430030

目的:分析新发展格局下基层卫生健康事业高质量发展内涵与实现路径,期望充分发挥基层卫生在优质高效整合型医疗卫生服务体系构建过程中的网底优势。方法:基于Donabedian结构—过程—结果三维质量理论分析基层卫生健康事业高质量发展的... 详细信息

目的:分析新发展格局下基层卫生健康事业高质量发展内涵与实现路径,期望充分发挥基层卫生在优质高效整合型医疗卫生服务体系构建过程中的网底优势。方法:基于Donabedian结构—过程—结果三维质量理论分析基层卫生健康事业高质量发展的核心内涵与实现路径。结果:基层卫生健康事业高质量发展内涵包括整合协同式的资源结构、创新内涵式的服务过程、优质高效的结果产出三个方面。通过体系创新与发展、创新供给侧结构性改革促进供需双方的健康主体责任落实、建立以健康结果考核为激励导向的评价机制,助力基层卫生健康事业实现高质量发展。结论:基层卫生健康事业高质量发展需要多要素之间协同联动,重点关注供给与需求之间的协调与平衡,围绕健康目标,创新服务模式,延伸服务提供,实现基层卫生健康从治疗服务型向健康管理型转变,促进基层卫生健康事业形成生存与发展的良性循环。

关键词：基层卫生高质量发展内涵路径

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基于特征变换和度量网络的小样本学习算法

自动化学报 2024年第7期50卷 1305-1314页

作者：王多瑞杜杨董兰芳胡卫明李兵中国科学技术大学合肥230026 中国科学院自动化研究所模式识别国家重点实验室北京100190 阿里巴巴科技(北京)有限公司北京100016

在小样本分类任务中,每个类别可供训练的样本数量非常有限.因此在特征空间中同类样本分布稀疏,异类样本间边界模糊.提出一种新的基于特征变换和度量网络(Feature transformation and metric networks,FTMN)的小样本学习算法用于小样本... 详细信息

在小样本分类任务中,每个类别可供训练的样本数量非常有限.因此在特征空间中同类样本分布稀疏,异类样本间边界模糊.提出一种新的基于特征变换和度量网络(Feature transformation and metric networks,FTMN)的小样本学习算法用于小样本分类任务.算法通过嵌入函数将样本映射到特征空间,并计算输入该样本与所属类别中心的特征残差.构造一个特征变换函数对该残差进行学习,使特征空间内的样本特征经过该函数后向同类样本中心靠拢.利用变换后的样本特征更新类别中心,使各类别中心间的距离增大.算法进一步构造了一种新的度量函数,对样本特征中每个局部特征点的度量距离进行联合表达,该函数能够同时对样本特征间的夹角和欧氏距离进行优化.算法在小样本分类任务常用数据集上的优秀表现证明了算法的有效性和泛化性.

关键词：特征变换度量学习小样本学习残差学习

Porous framework materials for energy&environment relevant applications:A systematic review

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Green Energy & Environment 2024年第2期9卷 217-310页

作者： Yutao Liu Liyu Chen Lifeng Yang Tianhao lan Hui Wang Chenghong Hu Xue Han Qixing Liu Jianfa Chen Zeming Feng Xili Cui Qianrong fang Hailong Wang Libo Li Yingwei Li Huabin Xing Sihai Yang Dan Zhao Jinping Li College of Chemical Engineering and Technology Shanxi Key Laboratory of Gas Energy Efficient and Clean UtilizationTaiyuan University of TechnologyTaiyuan030024China School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou510640China Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China Department of Chemistry The University of ManchesterManchesterM139PLUK Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou311215China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin UniversityChangchun130012China Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials Department of ChemistryUniversity of Science and Technology BeijingBeijing100083China

Carbon peaking and carbon neutralization trigger a technical revolution in energy&environment related *** of new technologies for green energy production and storage,industrial energy saving and efficiency reinforcement,carbon capture,and pollutant gas treatment is in highly imperious *** emerging porous framework materials such as metal–organic frameworks(MOFs),covalent organic frameworks(COFs)and hydrogen-bonded organic frameworks(HOFs),owing to the permanent porosity,tremendous specific surface area,designable structure and customizable functionality,have shown great potential in major energy-consuming industrial processes,including sustainable energy gas catalytic conversion,energy-efficient industrial gas separation and ***,this manuscript presents a systematic review of porous framework materials for global and comprehensive energy&environment related applications,from a macroscopic and application perspective.

关键词： Porous framework materials Catalysis Separation Gas storage Carbon neutrality

Chir99021调控Wnt/β-catenin信号通路抑制大鼠牙髓干细胞成骨诱导分化的机制

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解剖学报 2024年第1期55卷 67-72页

作者：谢惠兰方芳林毅福建省立医院口腔科福建医科大学省立临床医学院福州350000

目的探讨Chir99021对大鼠牙髓干细胞(DPSCs)成骨诱导分化的影响及机制。方法原代分离大鼠DPSCs,利用荧光免疫法进行验证。设置不同浓度的Chir99021,通过CCK-8检测细胞增殖情况挑选最适浓度。利用茜素红染色验证细胞成骨诱导分化。最后通... 详细信息

目的探讨Chir99021对大鼠牙髓干细胞(DPSCs)成骨诱导分化的影响及机制。方法原代分离大鼠DPSCs,利用荧光免疫法进行验证。设置不同浓度的Chir99021,通过CCK-8检测细胞增殖情况挑选最适浓度。利用茜素红染色验证细胞成骨诱导分化。最后通过Real-time PCR、Western blotting检测成骨诱导分化相关基因与蛋白无翅型MMTV整合位点家族成员1(Wnt1)、无翅型MMTV整合位点家族成员3A(Wnt3a)、β-连环蛋白(β-catenin)、轴抑制蛋白2抗体(Axin2)、骨钙素(OCN)、牙本质基质蛋白1(DMP1)的mRNA和蛋白表达情况。结果牙本质涎磷蛋白(DSPP)和干细胞标记物波形蛋白(vimentin)阳性表达,说明大鼠DPSCs分离成功。大鼠DPSCs成骨诱导后钙沉积物显著上升,加入糖原合成酶激酶-3β(GSK-3β)的小分子抑制剂Chir99021后钙沉积物明显减少。大鼠DPSCs成骨诱导分化后Wnt1、Wnt3a、β-catenin、Axin2、OCN和DMP1表达明显上升,而加入Chir99021后Wnt1、Wnt3a、β-catenin、Axin2、OCN和DMP1蛋白表达均显著下降。结论Chir99021对诱导7 d后的大鼠DPSCs成骨诱导分化有一定的抑制作用。

关键词：牙髓干细胞成骨诱导分化 Chir99021 实时定量聚合酶链反应大鼠

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次边缘柱失效下RC框架连续倒塌响应研究

工程力学 2024年第10期41卷 12-23页

作者：邓小芳兰冬璆金浏杜修力北京工业大学城市减灾与防灾防护教育部重点实验室北京100124 桂林理工大学广西建筑新能源与节能重点实验室广西桂林541004

在次边缘柱失效工况下,关键子结构处于非对称的水平约束条件,比中柱失效面临更大的倒塌风险。为探究非对称边界条件对钢筋混凝土(RC)结构抗连续倒塌性能的影响,该文对3个次边缘柱失效的1/2缩尺RC梁柱子结构进行拟静力Pushdown试验,分析... 详细信息

在次边缘柱失效工况下,关键子结构处于非对称的水平约束条件,比中柱失效面临更大的倒塌风险。为探究非对称边界条件对钢筋混凝土(RC)结构抗连续倒塌性能的影响,该文对3个次边缘柱失效的1/2缩尺RC梁柱子结构进行拟静力Pushdown试验,分析了抗震设计/非抗震试件以及不同柱截面尺寸对承载能力、破坏模式和抗力机制演变的影响。结果表明:抗震设计配筋可以使梁的悬索机制得到充分发展,进而显著提高结构抗力;无论是否考虑抗震设计,子结构边节点均具有足够的抗剪切能力,其失效由梁端纵筋断裂控制。此外,基于有限元软件LS-DYNA分析了梁纵筋直径、柱截面尺寸和节点配箍率的影响。结果表明:增大梁纵筋直径可以显著提高结构抗力,但纵筋产生的更大的水平拉力会导致外侧边柱发生大偏心受压破坏;增加边柱尺寸对结构抗力提高不明显。

关键词：钢筋混凝土结构连续倒塌试验研究数值分析次边缘柱失效

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从敌人到战略伙伴:越美关系发展的原因与限度

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东南亚研究 2024年第2期 70-92,155,156页

作者：方晓王岚广东外语外贸大学广东国际战略研究院安徽大学马克思主义学院

2023年9月,越南与美国领导人在河内宣布建立全面战略伙伴关系,越美关系进入历史最好时期。为何越南与美国能从曾经的生死敌手演变为如今的战略伙伴?在越美关系的演变历程中,两国关系的发展受到多重因素的综合影响。首先,越美两国对解决... 详细信息

2023年9月,越南与美国领导人在河内宣布建立全面战略伙伴关系,越美关系进入历史最好时期。为何越南与美国能从曾经的生死敌手演变为如今的战略伙伴?在越美关系的演变历程中,两国关系的发展受到多重因素的综合影响。首先,越美两国对解决越战遗留问题的积极态度有助于消解双方对彼此负面的历史记忆,为两国关系改善提供了前提条件。其次,大国关系变化也催化了越美关系发展。冷战后期越南跟随苏联主动改善与美国关系,实现了关系正常化并开展初步合作。自2009年起,随着美国发起对华竞争并拉拢越南,越美关系进入战略合作阶段。最后,越南对美国的发展需求、安全需求与美国对越南的经济战略需求和安全战略需求相交织,共同推动了越美合作水平的不断提升。然而,越美战略合作进一步发展仍存在制约因素,包括两国意识形态分歧、美国可靠性不足及越南避免“选边站队”的政策倾向。对此,中国在大国竞争的变局下应未雨绸缪,通过理性审慎的对越政策,管控分歧、推进合作,妥善处理好中越关系。

关键词：越美关系亚太再平衡印太战略南海中美战略竞争中越关系